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Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives

World Journal of Gastroenterology 2019年第38期25卷 5773-5788页

作者： Antonio Pellino erika riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah Sara Lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan Department of Oncology Veneto Institute of Oncology IOV-IRCCSPadua 35100Italy Department of Surgery Oncology and GastroenterologyUniversity of PaduaPadua 35100Italy Surgical Pathology&Cytopathology Unit Department of MedicineUniversity of PaduaPadua 35100Italy Veneto Cancer Registry Padua 35100Italy

Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every *** the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the *** the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression ***,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival ***,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent *** aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC.

关键词： Gastric cancer Personalized medicine Predictive biomarkers Molecular diagnostic The Cancer Genome Atlas Asian Cancer Research Group

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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy erika Orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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WTR:A Reputation Metric for Distributed Hash Tables Based on a Risk and Credibility Factor

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Journal of Computer Science & Technology 2009年第5期24卷 844-854页

作者： Xavier Bonnaire erika Rosas Departamento de Informatica Universidad Tecnica Federico Santa MariaValparaisoChile Laboratoire d'Informatique de Paris 6 Universite Pierre et Marie CurieCNRS UMR 7606 INRIA REGALParisFrance

The growing number of popular peer to peer applications during the last five years has implied for researchers to focus on how to build trust in such very large scale distributed systems. Reputation systems have shown to be a very good solution to build trust in presence of malicious nodes. We propose in this paper a new metric for reputation systems on top of a Distributed Hash Table that uses a notion of risk to make the applications aware of certain behaviours of malicious nodes. We show that our metric is able to significantly reduce the number of malicious transactions, and that it also provides very strong resistance to several traditional attacks of reputations systems. We also show that our solution can easily scale, and can be adapted to various Distributed Hash Tables.

关键词： peer to peer reputation system risk evaluation

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Functional Design for Customizing Sit-To-Stand Assisting Devices

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Journal of Bionic Engineering 2018年第1期15卷 83-93页

作者： Pierluigi Rea erika Ottaviano DICeM-Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via Di Biasio 43 03043 Cassino (FR) Italy

Standing up refers to the transition from the seating to the standing postures to perform a movement that involves several body segments and requires both voluntary action and equilibrium control during an important displacement of the body Centre of Gravity （COG）. This task can be considered very important for people with reduced mobility to achieve minimal independence in Activity of Daily Living （ADL）. In this paper, we propose solutions for the homecare of persons with reduced mobility, describing a functional design to customize assisting devices for the Sit-to-Stand （STS）. In particular, the support mechanism that generates the requested motion and sustains the body of a person can be synthesized ad-hoc according to the experimental data of the subject. Experimental tests carried out during the Sit-To-Stand are used to track and record point trajectories and the orientation of the trunk of an individual, and they are used to design a 1-DOF mechanism able to reproduce the assigned rigid-body motion. A four-bar linkage has been synthesized according to the desired features. Simulation results are reported to illustrate the engineering soundness of the proposed mechatronic solution.

关键词： assisting device Sit-to-Stand bionic design kinematic synthesis experimental evaluation simulation

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TOL Keepers for Ubiquitin-Mediated Trafficking Routes in Plant Cells

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Molecular Plant 2020年第5期13卷 685-687页

作者： erika Isono Department of Biology University of KonstanzKonstanz 78464Germany

Plasma membrane proteins,especially transmembrane receptors and transporters,play central roles in the maintenance of cell homeostasis and in the adaptation of the cells and organisms to changes in the *** transcriptional regulation,protein targeting,posttranslational modification,ligandbinding,protein-protein interactions,and protein degradation are all key regulatory processes that can influence the abundance and activity of these receptors and *** research in the last decades have shown that posttranslational modification with the small modifier protein ubiquitin is crucial for selective protein degradation.

关键词： homeostasis environment. Plant

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Structural and optical properties of nanostructured copper sulfide semiconductor synthesized in an industrial mill

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 164-170页

作者： Marcela Achimovicova erika Dutkova erika Tothova Zdenka Bujnakova Jaroslav Briancin Satoshi Kitazono Institute of Mineral and Waste Processing Waste Disposal and Geomechanics Clausthal University of Technology Clausthal 38678 Germany Institute of Geotechnics Slovak Academy of Sciences Kosice 04001 Slovakia Nakase Refinery Nihon Seiko Co. Ltd. Yabu-shi Hyogo 667-1111 Japan

Chalcogenide nanostructured semiconductor, copper sulfide (CuS) was prepared from copper and sulfur powders in stoichiometric ratio by a simple, fast, and convenient one-step mechanochemical synthesis after 40 min of milling in an industrial eccentric vibratory mill. The kinetics of the mechanochemical synthesis and the influence of the physical properties of two Cu powder precursor types on the kinetics were studied. The crystal structure, physical properties, and morphology of the product were characterized by X-ray diffraction (XRD), the specific surface area measurements, particle size distribution and scanning electron microscopy. The XRD analysis confirmed the hexagonal crystal structure of the product-CuS (covellite) with the average size of the crystallites 11 nm. The scanning electron microscopy analysis has revealed that the agglomerated grains have a plate-like structure composed of CuS nanoparticles. The thermal analysis was performed to investigate the thermal stability of the mechanochemically synthesized CuS. The optical properties were studied using UV-Vis and photoluminescence spectroscopy. The determined optical band gap energy 1.80 eV responds to the value of the bulk CuS, because of agglomerated nanoparticles. In addition, a mechanism of CuS mechanochemical reaction was proposed, and the verification of CuS commercial production was performed.

