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*** of a novel anti-angiogenic protein for the treatment of exudative age-related macular degeneration

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Annals of Eye Science 2018年第1期 429-429页

作者： erika Hooker Natalija Popovic Andrea Barabino Anthony Flamier Gilbert Bernier Bruno Larrivée Department of Biochemistry Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada Department of Ophthalmology Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada

Background:Age-related macular degeneration(AMD)is a leading cause of blindness in *** exudative(wet)form of AMD accounts for approximately 15%of AMD patients,but is responsible for the majority of severe vision loss associated with the *** AMD is characterized by choroidal neovascularization,the abnormal growth of blood vessels from the choroid into the sub-retinal *** therapies for exudative AMD directly target and inhibit the vascular endothelial growth factor(VEGF)signaling pathway,a signaling axis that promotes endothelial cell *** initially effective at restoring visual acuity,recent studies suggest that chronic use of anti-VEGF therapies can lead to further vision impairment through off-target effects on photoreceptors and other non-vascular *** off-target effects of anti-VEGF therapy highlights the need for alternative treatments for this increasingly common *** have recently identified a novel anti-angiogenic protein,AAP1 that inhibits retinal angiogenesis during *** a regulator of the vasculature,our current work aims to characterize the function of AAP1 in endothelial cells and determine the potential of AAP1 as a therapy for exudative ***:To address our aims,we used various in vivo and in vitro models of normal and pathological vascular *** were injected intravitreally with AAP1 to investigate its effects on developmental and pathological *** HUVECs,we employed immunofluorescent quantifications to determine the impact of AAP1 on sprouting angiogenesis by measuring cellular proliferation,apoptosis and *** investigate the signaling events that mediate the actions of AAP1,we examined key signaling pathways involved in angiogenesis by western blotting and ***:We evaluated the role of AAP1 as a regulator of angiogenesis during retinal development and mouse models of *** pilot data show that AAP1 prevents angiogenesis in vitro and in vivo,and th

关键词： Age-related macular degeneration(AMD) angiogenesis

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毕达哥拉斯博物馆

建筑实践 2017年第15期 16-23页

作者： OBR Paolo Brescia and Tommaso Principi(Architecture) erika Skabar(Landscape) Favero & Milan Ingegneria S.p.A.(Engineering) Claudia La Monarca(Safe and Security) Giovanni Panizon(External Exhibits)

该项目在全球和地方水平上有双重的目的:一方面它推进城市的发展,提升克罗托内作为文化旅游目的地的地位,另一方面激活城市和社会的更新进程。博物馆的建造设计旨在创造一个与地形紧密结合的新景观,设计通过延续山体的趋势将博物馆与景... 详细信息

该项目在全球和地方水平上有双重的目的:一方面它推进城市的发展,提升克罗托内作为文化旅游目的地的地位,另一方面激活城市和社会的更新进程。博物馆的建造设计旨在创造一个与地形紧密结合的新景观,设计通过延续山体的趋势将博物馆与景观融为一体,同时突出了山体的形象。建筑和景观的关系在室内通过框定室外景色的前厅空间和咖啡餐厅被突显出来,感觉就像用望远镜看东西。博物馆可

关键词：博物馆克罗托内

Opening the doors of the intensive care unit to cancer patients: A current perspective

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World Journal of Critical Care Medicine 2015年第3期4卷 159-162页

作者： Silvio A ?amendys-Silva erika P Plata-Menchaca Eduardo Rivero-Sigarroa Angel Herrera-Gómez Department of Critical Care Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Critical Care Medicine Instituto Nacional de Cancerología

The introduction of new treatments for cancer and advances in the intensive care of critically ill cancer patients has improved the prognosis and survival. In recent years, the classical intensive care unit(ICU) admission comorbidity criteria used for this group of patients have been discouraged since the risk factors for death that have been studied, mainly the number and severity of organic failures, allow us to understand the determinants of the prognosis inside the ICU. However, the availability of intensive care resources is dissimilar by country, and these differences are known to alter the indications for admission to critical care setting. Three to five days of ICU management is warranted before making a final decision(ICU trial) to consider keep down intensive management of critically ill cancer patients. Nowadays, taking into account only the diagnosis of cancer to consider ICU admission of patients who need full-supporting management is no longer justified.

关键词： Intensive care unit Critical care setting Cancer patients Critically ill cancer patients Organ failures

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基因组黑客

环球科学 2013年第8期 59-61页

作者：艾利卡·杏克·海登(erika Check Hayden) 赵旭丹(翻译)

公开的基因组数据库中有大量匿名记录，一些新技术可以利用这些信息，挖出数据提供者的个人隐私。甚至只须连上互联网，就可以成为“基因组黑客”。

关键词：基因组黑客数据提供者个人隐私数据库新技术互联网匿名

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创业邦 2013年第6期 76-76页

作者： erika Napoletano Kai Shan

当你有了客户、有了团队、有了稳定收益，别以为能一劳永逸，你该做出一些改变了。

关键词：品牌战略忠诚度经营策略客户

Prevalence of congenital cytomegalovirus infection in preterm,small for gestational age and low birth weight newborns:characteristics and cytokines profile

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World Journal of Pediatrics 2022年第7期18卷 498-504页

作者： Janaina Fortes Lino Llian Martins Oliveira diniz Debora Marques de Miranda Daniela Valadao Freitas Rosa Nathalia Gualberto Souza e Silva Eduardo de Souza Nicolau Larissa Goncalves Rezende Lais Silva Carvalho Marianna Fischer de Paula Lopes Luisa Petri Correa Gabriela Mafra de Oliveira Flavia Miranda da Silva Alves Lorena Batista Pascoal erika Lima Dolabella Teixeira da Costal Leni Marcia Anchieta Roberta Maia de Castro Romaneli Odete Valadares Maternity Hospital Belo HorizonteBrazil Pediatrics Department.Faculy of Medice of Federal University of Minas Gerais Belo Horizonte.Brazil Molecular Laboratory of the INCT-MM.Faculy of Medicine.Federal University of Minas Gerais-UFMG.Belo Horizonte Brazil Faculty of Medicine.Federal University of Minas Gerais-UFMG Belo Horizonte.Brazil Risoleta Tolentino.Neves University Hospital's Maternity Belo HorizonteBrazil Sofia Feldman Maternity Hospital Belo HorizonteBrazil Hospital das Clinicas Maternity-Federal University of Minas Gerais.Belo Horizonte Brazil Pediatrics Department of Federal University of Minas Gerais School Medicine.Minas Gerais.Av Professor Alfredo Balena 190.Belo Horizonte 30130-100Brazil

Cytomegalovirus is the most frequent agent of congenital viral infections,affecting approximately 0.2%-2.4%of live births in different countries[1-7].Universal screening for congenital cytomegalovirus infection in newborns is not a standard practice considering cost-benefit issues and viabil-ity of diagnostic ***,most newborns are asympto-matic and there is no effective treatment for this population[2-5].

关键词： weight birth characteristics