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Transcriptome changes in stages of non-alcoholic fatty liver disease

World Journal of Hepatology 2022年第7期14卷 1382-1397页

作者： Jihad Aljabban Michael Rohr Saad Syed Kamal Khorfan Vincent borkowski Hisham Aljabban Michael Segal Mohamed Mukhtar Mohammed Mohammed Maryam Panahiazar Dexter Hadley Ryan Spengler erin Spengler Department of Medicine University of Wisconsin Hospital and ClinicsMadisonWI 53792United States Department of Medicine University of Central Florida College of MedicineOrlandoFL 32827United States Department of Medicine Northwestern Memorial HospitalChicagoIL 60611United States Department of Gastroenterology and Hepatology University of California San Francisco-FresnoFresnoCA 93701United States Department of Medicine Barry UniversityMiamiFL 33161United States Department of Medicine Michigan State University College of Human MedicineEast LansingMI 49503United States Department of Medicine Windsor University School of MedicineSaint Kitts 1621CayonSaint Kitts and Nevis Department of Surgery University of California San FranciscoSan FranciscoCA 94305United States Department of Artificial Intelligence PathologyUniversity of Central Florida College of MedicineOrlandoFL 32827United States Department of Gastroenterology and Hepatology University of Wisconsin Hospital and ClinicsMadisonWI 53792United States

bACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the United States and *** currently understood model of pathogenesis consists of a‘multiple hit’hypothesis in which environmental and genetic factors contribute to hepatic inflammation and *** To examine the genetic expression of NAFLD and non-alcoholic steatohepatitis(NASH)tissue samples to identify common pathways that contribute to NAFLD and NASH *** We employed the Search Tag Analyze Resource for Gene Expression Omnibus platform to search the The National Center for biotechnology Information Gene Expression Omnibus to elucidate NAFLD and NASH *** NAFLD,we conducted meta-analysis of data from 58 NAFLD liver biopsies and 60 healthy liver biopsies;for NASH,we analyzed 187 NASH liver biopsies and 154 healthy liver *** Our results from the NAFLD analysis reinforce the role of altered metabolism,inflammation,and cell survival in pathogenesis and support recently described contributors to disease activity,such as altered androgen and long non-coding RNA *** top upstream regulator was found to be sterol regulatory element binding transcription factor 1(SREbF1),a transcription factor involved in lipid *** of SREbF1,we observed upregulation in CXCL10,HMGCR,HMGCS1,fatty acid binding protein 5,paternally expressed imprinted gene 10,and downregulation of sex hormone-binding globulin and insulin-like growth factor *** molecular changes reflect low-grade inflammation secondary to accumulation of fatty acids in the *** results from the NASH analysis emphasized the role of cholesterol in *** canonical pathways,disease networks,and disease functions were related to cholesterol synthesis,lipid metabolism,adipogenesis,and metabolic *** upstream regulators included proinflammatory cytokines tumor necrosis factor and IL1b,PDGF bb,and *** of beta-estradiol

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis bioinformatics AKT inhibitor Therapy

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Over 100-THz bandwidth selective difference frequency generation at LaAlO_(3)/SrTiO_(3) nanojunctions

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Light(Science & Applications) 2019年第1期8卷 968-974页

作者： Lu Chen erin Sutton Hyungwoo Lee Jung-Woo Lee Jianan Li Chang-beom Eom Patrick Irvin Jeremy Levy Department of Physics and Astronomy University of PittsburghPittsburghPA 15260USA Pittsburgh Quantum Institute PittsburghPA 15260USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWA 53706USA

The ability to combine continuously tunable narrow-band terahertz(THz)generation that can access both the farinfrared and mid-infrared regimes with nanometer-scale spatial resolution is highly promising for identifying underlying light-matter interactions and realizing selective control of rotational or vibrational resonances in nanoparticles or ***,we report selective difference frequency generation with over 100 THz bandwidth via femtosecond optical pulse *** THz emission is generated at nanoscale junctions at the interface of LaAlO_(3)/SrTiO_(3)(LAO/STO)that is defined by conductive atomic force microscope lithography,with the potential to perform THz spectroscopy on individual nanoparticles or *** simulation of the time-domain signal facilitates the identification of components that contribute to the THz *** ultra-wide-bandwidth tunable nanoscale coherent THz source transforms the LAO/STO interface into a promising platform for integrated lab-on-chip optoelectronic devices with various functionalities.

关键词： tunable lithography selective

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2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents

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Acta Pharmaceutica Sinica b 2017年第1期7卷 73-79页

作者： erin Marie Kirwen Tarun batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari Department of Pharmacology and Experimental Therapeutics College of Pharmacy & Pharmaceutical SciencesUniversity of Toledo School of Pharmaceutical Sciences Rajiv Gandhi Technical University The University of Queensland School of Pharmacy Dr. Reddy’s Institute of Life Sciences University of Hyderabad Campus The University of Queensland School of Biomedical Sciences Department of biosciences Sri Satya Sai Institute of Higher LearningAnantapur campus Clearsynth Labs Ltd. Research CentreIDA-Mallapur Molecular Endocrinology Lab Department of ZoologyUniversity of Lucknow University Institute of Pharmacy Chhatrapati Shahu Ji Maharaj University

In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-Mb-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme.

