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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani marques PhD Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

The Role of Institutions:A Cross-country Analysis of Renminbi Trading in Foreign Exchange Markets

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China & World Economy 2022年第3期30卷 42-74页

作者： Marina Zucker-marques Pedro Perfeito da silva Division on Globalization and Development Strategies United Nations Conference on Trade and Development(UNCTAD)Switzerland Political Science Department Central European UniversityAustria

We explore how China's geographically targeted policies impact RMB overseas use individually or in *** policies include swap agreements,clearing banks,investment quotas,and direct trading between Chinese renminbi(RMB)and non-USD *** a fuzzy-set qualitative comparative analysis and using Bank of International Settlements cross-country data on foreign exchange markets,we find that institution building has lowered the barriers to international adoption of the ***,for countries economically close to China,high RMB trading is explained by either(i)having a clearing bank in the host market and direct quotations between the RMB and the local currency,or(ii)being a financial center and having access to the Chinese capital *** combination of policies is explained by the creation of(i)"trading posts"that provide RMB liquidity abroad,and(ii)channels that allow actors to " recycle" offshore RMB *** triangulate our results with interviews conducted with senior People’s Bank of China officials.

关键词： foreign exchange markets fuzzy-set qualitative comparative analysis institutional context international monetary system offshore RMB trading RMB internationalization

Prognosis of forest production using machine learning techniques

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Information Processing in Agriculture 2023年第1期10卷 71-84页

作者： Jeferson Pereira Martins silva Mayra Luiza marques da silva Adriano Ribeiro de Mendonca Gilson Fernandes da silva Antoˆnio Almeida de Barros Junior Evandro Ferreira da silva Marcelo Otone Aguiar Jeangelis silva Santos Nı´vea Maria Mafra Rodrigues Federal University of Espirito Santo UFESDepartment of Forestry and Wood ScienceAvenue Governor Lindemberg31629550-000 Jeroˆnimo MonteiroESBrasil b Departamento de Cieˆncias Agra´riasUniversidade Federal de Sa o Joa del-Rei Sete Lagoas CampusHighway MG 424-Km 47Sete LagoasMinas Gerais 35701-970Brazil Federal University of Para(UFPA) University Campus of AltamiraStreet Cel.Jose Porfırio2515Sa o Sebastiao68372-040 AltamiraPABrazil

Forest production and growth are obtained from statistical models that allow the generation of information at the tree or forest stand *** the use of regression models is common in forest measurement,there is a constant search for estimation procedures that provide greater ***,machine learning techniques have been used with satisfactory performance in measuring ***,methods such as Adaptive NeuroFuzzy Inference System(ANFIS)and Random Forest are relatively poorly studied for predicting the volume of wood in eucalyptus plantations in ***,it is essential to check whether these techniques can provide gains in terms of ***,this study aimed to evaluate the use of Random Forest and ANFIS techniques in the prognosis of forest *** data used come from continuous forest inventories carried out in stands of eucalyptus *** data were divided into 70%for training and 30%for *** algorithms used to generate rules in ANFIS were Subtractive Clustering and ***,training was done with the hybrid algorithm(descending gradient and least squares)with the number of seasons ranging from 1 to *** RFs were trained,varying the number of trees from 50 to 850 and the number of observations by five leaves to *** neural networks and decision trees were also trained to compare the feasibility of the *** evaluation of the estimates generated by the techniques for training and validation was calculated based on the following statistics:correlation coefficient(r),relative Bias(RB),and the relative root mean square error(RRMSE)in *** general,the techniques studied in this work showed excellent performance for the training and validation data set with RRMSE values*** RF presented inferior statistics about the ANFIS for the prognosis of forest *** Subtractive Clustering(SC)and Fuzzy-C-Means(FCM)algorithms provide accurate baseline

关键词： Artificial Intelligence Ensemble Learning Forest Measurement Forest inventory Artificial Neural Networks Regression

Metal alginates for polyphenol delivery systems: Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skin

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Bioactive Materials 2020年第3期5卷 447-457页

作者： João silva Pavlo Vanat Dorinda marques-da-silva Joaquim Rui Rodrigues Ricardo Lagoa School of Technology and Management Polytechnic Institute of LeiriaPortugal Laboratório Associado LSRE-LCM School of Technology and ManagementPolytechnic Institute of LeiriaPortugal UCIBIO-Faculty of Science and Technology NOVA University of LisbonPortugal

