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Evolution of liver transplantation in the metabolic dysfunctionassociated steatotic liver disease era: Tracking impact through time

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World Journal of Transplantation 2024年第4期14卷 84-94页

作者： Karina Sato-Espinoza Perapa Chotiprasidhi estefanía Liza Zuly Placido-Damian Javier Diaz-Ferrer Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Medicine Faculty Universidad San Martin de PorresLima 02002Peru Gastroenterology Service Clinica InternacionalLima 02002Peru

Liver transplantation(LT)for metabolic dysfunction-associated steatotic liver disease(MASLD)is increasing globally due to rising rates of obesity and metabolic syndrome,posing significant *** patients typically present with advanced age,higher body mass index(BMI),and metabolic com-orbidities such as diabetes,hypertension,and *** pre-transplant evaluations are crucial for assessing surgical risks and preparing patients for *** patients with higher BMI may experience longer operative times,potentially affecting intraoperative *** the months following LT,MASLD recipients face persistent challenges,including a higher incidence of metabolic syndrome and cardiovascular events compared to non-MASLD ***,survival rates at 1-,3-,and 5-years post-LT do not markedly differ from other etiologies,indicating comparable surgical *** outcomes in MASLD patients undergoing LT demands a multidisciplinary approach from pre-transplant assessment to post-transplant *** must address metabolic comorbidities,manage cardiovascular health,and monitor steatosis recurrence,which can be exacerbated by obesity and *** approach aims to mitigate long-term graft complications and mortality risks,ultimately enhancing transplant success and patient *** research is essential to refine these approaches and meet the evolving challenges posed by MASLD as a leading indication for LT worldwide.

关键词： Liver transplantation Metabolic dysfunction-associated steatotic liver disease Alcohol liver disease Hepatitis C Hepatitis B Hepatocellular carcinoma

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Production of Volatile Moth Sex Pheromones in Transgenic Nicotiana benthamiana Plants

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BioDesign Research 2021年第1期2021卷 79-95页

作者： Rubén Mateos-Fernández Elena Moreno-Giménez Silvia Gianoglio Alfredo Quijano-Rubio Jose Gavaldá-García Lucía Estellés Alba Rubert JoséLuis Rambla Marta Vazquez-Vilar estefanía huet Asunción Fernández-del-Carmen Ana Espinosa-Ruiz Mojca Juteršek Sandra Vacas Ismael Navarro Vicente Navarro-Llopis Jaime Primo Diego Orzáez Institute for Plant Molecular and Cell Biology(IBMCP) Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Politécnica de Valencia(UPV)ValenciaSpain Jaume I University Castellon de la PlanaSpain Department of Biotechnology and Systems Biology National Institute of BiologyLjubljanaSlovenia Jožef Stefan International Postgraduate School LjubljanaSlovenia Centro de Ecología Química Agrícola Instituto Agroforestal del MediterráneoUniversitat Politècnica de ValènciaValenciaSpain Ecología Y Protección Agrícola SL ValenciaSpain

Plant-based bioproduction of insect sex pheromones has been proposed as an innovative strategy to increase the sustainability of pest control in ***,we describe the engineering of transgenic plants producing(Z)-11-hexadecenol(Z11-16OH)and(Z)-11-hexadecenyl acetate(Z11-16OAc),two main volatile components in many Lepidoptera sex pheromone *** assembled multigene DNA constructs encoding the pheromone biosynthetic pathway and stably transformed them into Nicotiana benthamiana *** constructs contained the Amyelois transitella AtrΔ11 desaturase gene,the Helicoverpa armigera fatty acyl reductase HarFAR gene,and the Euonymus alatus diacylglycerol acetyltransferase EaDAct gene in different *** the pheromone-producing plants showed dwarf phenotypes,the severity of which correlated with pheromone *** but one of the recovered lines produced high levels of Z11-16OH,but very low levels of Z11-16OAc,probably as a result of recurrent truncations at the level of the EaDAct *** one plant line(SxPv1.2)was recovered that harboured an intact pheromone pathway and which produced moderate levels of Z11-16OAc(11.8μg g^(-1) FW)and high levels of Z11-16OH(111.4μg g^(-1)).Z11-16OAc production was accompanied in SxPv1.2 by a partial recovery of the dwarf ***1.2 was used to estimate the rates of volatile pheromone release,which resulted in 8.48 ng g-1 FW per day for Z11-16OH and 9.44 ng g^(-1 )FW per day for *** results suggest that pheromone release acts as a limiting factor in pheromone biodispenser strategies and establish a roadmap for biotechnological improvements.

