检索结果-南通市图书馆

Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity

The Journal of Biomedical Research 2017年第6期31卷 503-511页

作者： Jieun choi eun Suk An Young-Hwan Ban Da Woom Seo Tae-Su Kim Sung-Pyo Lee You Lin Ehn-Kyoung choi Yun-Bae Kim College of Veterinary Medicine and Veterinary Medical Center Chungbuk National UniversityCheongffuChungbukRepublic of Korea Anydoctor Healthcare Co. Ltd.CheonanChungnamRepublic of Korea Hotan Dichen Medicine Biotechnology Co.Ltd Hotan Xinjiang China

Particulate matters（PM） are one of the major body burdens leading to diseases. We investigated the capacities of a hydrogen-enriched water（HW） eliminating carbon nanoparticles（CNP） and carbon microparticles（CMP） from the lungs and blood, respectively. In CNP-elimination test, rats were orally administered with purified water（PW） or HW（10 or 30 mL/kg/day） for 10 weeks. At the time point of 4 weeks, the rats were challenged with intratracheal instillation of CNP（4 mg）. CNP accumulated in the airways and alveoli, and induced inflammatory lesions. Such pneumoconiosis was markedly improved by feeding HW, while PW was ineffective. CNP-induced pneumoconiosis caused systemic hematological alterations, decreasing major inflammatory cells, but markedly increasing eosinophils,indicative of an allergic reaction, which were attenuated by treatment with HW. Such PM-eliminating and antiallergic effects of HW reduced body burden as confirmed from the facilitated recovery of body and lung weights. In CMP-clearance test, mice were orally administered with PW or HW for 7 days, and intravenously injected with CMP（300 mg/kg）. CMP was rapidly eliminated from the blood in HW-fed mice. Indeed, the phagocytic indices increased to 3.5 and 6.7 folds at 10 and 30 mL/kg of HW, in comparison with a negligible effect of PW. As a mechanism study,only HW significantly inhibited lipid peroxidation in vitro Fenton reaction-mediated ·OH-generating ***, the results indicate that HW not only effectively eliminated PM from the lungs and blood by enhancing phagocytic activity, but also attenuated the lung injuries by inhibiting lipid peroxidation.

关键词： particulate matter pneumoconiosis hydrogen-enriched water particle clearance antioxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phase separations in graded-indium content InGaN/GaN multiple quantum wells and its function to high quantum efficiency

引用

Journal of Semiconductors 2012年第5期33卷 13-16页

作者：郭洪英孙元平 Yong-Hoon Cho eun-Kyung Suh Hai-Joon Lee Rak-Jun choi Yoon-Bong Hahn Institute of Science and Technology for Opto-Electronic Information Yantai University Department of Physics Korea Advanced Institute of Science and Technology School of Semiconductor and Chemical Engineering Semiconductor Physics Research CenterChonbuk National University School of Chemical Engineering Chonbuk National University

Phase separations have been studied for graded-indium content In_xGa_（1-x）N/GaN multiple quantum wells（MQWs） with different indium contents by means of photoluminescence（PL）,cathodeluminescence（CL） and time-resolved PL（TRPL） *** the main emission peaks,all samples show another 2 peaks at the high and low energy parts of the main peaks in PL when excited at 10 *** images show a clear contrast for 3 samples,which indicates an increasing phase separation with increasing indium *** spectra at 15 K of the main emissions show an increasing delay of rising time with indium content,which means a carrier transferring from low indium content structures to high indium content structures.

关键词： carrier transfer phase separation graded-indium content multiple quantum wells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A critical regulation of Th2 cell responses by RORa in allergic asthma

引用

Science China(Life Sciences) 2021年第8期64卷 1326-1335页

作者： Jeong-eun Lee Garam Cho Minkyoung Cho Daehong Kim Mi-Ock Lee Yeonseok Chung Laboratory of Immune Regulation Research Institute of Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul 08826Republic of Korea BK21 Plus Program College of PharmacySeoul National UniversitySeoul 08826Republic of Korea