Incorporation of bioactive natural compounds like polyphenols is an attractive approach for enhanced functionalities of *** particular flavonoids have important pharmacological activities,and controlled release systems may be instrumental to realize the full potential of these *** presents interesting attributes for dermal and other biomaterial applications,and studies were carried here to support the development of polyphenol-loaded alginate *** of capillary viscosity indicated that ionic medium is an effective strategy to modulate the polyelectrolyte effect and viscosity properties of *** gelation,considerable differences were observed between alginate gels produced with Ca^2+,Ba^2+,Cu^2+,Fe^2+,Fe^3+and Zn^2+as crosslinkers,especially concerning shrinkage and morphological *** assays with different polyphenols in the presence of alginate-gelling cations pointed to the choice of calcium,barium and zinc as safer ***-based films loaded with epicatechin were prepared and the kinetics of release of the flavonoid *** results with calcium,barium and zinc alginate matrices indicated that the release dynamics is dependent on film thicknesses,but also on the crosslinking metal *** these grounds,an alginate-based system of convenient use was devised,so that flavonoids can be easily loaded at simple point-of-care conditions before dermal *** epicatechin-loaded patch was tested on an ex-vivo skin model and demonstrated capacity to deliver therapeutically relevant concentrations on skin ***,the flavonoid released was not modified and retained full antioxidant *** alginate-based system proposed offers a multifunctional approach for flavonoid controllable delivery and protection of skin injured or under risk.

关键词： Topical drug delivery Intrinsic viscosity Biopolymer Epigallocatechin-gallate Antioxidant dressing

Performance index: An expeditious tool to screen for improved drought resistance in the Lathyrus genus

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Journal of Integrative Plant Biology 2014年第7期56卷 610-621页

作者： Susana Silvestre Susana de Sousa Araújo Maria Carlota Vaz Patto Jorge marques da silva Center for Biodiversity Functional and Integrative Genomics(BioFIG)and Department of Plant BiologyFaculty of ScienceUniversity of LisbonCampo Grande Animal and Veterinary Sciences Research Center Tropical Research Institute(IICT‐CVZ)Faculty of Veterinary Medicine Plant Cell Biotechnology Lab Institute for Chemistry and Biological Technology António Xavier-New University of Lisbon(ITQB‐UNL)

Some species of the Lathyrus genus are among the most promising crops for marginal lands, with high resilience to drought, flood, and fungal diseases, combined with high yields and seed nutritional value. However, lack of knowledge on the mechanisms underlying its outstanding performance and methodologies to identify elite genotypes has hampered its proper use in breeding. Chlorophyl a fast fluorescence transient （JIP test）, was used to evaluate water deficit （WD） resistance in Lathyrus genus. Our results reveal unaltered photochemical values for al studied genotypes showing resistance to mild WD. Under severe WD, two Lathyrus sativus genotypes showed remarkable resilience maintaining the photochemical efficiency, contrary to other genotypes studied. Performance index （PIABS） is the best parameter to screen genotypes with improved performance and grain production under WD. Moreover, we found that JIP indices are good indicators of genotypic grain production under WD. Quantum yield of electron transport （wEo） and efficiency with which＆trapped excitons can move electrons further than QA （c0） revealed as important traits related to improved photosyn-thetic performance and should be exploited in future Lathyrus germplasm improvements. The JIP test herein described showed to be an expeditious tool to screen and to identify elite genotypes with improved drought resistance.

关键词： Grain production JIP test Lathyrus germplasm photochemical performance water deficit

Evaluation and modeling of runoff and sediment yield for different land covers under simulated rain in a semiarid region of Brazil

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International Journal of Sediment Research 2018年第2期33卷 117-125页

作者： Richarde marques da silva Celso Augusto Guimares Santos José Yure Gomes dos Santos Department of Geosaences Federal University of Paraíba Department of Civil and Environmental Engineering Federal University of Paraíba Federal University of Western Bahia Center for Humanities

This paper quantifies the runoff and sediment yield for four different land covers in a semiarid region of Brazil. The WESP model, a distributed, event-oriented runoff-erosion model, was applied and its physical parameters, NSand KR, were adjusted based on observed runoff and sediment yield data using simulated rainfall with an average intensity of 53 mm h-1. The sediment yield obtained was 53.02 kg ha-1(caatinga vegetation), 231.96 kg ha-1(bare soil), 309.75 kg ha-1(beans), and 847.38 kg ha-1(corn). The results showed that caatinga cover yields the lowest erosion and runoff when compared to the other *** results also show that the sediment yield and runoff values simulated with NS, KI, and KR parameters were well calibrated, within acceptable deviations. The caatinga vegetation was more effective in protecting the soil, when compared to the other types of coverage. The beans and corn covers had the highest values of runoff and sediment yield, even higher than those observed for bare soil.

