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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo Jung haesong lee eun-Ae Shin Yangie Pinanga Kyung-hee Pyo eun hae lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Power Law Exponents for Vertical Velocity Distributions in Natural Rivers

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Engineering（科研） 2013年第12期5卷 933-942页

作者： hae-eun lee Chanjoo lee Youg-Jeon Kim Ji-Sung Kim Won Kim Department of Computational Science and Engineering Yonsei University Seoul South Korea Water Resources Research Department Korea Institute of Construction Technology Goyang South Korea

While log law is an equation theoretically derived for near-bed region, in most cases, power law has been researched by experimental methods. Thus, many consider it as an empirical equation and fixed power law exponents such as 1/6 and 1/7 are generally applied. However, exponent of power law is an index representing bed resistance related with relative roughness and furthermore influences the shapes of vertical velocity distribution. The purpose of this study is to investigate characteristics of vertical velocity distribution of the natural rivers by testing and optimizing previous methods used for determination of power law exponent with vertical velocity distribution data collected with ADCPs during the years of 2005 to 2009 from rivers in South Korea. Roughness coefficient has been calculated from the equation of Limerinos. And using theoretical and empirical formulae, and representing relationships between bed resistance and power law exponent, it has been evaluated whether the exponents suggested by these equations appropriately reproduce vertical velocity distribution of actual rivers. As a result, it has been confirmed that there is an increasing trend of power law exponent as bed resistance increases. Therefore, in order to correctly predict vertical velocity distribution in the natural rivers, it is necessary to use an exponent that reflects flow conditions at the field.

关键词： Vertical Velocity Distribution Power Law Exponent Natural Rivers Field Measurement Flow Resistance

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Effect of silicon carbide-based iron catalyst on reactor optimization for non-oxidative direct conversion of methane

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Journal of Energy Chemistry 2023年第6期81卷 519-532,I0012页

作者： eun-hae Sim Sung Woo lee Jin Ju lee Seung Ju Han Jung Ho Shin Gracia lee Sungrok Ko Kwan-Young lee Yong Tae Kim C1 Gas&Carbon Convergent Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Department of Chemical and Biological Engineering Korea University145 Anam-roSeoul 02841Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeoul 03722Republic of Korea Chemical Data-Driven Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Prospective Tech.Exploring Section Basic Chemical R&D centerLottechemical Corp.Daejeon 34059Republic of Korea Department of Advanced Materials and Chemical Engineering University of Science and Technology(UST)Gajeong-dongYuseongDaejeon 34113Republic of Korea

The conversion of methane to olefins,aromatics,and hydrogen(MTOAH)can be used to stably obtain hydrocarbons when the effect of the catalytic surface is optimized from the reaction engineering *** this study,Fe/Si C catalysts were packed into a quartz tube *** catalytic surfaces of Si C and the impregnated Fe species decreased the apparent activation energies(E_a)of methane consumption in the blank reactor between 965 and 1020℃.Consequently,the hydrocarbon yield increased by 2.4times at 1020℃.Based on the model reactions of ethane,ethylene,and acetylene mixed with hydrogen in the range of 500-1020℃,an excess amount of Fe in the reactor favored the C-C coupling reaction over the selective hydrogenation of acetylene;consequently,coke formation was favored over the hydrogenation *** gas-phase reactions and catalyst properties were optimized to increase hydrocarbon yields while reducing coke *** 0.2Fe catalyst-packed reactor(0.26 wt%Fe)resulted in a hydrocarbon yield of 7.1%and a coke selectivity of<2%when the ratio of the void space of the postcatalyst zone to the catalyst space was adjusted to be≥*** on these findings,the facile approach of decoupling the reaction zone between the catalyst surface and the gas-phase reaction can provide insights into catalytic reactor design,thereby facilitating the scale-up from the laboratory to the commercial scale.