关键词： 3H-Imidazo[4,5-b]pyridine Cytotoxicity MTT assay COX inhibitors Docking studies

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Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup

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World Journal of Gastroenterology 2012年第26期18卷 3400-3408页

作者： Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez brian P Saunders Anthony N Kalloo bradley creel Vikas Singh Anne Marie Lennon Daniel C DeMarco Department of Gastroenterology and Hepatology University Medical Center Utrecht3508 GA UtrechtThe Netherlands Division of Gastroenterology and Hepatology Kansas City Veterans Administration Medical CenterKansas CityMO 64128United States Department of Gastroenterology Bayside Endoscopy Center33 Staniford StreetProvidenceRI 02905United States Department of Gastroenterology Cliniques Universitaires Saint-LucUniversité Catholique de LouvainB-1200 BrusselsBelgium Department of Gastroenterology and Hepatology Dartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756United States Department of Gastroenterology Istituto Clinico Humanitas20089 RozzanoItaly Department of Internal Medicine Division of Gastroenterology and HepatologyJohns Hopkins HospitalBaltimoreMD 21205United States Wolfson Unit for Endoscopy St.Mark's HospitalHarrow HA1 3UJUnited Kingdom Department of Internal Medicine Division of GastroenterologyBaylor University Medical CenterDallasTX 75246United States

AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial ***:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward *** performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the *** were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice ***:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was *** reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to *** risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic *** RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic *** a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically ***

关键词： Colonoscopy Colorectal cancer Adenomas Miss rates Retrograde-viewing

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激光辅助扫描隧道显微镜对纳米碳管的研究

激光辅助扫描隧道显微镜对纳米碳管的研究

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中国化学会第二十五届学术年会

作者：时东霞 Joshua b.ballard erin S.Carmichael Joseph W.Lyding Martin Gruebele 中国科学院物理研究所纳米物理实验室 beckman Institute of Advanced Science and Technology University of IllinoisUrbanaIllinois61801 beckman Institute of Advanced Science and Technology University of IllinoisUrbanaIllinois61801 beckman Institute of Advanced Science and Technology University of IllinoisUrbanaIllinois61801 beckman Institute of Advanced Science and Technology University of IllinoisUrbanaIllinois61801

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Corrigendum to“Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases”[Synth Syst biotechnol 5(2)(2020)62–80]

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Synthetic and Systems biotechnology 2020年第4期5卷 268-268页

作者： erin E.Drufva Elijah G.Hix Constance b.bailey Department of Chemistry University of Tennessee-KnoxvilleKnoxvilleTN37996USA

The authors regret that following the publication of the original article,the authors noticed that some of the structures in Fig.10 were *** is the corrected figure.

关键词： enable directed Site

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含并五苯二醌聚芳醚的近红外电致变色性质研究

含并五苯二醌聚芳醚的近红外电致变色性质研究

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2005年全国高分子学术论文报告会

作者：王圣 erin K．Todd Maria birau 张继东宛新华王植源高分子化学与物理教育部重点实验室北京大学化学学院高分子科学与工程系 Department of Chemistry Carleton University1125 Colonel By DriveOttawaOntarioCanada K1S 5B6 Department of Chemistry Carleton University1125 Colonel By DriveOttawaOntarioCanada K1S 5B6 Department of Chemistry Carleton University1125 Colonel By DriveOttawaOntarioCanada K1S 5B6 高分子化学与物理教育部重点实验室北京大学化学学院高分子科学与工程系高分子化学与物理教育部重点实验室北京大学化学学院高分子科学与工程系

＜正＞我们合成了一系列具有近红外电致变色性质的含并五苯二醌结构单元的聚芳醚以及它们的模型化合物,并对它们进行了结构表征和性质研究。通过缩聚共聚的方法我们将具有电活性的并五苯二醌单元引入聚芳醚中,所得到的聚合物都有好的热... 详细信息

＜正＞我们合成了一系列具有近红外电致变色性质的含并五苯二醌结构单元的聚芳醚以及它们的模型化合物,并对它们进行了结构表征和性质研究。通过缩聚共聚的方法我们将具有电活性的并五苯二醌单元引入聚芳醚中,所得到的聚合物都有好的热稳定性以及较高的玻璃化

关键词：近红外光活性电致变色并五苯二醌聚芳醚

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家庭中杀虫剂浓度的时间变异性和对流行病学研究中衰减偏倚的启示

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环境与职业医学 2013年第8期30卷 647-647页

作者： Nicole C.Deziel Mary H.Ward erin M.bell Todd P.Whitehead Robert b.Gunier Melissa C.Friesen John R.Nuckols

[背景]已证实住宅杀虫剂暴露与成人和儿童的不良健康结局相关。高质量的暴露评估是确认这些关联的关键。以往的流行病学研究采用一次测量地毯灰尘中杀虫剂浓度来描述个体长期暴露的平均值。如果浓度随着时间的推移而变化，那么这种方法... 详细信息

