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Severe acute respiratory syndrome coronavirus 2 may cause liver injury via Na^(+)/H^(+) exchanger

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World Journal of Virology 2023年第1期12卷 12-21页

作者： Medine Cumhur Cure erkan Cure Department of Biochemistry Private Tanfer HospitalIstanbul 34394Turkey Department of Internal Medicine Bagcilar Medilife HospitalIstanbul 34200Turkey

the liver has many significant functions,such as detoxification,the urea cycle,gluconeogenesis,and protein *** diseases,hypoxia,infections,drugs,and toxins can easily affect the liver,which is extremely sensitive to *** infection of severe acute respiratory syndrome coronavirus 2 can cause liver *** primary regulator of intracellular pH in the liver is the Na+/H+exchanger(NHE).Physiologically,NHE protects hepatocytes from apoptosis by making the intracellular pH *** acute respiratory syndrome coronavirus 2 increases local angiotensin II levels by binding to angiotensinconverting enzyme *** severe cases of coronavirus disease 2019,high angiotensin II levels may cause NHE overstimulation and lipid accumulation in the *** overstimulation can lead to hepatocyte *** overstimulation may trigger a cytokine storm by increasing proinflammatory cytokines in the *** the release of proinflammatory cytokines such as interleukin-6 increases with NHE activation,the virus may indirectly cause an increase in fibrinogen and D-dimer *** overstimulation may cause thrombotic events and systemic damage by increasing fibrinogen levels and cytokine ***,NHE overstimulation causes an increase in the urea cycle while inhibiting vitamin D synthesis and gluconeogenesis in the *** NHE3 activity leads to Na+loading,which impairs the containment and fluidity of bile *** overstimulation can change the gut microbiota composition by disrupting the structure and fluidity of bile acid,thus triggering systemic *** other tissues,tumor necrosis factor-alpha and angiotensin II decrease NHE3 activity in the ***,increased luminal Na+leads to diarrhea and cytokine *** acute respiratory syndrome coronavirus 2-induced local and systemic damage can be improved by preventing virus-induced NHE overstimulation in the liver.

关键词： Liver Hepatocyte Severe acute respiratory syndrome coronavirus 2 COVID-19 Na+/H+exchanger Sodium-proton pump

An In-depth Analysis for Optimal Cable tray Support Span

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Sustainable Marine Structures 2020年第1期2卷 46-59页

作者： Sung Wuk Jung erkan Oterkus University of Strathclyde United Kingdom

Nowadays,it is crucial to reduce the cost of the overall project so that the competitiveness of offshore oil and gas without compromising on quality or safety can be *** study investigates how to define the longest cable tray support span considering constructability in order to reduce the number of supports which is a chief cost of a cable tray *** study presents not only material and geometry frequently used for cable tray but also the formula to estimate the maximum cable load which can be installed within cable *** verify the longest span without increasing the crosssection of cable tray,finite element modelling approach was employed based on ANSYS and comparisons were made between numerical analysis and simplified hand *** constructability for the longer span obtained from finite element analysis has been validated in view of manual handling of the cable *** is shown that the optimal span suggested in this paper can lead to a better economic benefit without degrading the *** instance,as the span is longer,the cost of material as well as construction manpower can be *** is also expected that this approach will contribute to enhance the competitiveness of offshore oil and gas.

关键词： Cable tray system Finite element method ANSYS Oil and gas Offshore

平坦部玻璃体切割治疗眼部Behcet并发症

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 35-36页

作者： Sullu Y. Alotaiby H. Beden U. erkan D. 邢咏新 Department of Ophthalmology Faculty of Medicine Ondokuz Mayis University 55139 Samsun Turkey