关键词： Non-oxidative methane conversion Ethylene Aromatic Methane pyrolysis Fe/SiC Coke resistance Catalytic reactor

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Prevalence of focal lamina cribrosa defects in eyes with pachychoroid disease spectrum

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 77-82页

作者： hae Min Kang Na eun lee Jeong Hoon Choi Hyoung Jun Koh Sung Chul lee Harvard School of Public Health BostonMA 02115USA Catholic Kwandong University Incheon 22711Republic of Korea Gongdoek Seoul Eye Clinic Seoul 04214Republic of Korea Choikang Seoul Eye Clinic Seoul 01110Republic of Korea Institute of Vision Research Department of OphthalmologyYonsei University College of MedicineSeoul 03722Republic of Korea Konyang University Hospital Daejeon 35365Republic of Korea

AIM:To determine the prevalence of focal lamina cribrosa(LC)defect among patients with pachychoroid disease spectrum(PDS)in the absence of peripapillary ***:This retrospective,cross-sectional study comprised of 180 patients with PDS,including polypoidal choroidal vasculopathy(PCV),central serous chorioretinopathy,and pachychoroidal *** records and optic ner ve head evaluations conducted using spectral-domain optical coherence tomography with enhanced depth imaging were *** a control group,236 patients who underwent ophthalmologic evaluation for vitreous floaters,without obvious ocular disease,were also ***:The mean age of the PDS group,which included 118 male patients(65.6%),was 57.4±11.1 *** was no significant difference between the two groups in age(P=0.710)or sex(P=0.248).Six patients(3.3%)in the PDS group and none in the control group showed focal LC defect(P=0.318).Among the six patients with focal LC defect in the PDS group,four eyes had PCV,one eye was the fellow eye of a PCV eye,and one eye had pachychoroidal ***:Focal LC defect can be defected in patients with PDS in the absence of peripapillar y ***,the prevalence of focal LC defect was not different significantly between PDS patients and those who did not have PDS.

关键词： central serous chorioretinopathy lamina cribrosa pachychoroid polypoidal choroidal vasculopathy

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The Effect of Sleep and Cognition Enhancement Multimodal Intervention for Mild Cognitive Impairment with Sleep Disturbance in the Community-Dwelling Elderly

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International Journal of Mental Health Promotion 2023年第11期25卷 1197-1208页

作者： eun Kyoung Han hae Kyoung Son Department of Nursing Eulji UniversitySeongnam13135South Korea

Dementia prevalence has soared due to population aging. In Mild Cognitive Impairment (MCI) as a pre-dementia stage, sleepdisturbances have raised much interest as a factor in a bidirectional relationship with cognitive decline. Thus, this studydeveloped the Sleep and Cognition Enhancement Multimodal Intervention (SCEMI) based on Lazarus’ multimodal approachand conducted a randomized controlled experiment to investigate the effects of the novel program on sleep and cognition inMCI elderly. The participants were 55 MCI elderly with sleep disturbances at two dementia care centers located in S-city,Gyeonggi-do, South Korea (n = 25 in the experimental group and n = 30 in the control group). The study period was fromNovember 01 to December 27, 2022. The experimental group received 8 sessions of SCEMI, 60 min per session once a *** control group received general education and guidance using a simplified booklet on the sleep and cognitive *** data collection, a self-reported questionnaire was used to investigate sleep quality, presleep arousal, cognitive function,stress, and depression. The results showed that, compared to the control group, the experimental group had significantlyimproved across all variables: sleep quality (U = 109.50, p leep arousal (U = 11.50, p leep and cognition in community-dwelling MCI elderly with sleep disturbances.

