检索结果-南通市图书馆

Additive Effects of Water-Soluble Propolis(Greit 120)and Human Interferon Alfa(HuIFN-αN3)against Influenza Viruses in Vitro

引用

Journal of Agricultural Science and Technology(A) 2018年第1期8卷 36-47页

作者： Bratko Filipic Lidija Gradisnik Adriana Pereyra Rok Kopino Klemen Rihar Eva Ruzic-Sabljic Snezana Kramar Damir Dermie eugen soos Nicola Volpi Alfredo Fachini and Hrvoje Mazija Croatian Institute of Experimental and Translation Oncology Koledinecka 3Zagreb 10040Croatia Institute of Biomedical Sciences Medical Faculty of MariborTaborska 8Maribor 2000Slovenia Medex D.o.o. Linhartova 49bLjubljana 1000Slovenia Chengdujska 4 Ljubljana 1000Slovenia Institute of Microbiology and Immunology Medical FacultyZaloska 4Ljubljana 1105Slovenia Division of Molecular Biology Ruaer Boskovic InstituteBijenicka 54Zagreb 10000Croatia Trg Sv.Ivana 5 Klostar Ivanic 10312Croatia Department of Life Sciences University of Modena&Reggio EmiliaModena 41125Italy BNatural Via Gran Sasso 33Corbetta-MI 20011Italy

Influenza virus affects the respiratory tract in humans causing a range of distinct manifestations including fever, nasal secretions, cough, headaches, muscle pain and pneumonia, which could become violent and severe. It was found that influenza A viruses remain resistant to amantadine and rimantadin with high level of oseltamvir resistance. Therefore, there is a need for constant improvement of drugs active against resistant influenza viruses. Propolis has anti-influenza activity both in vitro and in vivo. Human leukocyte interferon （HuIFN-αN3） is a multi-subtype protein that displays an antiviral activity against influenza virus. In this study we elucidated the anti-influenza activity of the mixes of water-soluble propolis （WSP）（Greit 120） and HuIFN-αN3 at different ratios. Greit 120 polyphenols, total phenol acids and bioflavonoid were characterized by HPLC-UV-ESI-MS504971 and HuIFN-αN3 by reverse-phase high-performance liquid chromatography （RP-HPLC）. Influenza A and B viruses were separately added to the LLC-MK2 cells treated with WSP （Greit 120） and HuIFN-αN3 alone or in proportions 1：1, 1：2 and 2：1. Plates were incubated and cytopathic effect was determined. The best results （ID50） were obtained with the mix of 10% WSP and HuIFN-αN3 in proportion 1：2, showing ID50 at 12 ± 0.2 μg/mL and 19 ± 0.6 μg/mL for influenza A and B viruses, respectively. When comparing anti-influenza activity of WSP （Greit 120）/HuIFN-αN3 with that of ribavirin, it was found that 1：2 was the optimal ratio for WSP （Greit 120）/HuIFN-αN3 （0.5 and 0.6 for influenza A and B, respectively）. This new formulation of WSP （Greit 120） and HuIFN-αN3, showing better anti-Influenza activity, will definitely improve its application in flu infections.

关键词： Water-soluble propolis Greit 120 HuIFN-αN3 anti-influenza activity ribavirin ID_(50)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长寿命UHPFRC组合钢桥面板研究综述

引用

交通运输工程学报 2024年第1期24卷 68-84页

作者：段兰袁翊竑王春生 BRÜHWILER eugen 长安大学公路学院陕西西安710064 瑞士洛桑联邦理工学院结构维护与安全实验室沃州洛桑CH-1015

从三方面归纳与剖析了超高性能纤维增强水泥基(UHPFRC)复合材料组合钢桥面板的研究进展,包括强韧性组合层选材、界面传力机制与损伤累积机理、设计方法与工程应用;总结了纤维类型、纤维掺量对UHPFRC轴拉性能和抗弯性能的影响规律,确定... 详细信息

