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Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

World Journal of Gastroenterology 2012年第30期18卷 3923-3930页

作者： Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum ester khin Nikki P Lee Guo-Hao Wu John M Luk Department of Pharmacology and Department of Surgery National University Health SystemNa-tional University of SingaporeSingapore 117597Singapore Department of General Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Oncology Roche R and D Center(China)Ltd.Shanghai 201203China Department of Surgery The University ofHong KongHong KongChina

Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence ***,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic *** (OPN) is overexpressed in most patients with gastric and liver *** the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such *** studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further *** signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver *** editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver *** understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies.

关键词：治疗方案生物标志物骨桥蛋白肝癌胃癌恶性肿瘤靶标病理特点

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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei khine khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin khin Than Oo Myat Myat Moe San San Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

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Multiscale and Auto-Tuned Semi-Supervised Deep Subspace Clustering and Its Application in Brain Tumor Clustering

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Computers, Materials & Continua 2024年第6期79卷 4741-4762页

作者： Zhenyu Qian Yizhang Jiang Zhou Hong Lijun Huang Fengda Li khin Wee Lai Kaijian Xia School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China Department of Medical Imaging The Changshu Affiliated Hospital of Soochow UniversitySuzhou215500China Department of Neurosurgery The Changshu Affiliated Hospital of Soochow UniversityChangshu215500China Department of Scientific Research The Changshu Affiliated Hospital of Soochow UniversitySuzhou215500China Changshu Key Laboratory of Medical Artificial Intelligence and Big Data Suzhou215500China Department of Biomedical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

In this paper,we introduce a novel Multi-scale and Auto-tuned Semi-supervised Deep Subspace Clustering(MAS-DSC)algorithm,aimed at addressing the challenges of deep subspace clustering in high-dimensional real-world data,particularly in the field of medical *** deep subspace clustering algorithms,which are mostly unsupervised,are limited in their ability to effectively utilize the inherent prior knowledge in medical *** MAS-DSC algorithm incorporates a semi-supervised learning framework that uses a small amount of labeled data to guide the clustering process,thereby enhancing the discriminative power of the feature ***,the multi-scale feature extraction mechanism is designed to adapt to the complexity of medical imaging data,resulting in more accurate clustering *** address the difficulty of hyperparameter selection in deep subspace clustering,this paper employs a Bayesian optimization algorithm for adaptive tuning of hyperparameters related to subspace clustering,prior knowledge constraints,and model loss *** experiments on standard clustering datasets,including ORL,Coil20,and Coil100,validate the effectiveness of the MAS-DSC *** results show that with its multi-scale network structure and Bayesian hyperparameter optimization,MAS-DSC achieves excellent clustering results on these ***,tests on a brain tumor dataset demonstrate the robustness of the algorithm and its ability to leverage prior knowledge for efficient feature extraction and enhanced clustering performance within a semi-supervised learning framework.

关键词： Deep subspace clustering multiscale network structure automatic hyperparameter tuning semi-supervised medical image clustering

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微藻对养殖废水中污染物的净化效果综述

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农业资源与环境学报 2024年第4期41卷 901-917页

作者：曹宇昂王涵 PHYU khin khin 梁军锋徐晓钰张克强支苏丽东北农业大学资源与环境学院哈尔滨150036 农业农村部环境保护科研监测所天津300191 农业农村部环境保护科研监测所大理综合实验站云南大理671004

养殖废水具有常规污染物浓度高,含有重金属、抗生素、激素等多种有毒有害污染物的特点,在养殖废水污染物净化方面,微藻转化技术展现出了巨大潜力。为探究微藻处理养殖废水的效果、机制机理、影响因素等,本文采用文献调研的方法,总结了... 详细信息

养殖废水具有常规污染物浓度高,含有重金属、抗生素、激素等多种有毒有害污染物的特点,在养殖废水污染物净化方面,微藻转化技术展现出了巨大潜力。为探究微藻处理养殖废水的效果、机制机理、影响因素等,本文采用文献调研的方法,总结了微藻对养殖废水中主要污染物的去除效果及去除机制,分析了微藻处理养殖废水效果的不同影响因素,并重点讨论了不同处理工艺中微藻的作用机理及其对污染物的去除效率。结果表明:微藻可以通过光合作用和同化作用去除养殖废水中碳、氮、磷等常规污染物,并可以通过系列生物学过程去除重金属、抗生素、悬浮物、激素、致病菌等,同时,微藻对污染物的去除效果受藻种类型、接种浓度、温度、光照、废水性质的影响,多藻协同、固定化处理均可提升微藻的去除能力,而藻菌共生技术能使微藻和细菌互利共生,达到更高效去除污染物的目的。综上,微藻在养殖废水处理中潜力较大,在实际处理过程中应考虑其最佳环境条件及适宜的处理工艺,以构建高效微藻养殖废水净化系统。

关键词：养殖废水微藻去除效果影响因素固定化藻菌共生

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威廉·博尔科姆的《三块幽灵破布》（1970-1971）和《伊甸园》（1969）中的拉格泰姆音乐研究

威廉·博尔科姆的《三块幽灵破布》（1970-1971）和《伊甸园》（1...