BACKGROUND AND OBJECtIVES: to evaluate the outcomes of vitreoretinal surgery f or the ocular complications of Behet’s disease. PAtIENtS AND MEtHODS: this re trospective study included 20 eyes of 15 patients with Behet’s disease (9 men , 6 women; mean age at surgery, 31.0±1.8 years; range, 21-44 years) who had un dergone vitreoretinal surgery for Behet’s disease at Ondokuz Mayis University , Faculty of Medicine, Department of Ophthalmology, Samsun, turkey, between Janu ary 2000 and September 2003. Postoperative visual acuity outcome, course of uvei tis, and complications were evaluated in all patients. RESULtS: Indications for surgery were vitreous opacities in 10 eyes (50%), cystoid macular edema in 5 ey es (25%), epiretinal membrane in 3 eyes (15%)-, and vitreous hemorrhage in 2 eyes (10%). At the last postoperative follow-up, visual acuity had increased 2 Snellen lines or more in 10 (50%) of 20 eyes. Cystoid macular edema completely improved in 3 (60%) of 5 eyes after vitrectomy. Uveitis attacks significantly decreased during follow-up (P=.015). Immunosuppressive treatment was stopped in 11 (73%) of 15 patients. Retinal detachment and phthisis were not observed in any eye. CONCLUSION: Vitreoretinal surgery may be useful in the treatment of pos terior segment complications of Behet’s disease.

关键词：玻璃体切割 Behcet 玻璃体切除术视网膜脱离术后视力葡萄膜炎玻璃体出血黄斑囊样水肿视网膜前膜玻璃体混浊

Impact of Polymer Coating on the Flexural Strength and Deflection Characteristics of Fiber-Reinforced Concrete Beams

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Journal of Building Material Science 2022年第2期4卷 26-35页

作者： Salih Kocak Kasim Korkmaz erkan Boztas University of West Florida PensacolaFlorida32514US Construction Management Program Eastern Michigan UniversityYpsilantiMichigan48197US

Liquid polymers(LP)have become an important structural material used in the construction industry in the last *** paper investigates the viability of using commercially available LPs as a coating material to improve the flexural strength of fiber-modified concrete *** scope included preparing rectangular prism concrete beams with a concrete mixture including fly ash and fiber and coating them with four different liquid polymers at a uniform thickness following the curing process while one set of samples was maintained under the same conditions as a control group without *** addition,cylindrical samples were prepared to determine the compressive strength of the concrete *** the curing process in an unconfined open-air laboratory environment for another 28 days,concrete samples were tested to determine the flexural strength and deflection characteristics under center point loading *** results revealed that all four coating types enhanced both the flexural strength and the average maximum deflection of the beams compared to the control *** the enhancement in the flexural strength changed approximately between 5%and 36%depending on the coating type,the improvements in average maximum deflections varied between 3.7%and 28.4%.

关键词： Concrete coating Liquid polymers Flexural strength Deflection Magnetic induction

指数预测模型和Smith预估器在SCR烟气脱硝控制系统中的应用

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热力发电 2016年第12期45卷 114-118页

作者：孙育红侯玉婷焦力刚李尔堪山东女子学院山东济南250300 西安热工研究院有限公司陕西西安710032 华能丹东电厂辽宁丹东118300

针对选择性催化还原（SCR）烟气脱硝系统喷氨量控制的大延迟特性使得常规PID控制难以取得较好控制效果的问题,本文采用非线性拟合法建立了SCR烟气脱硝入口NOx质量浓度指数预测模型,以该指数模型预测值为前馈信号,设计了SCR烟气脱硝喷氨... 详细信息

针对选择性催化还原（SCR）烟气脱硝系统喷氨量控制的大延迟特性使得常规PID控制难以取得较好控制效果的问题,本文采用非线性拟合法建立了SCR烟气脱硝入口NOx质量浓度指数预测模型,以该指数模型预测值为前馈信号,设计了SCR烟气脱硝喷氨系统的改进型串级Smith预估控制器,并在DCS中实现组态优化控制.实际应用结果表明：新型指数预测串级Smith预估控制能有效预测SCR烟气脱硝入口NOx质量浓度变化,补偿喷氨系统的迟延特性,改善喷氨系统的控制效果,节约脱硝系统喷氨量约15%~20%.