关键词： copper sulfide industrial mechanochemical synthesis thermal analysis optical properties

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Pathology-induced NG2 proteoglycan expression in microglia

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Neural Regeneration Research 2023年第4期18卷 801-802页

作者： erika Meyer Anja Scheller Molecular Physiology Center for Integrative Physiology and Molecular MedicineUniversity of SaarlandHomburgGermany(Meyer EScheller A)Laboratory of Brain Ischemia and NeuroprotectionDepartment of Pharmacology and TherapeuticsState University of MaringáMaringáBrazil

Oligodendrocyte precursor cells(OPCs)and microglia are two very fascinating cell types with a multitude of important but different *** a first glance,they appear not to share many cellular properties,nor are directly related to one another or derived from a common *** all differences,emerging data show that both cell types express the protein nerve/glial antigen 2(NG2)after pathological insults(Figure 1).For years,it remained controversial whether microglia really could express NG2 upon injury,with contradictory results reported among different disease *** this question,we could recently show by using triple transgenic knock-in mice and either an acute injury model(stab wound injury)or the middle cerebral artery occlusion combined with immunohistochemistry that a subset of microglia activates the cspg4 gene in a disease dependent manner leading to a bonafide microglia-specific NG2 protein expression besides OPCs and *** data show that the cspg4 gene not only gets transcribed in microglia based on reporter expression after recombination,but also the protein itself is expressed(Huang et al.,2020).

关键词： NG2 wound Figure

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A Procedure for the Design of Novel Assisting Devices for the Sit-to-Stand

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Journal of Bionic Engineering 2013年第4期10卷 488-496页

作者： Pierluigi Rea erika Ottaviano Gianni Castelli Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via G. Di Biasio 43 03043 Cassino (FR) Italy

The Sit-to-Stand （STS） is an activity most people perform numerous times daily. Standing up deals with the transition from two stabilized postures, namely seated to standing, with movement of all body segments except the feet. During the STS the body＇s Center of Gravity （COG） is moved upward from a sitting position to a standing position without losing balance and requiring a good coordination of many muscles. Three main phases of the STS movement can be recognized. One begins to stand up by inclining the upper body forward, which moves body mass toward the feet in order to maintain balance after lift-off. Prior to leaving the chair, hip and knee extensor muscles are activated to provide antigravity support for these joints, this action is commonly referred to as ＂weight shift＂. Finally; after leaving the chair, the leg and trunk joints are straightened to achieve upright stance. The STS task can be considered of major importance for impaired and elderly people to achieve minimal mo- bility and independence. In this paper we detail a procedure for the design of assisting devices to be used for the STS. In par- ticular, an experimental procedure is described firstly to track and record point trajectories and the orientation of the trunk during the STS. This analysis is then used to get information for the design of assisting devices. A proposal and simulation results are presented for a novel mechatronic system. In particular, for the case under study experimental tests are used to drive the actua- tion system for the reported simulation. A functional mechatronic scheme is then proposed to control the device during its operation.

关键词： Sit-to-Stand assisting devices mechatronic design experimental evaluation simulation

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Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第22期23卷 3954-3963页

作者： erika utzeri paolo usai department of medical sciences university of cagliari

The use of non-steroidal anti-inflammatory drugs(NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites. Thus leading to so-called topical effects, which, in turn, lead to an impairment of the intestinal barrier. This process determines bacterial translocation and toxic substances of intestinal origin in the portal circulation, leading to an endotoxaemia. This condition could determine a liver inflammatory response and might promote the development of nonalcoholic steatohepatitis, mostly in patients with risk factors such as obesity, metabolic syndrome and a high fat diet, which may induce a small intestinal bacterial overgrowth and dysbiosis. This alteration of gut microbiota may contribute to nonalcoholic fatty liver disease and its related disorders in two ways: firstly causing a malfunction of the tight junctions that play a critical role in the increase of intestinal permeability, and then secondly leading to the development of insulin resistance, body weight gain, lipogenesis, fibrogenesis and hepatic oxidative stress.

关键词： Non-steroidal anti-inflammatory drugs Intestinal barrier Intestinal permeability Non-steroidal anti-inflammatory drugs - enteropathy Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Microbiota Metabolic syndrome Proton pump inhibitors Endotoxaemia

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The impact of different corona models on FD algorithms for the solution of multiconductor transmission lines equations

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High Voltage 2021年第5期6卷 822-835页

作者： erika Stracqualursi Rodolfo Araneo Amedeo Andreotti DIAEE-Electrical Engineering Division University of Rome“La Sapienza”RomeItaly Electrical Engineering Department University Federico II of NapoliNapoliItaly

In this study,the implementation of different corona discharge models in a transient program for overhead multiconductor lines based on the implicit Crank‐Nicolson Finite Difference Time Domain method is *** different corona models available in the literature,two empirical models(Gary's and Suliciu's models)and a physics‐based model(Malik's model)are discussed,which are broadly used in EMT programs,and their predictions under fast‐front lightning surges and slow‐front switching impulses are *** authors critically review the dynamic capacitance approach in terms of numerical accuracy,when dealing with slowly varying voltages,and applicability,regarding dispersive models assuming a non‐instantaneous charge‐voltage *** alternative voltage‐controlled generator approach is proposed,which is successfully included in the implicit Crank‐Nicolson *** of the objectives of this study is to show how different corona models may predict overvoltages with huge discrepancies,depending on the transient waveform and the propagation distance,despite the similarity of the q‐v hysteresis *** evident discrepancies between models under fast‐front voltage waves are reported,rather than for switching *** consistency of these results in terms of the models'features and q‐v curves is analysed,highlighting the necessity for new engineering tools for corona simulation of general predictive capability.

关键词： conductor transient dealing

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