从三方面归纳与剖析了超高性能纤维增强水泥基(UHPFRC)复合材料组合钢桥面板的研究进展,包括强韧性组合层选材、界面传力机制与损伤累积机理、设计方法与工程应用;总结了纤维类型、纤维掺量对UHPFRC轴拉性能和抗弯性能的影响规律,确定了支撑组合钢桥面板结构分析的多种本构模型;对比分析了热连接、冷连接和混合连接组合界面设计方式的技术特点,归纳了胶粘界面、冷连接剪力键界面与混合连接界面的传力机理试验与理论研究成果;总结了基于冷连接设计理念的组合钢桥面板在合理构造、设计方法、规范规程与工程实践等方面的研究成果,并探讨了长寿命组合钢桥面板的创新与发展方向。研究结果表明:单一或混杂纤维的掺入综合提升了UHPFRC的应变强化能力、弯曲变形能力、抗断裂能力、裂缝宽度控制能力和抗疲劳性能,轴拉条件下UHPFRC三线型简化本构模型有力支撑了组合钢桥面板的设计计算,弹塑性损伤本构模型可描述不可逆疲劳损伤累积;验证了冷连接组合界面的增韧效果与可靠性,新型剪力键既可以提高组合效应,也能增韧UHPFRC层,混合连接界面具有降低界面局部应力集中、提高整体界面抗剪刚度、改善界面传力、提升施工效率等综合技术优势,内聚界面本构模型可实现冷连接界面损伤累积反演分析,界面损伤预测结果准确可靠;基于冷连接的UHPFRC组合钢桥面板可以有效提高钢桥面板的局部刚度,相关设计方法可支撑标准的编制与工程实践;应进一步提升UHPFRC的性价比和界面连接的高效性和可靠性,以支撑组合钢桥面板的长寿命、强韧性、轻量化、易维护、低能耗设计与建造。

关键词：桥梁工程长寿命 UHPFRC组合钢桥面板冷连接件组合界面设计准则免蒸养

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reorganization of spinal neural circuitry and functional recovery after spinal cord injury

引用

Neural Regeneration Research 2015年第2期10卷 201-202页

作者： Raffaele Nardone eugen Trinka Department of Neurology Christian Doppler Klinik Paracelsus Medical University Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University Department of Neurology Franz Tappeiner Hospital

The ability of the adult central nervous system to reorganize its circuits over time is the key to understand the functional improvement in subjects with spinal cord injury （SCI）. Adaptive changes within spared neuronal circuits may occur at cortical, brainstem, or spinal cord level, both above and below a spinal lesion （Bareyre et al., 2004）. At each level the reorganization is a very dynamic process, and its degree is highly variable, depending on several factors, including the age of the subject when SCI has occurred and the rehabilitative therapy. The use of electrophysiological techniques to assess these functional changes in neural networks is of great interest, because invasive methodologies as employed in preclinical models can obviously not be used in clinical studies.

关键词： SCI Reorganization of spinal neural circuitry and functional recovery after spinal cord injury TSR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection of pathogenic bacteria by magneto-immunoassays:a review

引用

The Journal of Biomedical Research 2021年第4期35卷 277-283页

作者： eugen Gheorghiu International Centre of Biodynamics Bucharest 060101Romania.

Magnetic particle-based immunoassays are widely used in microbiology-related assays for both microbial capture,separation,analysis,and *** facilitating sample operation,the implementation of micro-to-nanometer scale magnetic beads as a solid support potentially shortens the incubation time(for magnetic immuno capture)from several hours to less than an *** technologies based on magnetic beads offer a rapid,effective and inexpensive way to separate and concentrate the target analytes prior to ***-immuno separation uses magnetic particles coated with specific antibodies to capture target microorganisms,bear the corresponding antigens,and subsequently separate them from the sample matrix in a magnetic *** method has been proven effective in separating various types of pathogenic bacteria from environmental water samples and in eliminating background *** particles are often used to capture target cells(pathogenic bacteria)from *** most commercially available assays,the actual identification and quantitation of the captured cells is then performed by classical microbiological *** review highlights the most sensitive analytic methods(i.e.,long-range surface plasmon resonance and electrochemical impedance spectroscopy)to detect magnetically tagged bacteria in conjunction with magnetic actuation.

