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Coronary artery calcium score on low-dose computed tomography for lung cancer screening

World Journal of Radiology 2014年第6期6卷 381-387页

作者： Teresa Arcadi erica maffei Nicola Sverzellati Cesare Mantini Andrea I Guaricci Carlo Tedeschi Chiara Martini Ludovico La Grutta Filippo Cademartiri Department of Radiology SDN Foundation IRCCS 80131 Naples Italy Cardio-vascular Imaging Unit Department of Radiology Giovanni XXIII Clinic Monas-tier di Treviso 31050 Treviso Italy Department of Radiology Erasmus Medical Center University Rotterdam 3015 CE Ro-tterdam The Netherlands Department of Radiology Azienda Ospeda-liero-Universitaria 43100 Parma Italy Department of Radiology Università di Chieti 66100 Chieti Italy Department of Cardiology Università di Foggia 71121 Foggia Italy Department of Cardiology San Gennaro Hospi-tal Naples 80136 Napoli Italy Department of Radiology University of Palermo Italy

AIM: To evaluate the feasibility of coronary artery calcium score(CACS) on low-dose non-gated chest CT(ngCCT).METHODS: Sixty consecutive individuals(30 males; 73 ± 7 years) scheduled for risk stratification by means of unenhanced ECG-triggered cardiac computed to-mography(gCCT) underwent additional unenhanced ngCCT. All CT scans were performed on a 64-slice CT scanner(Somatom Sensation 64 Cardiac, Siemens, Germany). CACS was calculated using conventional methods/scores(Volume, Mass, Agatston) as previ-ously described in literature. The CACS value obtained were compared. The Mayo Clinic classification was used to stratify cardiovascular risk based on Agatston CACS. Differences and correlations between the two methods were compared. A P-value 0 in the ngCCT. Of the 3 patients with 1-10 Agatston score on gCCT, 1(33%) showed an Agatston score of 0 in the ngCCT. Overall, 23(38%) patients were reclassified in a different car-diovascular risk category, mostly(18/23; 78%) shifting to a lower risk in the ngCCT. The estimated radiation dose was significantly higher for gCCT(DLP 115.8 ± 50.7 vs 83.8 ± 16.3; Effective dose 1.6 ± 0.7 mSv vs 1.2 ± 0.2 mSv; P < 0.01).CONCLUSION: CACS assessment is feasible on ngCCT; the variability of CACS values and the associated re-stratification of patients in cardiovascular risk groups should be taken into account.

关键词： Coronary artery calcium score Lung cancer screening High-resolution computed tomography unenhanced chest computed tomography Cardiovascular risk stratification

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Plaque imaging with CT coronary angiography:Effect of intra-vascular attenuation on plaque type classification

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World Journal of Radiology 2012年第6期4卷 265-272页

作者： erica maffei Chiara Martini Teresa Arcadi Alberto Clemente Sara Seitun Alessandra Zuccarelli Tito Torri Nico R Mollet Alexia Rossi Onofrio Catalano Giancarlo Messalli Filippo Cademartiri Cardiovascular Imaging Unit Giovanni XXIII Hospital31050 Monastier di TrevisoTrevisoItaly Department of Radiology Academic Hospital of Parma43100 ParmaItaly Department of Radiology Ospedale di Carrara54033 CarraraItaly Department of Radiology Erasmus Medical Center University3015 CE RotterdamThe Netherlands Filippo Cademartiri Department of Radiology SDN FoundationIRCCS80143 NaplesItaly Department of Radiology Erasmus Medical Center University3015 CE RotterdamThe Netherlands