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作者： Darli khin Zaw 成都大学

学位级别：硕士

本文研究了拉格泰姆音乐的起源、演变和特征,以及1890年代末至1910年代末的传统形式。本文还对威廉·博尔科姆的背景,他对拉格泰姆音乐的体验,以及拉格泰姆音乐的复兴进行了讨论。笔者以作品《三块幽灵破布》和《伊甸园》为例,对其曲式... 详细信息

本文研究了拉格泰姆音乐的起源、演变和特征,以及1890年代末至1910年代末的传统形式。本文还对威廉·博尔科姆的背景,他对拉格泰姆音乐的体验,以及拉格泰姆音乐的复兴进行了讨论。笔者以作品《三块幽灵破布》和《伊甸园》为例,对其曲式和节奏进行了分析,并提供了演奏指导。Bolcom将不同的音乐风格结合在了这些拉格泰姆音乐当中,像经典拉格泰姆风格和跨步拉格泰姆风格。本研究论文旨在描述Bolcom在复兴和传播拉格泰姆音乐方面所做的努力。《三块幽灵破布》是Bolcom最著名的钢琴作品之一。在《伊甸园》中第三首作品《蛇之吻》中,音乐风格与传统的拉格泰姆风格有着巨大的不同。《蛇之吻》还使用了许多二十世纪的作曲风格,例如无调性、不协和音程以及音丛。本文还提供了关于演奏风格、演奏技法、触键和技术困难等方面的演奏指南。本文通过分析博尔科姆作品《三块幽灵破布》和《伊甸园》,探索了博尔科姆对拉格泰姆风格的影响。

关键词：拉格泰姆音乐音乐分析演奏指导

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行走在中国的土地上

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神州学人 2024年第7期 42-44页

作者： [缅甸]可依东南大学建筑学院

因为被中国的建筑吸引,我决定离开自己的国家,来到中国学习。我的中国求学之旅始于2022年12月,我怀着满心的憧憬踏上这段未知的旅程,在飞机上听到周围的人们用流利的普通话交谈,我满心激动。终于,我抵达了这座历史文化名城——南京。

关键词：历史文化名城普通话行走

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Novel Apodized Fiber Bragg GratingApplied for Medical Sensors:Performance Investigation

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Computer Modeling in Engineering & Sciences 2023年第4期135卷 301-323页

作者： Ramya Arumugam Ramamoorthy Kumar Samiappan Dhanalakshmi khin Wee Lai Lei Jiao Xiang Wu Department of Electronics and Communication Engineering College of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathurChengalpattu603203India Department of Biomedical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur50603Malaysia General Hospital of Xuzhou Mining Group Xuzhou221000China School of Medical Information&Engineering Xuzhou Medical UniversityXuzhou221000China

Sensors play an important role in shaping and monitoring human *** of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical *** this paper,a novel apodization function is proposed and performance evaluation and optimization of the same have been made.A comparison was conducted between various existing apodization functions and the proposed one based on optical characteristics and sensor *** results evince the implementation of the proposed apodization function for vital sign *** optical characteristics considered for evaluation are Peak Resonance Reflectivity level,Side Lobes Reflectivity level and FullWidth HalfMaximum(FWHM).The proposed novel apodization novel function has better FWHM,which is narrower than the FWHM of uniform *** characteristics like a quality parameter,detection accuracy and sensitivity also show *** proposed novel apodization function is demonstrated to have a better shift in wavelength in terms of temperature and pulse measurement than the existing *** sensitivity of the proposed apodized function is enhanced with a Poly-dimethylsiloxane coating of varying thickness,which is 6 times and 5.14 times greater than uniform Fiber Bragg grating and FBG with the proposed novel apodization function,respectively,enhancing its utilization in the field of medicine.

关键词： Fiber bragg grating apodization optical sensing temperature strain sensitivity

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Origin and Evolution of Ultramafic Rocks along the Sagaing Fault, Myanmar

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Journal of Earth Science 2023年第1期34卷 122-132页

作者： Tomoaki Morishita Hnin Min Soe Hla Htay Than Htut Lwin Juan Miguel Guotana Akihiro Tamura Tomoyuki Mizukami khin Zaw 无 Faculty of Geosciences and Civil Engineering Kanazawa UniversityKanazawa920-1192Japan Lamont-Doherty Earth Observatory Columbia UniversityPalisadesNY10964USA Volcanoes and Earth’s Interior Research Center Japan Agency for Marine-Earth Science and Technology2-15 NatsushimaKanagawa237-0061Japan Geology Department University of MandalayMandalay05092Myanmar Geology Department Dagon UniversityNorth Dagon11422Myanmar Taunggoke Degree College TaunggokeTaunggoke Township07161Myanmar Graduate School of Natural Science and Technology Kanazawa UniversityKanazawaIshikawa920-1192Japan CODES ARC Centre of Excellence in Ore Deposits University of TasmaniaTasmania7001Australia

