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Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal

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World Journal of Gastroenterology 2017年第29期23卷 5313-5323页

作者： Hyun Jung kim Guem San Lee Hyungwoo kim Byung joo kim Division of Longevity and Biofunctional Medicine Healthy Aging Korean Medical Research Center School of Korean Medicine Pusan National University Wonkwang University College of Korean Medicine Division of Pharmacology School of Korean Medicine Pusan National University Division of Longevity and Biofunctional Medicine School of Korean Medicine Pusan National University

AIM To investigate the effects of a water extract of Hwangryunhaedok-tang(HHTE) on the pacemaker potentials of mouse interstitial cells of Cajal(ICCs).METHODS We dissociated ICCs from small intestines and cultured. ICCs were immunologically identified using an antic-kit antibody. We used the whole-cell patch-clamp configuration to record the pacemaker potentials generated by cultured ICCs under the current clamp mode(I = 0). All experiments were performed at 30 ℃-32 ℃RESULTS HHTE dose-dependently depolarized ICC pacemaker potentials. Pretreatment with a 5-HT_3 receptor anta-gonist(Y25130) or a 5-HT_4 receptor antagonist(RS39604) blocked HHTE-induced pacemaker potential depolarizations, whereas pretreatment with a 5-HT7 receptor antagonist(SB269970) did not. Intracellular GDPβS inhibited HHTE-induced pacemaker potential depolarization and pretreatment with a Ca^(2+)-free solution or thapsigargin abolished the pacemaker potentials. In the presence of a Ca^(2+)-free solution or thapsigargin, HHTE did not depolarize ICC pacemaker potentials. In addition, HHTE-induced pacemaker potential depolarization was unaffected by a PKC inhibitor(calphostin C) or a Rho kinase inhibitor(Y27632). Of the four ingredients of HHT, Coptidis Rhizoma and Gardeniae Fructus more effectively inhibited pacemaker potential *** These results suggest that HHTE dose-dependently depolarizes ICC pacemaker potentials through 5-HT_3 and 5-HT_4 receptors via external and internal Ca^(2+) regulation and via G protein-, PKC-and Rho kinase-independent pathways.

关键词： Hwangryunhaedok-tang Interstitial cells of Cajal Pacemaker potentials Gastrointestinal tract Motility

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Inverted Meckel's diverticulum: Two case reports and a review of the literature

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World Journal of Gastrointestinal Surgery 2018年第6期10卷 70-74页

作者： eui Hyuk Chong Dae Jung kim Sewha kim Gwangil kim Woo Ram kim Department of Surgery CHA Bundang Medical Center CHA University Department of Radiology CHA Bundang Medical Center CHA University Department of Pathology CHA Bundang Medical Center CHA University

Gastrointestinal surgeons seldom encounter inverted Meckel's diverticulum in their clinical practice. We describe two cases of inverted Meckel's diverticulum. If the patient has a disease-related complication such as intussusception, as with our first case, it can be easily detected. However, if the patient has subacute or chronic symptoms, as with our second case, the diagnosis might be delayed. Regardless of the diseaserelated complication, intussusception of inverted Meckel's diverticulum can be easily managed with laparoscopic single-port surgery.

关键词： Inverted Meckel’s diverticulum Laparoscopic surgery Intermittent hematochezia Intussusception Abdominal pain

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Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity

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World Journal of Gastroenterology 2006年第5期12卷 796-799页

作者： Byung joo kim Jae Yeoul Jun Insuk So Ki Whan kim Department of Physiology and Biophysics College of MedicineSeoul National UniversityRepublic of Korea Department of Physiology College of MedicineChosun UniversityRepublic of Korea

AIM： Interstitial cells of Cajal （ICCs） are the pacemaker cells that generate slow waves in the gastrointestinal （GI） tract. We have aimed to investigate the involvement of mitochondrial Na^＋-Ca^2＋ exchange in intestinal pacemaking activity in cultured interstitial cells of Cajal. METHODS： Enzymatic digestions were used to dissociate ICCs from the small intestine of a mouse. The whole-cell patch-clamp configuration was used to record membrane currents （voltage clamp） and potentials （current clamp） from cultured ICCs. RESULTS： Clonazepam and CGP37157 inhibited the pacemaking activity of ICCs in a dose-dependent manner. Clonazepam from 20 to 60 μmol/L and CGP37157 from 10 to 30 μmol/L effectively inhibited Ca^2＋ efflux from mitochondria in pacemaking activity of ICCs. The ICsos of clonazepam and CGP37157 were 37.1 and 18.2 μmol/ L, respectively. The addition of 20 μmol/L NiCl2 to the internal solution caused a ＂wax and wane＂ phenomenon of pacemaking activity of ICCs. CONCLUSION： These results suggest that mitochondria Na^＋-Ca^2＋ exchange has an important role in intestina pacemaking activity.