关键词： magneto-immuno separation long-range surface plasmon resonance electrochemical impedance spectroscopy periodic magnetic actuation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review of the technologies for wave energy extraction

引用

Clean Energy 2018年第1期2卷 10-19页

作者： eugen Rusu Florin Onea Department of Mechanical Engineering “Dunarea de Jos”University of GalatiDomneasca Street47Galati 800008Romania

The main objective of this article is to provide a comprehensive picture of existing wave technologies being used for wave energy *** overview will explain their potential and also the challenges wave technologies *** article will also briefly discuss the benefits of combined offshore wind-wave projects,also known as *** factors and impacts on relevant existing wave technologies will be outlined,including capacity factor and capture *** the levelized cost of energy(LCOE)targets for the most promising technologies will be discussed.

关键词： wave power wave energy converters capacity factor capture width hybrid solutions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intestinal pseudo-obstruction:An uncommon condition with heterogeneous etiology and unpredictable outcome

引用

World Journal of Gastroenterology 2008年第6期14卷 954-959页

作者： eugen Florin Georgescu Ion Vasile Reanina Ionescu Filantropia University Hospital from Craiova Department of Internal Medicine 2 University of Medicine and Pharmacy of Craiova Romania Departmental Emergency University Hospital from Craiova Department of General Surgery 2 University of Medicine and Pharmacy of Craiova Romania

Intestinal pseudo-obstruction (IPO) either acute or chronic is a condition including features of intestinal ileus in absence of mechanical obstruction. Our paper presents such a rare case of idiopathic IPO in a 53-year-old male patient with recurrent episodes of pseudo-obstruction, which were successfully resolved by anticholinesterase agents, motilin agonists or colonic decompression. However, the patient finally underwent total colectomy. Huge colonic dilatation was identified intraoperatorily, while histology showed a neuropathic variant of chronic intestinal pseudo-obstruction. Etiologic mechanisms and current therapeutic methods are reviewed in this paper, which concludes that IPO is a condition in which conservative treatment usually fails. Total colectomy with ileoanal pouch may be the only solution in these situations.

关键词： Intestinal pseudo-obstruction Anticholinesterase agents Motilin receptor agonists Colonoscopic decompression Total colectomy with ileoanal pouch

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Tibetan Local Self-defence Organizations in Amdo from 1900 to 1950

引用

中国藏学 1992年第S1期 315-321页

作者： eugen Wehrli

Introduction Several times explorers from western countries encounterd in Amdo well organised groups ofwarriors, and generally used the term "bandits" for them. The background of this explorers wascolonial, and for them it was out of question that such "primitive" nomads of farmers could ever or-ganize a regular army, which was in many aspects very similar to the ones in Europe at the

关键词：隆务寺部落马仲英阿坝白玉玉树

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis

引用

World Journal of Gastroenterology 2009年第8期15卷 942-954页

作者： eugen Florin Georgescu Reanina Ionescu Mihaela Niculescu Laurentiu Mogoanta Liliana Vancica Department of Internal Medicine 2 Filantropia University Hospital Str. Constantin Brancusi nr. 3 Craiova 200136 Romania Department of Internal Medicine University of Medicine and Pharmacy of Craiova Str.Petru Rares 4 Craiova 200349 Romania Department of Pathology University of Medicine and Pharmacy of Craiova Str.Petru Rares 4 Craiova 200349 Romania Department of Pathology Filantropia University Hospital Str. Constantin Brancusi nr. 3 Craiova 200136 Romania