关键词： Runoff Erosion Semiarid region WESP model

Development of Junction Elements from Study of the Bionics

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Journal of Bionic Engineering 2007年第1期4卷 41-46页

作者： Wilson Kindlein Junior Luis Henrique Alves Cndido André Canal marques Sandra Souza dos Santos Maurício da silva Viegas Laboratory of Design and Material Selection-LdSM-Materials Department (DEMAT) School of Engineering–EE Federal University of Rio Grande do Sul-Brazil-UFRGS Brazil

The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effectiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation, the development and the confection of new junction elements were described, and case studies of new products developed specifically with this purpose were presented.

关键词： bionics Ecodesign junction elements

Physiological plasticity in eucalyptus clones in the vegetative stage contributes to drought tolerance

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Journal of Forestry Research 2023年第5期34卷 1549-1561页

作者： Vilma marques Ferreira Jailma Ribeiro de Andrade Claudiana Moura dos Santos Sebastiao de Oliveira Maia Júnior Joao Correia de Araújo Neto Andrea Francisca da silva Santos Vicente Mota da silva Lucas Teles Bezerra Laurício Endres Laboratório de Fisiologia Vegetal Campus de Engenharia e Ciências AgráriasUniversidade Federal de AlagoasRio LargoAL57072-900Brazil Laboratório de Ciências Ambientais e Biodiversidade Departamento de Zootecnia.Centro de Ciências AgráriasUniversidade Estadual do MaranhãoSão LuísMA65300-000Brazil Laboratório de Propagação de Plantas.Campus de Engenharia e Ciências Agrárias Universidade Federal de AlagoasRio LargoAL57072-900Brazil Laboratório de Lepidoptera Museu de ZoologiaUniversidade de São PauloIpirangaSão PauloSP04263-000Brazil

With the expansion of eucalyptus crops to areas with severe water limitations,physiological studies involving eucalyptus clones to identify those that are tolerant to water stress become *** objective of this study was to assess morphological and physiological responses by eucalyptus clones subjected to drought stress and *** experiment consisted of three eucalyptus clones:VC865,I224 and I144 and two water regimes:control and water stress followed by rehydration,with six *** water potential,gas exchange,maximum quantum efficiency of photo systemⅡand plant height and stem diameter were evaluated under drought stress and ***6 d of rehydration,the number of leaves,leaf area and dry mass of root,leaf,stem and their total were *** clones showed intense reduction of gas exchange during the drought stress period,and only VC865 and 1144 showed rapid recovery with 3 d of *** 1224 showed greater reduction in height,stem diameter,number of leaves,water potential at midday(Ψ_(w)_(Midday)),and maximum quantum efficiency of photosystemⅡ(F_(v)/F_(m)).Clones VC865and T144 showed lower reductions inΨ_(wMidday)and F_(v)/F_(m) under ***865 had lower reductions in leaf number,leaf area and higher leaf dry mass,while clone I144 had higher height and lower reduction in root dry mass *** these clones showed higher water use efficiency with 3d of *** different phenotypic plasticities gave the clones VC865 and 1144 efficient mechanisms of acclimatization to stress and more drought tolerance,enhancing their greater capacity for recovery after stress,which allowed lower dry mass *** 1224,however,was more susceptible to drought stress,undergoing greater physiological damage with only partial recovery during rehydration.

关键词： Drought Eucalyptus species Gas exchanges Post-stress Root dry mass

Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?

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World Journal of Gastroenterology 2014年第18期20卷 5235-5243页

作者： Camila A Figueiredo Cintia Rodrigues marques Ryan dos Santos Costa Hugo Bernardino F da silva Neuza M Alcantara-Neves Instituto de Ciências da Saúde Universidade Federal da BahiaSalvadorBahia 41110-100Brazil

Helicobacter pylori(***)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human *** is a risk factor for gastritis,ulcer disease and stomach *** against *** is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including ***,host genetic factors that affect cytokines may determine differences in the susceptibility to many *** this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to *** and discuss how such polymorphisms may influence infection/disease outcomes.

关键词： Helicobacter pylori Stomach cancer Immunity Cytokines Polymorphisms