Allergic asthma is a chronic inflammatory disease of the lung and the airway,which is characterized by aberrant type 2 immune responses to otherwise unharmful *** the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented,the regulation and plasticity of Th2 cells remain incompletely *** using an animal model of allergic asthma in IL-4-reporter mice,we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes,and that treatment with an RORa agonist SRI 078 resulted in diminished Th2 cell responses in *** determine the T cell-intrinsic role of RORa in allergic asthma in vivo,we established T cell-specific RORa-deficient^(f/f)fyf(Cd4creRora^(f/f))*** intranasal allergen challenges,Cd4creRora^(f/f)mice exhibited a significantly increased Th2 cells in the lungs and the airway and showed an enhanced eosinophilic inflammation compared to littermate control *** with Foxp3^(YFP-cre)Rora^(f/f)mice and CD^(8+)T cell depletion showed that the increased Th2 cell responses in the Cd4creRora^(f/f)mice were independent of Treg cells and CD^(8+)T *** findings demonstrate a critical regulatory role of RORa in Th2 cells,which suggest that RORa agonists could be effective for the treatment of allergic diseases.

关键词： Th2 allergic critical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?

引用

Asian Journal of Pharmaceutical Sciences 2019年第5期14卷 465-479页

作者： Shrawani Lamichhane Santosh Bashyal Taekwang Keum Gyubin Noh Jo eun Seo Rakesh Bastola Jaewoong choi Dong Hwan Sohn Sangkil Lee College of Pharmacy Keimyung University

3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and the technology has found widespread industrial applications for production from automotive parts to machine tools,its application in pharmaceutical area is still limited. However,the potential of 3 D printing in the pharmaceutical industry is now being recognized. The ability of 3 D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes,sizes and textures that are difficult to produce using traditional techniques. However,there are various challenges associated with the proper application of3 D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review,an overview is provided on the various 3 D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations.

关键词： Three-dimensional printing Personalized medicine Fused deposition modeling Inkjet printing Complex formulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization

引用

International Journal of Ophthalmology(English edition) 2016年第11期9卷 1541-1548页

作者： Jin Woo Kwon Jin A choi eun Young Shin Tae Yoon La Dong Hyun Jee Yeon Woong Chung Yang Kyung Cho Department of Ophthalmology St.Vincent's HospitalCollege of Medicinethe Catholic University of Korea Research Institute of Medical Science St.Vincent's Hospitalthe Catholic University of Korea

AIM： To evaluate whether trapping vascular endothelial growth factor-A（VEGF-A） would suppress angiogenesis and inflammation in dry eye corneas in a murine corneal suture ***： We established two groups of animals, one with non-dry eyes and the other with induced dry *** both groups, a corneal suture model was used to induce inflammation and neovascularization. Each of two groups was again divided into three subgroups according to the treatment; subgroup I（aflibercept）,subgroup II（dexamethasone） and subgroup III（phosphate buffered saline, PBS）. Corneas were harvested and immunohistochemical staining was performed to compare the extents of neovascularization and CD11b＋ cell infiltration. Real-time polymerase chain reaction was performed to quantify the expression of inflammatory cytokines and VEGF-A in the ***： Trapping VEGF-A with aflibercept resulted in significantly decreased angiogenesis and inflammation compared with the dexamethasone and PBS treatments in the dry eye corneas（all P 〈0.05）, but with no such effects in non-dry eyes. The anti-inflammatory and antiangiogenic effects of VEGF-A trapping were stronger than those of dexamethasone in both dry eye and non-dry eye corneas（all P 〈0.05）. The levels of RNA expression of VEGF-A, TNF-alpha, and IL-6 in the aflibercept subgroup were significantly decreasedcompared with those in the PBS subgroup in the dry eye ***： Compared with non-dry eye corneas,dry eye corneas have greater amounts of inflammation and neovascularization and also have a more robust response to anti-inflammatory and anti-angiogenic agents after ocular surface surgery. Trapping VEGF-A is effective in decreasing both angiogenesis and inflammation in dry eye corneas after ocular surface surgery.

