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Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats

Acta Pharmacologica Sinica 2005年第4期26卷 417-422页

作者： Giyasettin BAYDAS ertugrul sonkaya Mehmet TUZCU Abdullah YASAR Emir DONDER Department of Physiology Department of Internal Medicine College of Medicine Firat University Department of Biology Faculty of Science Firat University Elazig 23119 Turkey Department of Physiology Department of Internal Medicine College of Medicine Firat University

Aim:To investigate the effect of gabapentin on neural [neuron-specific enolase（NSE）] and glial markers [glial fibrillary acidic protein （GFAP） and S 100B] in differ-ent brain regions of diabetic ***:Diabetes was induced by a singleintraperitoneal injection of streptozotocine （50 mg/kg body weight）.Rats in onediabetic group received gabapentin (50 ***-1.d-1) and rats in the other diabeticgroup received vehicle only for 6 *** levels of GFAP,S100B,and NSE weredetermined by immunoblotting in the hippocampus,cortex,and *** （LPO as malondialdehyde+ 4-hydroxyalkenals） and glutathione （GSH）levels were also determined in the same brain ***:Total and degradedGFAP content and S100B protein expression in different areas of brain tissuessignificantly increased in diabetic rats compared to control ***,NSElevels were also significantly elevated in hyperglycemic *** addition,therewas a significant increase in LPO levels in the diabetic rat brain compared tocontrol rat *** with gabapentin prevented the upregulation ofGFAP,S 100B,and NSE in all brain regions of diabetic *** level of LPO wasreduced,but not completely halted,by treatment with ***:These results suggest that diabetes causes glial and neuronal injury,possibly asa result of elevated oxidative stress,and that gabapentin protects neurons andglial ***,we predict that gabapentin treatment will attenuate the hippo-campal and cortical neurodegeneration observed during diabetes mellitus in rats.

关键词： gabapentin glial fibrillary acidic protein neurotrophic protein S100beta phosphopyruvate hydratase lipid peroxidation

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Energy use, CO2 emission and foreign direct investment： Is there any inconsistence between causal relations？

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Frontiers in Energy 2014年第3期8卷 269-278页

作者： ertugrul YILDIRIM Department of Economics Bulent Ecevit University Zonguldak 67100Turkey

In this study, the causal relations between inward foreign direct investment （FDI）-energy use per capita and inward FDI-CO2 emission per capita were analyzed and the inconsistency between the causal relations was investigated via bootstrap-corrected panel causality test and cross-correlation analysis. In this direction, data from 76 countries including the period of 1980-2009 was processed. No supportive evidence was found for changing causal relations to country group which was classified into income level. The findings indicated that while the pollution haven hypothesis was supported for Mozambique, United Arab Emirates and Oman, the pollution halo hypothesis was supported in the case of India, Iceland, Panama and Zambia. For other countries, energy use and CO2 emission were neutral to inward FDI flows in aggregated level. Furthermore, this study urged that increased （decreased） energy use due to the inward FD1 flows did not necessarily mean an increase （decrease） in pollution level, and vice versa. For policy purpose, FDI attractive policy should be regulated by taking into account this possibility.

关键词： CO2 emissions energy consumption liberalization

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Reconfigurable intelligent surface-empowered MIMO systems

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National Science Review 2023年第8期10卷 11-12页

作者： ertugrul Basar Department of Electrical and Electronics Engineering Koc University

Fifth-generation(5G) wireless networks,which are being deployed massively worldwide these days, provide higher flexibility and spectrum/energy efficiency compared with their earlier counterparts. However, sixth-generation(6G) wireless networks that are expected to roll out in around 2030 will require more radical communication paradigms,especially at the physical layer of the communication stack.

关键词： TRANSMISSION DESIGN

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Analysis of the forest fires in the Antalya region of Turkey using the Keetch–Byram drought index

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Journal of Forestry Research 2016年第4期27卷 811-819页

作者： Tugrul Varol Mertol ertugrul Forest Engineering Department Faculty of Forestry Bart?n University

We investigated the correlation of large fires（[300 ha） from 1992 to 2013 within the borders of the Antalya Regional Directorate of Forestry using the Keetch–Byram drought index（KBDI）. Daily KBDI values were calculated for each year, and values for the period before the year 2000 differed significantly from those after2000. After 2000（large fires occurred in 2004, 2006, 2007,2008, 2010, and 2013）, when KBDI values increased, the KBDI, but not the number of fires, was inversely correlated with the natural log of the burned area（NLBA）. While there were both high and low KBDI values when the NLBA was small, only high KBDI values were associated with high NLBA values. Particularly for logarithmic values of 4 and higher, KBDI values increased in parallel with increases in NLBA values. On the basis of a Mann–Whitney U test done in addition to a Pearson correlation test, we found that when the burned areas were grouped according to small and large areas, the KBDI could be used to distinguish the two groups. Using a conditional probability analysis, we found that 4th, 5th and 6th class KBDI values may lead to large fires at the 60 % ***, the possibility of large fires greater than the median burned area in any given 6 years was found to be48 %. In addition, while the mean value of KBDI is 390.51 for the period from May to September for these 6 years, it is 359.93 for the other years. Consequently, the area burned also increased as the KBDI classes（Class 0： 0–99, Class 1：100–199, Class 2： 200–299, Class 3： 300–399, Class 4：400–499, Class 5： 500–599, Class 6： 600–699, and Class 7：700–800） increase.