AIM: To assess the attenuation of non-calcified atherosclerotic coronary artery plaques with computed tomography coronary angiography (CTCA). METHODS: Four hundred consecutive patients underwent CTCA (Group 1: 200 patients, Sensation 64 Cardiac, Siemens; Group 2: 200 patients, VCT GE Healthcare, with either Iomeprol 400 or Iodixanol 320, respectively) for suspected coronary artery disease (CAD). CTCA was performed using standard protocols. Image quality (score 0-3), plaque (within the accessible non-calcified component of each non-calcified/mixed plaque) and coronary lumen attenuation were measured. Data were compared on a per-segment/per-plaque basis. Plaques were classified as fibrous vs lipid rich based on different attenuation thresholds. A P < 0.05 was considered significant. RESULTS: In 468 atherosclerotic plaques in Group 1 and 644 in Group 2, average image quality was 2.96 ± 0.19 in Group 1 and 2.93 ± 0.25 in Group 2 (P ≥ 0.05). Coronary lumen attenuation was 367 ± 85 Hounsfield units (HU) in Group 1 and 327 ± 73 HU in Group 2 (P < 0.05); non-calcified plaque attenuation was 48 ± 23 HU in Group 1 and 39 ± 21 HU in Group 2 (P < 0.05). Overall signal to noise ratio was 15.6 ± 4.7 in Group 1 and 21.2 ± 7.7 in Group 2 (P < 0.01). CONCLUSION: Higher intra-vascular attenuation modifies significantly the attenuation of non-calcified coronary plaques. This results in a more difficult characterization between lipid rich vs fibrous type.

关键词： Computed tomography coronary angiography Coronary artery plaque Plaque characterization Contrast material Lumen enhancement

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How physical and motor training affect cognitive performance: lessons from an inflammatory molecule

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Neural Regeneration Research 2022年第12期17卷 2689-2690页

作者： Margherita maffei Marco Mainardi Institute of Clinical Physiology National Research Council(IFC-CNR)and Obesity/Lipodystrophies CenterPisa University HospitalPisaItaly Neuroscience Institute National Research Council(IN-CNR)PisaItaly

Our phenotype includes not only physical features,but also behavioral outputs such as motor schemes and learned skills,and is the result of a complex interaction between genetic background and *** fact,a good fraction of last decades’biomedical efforts were dedicated to understanding how different elements(e.g.,genetic polymorphisms,lifestyle components)participate in this interplay,ultimately contributing to affect a given phenotype up to the point of steering it towards *** and epigenetic elements are relatively easy to analyze individually using a reductionist approach,for instance via loss-or gain-of-function studies in cellular and animal models;the effects of nutrients,drugs,pollutants can be similarly tested as single specific stimuli.

关键词： instance drugs lesson

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Oxidative status and cardiovascular risk in women:Keeping pink at heart

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World Journal of Cardiology 2009年第1期1卷 26-30页

作者： Cristina Vassalle Antonella Mercuri Silvia maffei G.Monasterio Foundation & Institute of Clinical Physiology-CNR I-56124PisaItaly

Although cardiovascular disease(CVD) has always been perceived as a pathology regarding essentially males,incidence and death from cardiovascular events dramatically increase after menopause in ***,while many aspects of CVD are similar in both sexes,it is now clear that there are significant differences as *** of these gender-related differences in CVD might provide a basis for the development of new strategies in the management of patients with CVD from a gender point of *** particular,a growing amount of data suggested the possible major role of oxidative stress in female patients and the possibility to integrate this new biomarker in future study evaluating CVD risk in women.

关键词： Cardiovascular Risk factors Menopause Gender Women Oxidative stress

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Two in One-Combining Mechanical and Thermal Solids/Liquids Separation Technology

Two in One-Combining Mechanical and Thermal Solids/Liquids S...

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第六届化学工程与生物技术展览暨会议

作者： C.Martin Y.Lu Krauss-maffei Process Technology AG Postfach 500332 80973 Munchen Process Technology AG Postfach 500332 80973 Munchen Process Technology AG Postfach 500332 80973 Munchen

＜正＞ When planning separation processes the thermal and mechanical separation step arefrequently evaluated individually. By looking at these unit operations together,substantialbenefits could be gained from the optimization of the process scheme to the minimization ofinterfaces, This is demonstrated by the following example of an application to dry a chemicalor pharmaceutical product.

