检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长沙航电枢纽三叶片转轮改造四叶片转轮浅析

水电站机电技术 2024年第5期47卷 14-18页

作者：尹斌勇纪攀佳李卫黎泽文贺玉平长沙市湘江综合枢纽工程办公室湖南长沙410200

针对长沙航电枢纽水电站机组在枯水期因下游水位下降严重,致使实际水头高于机组最大运行水头而不能运行的问题,以三叶片转轮改造为四叶片转轮技术方案为基础,论述了具体改造方案和相关技术复核工作,经理论分析和实践检验,得出结论:三叶... 详细信息

针对长沙航电枢纽水电站机组在枯水期因下游水位下降严重,致使实际水头高于机组最大运行水头而不能运行的问题,以三叶片转轮改造为四叶片转轮技术方案为基础,论述了具体改造方案和相关技术复核工作,经理论分析和实践检验,得出结论:三叶片转轮改造为四叶片转轮技术方案可行,改造效果良好。机组改造具体方案:①三叶片转轮改造为四叶片转轮,发电机功率因素由0.85调整至0.95,机组容量由9.5 MW增至10.6 MW;②机组改造后,转轮重量增加,水推力增大,进行厂房流道强度复核、振动复核,满足安全运行要求;③同时对机组导水机构、推力轴承、主轴、水导轴承进行改造或更换。供类似航电枢纽的问题处理提供借鉴参考。

关键词：航电枢纽转轮改造

Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer:An update

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第48期24卷 5454-5461页

作者： Rafael I jaén Patricia Prieto Marta Casado Paloma Martín-sanz Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Department of Biomedicine Instituto de Biomedicina de Valencia (CSIC) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares y Hepáticas y DigestivasISCⅢ Unidad Asociada IIBMULPGC Universidad de las Palmas de Gran Canaria (ULPGC)

The biosynthesis of prostanoids is involved in both physiological and pathological processes. The expression of prostaglandin-endoperoxide synthase 2(PTGs2; also known as COX-2) has been traditionally associated to the onset of several pathologies, from inflammation to cardiovascular, gastrointestinal and oncologic events. For this reason, the search of selective PTGs2 inhibitors has been a focus for therapeutic interventions. In addition to the classic non-steroidal anti-inflammatory drugs, selective and specific PTGs2 inhibitors, termed coxibs, have been generated and widely used. PTGs2 activity is less restrictive in terms of substrate specificity than the homeostatic counterpart PTGs1, and it accounts for the elevated prostanoid synthesis that accompanies several pathologies. The main regulation of PTGs2 occurs at the transcription level. In addition to this, the stability of the mRNA is finely regulated through the interaction with several cytoplasmic elements, ranging from specificmicroR NAs to proteins that control mR NA degradation. Moreover, the protein has been recognized to be the substrate for several post-translational modifications that affect both the enzyme activity and the targeting for degradation via proteasomal and non-proteasomal mechanisms. Among these modifications, phosphorylation, glycosylation and covalent modifications by reactive lipidic intermediates and by free radicals associated to the proinflammatory condition appear to be the main changes. Identification of these post-translational modifications is relevant to better understand the role of PTGs2 in several pathologies and to establish a correct analysis of the potential function of this protein in diseases progress. Finally, these modifications can be used as biomarkers to establish correlations with other parameters, including the immunomodulation dependent on molecular pathological epidemiology determinants, which may provide a better frame for potential therapeutic interventions.

关键词： Prostaglandins Prostaglandin-endoperoxide synthase 2 Post-translational modifications Glycosylation Colorectal cancer Inflammation

The promise and challenge of therapeutic genome editing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2020年第1期42卷 20-20,25,34,47,51,55,59,63,70,83,89,122页

作者： Doudna ja 不详

Genome editing,which involves the precise manipulation of cellular DNA sequences to alter cell fates and organism traits,has the potential to both improve our understanding of human genetics and cure genetic *** I discuss the scientific,technical and ethical aspects of using CRIsPR(clustered regularly interspaced short palindromic repeats)technology for therapeutic applications in humans,focusing on specific examples that highlight both opportunities and *** editing is-or will soon be-in the clinic for several diseases,with more applications under *** rapid pace of the field demands active efforts to ensure that this breakthrough technology is used responsibly to treat,cure and prevent genetic disease.

关键词： traits breakthrough editing

通心络胶囊对糖尿病大鼠心功能和心肌重塑的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

宁夏医学杂志 2024年第3期46卷 185-189页

作者：张雄慧贾丽张常喜闫文瑞杨珂珂宁夏中西医结合医院宁夏银川750021 宁夏回族自治区体检康复保健中心宁夏银川750002 宁夏回族自治区中医医院宁夏银川750021 宁夏医科大学宁夏银川750004

目的研究通心络胶囊对糖尿病大鼠心功能及心肌重塑的影响。方法选取spargue Dawley(sD)雄性大鼠83只,用2%链脲佐菌素(sTZ)30 mg/kg造模后,将其随机分为通心络高、中、低剂量组、缬沙坦组、糖尿病组。各组灌胃10周;监测其体重及血糖;大... 详细信息