关键词：烟气脱硝 SCR 喷氨控制大滞后系统指数预测模型 Smith预估器

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江西相山济河口地区铀成矿规律及找矿方向

矿产勘查 2021年第5期12卷 1176-1183页

作者：魏欣吕川陶尔侃核工业二七○研究所江西南昌330200

济河口地区位于江西省相山矿田西部,邹家山和居隆庵矿床的中间过渡部位。前人认为该区的矿体主要以"邹家山"式规律赋存,重点对NE向断裂进行揭露。近年来随着钻探揭露,笔者首次提出济河口地区矿体赋存规律更倾向于"居隆庵式",即铀矿化受... 详细信息

济河口地区位于江西省相山矿田西部,邹家山和居隆庵矿床的中间过渡部位。前人认为该区的矿体主要以"邹家山"式规律赋存,重点对NE向断裂进行揭露。近年来随着钻探揭露,笔者首次提出济河口地区矿体赋存规律更倾向于"居隆庵式",即铀矿化受断裂和火山岩组间界面变异部位控制但基底并未扰动,矿体集中分布在碎斑熔岩与流纹英安岩界面"S"型凹兜底部。NW向济河口断裂是区内重要的控矿断裂,该断裂与火山岩岩性界面联合控制铀矿化的产出,两者复合处是第一有利成矿部位,而流纹英安岩与基底片岩界面与济河口断裂复合部位是第二有利成矿部位。第二有利部位将是相山西部未来深部找矿的主要方向,其内外侧的花岗斑岩是有利找矿标志。

关键词：相山铀矿地质调查工程 “居隆庵”式赋矿规律

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白面石矿田贯入玄武岩与铀成矿作用研究

铀矿地质 2021年第3期37卷 406-411页

作者：董昕昱陈欣陶尔侃核工业二七〇研究所江西南昌330200

白面石矿田铀矿化与贯入玄武岩有密切的时空关系,但前人往往将贯入玄武岩和第一层玄武岩归为一类进行研究,未单独研究贯入玄武岩与铀成矿的关系。文章在收集前人资料和野外工作的基础上对白面石矿田贯入玄武岩进行分析,认为在矿田内贯... 详细信息

白面石矿田铀矿化与贯入玄武岩有密切的时空关系,但前人往往将贯入玄武岩和第一层玄武岩归为一类进行研究,未单独研究贯入玄武岩与铀成矿的关系。文章在收集前人资料和野外工作的基础上对白面石矿田贯入玄武岩进行分析,认为在矿田内贯入玄武岩为多期次贯入的结果,可为铀成矿提供热源;贯入玄武岩贯入于第一层砂岩所形成的层间滑动带及次级裂隙,是导矿和储矿的有利场所;片理化褪色条带状贯入玄武岩为白面石矿田典型找矿标志。在未来工作中应着重注意白面石盆地内贯入玄武岩密集分布的地段,这些地段是成富矿的有利部位。

关键词：白面石矿田贯入玄武岩层间破碎带片理化

江西相山矿田鹏姑山地区铀成矿条件及资源潜力分析

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矿产勘查 2020年第1期11卷 114-120页

作者：许健俊陶尔侃魏欣核工业二七○研究所

鹏姑山地区位于相山矿田西部的居隆庵菱形断块与芙竹坪菱形断块所夹持的"锐角"部位,东邻邹家山、船坑及平顶山矿床,西靠书塘、李家岭及居隆庵矿床,是书塘的北东段与邹家山4号带西南延伸段。区内断裂构造发育,主要有贯穿整个鹏姑山地区... 详细信息