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Aminated (Cyclopropylmethyl)Phosphonates: Synthesis and Anti-Pancreatic Cancer Activity

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International Journal of Organic Chemistry 2023年第4期13卷 129-136页

作者： Abed Al Aziz Al Quntar Ibrahim Abasy Hasan Dweik Michel maffei Valery M. Dembitsky Department of Chemistry and Chemical Technology Faculty of Science and Technology Al-Quds University Jerusalem Palestine Department of Microbiology and Immunology Al-Quds University Jerusalem Palestine Institut des Sciences Moleculaires de Marseille (iSm2) Aix-Marseille University CNRS Centrale Marseille Marseille France Bio-Geo-Chem Laboratories Ltd. Aliso Viejo USA

Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of Hunig’s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.

关键词： Phosphonates Aminophosphonates Pancreatic Cancer Cancer Cyclopropylphosphonates

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Care Measures and Health Outcomes in a Pediatric Intensive Care Unit in Brazil

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Open Journal of Pediatrics 2023年第5期13卷 697-706页

作者： Arnildo Linck Junior Flávia Lopes Gabani Edmarlon Girotto Ana Maria Rigo Silva Selma maffei Andrade Department of Pediatrics and Pediatric Surgery Universidade Estadual de Londrina Londrina Brazil

Introduction: In low- and middle-income countries, including Brazil, conditions that favor mortality in the PICU remain significant. Compared to developed countries, there is a shortage of skilled human resources, lower availability of technological resources, greater difficulty of access and a higher incidence of infections, including both those acquired prior to admission and those resulting from treatment and hospitalization (i.e., healthcare-associated infections (HAIs)). HAIs in the PICU include ventilator-associated pneumonia and catheter-related bloodstream infections. Actions for the prevention of HAIs can minimize the occurrence of negative outcomes. Materials and Methods: This is an epidemiological study comparing admissions at the PICU of a high-complexity hospital in South Brazil over two three-year periods: 2012-2014 (before the measures were adopted) and 2015-2017 (after the measures). The care measures were adopted mainly at the beginning of 2015 and consisted of expansion of physical therapy care, adoption of care protocols, acquisition of new materials and equipment (transparent dressings for central catheters, high-tech mechanical ventilators and multiparametric monitors) and multidisciplinary team training. The frequency of the outcomes mortality, length of PICU stay, diagnosis of catheter-related bloodstream infection, need for and duration of ventilatory support and diagnosis of ventilator-associated pneumonia were compared between the two trienniums using logistic regression with adjustment for age in months and need of vasoactive drugs. Results: A total of 1140 admissions were analyzed (470 in the first triennium and 670 in the second), representing an increase in the admission rate of 42.6% after the adoption of the measures. After adjustments, significant reductions in the frequency of mortality (adjusted OR [adjOR] = 0.54;CI 95%: 0.34 - 0.84), length of PICU stay > 7 days (adjOR = 0.75;CI 95%: 0.57 - 0.97) and duration of ventilatory suppor

关键词： Pediatric Intensive Care Units Outcomes Assessment In-Hospital Mortality Hospital Stay Mechanical Ventilation Catheter-Related Infections

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Risk of fracture in celiac disease:Gender,dietary compliance,or both?

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World Journal of Gastroenterology 2011年第25期17卷 3035-3042页

作者： María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai Small Bowel Section Department of Medicine"Dr.C.Bonorino Udaondo" Gastroenterology Hospital Department of Gastroenterology German Hospital Nutritional Support Unit and Malabsortion "San Martin" HIGA1900 La PlataArgentina Department of Gastroenterology Italian Hospital

AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture ***:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal *** were collected through in-person interviews with an *** overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P < 0.002] and in men (HR:2.67,95% CI:1.37-5.22,P < 0.004).Fracture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P < 0.003).In the time period after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before *** is associated with male sex and classic clinical *** fracture risk was reduced after the treatment.

