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Cholecystoenteric fistula with and without gallstone ileus: A case series

Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 36-40页

作者： Mauricio Gonzalez-Urquijo Mario Rodarte-shade Gerardo lozano-Balderas Gerardo Gil-Galind Tecnologico de Monterrey Escuela de MedicinaCiencias de la SaludDr.Ignacio Morones Prieto O 3000Monterrey 64710México Department of surgery Hospital Metropolitano“Dr.Bernardo Sepúlveda”Secretaria de Salud de Nuevo LeónAdolfo López Mateos No.4600San Nicolás de los Garza 66400México

Background: A cholecystoenteric stula (CEF) is an uncommon complication of gallstone disease. The aim of this study was to present our experience of a series of patients with CEF, presenting with or without gallstone ileus, along with their surgical outcomes. Methods: From 2015 to 2018, 3245 consecutive patients underwent cholecystectomy for gallbladder disease at our institution, of which 15 were diagnosed with a CEF. All electronic medical records were retrospectively reviewed. Results: Fifteen patients presented with CEF. Ten patients presented cholecystoduodenal stula, four pa- tients cholecystocolonic, and one patient cholecystogastric counterparts. Twelve patients were female. The median patient age was 61 years (range 33 86 years). Five patients presented with gallstone ileus treated by laparotomy and enterolithotomy. In ten patients, a laparoscopic approach was attempted, but conversion to open surgery was necessary for eight of them. The median operative time was 140 min (range 60 240 min), and the median operative blood loss was 50 mL (range 10600mL). The procedure-related morbidity and mortality rates were 13.3% and 6.7%, respectively. Conclusions: There is no consensus on the best treatment modality for a CEF, as the treatment outcome is mostly dependent on the surgeon’s expertise and the patient’s condition. Not all CEFs are accompanied by gallstone ileus. For such case, the main purpose is to resolve the intestinal obstruction and, unless necessary, avoidance of the gallbladder area.

关键词： Cholecystoenteric stula Gallbladder disease Biliary-enteric stula Gallstone ileus Intestinal obstruction

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Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering

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Neural Regeneration Research 2020年第5期15卷 783-789页

作者： Rocío Fernández-serra Rebeca Gallego Paloma lozano Daniel González-Nieto Center for Biomedical Technology Universidad Politécnica de Madrid. MadridSpain Departamento de Tecnología Fotónica y Bioingeniería ETSI TelecomunicacionesUniversidad Politécnica de MadridMadridSpain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) MadridSpain

The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal ***-performance preclinical results have failed at clinical level,as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke,Alzheimer’s and Parkinson’s *** unquestionable reality is the current absence of effective therapies to neuroprotect the brain,to arrest neurodegeneration and rewire the impaired brain *** of the problem might arise from the lack of adequate in vitro and in vivo models and that most of the underlying pathophysiological mechanisms are not yet *** contributing factor is the lack of efficient systems to sustain drug release at therapeutic concentrations and enhance the survival and function of grafted cells in transplantation *** medical applications the use of biomaterials of different compositions and formats has experienced a boom in the last *** the greater complexity of central nervous system has probably conditioned their extensive use with respect to other organs,the number of biomaterials-based applications to treat the injured brain or in the process of being damaged has grown ***-based biomaterials have constituted a turning point in the treatment of cerebral disorders using a new form of advanced *** show mechanical properties in the range of cerebral tissue resulting very suitable for local implantation of drugs and *** is also possible to fabricate three-dimensional hydrogel constructs with adaptable mesh size to facilitate axonal guidance and *** this article,we review the current trends in this area highlighting the positive impact of hydrogel-based biomaterials over the exhaustive control of drug delivery,cell engraftment and axonal reinnervation in brain p

关键词： advanced therapies Alzheimer’s disease biomaterials brain hydrogels neurological diseases Parkinson’s disease polymers stroke

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strategies for MsME’s When Facing Pandemic Event: A Research of Restaurants in Tlaxcala during the COVID-19 Outbreak

Strategies for MSME’s When Facing Pandemic Event: A Researc...

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作者： Jesus Adolfo Rodriguez lozano 北京第二外国语学院

学位级别：硕士

Near to 95% of Mexican restaurants had to close during the quarantine(（Mendoza,2020）meanwhile65% of restaurants in Mexico will ‘die’ or have ‘high risk of bankruptcy’ due to,directly affecting two million 187 thousand jobs coronavirus（Forbes,2020）and,with an accelerated spreading of coronavirus,the sector has seen an unprecedented drop in demand because of the progressively loss of confidence in the *** Tlaxcala the industry was also severely affected,and it has been difficult for restaurants in this region to face the crisis without a certain way to face it,strategically *** paper argues that micro,small and medium enterprise（MsME’s）owners and managers could aim for a more proactive approach to incorporate strategies that be helpful to counter the negative effects caused by the crisis caused by the Covid-19 pandemic in the restaurant *** carry out the study,statistical data on Tlaxcala’s city restaurants was retrieved and analyzed in order to verify if the business owners and managers of these eateries were aware of strategies recommended for crisis,especially crisis management,business continuity plan and business process ***,semi-structured interviews were applied with these subjects to identify similarities between the theory of these strategic management concepts and the strategies taken during the crisis in order to visualize the potential opportunities of incorporating these concepts to their operativity,while also incorporating to these study successful procedures used by these businesses that could help other restaurants during these critical *** findings of these research show that there is room for improvement in the restaurant of Tlaxcala when it comes to strategies related to endure the crisis and,while chain restaurants possess a more structured plan to cope against the negative effects of the pandemic due to the assistance of their respective corporates,a small part of independent restaurants shown th

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Photosynthetic and Molecular Markers of CO_2-mediated Photosynthetic Downregulation in Nodulated Alfalfa

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Journal of Integrative Plant Biology 2013年第8期55卷 721-734页

作者： Alvaro sanz-sez Gorka Erice Iker Aranjuelo Ricardo Aroca Juan Manuel Ruíz-lozano Jone Aguirreolea Juan Jos Irigoyen Manuel sanchez-Diaz Department of Plant Biology University of NavarraPamplonaE-31008Spain Department of Plant Biology University of BarcelonaBarcelonaE-8028Spain Department of Plant Biology University of Illinois at Urbana-Champaign61801USA Agrobiotechnology Institute Public University of NavarraMutilva BajaE-31192Spain Department of soil Microbiology and symbiotic systems Zaidin Experimental Station(CSIC)GranadaE-18008.Spain

Elevated CO2 leads to a decrease in potential net photosynthesis in long-term experiments and thus to a reduction in potential growth. This process is known as photosynthetic downregulation. There is no agreement on the definition of which parameters are the most sensitive for detecting CO2 acclimation. In order to investigate the most sensitive photosynthetic and molecular markers of CO2 acclimation, the effects of elevated CO2, and associated elevated temperature were analyzed in alfalfa plants inoculated with different sinorhizobium meliloti strains. Plants （Medicago sativa L. cv. Aragon） were grown in summer or autumn in temperature gradient greenhouses （TGG）. At the end of the experiment, all plants showed acclimation in both seasons, especially under elevated summer temperatures. This was probably due to the lower nitrogen （N） availability caused by decreased N2-fixation under higher temperatures. Photosynthesis measured at growth CO2 concentration, rubisco in vitro activity and maximum rate of carboxylation were the most sensitive parameters for detecting downregulation. severe acclimation was also related with decreases in leaf nitrogen content associated with declines in rubisco content （large and small subunits） and activity that resulted in a drop in photosynthesis. Despite the sensitivity of rubisco content as a marker of acclimation, it was not coordinated with gene expression, possibly due to a lag between gene transcription and protein translation.

关键词： Carbon dioxide Medicago sativa (alfalfa) photosynthetic downregulation RbcL and Rbcs sinorhizobium meliloti.

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Gut microbiota metabolites for sweetening type I diabetes

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Cellular & Molecular Immunology 2018年第2期15卷 92-95页

作者： Thamer Aljutaily Marta Consuegra-Fernández Fernando Aranda Francisco lozano Eduardo Huarte Department of Health and Nutritional sciences South Dakota State UniversityBrookingsSDUSA Group of Immunoreceptors of the Innate and Adaptive system Institute d’Investigacions Biomédiques August pi i Sunyer(IDIBAPS)BarcelonaSpain Department of Immunology Hospital Clínic of BarcelonaBarcelonaSpain Department de Biomedical sciences University of BarcelonaBarcelonaSpain

Type 1 diabetes(T1D),also referred to as insulin-dependent diabetes mellitus,is a debilitating disease that follows the destruction of pancreatic insulin-producingβcells by autologous T-cells.T1D primarily affects children and has a strong genetic component,with>50 susceptibility loci identified,including HLA-DQβchains.1 However,the striking differences between European regions with similar genetic backgrounds and a sharp rise in T1D incidence in developed countries over the last several decades suggest that environmental factor(s)also play a relevant etiopathogenic role.2 Given the accumulating evidence linking the gut microbiota to protection against metabolic diseases,3 Mariño et al.4 recently tested the hypothesis that short-chain fatty acids(sCFAs),which are the end products of fermentation of dietary fibers by anaerobic intestinal microbiota,can protect genetically susceptible mice from developing ***,the authors found that diets enriched in acetate or butyrate(two of the main sCFAs)can protect animals from developing diabetes through different and complementary cellular *** findings significantly enhance our understanding of the role of diet and gut microbiota in the development of autoimmune diseases and indicate that the use of medicinal foods may be a cost-effective treatment against T1D and other autoimmune diseases with a cellular *** that current anti-T1D approaches(which focus on prevention or modulation of the adaptive specific immune response against autoantigens)have been generally disappointing,5 such a new and refreshing strategy has attracted a great deal of attention(reviewed in Ref.2).

关键词： prevention striking linking

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The cartography of plant immunity: Proximity labeling puts a novel sGT1–NsL1 regulatory module on the map

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Molecular Plant 2024年第11期17卷 1645-1647页

作者： Huang Tan Chaonan shi Alberto PMacho Rosa lozano-Durán Department of Plant Biochemistry Center for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany shanghai Center for Plant stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China These authors contributed equally to this article

Keeping immune responses in an off state in the absence of a threat is essential to avoid the deleterious consequences of autoimmunity,while their timely activation upon perception of non-self determines the capacity of an organism to defend against potential *** plants,constitutive or untimely activation of immune responses dramatically limits growth and reproduction,highlighting the essential role of negative regulators of immunity for plant *** a number of such regulators have been identified in the past couple of decades,the full complexity of the molecular mechanisms deployed by plants to ensure an appropriately controlled activation of immune responses,as well as their coordination with growth and development,are still largely elusive.

关键词： immunity consequences constitutive

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Two viral proteins translated from one open reading frame target different layers of plant defense

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Plant Communications 2024年第4期5卷 177-193页

作者： Yuzhen Mei Tao Hu Yaqin Wang Rosa lozano-Duran Xiuling Yang Xueping Zhou state Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhouZhejiang 310058China state Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Department of Plant Biochemistry Center for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TubingenGermany

Multilayered defense responses are activated upon pathogen *** utilize a number of strategies to maximize the coding capacity of their small genomes and produce viral proteins for infection,including suppression of host ***,we reveal translation leakage as one of these strategies:two viral effec-tors encoded by tomato golden mosaic virus,chloroplast-localized C4(cC4)and membrane-associated C4(mC4),are translated from two in-frame start codons and function cooperatively to suppress ***4 localizes in chloroplasts,to which it recruits NbPUB4 to induce ubiquitination of the outer membrane;as a result,this organelle is degraded,and chloroplast-mediated defenses are ***,chloroplast-localized cC4 induces the production of singlet oxygen(^(1)O_(2)),which in turn promotes translo-cation of the ^(1)O_(2) sensor NbMBs1 from the cytosol to the nucleus,where it activates expression of the CERK1 ***,an antiviral effect exerted by CERK1 is countered by mC4,localized at the plasma ***4,like cC4,recruits NbPUB4 and promotes the ubiquitination and subsequent degradation of CERK1,suppressing membrane-based,receptor-like kinase-dependent ***,this translation leakage strategy seems to be conserved in multiple viral species and is related to host *** suggests that stacking of different cellular antiviral responses could be an effective way to abrogate viral infection and engineer sustainable resistance to major crop viral diseases in thefield.

关键词： geminivirus C4 PUB4 CERK1 subcellular localization antiviral defense

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Nucieocytoplasmic shuttling of Geminivirus C4 Protein Mediated by Phosphorylation and Myristoylation Is Critical for Viral Pathogenicity

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Molecular Plant 2018年第12期11卷 1466-1481页

作者： Yuzhen Mei Yaqin Wang Tao Hu Xiuling Yang Rosa lozano-Duran Garry sunter Xueping Zhou state Key Laboratory of Rice Biology Institute of Biotechnology Zhejiang University Hangzhou Zhejiang 310058 China state Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 China shanghai Center for Plant stress Biology CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences Shanghai 201602 China Department of Biology University of Texas at San Antonio San Antonio TX 78249 USA