鹏姑山地区位于相山矿田西部的居隆庵菱形断块与芙竹坪菱形断块所夹持的"锐角"部位,东邻邹家山、船坑及平顶山矿床,西靠书塘、李家岭及居隆庵矿床,是书塘的北东段与邹家山4号带西南延伸段。区内断裂构造发育,主要有贯穿整个鹏姑山地区的北东向邹家山-石洞和北西向济河口两个主断裂,其次是主断裂派生的近南北向断裂,以及包含火山塌陷构造。通过近几年的勘查工作,在区内西端初步发现一条受近南北向济河口断裂控制的铀成矿带。矿体受构造、岩性组间界面以及蚀变复合控制。现有的资料显示,该区铀成矿地质条件优越,铀资源潜力大。

关键词：铀矿成矿条件资源潜力矿产勘查工程相山矿田鹏姑山地区江西

Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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Chinese Journal of Cancer Research 2015年第4期27卷 408-416页

作者： Nedim turan Mustafa Benekli Olcun Umit Unal ?lkay tugba Unek Didem tastekin Faysal Dane Efnan Alg?n Sukran Ulger tulay Eren turkan Ozturk topcu Esma turkmen Nalan Akgül Babacan Gulnihal tufan Zuhat Urakci Basak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem Balvan Ercelep Burcu Yapar taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci erkan Dogan Veli Berk Ozan Balakan Ahmet ?iyar Ekinci Mukremin Uysal ?brahim Petekkaya Sel?uk Cemil Ozturk ?nder tonyal? Bülent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman Buyukberber Department of Medical Oncology Faculty of Medicine Cumhuriyet University Department of Medical Oncology Faculty of Medicine Gazi University Department of Medical Oncology Faculty of Medicine Dokuz Eylul University Department of Medical Oncology Faculty of Medicine Necmettin Erbakan University Department of Medical Oncology Faculty of Medicine Marmara University Department of Radiation Oncology Faculty of Medicine Gazi University Department of Medical Oncology Numune Education and Research Hospital Department of Medical Oncology Faculty of Medicine Karadeniz Technical University Department of Medical Oncology Faculty of Medicine Trakya University Department of Medical Oncology Rize Education and Research Hospital Department of Medical Oncology Faculty of Medicine Dicle University Department of Medical Oncology Dr.Lutfi Kirdar Kartal Education and Research Hospital Department of Medical Oncology Sakarya Education and Research Hospital Department of Medical Oncology Faculty of Medicine Pamukkale University Department of Medical Oncology Faculty of Medicine Inonu University Department of Medical Oncology Faculty of Medicine Firat University Department of Medical Oncology Dr.Abdurrahman Yurtaslan Education and Research Hospital Department of Medical Oncology Faculty of Medicine Yuzuncu Yil University Department of Medical Oncology Faculty of Medicine Erciyes University Department of Medical Oncology Faculty of Medicine Sutcu Imam University Department of Medical Oncology Diyarbakir Education and Research Hospital Department of Medical Oncology Faculty of Medicine Kocatepe University Department of Medical Oncology Dr.Ersin Arslan State Hospital Department of Medical Oncology Education and Research Hospital Ad?yaman University Department of Medical Oncology Faculty of Medicine Mustafa Kemal University Department of Medical Oncology Faculty of Medicine Ataturk University

Background： We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma（PAC）.Methods： A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and ***： Of 563 patients, 472 received adjuvant chemotherapy（Ct） alone, chemoradiotherapy（CRt） alone, and chemoradiotherapy plus chemotherapy（CRt-Ct） were analyzed. Of the 472 patients, 231 were given CRt-Ct, 26 were given CRt, and 215 were given Ct. the median recurrence-free survival（RFS） and overall survival（OS） were 12 and 19 months, respectively. When Ct and CRt-Ct groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRt-Ct, Ct and CRt groups. to further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRt-Ct than Ct. In contrast, there was no significant differencebetween groups when patients with node-negative disease or patients with or without positive surgical margins were ***： Addition of radiation to Ct has a survival benefit in patients with node-positive disease following pancreatic resection.

关键词： Pancreatic adenocarcinoma adjuvant chemotherapy(adjuvant Ct) adjuvant radiotherapy