关键词： Depression elderly mild cognitive impairment sleep disturbance stress

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Inoculation of Chlorella and Food Waste Improves the Physio-Morphological Features of Red Pepper by Regulating Activating Antioxidant Defense System

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Phyton-International Journal of Experimental Botany 2023年第9期92卷 2699-2711页

作者： Sang-Mo Kang Shifa Shaffique Muhammad Imran Su-Mi Jeon Shabir Hussain Wani Muhammad Aaqil Khan Peter Odongkara eun-hae Kwon Yosep Kang Joon-Ik Son Won-Chan Kim In-Jung lee Department of Applied Biosciences Kyungpook National UniversityDaegu41566Korea Biosafety Division National Institute of Agriculture ScienceRural Development AdministrationJeonju54874Korea Department of Technical Support Daegu City Agricultural Technology CenterDaegu41159Korea Department of Chemical and Life Sciences Qurtuba University of Science and Information TechnologyPeshawarPakistan Mountain Research for Field Crops Khudwani Shere-e-Kashmir University of Agriculture Sciences and Technology SrinagarJamu and KashmirIndia Corporate Affiliated Research Institute Seyen Co.Ltd.Kyungsan38561Korea

Food waste is recognized as a valuable source for potential agricultural applications to supply organic matter and nutrients to arable ***,the information on the combined application of food waste and the plant growth-promoting bacterial strain,Chlorella,related to plant metabolic features and sodium chloride content in arable soil is *** present study was conducted to investigate the exogenous application of food waste along with Chlorella,which improved the physio-morphological features of red *** results revealed that this combination enhanced the organic matter in the soil,ultimately improving the fertility rate of the soil,and the physio-morphological features,such as chlorophyll a content(24.5±0.7),root(7.8±0.7)cm and shoot length(12.1±0.7)cm,fresh weight(2.1±0.05)g,dry weight(0.19±0.05)g,mineral contents,and hormonal concentration(ABA by up to 2 folds).The combined treatment also minimized free radicals via the activation of the intrinsic antioxidant series cascade and electrolyte *** findings showed that adding Chlorella and food wastes improved growth characteristics and can be used as a green bio-fertilizer for sustainable agriculture.

关键词： Food waste Chlorella hormone antioxidant

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Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis

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Bioactive Materials 2022年第1期7卷 14-25页

作者： Bo-Bae Seo Youngjoong Kwon Jun Kim Ki Hyun Hong Sung-eun Kim hae-Ryong Song Young-Min Kim Soo-Chang Song Center for Biomaterials Korea Institute of Science&TechnologySeoul02792South Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea Department of Orthopedic Surgery and Rare Diseases Institute Korea University Medical College Guro HospitalSeoul08308South Korea

Treatment of osteoarthritis(OA)by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory *** administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration,but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the *** this study,we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic *** poly(organophosphazene),which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution,was synthesized for triamcinolone acetonide(TCA)*** hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA,the TCA was encapsulated into the self-assembled polymeric *** TCA-encapsulated polymeric nanoparticles(TePNs)were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular ***,the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body *** in vitro TCA release study showed sustained TCA release for six ***-time injection of the TePN hydrogel system in an early stage of OA-induced rat model showed a great inhibition effect against further OA *** OA-induced knees completely recovered as a healthy cartilage without any abnormal symptoms.

关键词： Thermosensitive hydrogel Triamcinolone acetonide Polymer nanoparticle Osteoarthritis Sustained release

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Sectoral changes of the peripapillary choroidal thickness in patients with unilateral branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 472-479页

作者： Na eun lee hae Min Kang Jeong Hoon Choi Hyoung Jun Koh Sung Chul lee Department of Ophthalmology Catholic Kwandong University College of Medicine International St. Mary's Hospital Choikang Seoul Eye Clinic Institute of Vision Research Department of Ophthalmology Yonsei University College of Medicine

