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Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates

Open Journal of Obstetrics and Gynecology 2016年第12期6卷 661-668页

作者： Dasom Chun eun hye yoo Ji Young Lee Hyun Mi Kim Mi Ju Kim Won Joon Seong Hyun-Hwa Cha Department of Obstetrics and Gynecology Kyungpook National University Hospital Kyungpook National University School of Medicine Daegu Korea

Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB) group (preterm labor with intact membranes and preterm premature rupture of membranes) or an indicated late preterm birth (iLPTB) group (hypertensive disorder in pregnancy, placental causes, and maternal diseases), according to the delivery indication. We then compared the maternal and neonatal characteristics and perinatal outcomes, including the Apgar score, admission to the neonatal intensive care unit (NICU) or special care nursery (SCN), duration of NICU stay, and the rate of composite morbidity (antibiotic use, hypoglycemia, hypocalcemia, hyperbilirubinemia requiring phototherapy, respiratory support, and respiratory distress syndrome). Results: A total of 198 neonates were in the sLPTB group and 91 were in the iLPTB group. In spite of greater gestational age at the time of delivery in the iLPTB group, the mean birth weight was lower than that in the sLPTB group. Additionally, the iLPTB group showed lower Apgar scores, and higher rates of NICU or SCN admission, respiratory support, and hypoglycemia, but there was no difference in the rate of composite morbidity between the two groups. Conclusion: iLPTB neonates had lower birth weights despite greater gestational age than those in the sLPTB group, but there was no difference in the rate of composite morbidity between the two groups.

关键词： Composite Morbidity Indicated Preterm Birth Late Preterm Birth Perinatal Outcomes Spontaneous Preterm Birth

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Insights into the pathogenesis of cystoid macular edema: leukostasis and related cytokines

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1202-1208页

作者： yoo-Ri Chung Young Ho Kim Seung Yeop Lee hye-eun Byeon Kihwang Lee Department of Ophthalmology Ajou University School of Medicine Suwon 16499 Korea Institute of Medical Science Ajou University School of Medicine Suwon 16499 Korea

Cystoid macular edema(CME) is the abnormal collection of intraretinal fluid in the macular region, especially in the inner nuclear and outer plexiform layers. CME leads to severe visual impairment in patients with various retinal diseases, such as diabetic retinopathy, retinal vascular occlusion, choroidal neovascularization, and uveitis. Although various retinal conditions lead to CME, a shared pathogenesis of CME is involved in these diseases. Accordingly, the pathogenesis of CME based on vasogenic mechanisms is first discussed in this review, including vascular hyperpermeability, leukostasis, and inflammation. We then describe cytotoxic mechanisms based on retinal Müller cell dysfunction. This comprehensive review will provide an understanding of the pathogenesis of CME for potential therapeutic strategies.

关键词： cystoid macular edema cytokine leukostasis pathogenesis

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The effectiveness of emotion-focused art therapy on the resilience and self-image of emergency physicians

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World Journal of Emergency Medicine 2022年第6期13卷 479-484页

作者： Soo Kyung Eo Chanwoong Kim Kyung hye Park eun Kyung Eo Graduate School of Art Therapy at CHA University Pocheon 11160Republic of Korea Department of Emergency Medicine Chung-Ang University College of MedicineSeoul 06974Republic of Korea Department of Medical Education Yonsei University Wonju College of MedicineWonju 26426Republic of Korea Department of Emergency Medicine Wonju Severance Christian HospitalWonju 26426Republic of Korea Department of Emergency Medicine Soonchunhyang University Bucheon HospitalBucheon 14584Republic of Korea

INTRODUCTION Resilience refers to the quality of being able to overcome adversity.[1]Studies conducted in the United States[2]and China[3]following the 2019 coronavirus disease(COVID-19)pandemic reported reduced resilience levels among medical *** resilience levels are associated with low burnout levels among residents.[4]Physician burnout affects patients’safety and quality of care.[5]In particular,emergency physicians(EPs)are more prone to exhaustion or poor resilience,as their turnover intention tends to be higher.[6]Therefore,improving EPs’resilience is imperative.

关键词： image physician overcome

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Recent aspects of ketogenic diet in neurological disorders

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Acta Epileptologica 2021年第1期3卷 134-140页

作者： hye eun Kwon Heung Dong Kim Department of Pediatrics International St.Mary’s HospitalCatholic Kwandong UniversityCollege of MedicineIncheonSouth Korea Division of Pediatric Neurology Severance Children’s HospitalYonsei University College of Medicine50 Yonsei-roSinchon-dongSeodaemun-guSeoulSouth Korea

The ketogenic diet(KD)is a high-fat,low-carbohydrate diet,in which fat is used as the primary energy source through the production of ketone bodies(KBs)in place of *** KD was formally introduced in 1921 to mimic the biochemical changes associated with fasting and gained recognition as a potent treatment for pediatric epilepsy in the *** clinical and basic scientific knowledge that supports the anti-seizure efficacy,safety,and feasibility of using the KD in patients with epilepsy is ***,the International Ketogenic Diet Study Group’s consensus guidelines provide practical information in 2009 and *** KD is a broad-spectrum therapy for drug resistant epilepsy and is gaining attention as a potential therapy for other neurological *** article will review recent aspects on the use of the KD,including its mechanisms of action,KD alternatives,expanding its use across different age groups and regions,its use as a treatment for other neurologic disorders,and future research subjects.