关键词： drought grouped possibility distinguish median Turkey conditional explained moisture ranged

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An enhanced damage plasticity model for predicting the cyclic behavior of plain concrete under multiaxial loading conditions

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1531-1544页

作者： Mohammad Reza AZADI KAKAVAND ertugrul TACIROGLU Unit of Strength of Materials and Structural Analysis Institute of Basic Sciences in Engineering SciencesUniversity of InnsbruckInnsbruck 6020Austria Department of Civil&Environmental Engineering University ofCaliforniaLos AngelesCA 90095USA

Some of the current concrete damage plasticity models in the literature employ a single damage variable for both the tension and compression regimes,while a few more advanced models employ two damage *** with a single variable have an inherent dificulty in accounting for the damage accrued due to tensile and compressive actions in appropriately different manners,and their mutual *** the current models that adopt two damage variables,the independence of these damage variables during cyclic loading results in the failure to capture the effects of tensile damage on the compressive behavior of concrete and *** study presents a cyclic model established by extending an existing monotonic constitutive *** model describes the cyclic behavior of concrete under multiaxial loading conditions and considers the influence of tensile/compressive damage on the compressive/tensile *** proposed model,dubbed the enhanced concrete damage plasticity model(ECDPM),is an extension of an existing model that combines the theories of classical plasticity and continuum damage *** most prior studies on models in the same category,the performance of the proposed ECDPM is evaluated using experimental data on concrete specimens at the material level obtained under cyclic multiaxial loading conditions including uniaxial tension and confined *** performance of the model is observed to be ***,the superiority of ECDPM over three previously proposed constitutive models is demonstrated through comparisons with the results of a uniaxial tension-compression test and a virtual test.

关键词： damage plasticity model plain concrete cyclic loading multiaxial loading conditions

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Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy

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World Journal of Gastroenterology 2004年第12期10卷 1838-1840页

作者： ertugrul Kayacetin Serra Kayacetin Department of Gastroenterology Selcuk UniversityMeram Medical FacultyKonyaTurkey Department of Pathology Selcuk UniversityMeram Medical FacultyKonyaTurkey

Liver penetration is a rare but serious complication of peptic ulcer *** the diagnosis is made by operation or *** and laboratory data were no specific.A 64-year-old man was admitted with upper gastrointestinal *** penetration was diagnosed as the cause of *** showed a large gastric ulcer with a pseudotumoral mass protruding from the ulcer *** diagnosis was established by endoscopic biopsies of the ulcer base.

关键词： Endoscopy, Digestive System Biopsy Gastrointestinal Hemorrhage Humans Liver Liver Diseases Male Middle Aged Stomach Ulcer

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Influence of Temperature and Frequency on Dielectric Permittivity and ac Conductivity of Au/SnO_(2)/n-Si (MOS) Structures

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Chinese Physics Letters 2012年第7期29卷 230-234页

作者： R.ertugrul A.Tataroglu Department of Physics Faculty of SciencesGazi University06500TeknikokullarAnkaraTurkey

The complex dielectric permit tivity (ε* =ε′-jε″ ) and ac conductivity (σac) of Au/SnO_(2)/n-Si(MOS) structures are studied using capacitance (C) and conductance (G(ω) ) measurements in a wide temperature range of 125-400 K for six different frequency *** is observed that the C and G(ω) values decrease with the increasing frequency,while they increase with the increasing *** observed nature of the C is due to the inability of the dipoles to orient in a rapidly varying electric *** experimental values of the dielectric constant ε′,dielectric loss ε",loss tangent tanδ and σac are found to be strong functions of frequency and *** values of the ε′ and ε″ are found to decrease with the increasing frequency and increase with the increasing *** σac is found to increase with the increasing frequency and *** energy (Ea),from the Arrhenius plot,is studied to discuss the conduction mechanism in a MOS structure.