[背景]已证实住宅杀虫剂暴露与成人和儿童的不良健康结局相关。高质量的暴露评估是确认这些关联的关键。以往的流行病学研究采用一次测量地毯灰尘中杀虫剂浓度来描述个体长期暴露的平均值。如果浓度随着时间的推移而变化，那么这种方法会导致对暴露明显的错误分类，削弱对风险的估计。[目的]评估地毯灰尘样本中杀虫剂浓度的可重复性和流行病学研究中依赖于一个样本的潜在衰减偏倚。[方法]在2003-2005年期间，从加州Fresno县的21个家庭中，重复收集地毯灰尘样本（中位数=3，范围1～7）。使用气相色谱-质谱法分析灰尘中的13种杀虫剂；采用混合效应模型估计家庭之间和家庭内的方差。计算每一种杀虫剂的组内相关系数（ICC），并估计收集单次灰尘样品的假设病例对照研究衰减回归系数。[结果]ICC的中位数为0．73（范围0．37—0．95），表明大多数杀虫剂家庭之间的变异性高于家庭内部的变异性。对于13种化合物中进行评估的7种，与使用单一灰尘样本相关的预期衰减偏倚估计为≤30％。[结论]对于研究的几种杀虫剂，使用一个灰尘样本代表约为2年的暴露期，其比值比不会大幅衰减。还需要进一步研究，以确定上述研究结果是否可以代表更长的暴露时间并且适用于其他杀虫剂。

关键词：灰尘环境暴露杀虫剂信度

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视网膜前体细胞异种移植于猪视网膜形态的整合及细胞化学水平上的分化

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美国医学会眼科杂志（中文版） 2006年第4期18卷 247-247页

作者： Karin Warfvinge Jens F. Külgaard erin b. Lavik Erik Scherfig Robert Langer Henry J. Klassen Michael J. Young 陈慧瑾（译）

目的：研究小鼠的视网膜前体细胞在移植到成年猪视网膜下腔后，细胞的成活，整合以及分化。

关键词：视网膜前体细胞细胞化学异种移植成年猪视网膜下腔

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The Global Soil Mycobiome consortium dataset for boosting fungal diversity research

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Fungal Diversity 2021年第6期111卷 573-588页

作者： Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken bobby P.Sulistyo boris Tamgnoue brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai Daniyal Gohar Dipon Sharmah Elisabeth Machteld biersma erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.brearley Franz buegger Genevieve Gates Geoffrey Zahn Gregory bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.barrio Jaan Pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta Alvarez-Manjarrez Jutamart Monkai Kadri Põldmaa Kadri Runnel Kalev Adamson Kari A.bråthen Karin Pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel Panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn bauters Miklós bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.Mortimer Peter Meidl RHenrik Nilsson Rasmus Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou Sergei Põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike Piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov Mycology and Microbiology Center University of TartuTartuEstonia Institute of Ecology and Earth Sciences TartuEstonia Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden Department of botany University of the PunjabQuaid-e-Azam CampusLahorePakistan Centro de Investigaciones en Microbiología y biotecnología-UR(CIMbIUR) Facultad de Ciencias NaturalesUniversidad del RosarioBogotáColombia Grupo de Microbiología Ambiental y bioMicro Escuela de MicrobiologíaUniversidad de Antioquia UdeAMedellínColombia Department of Agricultural Food and Forest SciencesUniversity of PalermoPalermoItaly Royal botanic Gardens SurreyUK Department of biomedical Sciences University of CagliariCagliariItaly Research Group Mycology Department of BiologyGhent UniversityGhentBelgium Department of biomedicine Indonesia International Institute for Life SciencesJakartaIndonesia Plant Pathology and Agricultural Zoology Research Unit Department of Plant ProtectionFaculty of Agronomy and Agricultural SciencesUniversity of DschangDschangCameroon Department of Ecology and Genetics Uppsala UniversityUppsalaSweden Eukaryotic Microbiology University of Duisburg-EssenEssenGermany Department of biological Sciences and biotechnology Botswana International University of Science and TechnologyPalapyeBotswana Natural History Museum of Zimbabwe BulawayoZimbabwe Institute of botany Czech Academy of SciencesPrůhoniceCzech Republic Center for Yunnan Plateau biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingPeople’s Republic of China Department of botany Jawaharlal Nehru Rajkeeya MahavidyalayaPondicherry UniversityPort BlairIndia british Antarctic Survey NERCCambridgeUK Natural History Museum of Denmark University of CopenhagenCopenhagenDenmark Department of Environmental Science Saint Mary’s UniversityHalifaxNSCanada Altai State University BarnaulRussia CSIRO Land and Water WembleyWAAustralia Department of N

Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and *** data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and *** dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from Pacbio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all *** plots are supplied with geographical and edaphic *** OTUs are taxonomically and functionally assigned to guilds and other functional *** entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential *** dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published *** GSMc dataset is available over the PlutoF repository.

关键词： Soil fungi Global dataset Pacbio sequencing Fungal richness

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