关键词： epilepsy disorders neurological

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Consecutive occurrence of benign epilepsy with centro-temporal spike and childhood absence epilepsy: true coexistence or atypical evolution?

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World Journal of Pediatrics 2018年第4期14卷 410-411页

作者： eun hye Lee Hoi Soo yoon Department of Pediatrics College of MedicineKyung Hee UniversitySeoulKorea

We read with great interest the recent review of benign epilepsy with centro-temporal spikes (BECTS) and child-hood absence epilepsy (CAE) by Verrotti et al. (1)BECTS and CAE are the most common epilepsy syndromes in childhood and share certain clinical features: similar age at onset, overall good prognosis, and genetic predispo-sition. Several studies have reported the coexistence of the two syndromes, and recently, Verrotti et al. analyzed 19 cases reported to have clinical features of CAE and BECTS. Among the total 19 cases, three cases had fea-tures of both syndromes contemporarily;three cases expe-rienced absence seizures initially followed by BECTS;and the other 13 cases experienced BECTS at onset and had absence seizures later.

关键词： Consecutive occurrence benign epilepsy centro-temporal spike childhood epilepsy true coexistence atypical evolution

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Transcriptome sequencing assisted discovery and computational analysis of novel SNPs associated with flowering in Raphanus sativus in-bred lines for marker-assisted backcross breeding

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Horticulture Research 2019年第1期6卷 248-259页

作者： Jinhee Kim Abinaya Manivannan Do-Sun Kim eun-Su Lee hye-eun Lee Vegetable Research Division National Institute of Horticultural and Herbal ScienceRural Development AdministrationJeonju 55365Republic of Korea

The sequencing of radish genome aids in the better understanding and tailoring of traits associated with economic *** order to accelerate the genomics assisted breeding and genetic selection,transcriptomes of 33 radish inbred lines with diverse traits were sequenced for the development of single nucleotide polymorphic(SNP)*** sequence reads ranged from 2,560,543,741 bp to 20,039,688,139 bp with the GC(%)of 47.80–49.34 and phred quality score(Q30)of 96.47–97.54%.A total of 4951 polymorphic SNPs were identified among the accessions after stringent filtering and 298 SNPs with efficient marker assisted backcross breeding(MAB)markers were generated from the polymorphic ***,functional annotations of SNPs revealed the effects and importance of the SNPs identified in the flowering *** SNPs were predominantly associated with the four major flowering related transcription factors such as MYB,MADS box(AG),AP2/EREB,and *** addition,SNPs in the vital flowering integrator gene(FT)and floral repressors(EMBRYONIC FLOWER 1,2,and FRIGIDA)were identified among the radish inbred ***,50 SNPs were randomly selected from 298 SNPs and validated using Kompetitive Allele Specific PCR genotyping system(KASP)in 102 radish inbred *** homozygosity of the inbred lines varied from 56 to 96%and the phylogenetic analysis resulted in the clustering of inbred lines into three *** together,the SNP markers identified in the present study can be utilized for the discrimination,seed purity test,and adjusting parental combinations for breeding in radish.

关键词： breeding Raphanus utilized

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Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor,SK-3530,in rats

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Acta Pharmacologica Sinica 2007年第8期28卷 1247-1253页

作者： hye-hyun yoo Nam-sun KIM Guang-jin Im Dong-hyun KIM Bioanalysis and Biotransformation Research Center Korea Institute of Science & Technology Seoul 136-791Korea Life Science RD Center SK ChemicalsGyeonggi-do 440-300Korea

Aim:To investigate the pharmacokinetic profile and tissue distribution of a novelphosphodiesterase type 5 inhibitor,5-ethyl-2-{5-[4-（2-hydroxy-ethyl）-piperazine-1-sulfonyl]-2-propoxy-phenyl}-7-propyl-3,5-dihydro-pyrrolo（3,2-d）pyrimidin-4-one（SK-3530）,in rats after administration of the14C-labeled ***:The pharmacokinetic parameters of SK-3530 were measured based on the totalradioactivity and parent SK-3530 concentration in rat plasma after intravenousand oral *** tissue distribution of total radioactivity after a singleoral administration of[14C]SK-3530 at a dose of 40 mg/kg was *** protein binding rates of SK-3530 were assessed by in vitro and ex ***:The total radioactivity profiles showed linear *** maximum plasma concentration and area under the curve of the parent SK3530were 10%-20% compared to those of the total *** the oral admin-istration of[14C]SK-3530,the radioactivity was widely distributed in all tissues,and the tissue/plasma ratio of the radioactivity 1 h after administration was calcu-lated as 0.5-2.6 with the exception of excretory organs.A relatively high penetra-tion was shown in the adrenal glands,liver,and *** vitro and ex vivo plasmaprotein binding assay by ultrafiltration showed a considerably high binding rateof more than 97%.Conclusion:SK-3530 was relatively well absorbed in the gas-trointestinal tract and showed linear pharmacokinetics over the investigated ***-3530 had low oral bioavailability due to a high,first-pass metabolism.

