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Correlation network analysis shows divergent effects of a long-term,high-fat diet and exercise on early stage osteoarthritis phenotypes in mice

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Journal of Sport and Health Science 2020年第2期9卷 119-131页

作者： Timothy M.Griffin Albert Batushansky Joanna Hudson Erika Barboza prado lopes Aging and Metabolism Research Program Oklahoma Medical Research Foundation(OMRF)Oklahoma CityOK 73104USA Reynolds Oklahoma Center on Aging and Departments of Biochemistry and Molecular Biology Physiologyand Geriatric MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

Background:Obesity increases knee osteoarthritis(OA) risk through metabolic,inflammatory,and biomechanical factors,but how these systemic and local mediators interact to drive OA pathology is not well *** tested the effect of voluntary running exercise after chronic diet-induced obesity on knee OA-related cartilage and bone pathology in *** then used a correlation-based network analysis to identify systemic and local factors associated with early-stage knee OA phenotypes among the different diet and exercise ***:Male C57 BL/6 J mice were fed a defined control(10% kcal fat) or high fat(HF)(60% kcal fat) diet from 6 to 37 weeks of *** 25 weeks,one-half of the mice from each diet group were housed in cages with running wheels for the remainder of the ***,micro computed tomography,and magnetic resonance imaging were used to evaluate changes in joint tissue structure and OA *** local variables were then compared to systemic metabolic(body mass,body fat,and glucose tolerance),inflammatory(serum adipokines and inflammatory mediators),and functional(mechanical tactile sensitivity and grip strength) outcomes using a correlation-based network *** and exercise effects were evaluated by two-way analysis of ***:An HF diet increased the infrapatellar fat pad size and posterior joint osteophytes,and wheel running primarily altered the subchondral cortical and trabecular *** HF diet nor exercise altered average knee cartilage OA scores compared to control ***,the coefficient of variation was≥25% for many outcomes,and some mice in both diet groups developed moderate OA(>33% maximum score).This supported using correlation-based network analyses to identify systemic and local factors associated with early-stage knee OA *** wheel-running cohorts,an HF diet reduced the network size compared to the control diet group despite similar running distances,suggesting that diet-induced obesi

关键词： Inflammation Knee Mouse Obesity Wheel running

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Functional traits shape size-dependent growth and mortality rates of dry forest tree species

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Journal of Plant Ecology 2017年第6期10卷 895-906页

作者： Jamir A.prado-Junior Ivan Schiavini Vagner S.Vale Diego Raymundo Sergio F.lopes Lourens Poorter Biology Institute Federal University of UberlandiaUberlandiaBrazil Forest Ecology and Forest Management Group Wageningen UniversityPO Box 476700 AA WageningenThe Netherlands Forestry Department State University of Goias-Ipameri CampusRoad GO-330 Km 24175780-000 IpameriBrazil Biological Sciences Institute Federal University of Juiz de Fora 36036-900Juiz de ForaBrazil Biology Department State University of ParaibaBaraunas street 58429-500Campina GrandeBrazil

Aims Functional traits have emerged as an important tool to evaluate plant ***,the environmental conditions and ecological pressures that plants face change with their size,and the relationship between traits and plant performance should therefore be size-dependent,which has rarely been *** Here,we evaluated over a broad range of tree sizes the interspe-cific relationship between tree growth and mortality and eight func-tional stem,leaf and seed *** did so across 59 tree species in Brazilian dry forests and evaluated whether the relationships found for wet forest types in the literature also hold for dry forests,where water rather than light might limit tree *** Findings We indeed found a strong size-dependent relationship between demographic rates and functional *** small sizes,when trees are in the shaded understory,species with functional trait values that enhance light capture or shade tolerance(*** maximum adult stature,taller heights,wider crowns,higher seed mass)have higher growth and/or lower mortality rates(MR).This relationship disappears at larger sizes when trees attain better light conditions in the *** adaptations play only a role at larger tree sizes;once trees are in the dry and exposed canopy,species with higher wood density(an indicator of cavitation resistance)have lower *** study shows that both drought and shade adaptations are important in this dry forest,and that the relationships between func-tional traits and plant performance changes with plant *** size should therefore explicitly be included as an axis of variation in functional analyses,to better understand the relationship between functional traits and demographic rates.

关键词： demographic rates leaf traits seed mass tree architecture wood density

Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats

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Acta Pharmacologica Sinica 2004年第10期 17-21页

作者： Gisele lopes,Vilma A F G GAZOLA,Sharize B GALENDE,Wilson ALVES-DO-prado,Rui CURI,Roberto B BAZOTTE CNPq fellowship Maringd PR 87020-900 State University of Maringd Maringd PR 87020-900 CNPq fellowship Maringa PR 87020-900 State University of Maringá Maringá PR 87020-900 "University of Sao Paulo Sao Paulo SP 05508-900 Brazil