关键词： release dwarf transformed

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AI有望解锁古罗马卷轴之谜

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商业周刊（中文版） 2024年第15期 52-57页

作者： Ashlee Vance Ellen huet 杨飞(译) 不详

几年前,在加利福尼亚州日益恶化的一个野火季,纳特·弗里德曼(Nat Friedman)家的房子被烧毁了。几个月后,弗里德曼因为新冠疫情被困在湾区,既煌恐又无聊。和许多中年老父亲一样,他从古罗马文化当中寻求安慰和指引。当我们中的一些人正... 详细信息

几年前,在加利福尼亚州日益恶化的一个野火季,纳特·弗里德曼(Nat Friedman)家的房子被烧毁了。几个月后,弗里德曼因为新冠疫情被困在湾区,既煌恐又无聊。和许多中年老父亲一样,他从古罗马文化当中寻求安慰和指引。当我们中的一些人正在观看《虎王》(Tiger King)或者玩孩子们的乐高积木时,他在阅读关于罗马帝国的书籍,还帮他女儿制作了罗马别墅的纸模型。他没有学着做酸面团。

关键词：古罗马文化弗里德曼加利福尼亚州纸模型乐高积木罗马帝国

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永生的信徒

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商业周刊（中文版） 2024年第2期 46-51页

作者： Ellen huet lan Loring Shiver(摄影) 王湛(译) 不详

当一个拿着夹纸写字板的人在旧金山街头热情地向你走来时,你通常可以预料到,他们的问题与某个公共政策目标有关。您有时间来谈谈堕胎权吗?住房问题?网络赌博投票倡议?然而如今,你可能会听到一个更加宏大、更加个人的问题,你怎么也想不到... 详细信息

当一个拿着夹纸写字板的人在旧金山街头热情地向你走来时,你通常可以预料到,他们的问题与某个公共政策目标有关。您有时间来谈谈堕胎权吗?住房问题?网络赌博投票倡议?然而如今,你可能会听到一个更加宏大、更加个人的问题,你怎么也想不到,那些看起来想要你签名的人会问出这句话:您想活多久?

关键词：写字板网络赌博住房问题公共政策目标旧金山

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Event analysis in social multimedia： a survey

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Frontiers of Computer Science 2016年第3期10卷 433-446页

作者： Xueliang LIU Meng WANG Benoit huet School of Computer and Information Hefei University of Technology Hefei 230009 China Department of Multimedia EURECOM sophia-antipolis Nice 06560 France

Recent years have witnessed the rapid growth of social multimedia data available over the Internet. The age of huge amount of media collection provides users facihties to share and access data, while it also demands the revolution of data management techniques, since the exponential growth of social multimedia requires more scalable, effective and ro- bust technologies to manage and index them. The event is one of the most important cues to recall people＇s past memory. The reminder value of an event makes it extremely helpful in organizing data. The study of event based analysis on so- cial multimedia data has drawn intensive attention in research community. In this article, we provide a comprehensive sur- vey on event based analysis over social multimedia data, in- cluding event enrichment, detection, and categorization. We introduce each paradigm and summarize related research ef- forts. In addition, we also suggest the emerging trends in this research area.

关键词： event enrichment event detection event categorization

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Uremic Bleeding in 2 Patients with Dieulafoy’s Lesion: Case Report and Literature Review

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Open Journal of Gastroenterology 2024年第5期14卷 167-173页

作者： Gustavo Adolfo Hernández Valdez Diana estefanía Ibarra García Juan Antonio Contreras Escamilla Janette Alejandra Gamiño Gutierrez Francisco Manuel Tonatiuh Carrillo Beltran Ulises Solis Gomez Jocelyn Nataly Quintero Meléndez Ivan Alejandro Medina Jimenez Marco Antonio González Villar Jorge Rojas Morales Department of Internal Medicine ISSSTE APP General Hospital of Tepic Tepic Nayarit Mexico Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara Jalisco M&#233xico

Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage to this artery can cause severe and intermittent arterial bleeding from small vascular stumps that are difficult to visualize. Furthermore, these catastrophic bleeding episodes frequently result in hemodynamic instability and the need for transfusion of multiple blood products. Recently, uremic syndrome has been identified as a risk factor for gastric mucosal lesions. We present two clinical cases of acute digestive bleeding due to Dielafoy lesion with chronic kidney disease as the main cause, where two different therapies were performed endoscopically. We concluded with the results of our patients that the best therapy was the application of the hemostatic hemoclip on the injury vs the injection with adrenaline on the wound site. Uremia is identified as a risk factor for upper gastrointestinal bleeding in patients with pre-existing Dieulafoy’s lesion, as well as a higher incidence of new bleeding.

关键词： Dieulafoy’s Lesion Gastrointestinal Bleeding Endoscopy Endoscopy Hemostatic Clips Kidney Disease Adrenaline Thermal Coagulation Dieulafoy

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科技业就业市场迎来转折时刻

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人力资源开发与管理 2024年第1期

作者： Ellen huet

在AI成为硅谷的下一个巨大机遇之际，哪些人已经失业，哪些人在担心失业，还有哪些人身价大增？

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A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino Victor Martinez-Merino Jose F.Moran Institute for Multidisciplinary Research in Applied Biology(IMAB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

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Evolution of wheat architecture,physiology,and metabolism during domestication and further cultivation:Lessons for crop improvement

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The Crop Journal 2023年第4期11卷 1080-1096页