AIM： TO evaluate insulin resistance, cytolysis and nonalcoholic steatohepatitis （NASH） score （NAS） using the Kleiner and Brunt criteria in 54 patients with NASH and mild-to-moderate hypertension, treated with telmisartan vs valsartan for 20 mo. METHODS： All patients met the NCEP-ATP Ⅲ criteria for metabolic syndrome. Histology confirmed steatohepatitis, defined as a NAS greater than five up to 3 wk prior inclusion, using the current criteria. Patients with viral hepatitis, chronic alcohol intake, drug abuse or other significant immune or metabolic hepatic pathology were excluded. Subjects were randomly assigned either to the valsartan （V） group （standard dose 80 mg o.d., n = 26）, or to the telmisartan （T） group （standard dose 20 mg o.d., n = 28）. Treatment had to be taken daily at the same hour with no concomitant medication or alcohol consumption allowed. Neither the patient nor the medical staff was aware of treatment group allocation. Paired liver biopsies obtained at inclusion （visit 1） and end of treatment （EOT） were assessed by a single blinded pathologist, not aware of patient or treatment group. Blood pressure, BMI, ALT, AST, HOMA-IR, plasma triglycerides （TG） and total cholesterol （TC） were evaluated at inclusion and every 4 mo until EOT （visit 6）. RESULTS： At EOT we noticed a significant decrease in ALT levels vs inclusion in all patients and this decrease did not differ significantly in group T vs group V. HOMA-IR significantly decreased at EOT vs inclusion in all patients but in group T, the mean HOMA-IR decrease per month was higher than in group V. NAS significantly diminished at EOT in all patients with a higher decrease in group T vs group V. CONCLUSION： Angiotensin receptor blockers seem to be efficient in hypertension-associated NASH. Telmisartan showed a higher efficacy regarding insulin resistance and histology, perhaps because of its specific PPAR-gamma ligand effect.

关键词： Telmisartan Valsartan Non-alcoholic steatohepatitis Hypertension Insulin-resistance Hepaticsteatosis Necroinflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ischemic colitis and large bowel infarction:A case report

引用

World Journal of Gastroenterology 2012年第39期18卷 5640-5644页

作者： eugen Florin Georgescu Doina Carstea Daniela Dumitrescu Ramona Teodorescu Andrei Carstea Department of Internal Medicine 1/Gastroenterology Filantropia University Hospital of Craiova200136 CraiovaRomania Department of Cardiology Filantropia University Hospital of Craiova200136 CraiovaRomania Department of Radiology University of Medicine and Pharmacy of Craiova200349 CraiovaRomania

Ischemic bowel disease results from an acute or chronic drop in the blood supply to the bowel and may have various clinical presentations, such as intestinal angina, ischemic colitis or intestinal infarction. Elderly patients with systemic atherosclerosis who are symptomatic for the disease in two or more vascular beds have multiple comorbidities and are particularly at risk. The clinical evolution and outcome of this disease are difficult to predict because of its pleomorphic aspects and the general lack of statistical data. In this paper, we present the case of a patient who was monitored in our unit for six years. For this patient, we encountered iterative changes in the clinical pattern, beginning with chronic "intestinal angina" and finishing with signs of acute mesenteric ischemia after an episode of ischemic colitis. This evolution is particularly rare in clinical practice, and the case is instructive because it raises discussions about the natural history of the condition and the thera-peutic decisions that should be made at every stage of the disease. An important lesson is that ischemic bowel disease should always be considered in patients who have multiple risk factors for atherosclerosis and have experienced recurrent "indistinct" abdominal *** these cases, aggressive investigation and therapeutic decisions must be taken whenever possible. Despite an absence of standardized protocols, angiographic evaluation and revascularization procedures have beneficial outcomes. Current advances in endovascular therapy, such as percutaneous transluminal angioplasty with stenting, should be increasingly used in patients with chronic mesenteric ischemia. Such therapy can avoid the risks that are associated with open repair. However, technical difficulties, especially in severe stenotic lesions, frequently occur.

关键词： Ischemic colitis Intestinal infarction Mes-enteric thrombosis Acute mesenteric ischemia Intes-tinal angina Mesenteric atherosclerosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optical coherence tomography and Doppler optical coherence tomography in the gastrointestinal tract

引用

World Journal of Gastroenterology 2011年第1期17卷 15-20页

作者： eugen Osiac Adrian Sǎftoiu Dan Ionut Gheonea Ion Mandrila Radu Angelescu Centre for Research in Gastroenterology and Hepatology University of Medicine and Pharmacy200349 CraiovaRomania

Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in the field of gastroenterology in order to assist classical ***,3D-imaging and Doppler capabilities have been developed in different configurations,which make this type of investigation more *** paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures,and with the possibility to investigate angiogenesis in the gastrointestinal tract.

关键词： Optical coherence tomography Doppler Gastrointestinal tract Gastrointestinal cancer Angiogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：