AIM: To compare the acute effects of l-carnitine (LCT) and dl-carnitine (DLC) on hepatic catabolism of l-alanine and l-glutamine in rats. METHODS: Livers from 24 h fasted and fed rats were perfused in situ. The substrates l-alanine (5 mmol/L) and l-glutamine (5 mmol/L) were employed. The gluconeogenic and ureogenic activity was measured as the difference between the rates of glucose and urea released during and before the infusion of l-glutamine or l-alanine. RESULTS: LCT (60 umol/L) but not DLC (60 umol/L and 120 umol/L) increased the production of glucose and urea from l-glutamine. However, neither LCT (60 umol/L and 120 umol/L) nor DLC (60 umol/L and 240 μmol/L) showed any significant effect on hepatic glucose and urea production from l-alanine. CONCLUSION: The results showed a different acute effect of LCT and DLC on the activation of hepatic gluco-neogenesis and ureagenesis promoted by l-glutamine, reinforcing the idea that DLC could not replace LCT.

关键词： carnitine liver metabolism gluconeogenesis ureagenesis l-glutamine

Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum

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World Journal of Gastroenterology 2009年第28期15卷 3565-3568页

作者： Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira lopes Department of Pathology University Hospital of Brasília Department of Radiology University Hospital of Brasília Department of Hematology University Hospital of Brasília Department of Surgery University Hospital of Brasília

We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum. A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss. On computed tomography （CT） a wall thickening of the fourth part of the duodenum was observed. Multiple biopsies obtained from the lesion showed infiltration of plasma cells and lymphocytes, but they were not conclusive. The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse infiltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria. An extensive deposition of amyloid was also observed. Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ： light chain positive. These cells also were positive for CD138 and CD56 but negative for CD20 and CD79. The findings were consistent with extramedullary plasmocytoma associated with a massive deposit of amyloid in duodenum. A subsequent workup for multiple myeloma was completely negative. The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up. Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future.

关键词： Extramedullary plasmocytoma Amyloidosis Duodenum Plasma cell neoplasms Immunohistochemistry

Effect of overnight temperature on leaf photosynthesis in seedlings of Swietenia macrophylla King

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Journal of Forestry Research 2003年第2期14卷 130-134页

作者：张成军 Carlos Henrique B.de A.prado 祖元刚郭佳秋 Carlos Cesar Ronquim Leonnardo lopes Ferreira 东北林业大学森林植物生态学教育部重点实验室 Laboratory of Plant Physiology Department of BotanyFederal University of Sao Carlos 哈尔滨医科大学第二附属医院 Laboratory of Plant Physiology Department of BotanyFederal University of SaoCarlos

After exposure of one-year old seedlings of Swietenia macrophylla to an overnight temperature (13 C, 19 C, 25 C, 31 C or 35 C), the leaf net photosynthetic rate (Pn) was researched through measuring photosynthetic light-response curves at 360 mmolmol-1 CO2, and photosynthetic CO2-response curves at light-saturated intensity (1500 mmolm-2 s-1). The optimal temperature for photosynthesis measured at 360 mmol穖ol-1 CO2 was from 25 C to 31 C, but which was from 31C to 35 C at saturating CO2 concentration. At temperature of below 25 C, the decline in Pn was mainly due to the drop in carboxylation efficiency (Ce), while as temperature was over 31 C, the reduction in Pn resulted from both decrease in Ce and increase in leaf respiration. The CO2-induced stimulation of photosynthesis was strongly inhibited at temperatures below 13 C. The results showed that, the leaf photosynthesis of tropical evergreen plants should not be accelerated at low temperature in winter season with elevated CO2 concentration in the future.

关键词： Apparent quantum yield Carboxylation efficiency CO2-induced stimulation Swietenia macrophylla King Leaf temperature

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Analysis of Nursing Care Concept: Perspective of the Person Submitted to Care

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Open Journal of Nursing 2016年第6期6卷 491-496页

作者： Camila Brasil Moreira Ana Fátima Carvalho Fernandes Míria Conceição Lavinas Santos Altamira Mendonça Félix Gomes Carla Monique lopes Mourão Rosy Denyse Pinheiro de Oliveira Angelica Isabely de Morais Almeida Suzy Ramos Rocha Cláudia Rayanna Silva Mendes Sadrine Maria Eufrasino de Pinho Marinna Maria de Andrade Costa Jordana prado Benevides Caroline Batista de Queiroz Aquino Iarlla Silva Ferreira Raquel Vilanova Araujo Department of Nursing Federal University of Ceará Fortaleza Brazil

This study aimed to analyze the concept of nursing care to patients with breast cancer on chemotherapy treatment, according to the perspective of the person submitted to care. The study followed the conceptual analysis methodology proposed by Walker and Avant according to Waldow, and it was developed through consultation to SCOPUS and CINAHL databases. The selection was carried out by inclusion and exclusion criteria, constituting a sample of 7 articles. There have been identified the main uses of the risk concept, defining attributes, antecedents and consequences of the concept. The evaluation of the concept and nursing care to breast cancer patient on chemotherapy treatment allowed a broader understanding of the phenomenon, with emphasis on the skills and competencies in nursing care dispensed to woman on chemotherapy treatment for breast cancer.

关键词： Nursing Breast Neoplasms Analysis Research Nursing Care Chemotherapy