关键词： dry eye aflibercept neovascularization inflammation dexamethasone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Increased type III interferons and NK cell functions in SARS-CoV-2-infected children

引用

Signal Transduction and Targeted Therapy 2023年第3期8卷 888-890页

作者： Seong Dong Jeong Hoyoung Lee Ju Young Chang Seong Yong Lee Ji eun choi eunmi Yang Hye Won Jeong Jae-Phil choi Mi Seon Han Eui-Cheol Shin The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)Daejeon 34126Republic of Korea Department of Pediatrics Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University of College of MedicineSeoul 07061Republic of Korea Division of infectious diseases Seoul Medical CenterSeoul 02053Republic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Republic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is more likely to progress to severe disease in the elderly,and the rates of hospitalization for coronavirus disease 2019(COVID-19)increase with age.1,2 Herein,we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2.

关键词： infected acute respiratory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polymorphic ventricular tachycardia during phase Ⅱ cardiac rehabilitation in a patient with heart failure: a case report

引用

Journal of Geriatric Cardiology 2020年第1期17卷 64-66页

作者： Hee-eun choi Chul Kim Se-Heum Park Doo-Il Kim Ki-Hun Kim Dong-Kie Kim Seunghwan Kim Jino Park Department of Rehabilitation Medicine Inje University College of MedicineHaeundae Paik HospitalBusanSouth Korea Department of Rehabilitation Medicine Inje University College of MedicineSanggye Paik HospitalSeoulSouth Korea Department of Internal Medicine Inje University College of MedicineHaeundae Paik HospitalBusanSouth Korea

A 67-year-old man with a history of a prior cardiac arrest with ventricular fibrillation(VF)due to myocardial infarction underwent phase I(inpatient)and II(outpatient)cardiac rehabilitation(CR)exercise *** the 33th CR session,15 min after the start of exercise training,the patient had syncope with evidence of a polymorphic and wide QRS complex tachycardia on electrocardiogram(ECG)*** initiation of a polymorphic ventricular tachycardia was evidenced by the coupled premature ventricular complex observed in the ECG monitoring screen(Figure 1).

关键词： Cardiac rehabilitation Heart failure Ventricular tachycardia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identifying Driver Genes Mutations with Clinical Significance in Thyroid Cancer

引用

Computers, Materials & Continua 2021年第4期67卷 1241-1251页

作者： Hyeong Won Yu Muhammad Afzal Maqbool Hussain Hyungju Kwon Young Joo Park June Young choi Kyu eun Lee Department of Surgery Seoul National University Bundang HospitalSeongnam-siKorea Department of Software Sejong UniversitySeoulKorea Department of Surgery College of MedicineEwha Womans UniversitySeoulKorea Department of Internal Medicine Seoul National University Hospital and College of MedicineSeoulKorea Department of Surgery Seoul National University Hospital and College of MedicineSeoulKorea

Advances in technology are enabling gene mutations in papillary thyroid carcinoma(PTC)to be analyzed and clinical outcomes,such as recurrence,to be *** date,the most common genetic mutation in PTC is in BRAF kinase(BRAF).However,whether mutations in other genes coincide with those in BRAF remains to be *** aim of this study was to find mutations in other genes that co-exist with mutated BRAF,and to analyze their frequency and clinical relevance in *** and genetic data were collected from 213 PTC patients with a total of 36,572 mutation sites in 735 *** matching with genes from PTC entries in a global database(NCBI Gene),69 genes with mutations in coding regions were chosen for further *** frequency-based analysis,we identified commonly mutated genes co-existing with mutated BRAF and,using the mutation count correlation matrix(MCCM)method,analyzed their incidence according to age and *** designed Chord diagrams to reveal gene relationships concerning age and gender,and found that mutations in ALK,ATM,COL1A1,MSTIR,PRKCA,and WNK1 most commonly coincide with mutated BRAF,followed by APC,AURKA,and *** findings provide further insight into the genetic profile of PTC.