AIM: To investigate sectoral changes in the mean peripapillary choroidal thickness(PCT) in patients with unilateral branch retinal vein occlusion(BRVO). METHODS: This retrospective, interventional study included 41 patients with acute, unilateral BRVO without macular edema. All patients completed at least a 6-month follow-up period. The PCT was measured at eight locations(temporal, superotemporal, superior, superonasal, nasal, inferonasal, inferior, and inferotemporal). In addition to calculating the average of all locations, the peripapillary choroidal area was divided into four sectors: superior(average of superotemporal PCT, superior PCT, and superonasal PCT), temporal, inferior(average of inferotemporal PCT, inferior PCT, and inferonasal PCT), and nasal. RESULTS: In the BRVO-affected eyes, the mean PCT was 177.7±69.8 μm(range, 70.1-396.0 μm) at baseline and 127.8±54.8 μm(range, 56.4-312.1 μm) at 6 mo(P<0.001). In the non-affected contralateral eyes, the mean PCT was 192.5±60.6 μm(range, 61.4-365.0 μm) at baseline and 165.9±61.1 μm(range, 56.8-326.8 μm) at 6 mo(P<0.001). In sectoral analysis, the mean PCT in each sector was significantly reduced in over 6 mo in the BRVO-affected eyes(all P<0.001). In the non-affected contralateral eyes, the mean PCT was not significantly changed in any sector over the 6-month follow-up period(superior sector, P=0.143; temporal sector, P=0.825; inferior sector, P=0.192; and nasal sector, P=0.599).CONCLUSION: Sectoral analysis shows that the mean PCTs in all sectors are reduced significantly over 6 mo in the BRVO-affected eyes, but not in the non-affected contralateral eyes.

关键词： branch retinal vein occlusion choroid choroidal thickness peripapillary choroidal thickness

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Synthesis of Fe_3O_4-coated silica aerogel nanocomposites

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中国有色金属学会会刊：英文版 2012年第S3期22卷 702-706页

作者： Jun Sung lee eun Jung lee hae Jin HWANG Devision of Materials Science and Engineering Inha University

Fe3O4:SiO2 nanocomposite powders were synthesized by a two-step process,which included the precipitation of FeCl2 and FeCl3 and the gelation of silicic acid solution derived from water *** first,Fe3O4 nanoparticles having a crystallite size of 20 nm were obtained by controlling the ratio of Fe(II) and Fe(III) *** the second step,Fe3O4 particles were embedded in SiO2 matrix by the hydrolysis and subsequent condensation of the silicic acid solution containing Fe3O4 *** was found that the Fe3O4 nanoparticles homogenously disperse in the SiO2 *** Fe3O4:SiO2 nanocomposite exhibited an enhanced thermal stability against oxidation compared with pure ***-IR analysis indicates the presence of the Si-O-Fe bond in the Fe3O4:SiO2 (1:10,mole fraction) nanocomposite.

关键词： nanocomposite Fe3O4 SiO2 sol gel synthesis

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On-screen fingerprint sensor with optically and electrically tailored transparent electrode patterns for use on high-resolution mobile displays

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Microsystems & Nanoengineering 2020年第1期6卷 243-254页

作者： Hyun-Joon Kim-lee Seog Woo Hong Dong Kyun Kim Jinmyoung Kim Hong Suk Kim Seok-Whan Chung eun-Hyoung Cho hae-Sung Kim Byung-Kyu lee Device Research Center Samsung Advanced Institute of Technology130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 443-803Republic of Korea

In this study,a mutual capacitive-type on-screen fingerprint sensor,which can recognize fingerprints on a display screen to provide smartphones with full-screen displays with a minimal bezel area,is ***-screen fingerprint sensors are fabricated using an indium tin oxide transparent conductor with a sheet resistance of~10Ω/*** a transmittance of~94%(~86% with the substrate effect)in the visible wavelength range,and assembled onto a display *** at this high transmittance,the electrodes can degrade the display quality when they are placed on the *** interference between periodic display pixel arrays and sensor patterns can lead to the *** is necessary to find an appropriate sensor pattern that minimizes the Moirepattern,while maintaining the signal *** search for appropriate patterns,a numerical calculation is carried out over wide ranges of pitches and rotation *** range is narrowed for an experimental evaluation,which is used to finally determine the sensor *** the selected sensor pitches are too small to detect capacitance variations,three unit patterns are electrically connected to obtain a unit block generating a larger *** applying the selected sensor pattern and circuit driving by block,fingerprint sensing on a display is demonstrated with a prototype built on a commercial smartphone.

关键词： transparent pattern smart

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