关键词： SK-3530 PDE5 inhibitor pharmacokinetics tissue distribution rats

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Evaluation of the safety of hair essence containing 0.05% purified bee venom on the skin and eyes of rabbits

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Journal of Traditional Chinese Medicine 2020年第1期40卷 67-72页

作者： Mi Kyung Lim eun hye Han Sang Ho Lee Jee Hee Kim R&D Center KoreaeundanGyeonggi-do 13207Republic of Korea

OBJECTIVE:To investigate the safety of hair essence containing 0.05%purified bee venom(HE-PBV)on the skin and eyes of New Zealand White ***:HE-PBV which contained 0.05%PBV,purified water,and glycerin,was used as the test *** skin-irritation test(SIT)and eye-irritation test(EIT)were conducted according to the Draize *** the SIT,HE-PBV(0.5 m L)dropped gauze was attached both intact and abraded skin for 24 *** other side of the skin was used as *** 24 and 72 h,the treatment site was observed and scored according to evaluation criteria for skin *** the EIT,the rabbits were divided into two groups:eye-washed(three rabbits)and non-eye-washed(six rabbits).HE-PBV(0.1 m L)was squirted into the right eye of *** left eye was untreated and used as a ***,20-30-s later,the eyes of rabbits in the eye-washed group were washed with^50 m L of physiologic(0.9%)salt ***,1,2,3,4 and 7 d after the start of the EIT,the eyes and behavior of the rabbits were *** degree of eye irritation elicited by HE-PBV was determined in three steps and then the criteria of the classification of eye-irritation ***:The SIT revealed erythema and edema at the site of HE-PBV *** 72 h,the body weight of rabbits was reduced slightly,but other symptoms(except erythema and edema)were not *** Primary Irritation Index score was0.6,and HE-PBV was deemed to be a slight *** EIT did not show mortality or body-weight fluctuation,but hyperemic conjunctiva and eyelid closure were noted after HE-PBV *** for these results,the score for the ophthalmic response on days 1,2,3,4 and 7 was 0,and HE-PBV was deemed to be a ***:These data suggest that HE-PBV did not elicit eye irritation,but was a slight irritant to the skin of rabbits;the latter slight would have been due to the excipients used in manufacture of the hair essence because PBV has been shown to be safe.

关键词： Alopecia Bee Venoms Hair essence Skin irritancy tests Eye irritancy tests Complementary therapies

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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： eun Joo Lee Miyoung Choi Sang Bong Ahn Jeong-Ju yoo Seong Hee Kang Yuri Cho Do Seon Song Hong Koh Dae Won Jeon hye Won Lee Department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical Evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal Medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheonKorea Department of Internal Medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea Department of Internal Medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal Medicine Hanyang University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence

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Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-lnduced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 670-676页

作者： Ki Sun Kwon Hyun Lim Yong Soo Kwon Myong Jo Kim Ji hye yoo Nam Ho yoo Hyun Pyo Kim College of Pharmacy Kangwon National UniversityChuncheon(24341)Republic of Korea Department of Bio-Resource Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Bioherb Research Institute Kangwon National UniversityChuncheon(24341)Republic of Korea

Objective:To study the anti-inflammatory action and cellular mechanism of Oplopanax ***:A hot water extract of OE(WOE)was prepared and a major constituent,syringin,was successfully *** content in WOE was found to be 214.0 p.g/g dried plant(w/w).Their anti-inflammatory activities were examined using RAW 264.7 macrophages and a mouse model of croton oil-induced ear ***:In lipopolysaccharide(LPS)-treated RAW 264.7 cells,a mouse macrophage cell line,WOE was found to significantly and strongly inhibit cyclooxygenase-2(COX-2)-induced prostaglandin E2(PGE2)production[half maximal inhibitory concentration(IC50)=135.2μg/mL]and inducible nitric oxide synthase(iNOS)-induced NO production(IC50=242.9μg/mL).In the same condition,WOE was revealed to inhibit NO production by downregulating iNOS expression,mainly by interrupting mitogen activated protein kinases(MAPKs)/activator protein-1(AP-1)*** activation of all three major MAPKs,p38 MAPK,extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase,was inhibited by WOE(50-300μg/mL).On the other hand,WOE reduced PGE2 production by inhibiting COX-2 enzyme activity,but did not affect COX-2 expression *** addition,WOE inhibited the production of proinflammatory cytokines such as interleukin-6 and tumor necrosis factor-α.In croton oil-induced ear edema in mice,oral administration of WOE(50-300 mg/kg)dose-dependently inhibited edematic ***:Water extract of OE exhibited multiple anti-inflammatory action mechanisms and may have potential for treating inflammatory disorders.

关键词： Oplopanax elatus Chinese medicine stem syringin anti-inflammation RAW 264.7

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