Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

作     者：Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk 

作者机构：Department of Pharmacology and Department of SurgeryNational University Health SystemNa-tional University of SingaporeSingapore 117597Singapore Department of General SurgeryZhongshan HospitalFudan UniversityShanghai 200032China Department of OncologyRoche R and D Center(China)Ltd.Shanghai 201203China Department of SurgeryThe University ofHong KongHong KongChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第30期

页      面：3923-3930页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 081704[工学-应用化学] 081803[工学-地质工程] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0818[工学-地质资源与地质工程] 

主　　题：治疗方案 生物标志物 骨桥蛋白 肝癌 胃癌 恶性肿瘤 靶标 病理特点 

摘      要：Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence ***,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic *** (OPN) is overexpressed in most patients with gastric and liver *** the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such *** studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further *** signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver *** editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver *** understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies.