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Novel markers in predicting Brucella sacroiliitis:The platelet large cell ratio and basal immature reticulocyte fraction

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Asian Pacific Journal of Tropical Medicine 2023年第1期16卷 39-44页

作者： Neslihan Celik esra Laloğlu Hülya Aslan Depertmant of Infection Diseases and Clinical Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey Department of Biochemistry Ataturk University School of Medicine25240ErzurumYakutiyeTurkey Depertmant of Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey

Objective:To present platelet large cell ratio(P-LCR),reticulocyte,and immature reticulocyte fraction(IRF)values as novel parameters in diagnosis and response to treatment in patients developing ***:Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination(Wright)or Brucella Coombs agglutination test titers≥1:160 were included in the *** groups were established,one developing sacroiliitis and another with no sacroiliitis development.P-LCR,reticulocyte,and IRF levels were measured using a Sysmex XN-9000 device(Japan).These were then compared between the two ***:Reticulocyte(P=0.037)and IRF(P=0.026)levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group,while P-LCR(P=0.003)levels were significantly higher.P-LCR had the most powerful correlation with sacroiliitis *** negative correlation was observed between reticulocyte,IRF levels and ***:Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis,while low reticulocyte and IRF levels secondary to bone marrow involvement were *** three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in *** are presented as inexpensive,and easily accessible novel parameters.

关键词： Brucella sacroiliitis P-LCR Reticulocyte IRF

Ischemic stroke due to carbon monoxide intoxication: Two case reports

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World Journal of Emergency Medicine 2018年第1期9卷 73-75页

作者： Atif Bayramoglu Abdullah Osman Kocak esra Kadioglu Department of Emergency Medicine Faculty of Medicine University of Ataturk

Dear editor, Following its entrance into the human body through inhalation, carbon monoxide （CO） forms carboxyhemoglobin （COHb） by binding to hemoglobin （Hb） within the blood. Massive ischemic tissue necrosis occurs in 0.5%-1% of cases with CO poisoning. The affinity of CO to Hb is 200-250 times more when compared to the affinity of oxygen. As a result of CO binding to Hb, oxygen delivery to the tissues is reduced, and tissue hypoxia develops. This affects mostly the brain and heart, which are the organs with the highest demand for oxygen.

关键词： Ischemic stroke due to carbon monoxide intoxication Two case reports

Artifact-centric workflow management system

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计算机集成制造系统 2011年第8期17卷 1709-1721页

作者： SUN Yu-tian LIU Xi KUCUKOGUZ esra SU Jian-wen YANG Jian University of California Santa Barbara CA 93106-5110 USA Nanjing University Nanjing 210093 China Macquarie University Sydney NSW 2109 Australia

Data-centric modeling approach for workflow specification and design has received considerable attention from research and development *** architecture for a workflow management system named EZFLOWS was *** components... 详细信息

关键词： workflow artifact-centric modeling business process management

Radiotherapy of brain metastases from non-small cell lung cancer

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Journal of Cancer Metastasis and Treatment 2019年第2期4卷 39-50页

作者： esra Korkmaz KirakIi Ufuk YiImaz Department of Radiation Oncology Dr.Suat Seren Chest Disease and Surgery Training and Research Hospitalİzmir 35200Turkey Department of Pulmonology University of Health ScienceDr.Suat Seren Chest Disease and Surgery Training and Research Hospitalİzmir 35200Turkey

Brain metastases risk at the time of diagnosis or during the course of disease is high in non-small cell lung cancer (NSCLC). Even the incidence of brain metastases has increased in recent years, due to detection of smaller asymptomatic lesions with MRI screening as well as improved survival as a consequence of developments in systemic therapies. In the last decade, there have been many trials in the management of NSCLC patients with brain metastases, questioning the role of adjuvant whole brain radiotherapy (WBRT) after surgery or stereotactic radiosurgery (SRS), WBRT, compared to best supportive care in patients not amenable to surgery, aggressive local therapies in solitary brain metastases, postsurgical cavity SRS, SRS in non-oligometastatic patients, cranial radiotherapy in patients with driver mutations, thyrosine kinase inhibitors, immune check point inhibitors and the impact of therapies on neurocognitive functions and quality of life. The main objective of this review is to provide an update on current trends in radiotherapy in the management of newly diagnosed brain metastases from NSCLC.

关键词： Radiotherapy whole-brain radiotherapy stereotactic radiotherapy stereotactic radiosurgery brain metastases lung cancer

Labelling of a pyrazole derivative with ^(131)I and investigation of its radiopharmaceutical potential

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Chinese Science Bulletin 2013年第24期58卷 2964-2969页

作者： KURTDEDE esra BILDIRICI Ishak ENGINAR Hüseyin SENER Ahmet Department of Chemistry Faculty of Arts and Sciences Afyon Kocatepe University Department of Chemistry Faculty of Arts and Sciences Yuzuncu Yil University

We investigated the radiolabeling efficiency, in vitro stability, and biodistribution of radioactive iodine (131I)-labeled 4-benzoyl-1-(4-carboxyphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (P3CA). A quality-control study of the labeled substance ( 131I-P3CA) was conducted using electrophoresis and radio thin-layer chromatography (RTLC). Biodistribution studies were undertaken in 9 female albino Wistar rats. Rats were killed at various times (15, 60 and 180 min), their organs removed, and percentage of injected dose per gram (ID%/g) values calculated. The labeling yield of P3CA was 97.08%±0.80%. The maximum uptake of 131I-P3CA was seen in the lungs, stomach and spleen at 15 min. The uptake of labeled compound decreased over time in the lungs, whereas that in the stomach decreased. These data suggest that 131I-P3CA had high binding efficiency, high uptake in the lung, and sufficient stability to be used in diagnostic studies.

关键词：吡唑衍生物放射性药物 Wistar大鼠放射性标记体外稳定性标签羧基苯基放射性碘

富炭硬沥青基WO3/TiO2催化剂提升染料和药物降解的光催化行为研究

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新型炭材料 2020年第4期35卷 371-383页

作者： Zeynep Balta esra Bilgin Simsek Department of Chemical and Process Engineering Faculty of EngineeringYalova University77100 YalovaTurkey

采用溶剂热法制备出富炭硬沥青基WO3/TiO2催化剂。通过光电子能谱议(XPS)、红外光谱仪(FTIR)、拉曼光谱仪(Raman)、扫描电镜(SEM)和UV-Vis漫反射光谱仪(DRS)等手段表征催化剂的形貌、结构、光学和物理性质。SEM观察到硬沥青表面完全被WO... 详细信息

采用溶剂热法制备出富炭硬沥青基WO3/TiO2催化剂。通过光电子能谱议(XPS)、红外光谱仪(FTIR)、拉曼光谱仪(Raman)、扫描电镜(SEM)和UV-Vis漫反射光谱仪(DRS)等手段表征催化剂的形貌、结构、光学和物理性质。SEM观察到硬沥青表面完全被WO3/TiO2颗粒覆盖。Raman和XPS分析表明,富炭硬沥青与WO3,TiO2复合良好。DRS结果显示在带隙较低时(2.83 eV),富炭硬沥青基WO3/TiO2催化剂对可见光的吸收性能得到提高。在UV-A辐照下,通过降解橙色Ⅱ染料和药物来探讨所制催化剂的光催化性能。橙色Ⅱ染料降解度随着硬沥青添加比例增加而增加,这归因于吸附和光催化的协同效应,即光吸收的增加和光产生的空穴和电子在W/Ti界面容易转移。而且,为了对比硬沥青原料与所制催化剂的吸附性能,在不同pH值下进行了批量吸附实验,并采用等温线和动力吸附模型探讨了温度和吸附值。本研究提供了富炭硬沥青作为自然碳源应用于碳基光催化材料制备思路。

关键词：硬沥青 WO3 TiO2 光催化橙色Ⅱ染料药物

Treatment of solitary gastric carcinoid tumor by endoscopic polypectomy in a patient with pernicious anemia

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World Journal of Gastroenterology 2006年第26期12卷 4267-4269页

作者： Gurhan Kadikoylu Irfan Yavasoglu Vahit Yukselen esra Ozkara Zahit Bolaman Internist Hematologist Adnan Menderes University Medical FacultyDivision of HematologyAydinTurkey Internist Fellow in hematology Adnan Menderes University Medical FacultyDivision of HematologyAydinTurkey Internist Gastroenterologist Adnan Menderes University Medical FacultyDivision of GastroenterologyAydinTurkey Pathologist Adnan Menderes University Medical Faculty Division of PathologyAydinTurkey

Type I gastric cardnoid tumors result from hypergastrinemia in 1%-7% of patients with pernicious anemia. We diagnosed pernicious anemia in a 48-year-old female patient with complaint of fatigue for three months. She had no gastrointestinal symptoms. Endoscopic examination ot the upper gastrointestinal tract revealed atrophic gastritis and a polypoid lesion in the corpus of 3-4 mm in size. Endoscopic polypectomy was performed. Histopathological examination of the specimen revealed positive chromogranin A and synaptophysin stainings compatible with the diagnosis of a carcinoid tumor. Serum gastrin level was increased, urinary 5-hydroxyindoleacetic acid was within the normal range. There was no other symptom, sign, or laboratory finding of a carcinoid syndrome in the patient. No metastasis was found with indium-ill octreotide scan, computed tomographies of abdomen and thorax. Type I gastric carcinoid tumors are only rarely solitary and patients with tumors 〈 1 cm in size may benefit from endoscopic polypectomy.

关键词： Solitary Pernicious anemia Gastric carcinoid tumor Endoscopic polypectomy

Comparison of the effects of intravitreal bevacizumab and dexamethasone in experimental posterior penetrating eye injury

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 575-579页

作者： Ayse Oner Nisa Kahraman Saim Ozdamar esra Balcioglu Department of Ophthalmology Faculty of Medicine Erciyes University Department of Histology and Embryology Faculty of Medicine Erciyes University

AIM： To compare the effects of intravitreal anti-vascular endothelial growth factor（VEGF） and dexamethasone in an experimental rabbit model of posterior penetrating ocular ***： Thirty white New Zealand rabbits were included in the study. A posterior penetrating ocular injury was performed at the superotemporal quadrant. They were randomly divided into three groups. The rabbits in group 1 received intravitreal dexamethasone, in group 2 they received intravitreal bevacizumab and those in group 3 received intravitreal physiological saline solution in both eyes. All eyes were examined ophthalmologically on the 1^st, 3^rd, 7^th, 14^th and 28^th days following the injury and the clinical findings were scored. On the day 28, the eyes were enucleated, evaluated and scored macroscopically, histopathologically and scanning electron ***： The median clinical score on the 14 th and 28 th days and the median macroscopic score of the dexamethasone group was significantly better than that of control（P=0.004, 0.018）. Dexamethasone group was also better than that of bevacizumab group but the differences did not reach statistical significance. Retinal detachment rate was 8.3%, 16.6% and 12.5% in the dexamethasone group, bevacizumab group and control group, respectively（P=0.476）. More extensive fibrocelluler proliferations were observed in controls compared with dexamethasone and bevacizumab groups. But these differences did not reach the statistical significance（P=0.538）. In scanning electron microscopy all groups showed fibreous stalk and dense collagen fibrils in vitreous. CONCLUSION： This study shows that intravitreal injection of both dexamethasone and bevacizumab may reduce the intraocular fibrous proliferation after an experimental posterior penetrating ocular injury in rabbits.

关键词： posterior penetrating ocular injury experimental dexamethasone bevacizumab proliferative vitreoretinopathy

Optical and electrical conductivity properties of rare earth elements(Sm, Y, La, Er) co-doped CeO_(2)

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Journal of Rare Earths 2022年第10期40卷 1619-1627页

作者： Rabia Kιrkgecit Handan OzlüTorun Fatma Kιlc Dokan esra Oztürk Institute of Science Material Science and EngineeringKahramanmaras Süt?üImam UniversityKahramanmaras46050Turkey Department of Energy System Engineering Kahramanmaras Istiklal UniversityKahramanmaras46300Turkey Department of Chemistry and Chemical Processing Technologies Kayseri UniversityKayseriTurkey Department of Metallurgical and Materials Engineering Karamanoglu Mehmetbey UniversityKaramanTurkey

In this research,un-doped CeO_(2) and Ce_(0.85)La_(0.10)MO_(0.05)O_(2)(M:Sm,Er,Y) compounds were synthesized by hydrothermal method and the multi-functional properties are *** defects were created with the additives of rare earth *** electrical and luminescence behaviors of the synthesized compounds were investigated in accord with the types of *** synthesized products were characterized by X-ray diffraction(XRD) analysis,Brunauer-Emmett-Teller(BET) measurement,UV-vis diffuse reflectance spectroscopy(DRS),scanning electron microscopy(SEM),photoluminescence(PL)spectroscopy and electrochemical impedance spectroscopic(EIS).All synthesized compounds are found to be nano-structured and have cubic *** total conductivity of all samples was ***,the total conductivity of un-doped CeO_(2),Ce_(0.85)La_(0.10)Y_(0.05)O_(2),Ce_(0.85)La_(0.10)Er_(0.05)O_(2) and Ce_(0.85)La_(0.10)Sm_(0.05)O_(2) is found to be 2.07×10^(-10),5.70×10^(-4),1.0×10^(-3) and 0.0747 S/cm,***,bandgap energy(E_(g)) of these samples calculated from UV visible absorption spectra is discussed,and the optical results show variation between 3.2 and 2.15 ***,the luminescence properties of the compounds were investigated and different emissions occur depending on the additive ***,photoluminescent emission spectra of Ce_(0.85)La_(0.10)Y_(0.05)O_(2),Ce_(0.85)La_(0.10)Er_(0.05)O_(2) and Ce_(0.85)La_(0.10)Sm_(0.05)O_(2) phosphors indicate that these phosphors have red,green and orange-red colors,respectively.

关键词： Cerium oxide Co-doping Conductivity Luminescence Oxygen vacancy Rare earth elements