The active Sagaing fault in Myanmar defines the boundary between the Indian Plate and the Eurasian Plate and causes seismic damage in the major cities of Myanmar. Small bodies of serpentinite occur along the fault. We for the first time investigated the highly sheared serpentinite bodies in the Sheinmagar area and Yega Inn area along the Sagaing fault. Extensively sheared/brecciated serpentinites and related rocks, such as talc and/or chlorite-bearing rocks contains small rock fragments of serpentinites. Serpentine texture and mineral chemistry indicate that the protolith of these serpentinites were mainly harzburgite with minor amounts of dunite, some of which are cut by gabbroic veins. No shape-preferred orientation of the antigorite is present, indicating that the serpentinization was occurred under relatively static conditions. Protolith and serpentine minerals are similar to those of the jadeitite-bearing serpentinites in the north of the Sagaing fault(the Jade Mine belt). Chemical variations of spinels in the studied area are within the compositional range of forearc peridotites and those in the mantle section of nearby ophiolites. After the formation of antigorite serpentinite under static conditions, these serpentinites were subsequently, but locally deformed, probably due to the activity of the Sagaing fault, resulting in the formation of serpentinite schist/brecciated rock. The presence of the less-deformed antigorite serpentinite in the sheared/brecciated zone indicates the strain localization mainly along the surrounding serpentine-talc(±chlorite) schistose rocks, which is probably formed by the reaction between serpentinite and country rocks. Further studies are needed to better understand whether the distribution of serpentinized peridotites cause variations in the activity of the Sagaing fault.

关键词： Sagaing fault serpentinite deformation ophiolite

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Janus纳米金稳定的Pickering乳液界面催化氧化性能

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高等学校化学学报 2022年第6期43卷 177-185页

作者：王红 SAN khin Nyein Ei 方云张鑫宇樊晔江南大学化学与材料工程学院合成与生物胶体教育部重点实验室无锡214122

Janus纳米粒子的结构设计和简易合成是Pickering乳液界面催化的关键.本文通过在Pickering乳液保护法中操纵共轭亚油酸的自组装、自交联性和弱还原性,合成了Janus型自交联吸附胶束修饰的纳米Fe_(3)O_(4)(SCA-Fe_(3)O_(4)),并在其表面原... 详细信息

Janus纳米粒子的结构设计和简易合成是Pickering乳液界面催化的关键.本文通过在Pickering乳液保护法中操纵共轭亚油酸的自组装、自交联性和弱还原性,合成了Janus型自交联吸附胶束修饰的纳米Fe_(3)O_(4)(SCA-Fe_(3)O_(4)),并在其表面原位还原金后,合成了Janus型催化剂Au-SCA-Fe_(3)O_(4),考察其同时作为乳化剂和催化剂在乳液界面催化苯甲醇氧化生成苯甲醛的性能.结果表明,该Janus纳米粒子的金修饰量(质量分数)仅为0.66%,兼具乳化性、催化性和磁响应性.Au-SCA-Fe_(3)O_(4)可制备外观稳定(100μm)和热稳定(90℃)的苯甲醇/水型Pickering乳液,可显著提高互不相溶反应物与催化剂间的接触面积,使其催化活性达到均匀纳米催化剂的2倍和非乳液催化时的3倍,其在界面的不可转动性使苯甲醛的选择性高于99.9%,避免了苯甲醛被过度氧化成苯甲酸.

关键词： Janus纳米粒子金界面催化 Pickering乳液共轭亚油酸纳米四氧化三铁

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Pteropine Orthoreovirus(PRV7S)does not Establish Persistent Infection in NP460 Cells but with Inflammatory Response Triggered

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生物医学与环境科学:英文版 2023年第9期36卷 886-891页

作者： LOH Mun khin Alson SIEW Zhen Yun LEONG Pooi Pooi KOH Rhun Yian CHYE Soi Moi WONG Siew Tung VOON Kenny School of Postgraduate Studies International Medical University57000 Kuala LumpurMalaysia School of Pharmacy University of Nottingham Malaysia43500 SemenyihMalaysia Faculty of Medicine and Health Sciences Universiti of Tunku Abdul Rahman43000 KajangMalaysia School of Health Sciences International Medical University57000 Kuala Lumpur Malaysia School of MedicineInternational Medical University57000 Kuala LumpurMalaysia

Pteropine orthoreovirus(PRV)is a nonenveloped double-stranded RNA(dsRNA)virus of the genus Orthoreovirus under the family *** PRV genome is composed of 10 dsRNA segments,including three large(L)segments,three medium(M... 详细信息

关键词： PRV pine reovirus

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