关键词： Medical informatics papillary thyroid carcinoma cancer gene mutation analysis BRAF clinical significance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of multidetector computed tomography in patients with acute infectious colitis

引用

World Journal of Clinical Cases 2022年第12期10卷 3686-3697页

作者： Seung Jung Yu Jae Hyuk Heo eun Jeong choi Jong Hyuk Kim Hong Sub Lee Sun Young Kim Jae Hoon Lim Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Radiology Myongji HospitalHanyang University College of MedicineGoyang 10475South Korea Department of Cancer Control and Population Health National Cancer CenterGoyang 10408South Korea

BACKGROUND The role of multidetector computed tomography(MDCT)in patients with acute infectious colitis is still *** To examine the usefulness of MDCT in distinguishing the etiology of acute infectious *** Overall,244 patients who met the criteria for acute infectious colitis and visited the Hospital from February 2015 to 2018 were retrospectively enrolled and divided into two groups(bacterial:204,viral:40)according to causes of acute colitis,based on stool *** MDCT parameters,including wall thickening,submucosal edema,mucosal enhancement,serosa involvement,empty colon sign,small bowel involvement,comb sign,continuous distribution,accordion sign,mucosal thickening,and lymph node enlargement,were constructed in a blinded *** MDCT parameters of wall thickening(OR:13.60;95%CI:5.80–31.88;P<0.001),submucosal edema(OR:36.08;95%CI:13.54–96.13;P<0.001),mucosal enhancement(OR:22.55;95%CI:9.28–54.81;P<0.001),serosal involvement(OR:14.50;95%CI:3.33–63.23;P<0.001),empty colon sign(OR:6.68;95%CI: 2.44–18.32;P < 0.001), continuous distribution (OR: 24.09;95%CI: 9.38–61.90;P < 0.001), accordionsign (OR: 9.02;95%CI: 1.12–72.35;P = 0.038), mucosal thickening (OR: 46.41;95%CI: 10.38–207.51;P< 0.001), and lymph node enlargement (OR: 4.39;95%CI: 1.22–15.72;P = 0.023) were significantlyassociated with bacterial colitis. At least one positive finding in four CT outcomes (submucosaledema, mucosal enhancement, continuous distribution, mucosal thickening) in summer showed ahigh probability of bacterial colitis (sensitivity, 41.67;specificity, 92.50;OR: 24.95).CONCLUSIONMDCT provides many clues that can be useful in suggesting a specific etiology of acute infectiouscolitis.

关键词： Colitis Multidetector computed tomography Differential diagnosis Bacterial infections Viral infections

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathological findings following radical prostatectomy in patients who are candidates for active surveillance： impact of varying PSA levels

引用

Asian Journal of Andrology 2011年第6期13卷 838-841页

作者： Dong Il Kang Thomas L. Jang Jeongyun Jeong eun Young choi Kelly Johnson Dong Hyeon Lee Wun-Jae Kim Isaac Yi Kim Section of Urologic Oncology and Dean and Betty Gallo Prostate Cancer The Cancer Institute of New Jersey Robert Wood Johnson Medical School New Brunswick NJ 08903 USA Department of Urology Inje University Medical School Busan 614-735 Korea Department of Urology Ewha Womans University Seoul 158-710 Korea Department of Urology Chungbuk National University College of Medicine Cheongju 361-711 Korea

Active surveillance is an acceptable treatment option in men with a low-risk prostate cancer. In the present study, we have retrospectively reviewed the outcomes of 509 men who fit the criteria for active surveillance but selected radical prostatectomy. Then, the impact of varying prostate-specific antigen （PSA） levels on the risk of upstaging and upgrading in these patients was assessed. Pathological characteristics of patients who fulfilled the inclusion criteria under three active surveillance criteria--those of the University of California-San Francisco, the National Cancer Institute and the European Association of Urology--were examined. The proportion of men who were deemed candidates for active surveillance but were subsequently upstaged or upgraded was determined. Of 509 patients, 186 （36.5%）, 132 （25.9%） and 88 （17.3%） men fulfilled the active surveillance criteria, respectively. Upgrading （Gleason scores 7-10） ranged from 32.8% to 38.6%, while upstaging （≥ pT3） ranged from 10.2% to 12.5%, depending on the three active surveillance criteria. After a median follow-up of 24 months, three patients developed a biochemical recurrence. When the impact of varying PSA levels was examined using a test for trend analysis in the context of PSA for each protocol, rates of upstaging were lower in men with PSA 〈4 ng m1-1. However, there was no impact of varying PSA levels on upgrading. In conclusion, commonly used active surveillance protocols carry the risks of upgrading and upstaging. More reliable and accurate markers are needed to better stratify the risks of men who are appropriate candidates for active surveillance.

关键词： prostatectomy prostate-specific antigen prostatic neoplasm risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：