作者： Arturs Katamadze Omar Vergara-Díaz estefanía Uberegui Ander Yoldi-Achalandabaso José Luis Araus Rubén Vicente Plant Ecophysiology and Metabolism Group Instituto de Tecnologia Química e Biológica António XavierUniversidade Nova de LisboaP-2780 OeirasPortugal Genetics and Genomics of Plant Complex Traits Instituto de Tecnologia Química e Biológica António XavierUniversidade Nova de LisboaP-2780 OeirasPortugal FisioClimaCO_(2) Group Department of Plant Biology and EcologyFaculty of Science and TechnologyUniversity of the Basque CountryE-48940 LeioaSpain Integrative Crop Ecophysiology Group Section of Plant PhysiologyFaculty of BiologyUniversity of BarcelonaE-08028 Barcelona&AGROTECNIO-CERCA CenterE-25198 LleidaSpain

In recent decades,genetic advances in yield improvement in the major cereal crops,including wheat,has stagnated or proceeded at a slower rate than is required to meet future global food demand,particularly in the face of climate *** reverse this situation,and in view of the future climate scenario,there is a need to increase the genetic diversity of wheat to increase its productivity,quality,stability,and adaptation to local *** abundant genetic resources and literature are a basis for wheat ***,many species,such as wild relatives,landraces,and old cultivars have not been studied beyond their agronomic characteristics,highlighting the lack of understanding of the physiological and metabolic processes(and their integration) associated with higher productivity and resilience in limiting *** studies using wheat ancestors and modern cultivars may identify novel traits that have not previously been considered,or have been underestimated,during domestication and breeding,but that may contribute to future food *** review describes existing wheat genetic diversity and changes that occurred during domestication and breeding,and considers whether mining natural variation among wheat ancestors offers an opportunity to enhance wheat agronomic performance,spike architecture,canopy-and organ-level photosynthetic capacity,and responses to abiotic stress,as well as to develop new wheat hybrids.

关键词： Breeding Landraces Photosynthesis Wild relatives Yield

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Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis(Coss. & Dur.) Maire

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 537-543页

作者： Hanene Zater Joelle huet Veronique Fontaine Samir Benayache Caroline Stevigny Pierre Duez Fadila Benayache Unite de recherche : Valorisation des Ressources Naturelles Molecules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL) Faculte des Sciences Exactes Universite Freres Mentouri Constantine 125000 ConstantineAlgerie Universite Ziane Achour Cite du 5 JuilletRoute Moudjbara BP:311717000 DjelfaAlgerie Laboratoire de Pharmacognosie de Bromatologie et de Nutrition Humaine Universite Libre de Bruxelles (ULB)1050 BruxellesBelgique Laboratoire de Biopolymere et nanomateriaux supramoleculaire Universite Libre de Bruxelles (ULB)1050 BruxellesBelgique Unite de Microbiologie Pharmaceutique et Hygiene Faculte de Pharmacie Universite Libre de Bruxelles (ULB)1050 BrxellesBelgique Service de Chimie Therapeutique et de Pharmacognosie Universite de Mons (UMONS)7000MonsBelgique

Objective:To investigate the chemical composition of a moderately polar extract(CHC1_3 soluble part of the MeOH-H_2O extract) obtained from the aerial parts(leaves and flowers) of Centaurea diluta ***(Coss.& Dur.) Maire,a species endemic to Algeria and Morocco on which no reports are available to *** evaluate in vitro the cytotoxic,antifungal and antimicrobial activities of this extract and the cytotoxic and antimicrobial activities of its isolated secondary ***:The cytotoxic effects of the extract were investigated on 3 human cancer cell lines *** A549 non-small-cell lung carcinoma(NSCLC),the MCF7 breast adenocarcinoma and the U373 glioblastoma using a MTT colorimetric *** data allowed to guide the fractionation of the extract by separation and purification on silica gel 60(CC and TLC).The isolated compounds which were characterized by spectral analysis,mainly HR-ESIMS,HR-EIMS,UV and NMR experiments(~1H,^(13)C,COSY,ROESY,HSQC and HMBC) and comparison of their spectroscopic data with those reported in the literature,were evaluated for cytotoxic activities on six cancer cell lines(A549,MCF7,U373,Hs683 human glioma,PC3 human prostate and B16-F10 murine melanoma).The direct and indirect antibacterial and antifungal activities were determined using microdilution methods for the raw extract and TLC-bioautography and microdilution methods against standard and clinical strains for the isolated ***:The raw extract reduced cell viability with IC_(50)s of 27,25 and 21 μg/mL on A549,MCF7 and U373,*** secondary metabolites:two phenolic compounds(vanillin 1,paridol 3),a lignan[(-)-arctigenin 2]and two flavonoid aglycones(eupatilin 4 and jaceosidin 5),were then isolated from this *** cytotoxic effects were observed for(-)-arctigenin 2(IC_(50)s:28 and 33μM on Hs683 and B16-F10,respectively),eupatilin 4(IC_(50)s:33 and 47 μM on B16-F10 and PC3,respectively) and jaceosidin 5(IC_(50)s:32 a

关键词： Flavonoids Lignans Centaurea diluta Asteraceae Cytotoxic activity Direct and indirect antimicrobial activity MRSA

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