Many geminivirus C4 proteins induce severe developmental abnormalities in *** previously demon- strated that Tomato leaf curl Yunnan virus (TLCYnV)C4 induces plant developmental abnormalities at least partically by decreasing the accumulation of NbsKη,an ortholog of Arabidopsis BIN2 kinase involved in the brassinosteroid signaling pathway,in the nucleus through directing it to the plasma ***, the molecular mechanism by which the membrane-associated C4 modifies the localization of NbsKη in the host cell remains ***,we show that TLCYnV C4 is a nucleocytoplasmic shuttle protein,and that C4 shuttling is accompanied by nuclear export of *** C4 is phosphorylated by NbsKη in the nucleus,which promotes myristoylation of the viral *** of phosphorylated C4 favors its interaction with exportin-α(XPO I);which in turn facilitates nuclear export of the C4/NbsKTI complex. supporting this model,chemical inhibition of N-myristoyltransferases or exportin-α enhanced nuclear retention of C4,and mutations of the putative phosphorylation or myristoylation sites in C4 resulted in increased nuclear retention ofrC4 and thus decreased severity of C4-induced developmental abnormalities. The impact of C4 on development is also lessened when a nuclear localization signal or a nuclear export signal is added to its C-terminus,restricting it to a specific cellular niche and therefore impairing nucleocytoplasmic *** together,our results suggest that nucleocytoplasmic shuttling of TLCYnV C4,enabled by phosphorylation by NbsKη,myristoylation,and interaction with exportin-α is critical for its function as a pathogenicity factor.

关键词： Geminivirus C4 phosphorylation myristoylation pathogenicity nucleocytoplasmic shuttling

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Design and Implementation of a Rehabilitation Upper-limb Exoskeleton Robot Controlled by Cognitive and Physical Interfaces

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Journal of Bionic Engineering 2022年第5期19卷 1374-1391页

作者： Arturo Gonzalez‑Mendoza Ivett Quinones‑Uriostegui sergio salazar‑Cruz Alberto‑Isaac Perez‑sanpablo Ricardo Lopez‑Gutierrez Rogelio lozano LAFMIA UMI Center for Research and AdvancedStudies of National Polytechnic InstituteAv.Instituto Politecnico Nacional No.250807360 Mexico CityMexico Motion Analysis Lab National Institute of Rehabilitation Luis Guillermo Ibarra IbarraCalz.Mexico Xochimilco No.28914389 Mexico CityMexico CONACYT-CINVEsTAV Av.Instituto Politecnico Nacional 250807360 Mexico CityMexico UTC-CNRs UMR Sorbonne UniversitesUTC-CNRS UMR7253 HeudiasycCompiegneFrance

This paper presents an upper limb exoskeleton that allows cognitive(through electromyography signals)and physical user interaction(through load cells sensors)for passive and active exercises that can activate neuroplasticity in the rehabilitation process of people who suffer from a neurological *** the exoskeleton to be easily accepted by patients who suffer from a neurological injury,we used the IsO9241-210:2010 as a methodology design *** the first steps of the design process,design requirements were collected from previous usability tests and ***,as a second step,a technological solution is proposed,and as a third step,the system was evaluated through performance and user *** part of the technological solution and to allow patient participation during the rehabilitation process,we have proposed a hybrid admittance control whose input is load cell or electromyography *** hybrid admittance control is intended for active therapy exercises,is easily implemented,and does not need musculoskeletal modeling to ***,electromyography signals classification models and features were evaluated to identify the best settings for the cognitive human–robot interaction.

关键词： Human Robot interaction Hybrid admittance control surface electromyography Upper-limb exoskeletal robot

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stable NiO-CeO_(2) nanoparticles with improved carbon resistance for methane dry reforming

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Journal of Rare Earths 2022年第1期40卷 57-62页

作者： Andrea Cárdenas-Arenas Esther Bailón-García Dolores lozano-Castelló Patrick Da Costa Agustín Bueno-López Department of Inorganic Chemistry University of AlicanteCarretera de San Vicente s/nE03080AlicanteSpain sorbonne Universite Institut Jean Le Rond d'AlembertCNRS UMR 71902 place de la gare de ceinture78210Saint Cyr L'EcoleFrance

High surface area mixed oxide 8.7%NiO-CeO_(2) nanoparticles(122 m2/g;6-7 nm)were prepared using a reversed microemulsion method,and were tested for dry methane reforming(DRM).The catalytic activity of these nanoparticles remains stable under the severe conditions of DRM(700℃),and they show better carbon resistance than conventional NiO-CeO_(2) catalysts prepared without control of the *** activity and selectivity of nanoparticles and reference catalyst are similar,but nanoparticles reduce the accumulation of carbon by 63%during the DRM tests,which is a key feature for this *** and H_(2)-TPR suggest that the improved carbon resistance of the nanoparticles is due to the better interaction and cooperation between NiO and CeO_(2) mixed *** nanoparticles,the participation of cerium cations in the redox processes taking place during DRM stabilizes cationic species of *** the contrary,the catalyst prepared without control of the size suffers segregation of Ni during DRM reaction,and segregated Ni explains the higher catalytic formation of carbon.

关键词： Methane dry reforming Nickel Ceria Nanoparticle Rare earths

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