目的研究通心络胶囊对糖尿病大鼠心功能及心肌重塑的影响。方法选取spargue Dawley(sD)雄性大鼠83只,用2%链脲佐菌素(sTZ)30 mg/kg造模后,将其随机分为通心络高、中、低剂量组、缬沙坦组、糖尿病组。各组灌胃10周;监测其体重及血糖;大鼠麻醉后测定其心功能,测定心脏质量指数,ELIsA法测定大鼠心肌匀浆TGF-β1、Caspase-3、bcl-2蛋白含量。结果通心络胶囊的高、中、低剂量组及缬沙坦组较糖尿病组精神状态更活跃,毛色有光泽,多食、多饮、多尿症状减轻,大便较干燥,体重增加。造模后,通心络高、中、低剂量组、缬沙坦组及糖尿病组较空白对照组明显下降,灌胃4~10周,各组较空白对照组差异均有统计学意义(P0.05)。心室间隔厚度、室后壁厚度、室舒张末期内径、左室收缩末期内径、左室舒张末期容积、左室收缩末期容积指标比较,缬沙坦组和通心络高剂量组较糖尿病组各指标均明显降低(Pspase-3指标中,缬沙坦组和通心络高、中剂量组较糖尿病组均明显降低(P0.05)。bcl-2指标中,缬沙坦和通心络高、中剂量组较糖尿病组明显增加(P<0.05),通心络高剂量组明显高于缬沙坦组(P<0.05)。结论通心络胶囊可以明显改善糖尿病大鼠的心功能、抑制心肌重塑,疗效可观。

关键词：糖尿病心肌病 sD大鼠心功能心肌重塑

Phosphorylated p70s6K in urothelial carcinoma of the tumor recurrence noninvasive low-grade bladder： correlation with

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第4期16卷 611-617页

作者： soon-ja Kim Jung Hoon Kim Hui seok Jung Tae-Jin Lee Kyung Mee Lee In Ho Chang Department of Convergence Medicine and Pharmaceutical Biosciences Chung-Ang University Graduate School Seoul Department of Urology Department of Pathology Chung-Ang University College of Medicine Seoul Korea.

We investigated whether inhibiting phosphorylated p70s6K （p-p70s6K） suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma （LG-URCa） in vitro and whether p-p70s6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray （TMA） for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70s6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effect of rapamycin, its antiproliferative effect and the growth-inhibition effect of p70s6K siRNA transfection in RT4 and 253J cell lines. The pT1 staged group （P 〈 0.05; hazard ratio （HR）, 2.415） and the high p-p70s6K staining group （P 〈 0.05; HR, 2.249） were independent factors for predicting recurrence. Rapamycin inhibited RT4 and 253J cell proliferation in a dose-dependent manner （r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells）. RT4 and 253J cell proliferation and growth were inhibited by the transfection of p70s6K siRNA and rapamycin, respectively （P 〈 0.05）. Transfection of p70s6K siRNA resulted in inhibitory effects on cell proliferation and growth that were similar to those of rapamycin. Our results suggest that inhibiting p70s6K phosphorylation is important to prevent recurrence and that p70s6K phosphorylation can be used as a molecular biomarker to predict recurrence of certain LG-URCa of the bladder.

关键词： bladder cancer p7Os6K

Gastrointestinal stromal tumor of appendix incidentally diagnosed by appendiceal hemorrhage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第23期13卷 3265-3267页

作者： Kyu-Jong Kim Won Moon Moo In Park seun ja Park seung Hyun Lee Bong Kwon Chun Department of Internal Medicine Kosin University College of Medicine Busan South Korea Department of General surgery Kosin University College of Medicine Busan South Korea Department of Pathology Kosin University College of Medicine Busan South Korea

Gastrointestinal stromal tumor is rare, which arises from the mesenchymal tissues in the gastrointestinal tract, and it is extremely rare in the appendix. Only a few cases have been found in this location to date. Although the annual incidence of lower gastrointestinal bleeding has been increasing, bleeding related to the appendix is quite rare. We herein present a very rare case of gastrointestinal stromal tumor incidentally found by appendiceal hemorrhage.

关键词： Gastrointestinal stromal tumor Gastrointestinal tract Appendix Lower gastrointestinal bleeding Appendiceal hemorrhage

Hot Deformation Behavior and Microstructural Characteristics of Ti–46Al–8Nb Alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica sinica(English Letters) 2018年第9期31卷 933-944页

作者： Tian-Rui Li Guo-Huai Liu Mang Xu Tian-Liang Fu Yong Tian Ra-ja Devesh Kumar Misra Zhao-DongWang state Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Laboratory for Excellence in Advanced steel Research Department of MetallurgicalMaterials and BiomedicalEngineeringUniversity of Texas at E1 PasoE1 PasoTX 79968-0521USA