关键词： Celiac disease Fracture risk Peripheralfractures Gluten-free diet Sex difference

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Iron and Heart Failure: Current Concepts and Emerging Pharmacological Paradigms

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World Journal of Cardiovascular Diseases 2024年第4期14卷 195-216页

作者： Maria Rosaria De Pascale Maria Beatrice Rondinelli Flora Ascione Vincenzo maffei Chiara Di Lorenzo Sarah Scagliarini Raffaella Faraonio Antonio Faiella Immunohematology and Transfusion Medicine Unit Cardarelli Hospital Naples Italy Immunohematology and Transfusion Medicine Unit San Camillo-Forlanini Hospital Rome Italy Health Management Office Cardarelli Hospital Naples Italy Anesthesiology Unit Cardarelli Hospital Naples Italy Department of Medical and Translational Sciences University of Naples Federico II Naples Italy Oncology Unit Cardarelli Hospital Naples Italy Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy

Background: Emerging evidence has recognized that anemia and iron deficiency are recurrent comorbidities in chronic heart failure (HF) and several trials have established that iron administration improves myocardial asset and clinical scenario in HF. Purpose: Recent acquisitions suggest that iron deficiency represents a concrete bias in the pathogenetic mechanism of chronic HF, so we have investigated the putative role of the hepcidin/ferroportin axis in the cardiovascular setting to advocate novel pharmacological and clinical approaches. Methods: Here, after an excursus on iron metabolism, we first reviewed the ongoing studies on novel iron targeted compounds. Then, we summarize large clinical interventional studies conducted on patient suffering from iron deficiency and HF which have tested the effects of drugging iron regard QoL, hospitalizations and cardiovascular death. Results: Novel compounds such as hepcidin agonist (PTG 300), synthetic human hepcidin (LJPC-401) and anti FPN (Vamifeport) are ongoing in iron overloaded patients, while the hepcidin blocker (PRS-080) is under investigation in anemic patients. Noteworthy, novel insights could arise from the results of a Phase IV interventional study regarding the modification of hepcidin pathway in a large cohort of HF patients (n = 1992) by sodium glucose cotransporter 2 inhibitors. To date, several studies highlight the beneficial effect of iron administration in cardiovascular setting and latest evidences consider hepcidin level as a novel biomarker of cardiac injury and atherosclerosis. Conclusions: We advocate that data from ongoing studies will suggest novel iron targeted therapies for diagnosis, prognosis and therapy transferable in selected heart failed patients.

关键词： Heart Failure Iron Anemia Iron Deficiency Hepcidin

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微笑重建修复的数字化牙科工作流程

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中国口腔医学继续教育杂志 2020年第6期23卷 321-333页

作者： Alessandro Agnini Roberto Apponi Simone maffei Andrea Agnini 马驰(译) 林东(审) 不详山东大学口腔医院 250012

本文描述了数字化时代治疗计划和实施的新理念。所展示的工作流程的目的是为了完全通过数字化技术来设计、计划、交流、执行、制作、转移和重塑微笑修复。跨学科治疗计划贯穿设计、诊断饰面(mock-up)到最终修复。在数字化设计中,临床医... 详细信息

本文描述了数字化时代治疗计划和实施的新理念。所展示的工作流程的目的是为了完全通过数字化技术来设计、计划、交流、执行、制作、转移和重塑微笑修复。跨学科治疗计划贯穿设计、诊断饰面(mock-up)到最终修复。在数字化设计中,临床医生和技术人员看到的牙齿形态和牙齿形状由计算机转化为三维几何数字模型。通过调整牙齿的几何形状,使临床医生可以自由制定治疗计划,这样的数字化方式贯穿于整个治疗过程中。此外.结合计算机辅助设计技术使用的新型陶瓷材料极大地拓宽了口腔医师的选择范围,使可达到的效果更加理想。

关键词：数字化方式新型陶瓷材料计算机辅助设计技术数字化技术口腔医师临床医生数字化设计牙齿形态

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