关键词： Mitochondrial Na^+-Ca^2+ exchange Interstitial cells of Cajal

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Voxel-based statistical analysis of regional cerebral glucose metabolism in children with attention-deficit hyperactivity disorder

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Neural Regeneration Research 2011年第36期6卷 2850-2855页

作者： Ji-Hoon kim Young-In Chung Jung Sub Lee In-joo kim Yong-Ki kim Seong-Jang kim Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Medical Research Institute Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Psychiatry Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Orthopedic Surgery Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea Department of Nuclear Medicine Pusan National University School of Medicine Yangsan-si Gyeongnam Republic of Korea

The technique of region of interest-based positron emission tomography is limited by its poor reli-ability and relatively few examined brain regions. In the present study, we compared brain metabo-lism assessed using fluorine-18-fluorodeoxyglucose positron emission tomography between 14 at-tention-deficit hyperactivity disorder （ADHD） patients and 15 normal controls with scoliosis at resting state by statistical parametric mapping. Glucose metabolism was decreased in the left parahippo-campal gyrus, left hippocampus, left anterior cingulate gyrus, right anterior and posterior lobes of the cerebellum, left superior temporal gyrus, left insula, left medial and middle frontal gyri, right medial frontal gyrus, and left basal ganglia （putamen, amygdala, and caudate nucleus） in children with ADHD. These data suggest that children with ADHD exhibit hypometabolism in various brain regions compared to controls, indicating that ADHD symptoms are unlikely the result of abnormalities in specific areas.

关键词： attention-deficit hyperactivity disorder positron emission tomography statistical parametric mapping

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Relief of YAP-mediated inhibition by IKKε promotes innate antiviral immunity

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Cellular & Molecular Immunology 2018年第6期15卷 642-644页

作者： Nayoung kim Yun-Yong Park Chul Hyun joo Hun Sik kim Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Microbiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea

The innate immune response to invading viruses is critical for the mounting of protective immunity,in which type I interferons(IFN),for example,IFN-αandβ,are potent effector molecules.1 Most cell types,particularly fibroblasts and epithelial cells,produce IFN-β,whereas hematopoietic cells,notably plasmacytoid dendritic cells,are the predominant sources of IFN-α.IFNs potently stimulate a variety of innate and adaptive immune cells,including macrophages,NK cells and T *** binding of type I IFN to its cognate receptor triggers the activation of the Janus kinase signal transducer and activator of transcription pathway,which results in the transcription of IFNstimulated genes that play key roles in host resistance to viral infections.

关键词： immunity protective mount

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Asymmetric optical camouflage:tuneable reflective colour accompanied by the optical Janus effect

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Light(Science & Applications) 2020年第1期9卷 325-334页

作者： Taehyun kim eui-Sang Yu Young-Gyu Bae Jongsu Lee In Soo kim Seok Chung Seung-Yeol Lee Yong-Sang Ryu Sensor System Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Micro/Nano Systems Korea UniversitySeoul 02841Republic of Korea School of Electronic and Electrical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Nanophotonics Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea School of Mechanical Engineering Korea UniversitySeoul 02841Republic of Korea

Going beyond an improved colour gamut,an asymmetric colour contrast,which depends on the viewing direction,and its ability to readily deliver information could create opportunities for a wide range of applications,such as nextgeneration optical switches,colour displays,and security features in anti-counterfeiting ***,we propose a simple Fabry–Perot etalon architecture capable of generating viewing-direction-sensitive colour contrasts and encrypting pre-inscribed information upon immersion in particular solvents(optical camouflage).Based on the experimental verification of the theoretical modelling,we have discovered a completely new and exotic optical phenomenon involving a tuneable colour switch for viewing-direction-dependent information delivery,which we define as asymmetric optical camouflage.

关键词： asymmetric generating readily

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Evaluation of lubrication performance of crank pin bearing in a marine diesel engine

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Friction 2018年第4期6卷 464-471页

作者： Suk Man MOON Yong joo CHO Tae Wan kim School of Mechanical Engineering Pusan National University Department of Mechanical Engineering Pukyong National University

In this study, the lubrication performance of the crank pin bearing in a marine two–stroke diesel engine is evaluated to investigate the adhesional failure on the crank pin bearing. A numerical algorithm for the lubrication analysis considering motion analysis of the crank pin system is developed. The film pressure and thickness for three clearances and three lubricant temperatures are calculated. The results show that the lubricant temperature has a higher effect on film thickness than clearance. In terms of the film parameter, the operating condition that can result in solid–solid contact is investigated. We also suggest the desirable operating conditions of clearance and lubricant temperature to prevent the solid–solid contact.