关键词： temperature structure dielectric

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Helicobacter pylori infection in patients with autoimmune thrombocytopenic purpura

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World Journal of Gastroenterology 2004年第14期10卷 2113-2115页

作者： Erdal Kurtoglu ertugrul Kayacetin Aysegul Ugur Department of Hematology Selcuk UniversityKonya 42060Turkey Department of Gastroenterology Selcuk UniversityKonya 42060Turkey Department of Biochemistry Selcuk UniversityKonya 42060Turkey

AIM:To compare the prevalence of Helicobacter pylori (Hpylon)infection in autoimmune thrombocytopenic purpura (AITP)patients with that of nonthrombocytopenic controls, and to evaluate the efficacy of the treatment in H pylori(+) and H pylor(-)AITP patients. METHODS:The prevalence of gastric H pylori infection in 38 adult AITP patients(29 female and 9 male;median age 27 years;range 18-39 years)who consecutively admitted to our clinic was investagated. RESULTS:H pylori infection was found in 26 of 38 AITP patients(68.5%).H pylori infection was found in 15 of 23 control subjects(65.2%).The difference in H pylori infection between the 2 groups was not *** count of H pylori-positive AITP patients was significantly lower than that of H pylori-negative AITP patients(P<0.05). Thrombocyte recovery of H pylori-positive group was less than that of H pylori-negative group(P<0.05). CONCLUSION:H pylori infection should be considerecd in the treatment of AITP patients with H pylori infection.

关键词： Helicobacter pylori Adult Case-Control Studies Female Helicobacter Infections Humans Immunoglobulins, Intravenous Male Platelet Count Prevalence Purpura, Thrombocytopenic, Idiopathic Steroids Treatment Outcome

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Analysis of EST-SSRs in silver birch(Betula pendula Roth.)

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Journal of Forestry Research 2016年第3期27卷 639-646页

作者： ertugrul Filiz Ilhan Dogan Ibrahim Ilker Ozyigit Department of Crop and Animal Production Cilimli Vocational SchoolDuzce University Department of Molecular Biology and Genetics Izmir Institute of Technology Department of Biology Faculty of ScienceRahatlayadururken Manas University Department of Biology Faculty of Science and ArtsMarmara University

Simple sequence repeats（SSRs） defined as sequence repeat units between 1 and 6 bp occur abundantly in both coding and non-coding regions in eukaryotic genomes and these repeats can affect gene expression. In this study, ESTs（expressed sequence tags） of Betula pendula（silver birch） were analyzed for in silico mining of ESTSSRs, protein annotation, open reading frames（ORFs）,designing primers, and identifying codon repetitions. In ***, the frequency of ESTs containing SSRs was 7.8 %with an average of 1SSR/4. 78 kb of EST sequences. A total of 188 SSRs was identified by using MISA software and dinucleotide SSR motifs（65.9 %） were found to be the most abundant type of repeat motif followed by tri-（27.1 %）,tetra-（4.8 %）, and penta-（2.2 %） motifs. Based on ORF analysis, 175 of 178 sequences were predicted as ORFs and the most frequent SSRs were detected in 50 UTR（58.43 %）,followed by in ORF（31.46 %） and in 30UTR（8.43 %）. 102 of 178 ESTs were annotated as ribosomal protein, transport protein, membrane protein, carrier protein, binding protein,and transferase protein. For a total of 102 SSRs（57.3 %）with significant matches, a set of 102 primers（100 %） with forward and reverse strands was designed by using Primer 3 software. Serine（Ser, 19.6 %） was predominant in putative encoded amino acids and most of amino acids showed nonpolar（35.3 %） nature. Our data provide resources for *** and can be useful for in silico comparative analyses of Betulaceae species, including SSR mining.

关键词： Silver birch (Betula pendula) Betulaceae -EST-SSR SSR mining In silico analysis

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On attaining user-friendly hand gesture interfaces to control existing GUIs

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Virtual Reality & Intelligent Hardware 2020年第2期2卷 153-161页

作者： Egemen ertugrul Ping LI Bin SHENG Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Faculty of Information Technology Macao University of Science and TechnologyMacaoChina

Background Hand ge stur e interfaces are dedicated programs that principally perform hand tracking and hand gesture prediction to provide alternative controls and interaction *** take advantage of one of the most natural ways of interaction and communication,proposing novel input and showing great potential in the field of the human-computer *** a flexible and rich hand gesture interface is known to be a time-consuming and arduous *** published studies have demonstrated the significance of the finite-state-machine(FSM)approach when mapping detected gestures to GUI *** In our hand gesture interface,we broadened the FSM approach by utilizing gesture-specific attributes,such as distance between hands,distance from the camera,and time of occurrences,to enable users to perform unique GUI *** attributes are obtained from hand gestures detected by the RealSense SDK employed in our hand gesture *** means of these gesture-specific attributes,users can activate static gestures and perform them as dynamic *** also provided supplementary features to enhance the efficiency,convenience,and user-friendliness of our hand gesture ***,we developed a complementary application for recording hand gestures by capturing hand keypoints in depth and color images to facilitate the generation of hand gesture *** We conducted a small-scale user survey with fifteen subjects to test and evaluate our hand gesture *** feedback obtained from the users indicates that our hand gesture interface is adequately facile and self-explanatory to *** addition,we received constructive feedback about minor flaws regarding the responsiveness of the *** We proposed a hand gesture interface along with key concepts to attain use r-friendlines s and effectiveness in the control of existing GUIs.

关键词： Human-computer interaction Gesture recognition Computer vision applications

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