Hot deformation behavior, microstructural evolution and flow softening mechanism were investigated in Ti-46A1-8Nb alloy via isothermal compression approach. The true stress-strain curves exhibited typical work hardening and flow softening, in which the dependence of the peak stress on temperature and strain rate was obtained by hyperbolic sine equation with Zener-Hollomon （Z） parameter, and the activation energy was calculated to be 446.9 kJ/mol. The microstructural analysis shows that the alternate dark and light deformed ribbons of Al-rich and Nb-rich regions appeared and were associated with local flow involving solute segregation. The Al segregation promoted flow softening mainly arising from the recrystaUization of V phase with low stacking fault energy. The coarse recrystallized 7 and several massive phase were observed at grain boundaries. While in the case of Nb segregation, t/B2 phase harmonized bending of lamellae, combined with the growth of recrystallized γ grains and α ＋ β ＋ γ→α＋ γ transition under conditions of temperature and stress, leading to the breakdown of α2/γ lamellar colony. During the hot compression process, gliding and dissociation of dislocations occurred in γ phase that acted as the main softening mechanism, leading to extensive γ twins and cross twins in α/γ lamellae and at grain boundaries. In general, homogeneous microstructure during the hot defor- mation process can be obtained in TiAl alloy with high Nb addition and low Al segregation. The deformation substructures intrinsically promote the formability of Ti--46Al-8Nb alloy.

关键词： Titanium aluminides Deformation behavior Activation energy Dynamic recrystallization Local flow softening

在线全文

学校读者我要写书评

暂无评论

拟南芥AtJ3基因的克隆和分析

Acta Botanica sinica 1999年第6期41卷 597-602页

作者：周人纲 Mier.,ja 河北省农林科学院农业物理生理生化研究所

克隆并分析了拟南芥（Ａｒａｂｉｄｏｐｓｉｓｔｈａｌｉａｎａ（Ｌ．）Ｈｅｙｎｈ．）ＡｔＪ３的ｃＤＮＡ核苷酸序列，并证明其翻译产物与Ｅ．ｃｏｌｉ的ＤｎａＪ蛋白高度同源。ＡｔＪ３蛋白分子中具有全部这类蛋白的典型特征包括Ｊ结... 详细信息

克隆并分析了拟南芥（Ａｒａｂｉｄｏｐｓｉｓｔｈａｌｉａｎａ（Ｌ．）Ｈｅｙｎｈ．）ＡｔＪ３的ｃＤＮＡ核苷酸序列，并证明其翻译产物与Ｅ．ｃｏｌｉ的ＤｎａＪ蛋白高度同源。ＡｔＪ３蛋白分子中具有全部这类蛋白的典型特征包括Ｊ结构域（ｄｏｍａｉｎ）、Ｇ或ＧＦ结构域、富含半胱氨酸的锌指结构域，Ｃ末端的ＣＡＱＱ是一个蛋白法尼基化信号。用ＡｔＪ３的ｃＤＮＡ序列末端非翻译区作探针，从拟南芥基因组文库中分离获得ＡｔＪ３基因。基因序列分析表明该基因是由被５个内含子分隔的６个外显子组成。根据Ｓｏｕｔｈｅｒｎ杂交分析，ＡｔＪ３基因为单拷贝基因。Ｎｏｒｔｈｅｒｎ分析结果表明，ＡｔＪ３在子叶、叶、根、花及长角果中都表达。

关键词： cDNA 分子伴侣 AeJ3基因克隆序列分析

Two Types of Diurnal Variations in Heavy Rainfall during July over Korea

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric sciences 2021年第12期38卷 2201-2211页

作者： Chang-Kyun PARK Minhee CHANG Chang-Hoi HO Kyung-ja HA Jinwon KIM Byung-Ju sOHN school of Earth and Environmental sciences Seoul National UniversitySeoul 08826Korea school of Earth and Environmental systems Pusan National UniversityBusan 46241Korea Center for Climate Physics Institute for Basic ScienceBusan 46241Korea National Institute of Meteorological sciences Korean Meteorological AdministrationJeju 63568Korea

This study examined the characteristics of the diurnal variations of heavy rainfall(≥110 mm in 12 hours)in Korea and the related atmospheric circulation for July from 1980−*** the analysis period,two dominant pattens of diurnal variation of the heavy rainfall emerged:all-day heavy rainfall(AD)and morning only heavy rainfall(MO)*** the AD-type,the heavy rainfall is caused by abundant moisture content in conjunction with active convection in the morning(0000−1200,LsT;LsT=UTC+9)and the afternoon hours(1200−2400 LsT).These systems are related to the enhanced moisture inflow and upward motion induced by the strengthening of the western North Pacific subtropical high and upper-tropospheric *** the MO-type,heavy rainfall occurs mostly in the morning hours;the associated atmospheric patterns.are similar to the *** find that the atmospheric pattern related to severe heavy rainfalls in 2020 corresponds to a typical AD-type and resembles the 1991 heavy-rainfall system in its overall synoptic/mesoscale *** present results imply that extremely heavy rainfall episodes in Korea during the 2020 summer may occur again in the future associated with the recurring atmospheric phenomenon related to the heavy rainfall.

关键词： heavy rainfall diurnal cycle of rainfall 2020 summer summer rainy season Korea