关键词： crank pin bearing film thickness lubricant film parameter diesel engine

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Experimental and Modeling Studies on the Chemical Vapor Infiltration with Respect to the Effects of Thermal Gradient and Other Operating Parameters

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Journal of Wuhan University of Technology(Materials Science) 2018年第3期33卷 525-532页

作者： Kyung Do joo Do Hoon kim Gui Yung Chung Department of Chemical Engineering Hong Ik University

Effects of operating parameters in the thermal gradient chemical vapor infiltration of propane such as thermal gradient, diffusion, infiltrations time, and concentration of propane were studied by focusing on the visualizations of the intrinsic effects of these parameters. A uniform deposition in the preform was obtained with a gradually increasing temperature along the gas flow. The uniformity of deposition through the preform got improved with increasing deposition time. Results of numerical modeling estimated the experimental data very well when the pre-exponential factor of the overall rate of carbon deposition from propane reported by Vaidyaraman[1] was multiplied by 4. The average density of a preform increased by about 3 times from 0.38 to 1.15 g/cm3 after 60 hr deposition with a thermal gradient under the conditions of 3% propane in nitrogen and 840 to 900 ℃.

关键词： TG-CVI propane C/C composites uniform deposition mathematical modeling

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Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

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World Journal of Gastroenterology 2009年第46期15卷 5799-5804页

作者： Byung joo kim Kyu joo Park Hyung Woo kim Seok Choi Jae Yeoul Jun In Youb Chang Ju-Hong Jeon Insuk So Seon Jeong kim School of Korean Medicine Pusan National University Department of Surgery College of MedicineSeoul National University Department of Physiology College of MedicineChosun University Department of Anatomy College of MedicineChosun University Center for Bio-Artif icial Muscle and Department of Physiology College of MedicineSeoul National University Center for Bio-Artifi cial Muscle and Depart-ment of Biomedical Engineering Hanyang University

AIM： To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 （TRPM7） in the human gastrointestinal （GI） tract. METHODS： Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajat （ICCs）. RESULTS： The human GI tract generated slow electrical waves and had ICCs which functioned as pacemak er cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB （2-aminoethoxydiphenyl borate） and La3＋, TRPM7 channel blockers, inhibited the slowwaves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION： These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the gen- eration of the slow waves.

关键词： Electrophysiology Interstitial cells of Cajal TRPM cation channels Transient receptor potential melastatin-type 7 protein Human Gastrointestinal tract

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Endoscopic retrograde cholangiopancreatography in pancreatic and biliary tract disease in Korean children

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World Journal of Gastroenterology 2010年第4期16卷 490-495页

作者： joo Young Jang Chong Hyun Yoon Kyung Mo kim Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea Department of Pediatrics Ajou University School of MedicineSuwon 443-721South Korea Department of Pediatric Radiology Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea Department of Pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To assess the indications,findings,therapeutic procedures,safety,and complications of endoscopic retrograde cholangiopancreatography(ERCP) performed in Korean ***:The demographic characteristics,indications for ERCP,findings,therapeutic procedures,and complications of 122 pediatric patients who underwent 245 ERCPs in the Asan Medical Center between June 1994 and March 2008 were ***:The mean age of the 122 patients was 8.0 ± 4.2 *** were biliary pathology in 78(64.0%),pancreatic pathology in 43(35.2%),and chronic abdominal pain in *** indications included choledochal cysts in 40,choledocholithiasis in 24,suspected sclerosing cholangitis in 8,trauma in 2,and other conditions in *** indications includedacute pancreatitis in 7,acute recurrent pancreatitis in 11,chronic pancreatitis in 20,trauma in 3,and pancreatic mass in *** the 245 ERCPs,success rate was 98.4% and 190(77.6%) were for therapeutic purposes,including endoscopic nasal drainage(51.8%),biliary sphincterotomy(38.0%),pancreatic sphincterotomy(23.3%),stent insertion(15.1%),stone extraction(18.8%),and balloon dilatation(11.0%).Complications were postERCP pancreatitis in 16(6.5%),ileus in 23(9.4%),hemorrhage in 2(0.8%),perforation in 2(0.8%),sepsis in 1(0.4%),and impacted basket in 1(0.4%).There were no procedure-related deaths,and most complications improved under supportive ***:This study showed that there is a high incidence of choledochal cyst and diagnostic and therapeutic ERCP for the management of various biliary and pancreatic diseases was safe and effective in Korean children.

关键词： Endoscopic retrograde cholangiopancreatography Pancreatic diseases Biliary tract diseases Choledochal cyst Pancreatitis Pediatrics

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