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Influence of Atomization Parameters in the Obtention of Mango Pulp Powder

Journal of Food Science and Engineering 2013年第7期3卷 357-362页

作者： erica mil6 de freitas felipe rocha Luis Gomes de Moura Neto Sueli Rodrigues Marcos Rodrigues AmorimAfonso Jos6 Maria Correia da Costa3 Federal Institute of Education Science and Technology of Rio Grande do Norte (IFRN) Fortaleza Cear6 60.356-000 Brazil Federal Institute of Education Science and Technology of Pernambuco (IFPE) Fortaleza Ceard 60.356-000 Brazil Federal University of Cear6 (UFC) Department of Food Technology Bloco 858-Campus do Pici Av. Mister Hull FortalezaCeardt 60.356-000 Brazil

Mango is a widely cultivated and consumed fruit in Brazil and one of the most important alternatives to take advantage of the production excess is dehydration. Therefore, this work aims at establishing better operational conditions for ＂spray-drying＂ processes, in order to obtain the powder of mango pulp by means of a rotational central compounded planning, and also at carrying out the physicochemical characterization of both the integral mango pulp and the powder obtained from the operational conditions mentioned above. Both integral mango pulp and powder were analyzed as for the following physicochemical characteristics： humidity, pH, titratable acidity, soluble solids （~Brix）, vitamin C and color--through parameters L＊, a＊, b＊ and h0, Chrome （C＊） and color difference （AEL＊a＊b＊）. The experimental planning used presented significant differences at 5% of probability, showing that the model was adjusted to the data in accordance to F test, thus being possible to determine the best process conditions. In addition, the average results of the physicochemical parameters pointed out that the pulp used was in accordance with the patterns established by the quality and identity patterns for mango pulp. Moreover, it showed that the powder obtained had good physicochemical quality.

关键词： Mango spray-dryer concentration of maltodextrin paste feeding speed hot air output.

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Mathematical Modeling for Isotherms of Mango Pulp Powder,Obtained by Atomization

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Journal of Encapsulation and Adsorption Sciences 2014年第1期4卷 8-14页

作者： erica milôde freitas felipe rocha Sueli Rodrigues Marcos Rodrigues Amorim Afonso José Maria Correia da Costa Federal Institute of Education Science and Technology of Rio Grande do NorteFortalezaBrazil Federal University of Ceará FortalezaBrazil

Mango, as the other fruits, is a perishable food that can be easily deteriorated and presents high levels of post-harvest loss. Therefore, dehydration is an important alternative to use the production excess. In this context, this work aimed at evaluating the hygroscopic behavior of the integral mango pulp powder, obtained by atomization, by means of adsorption isotherm. After applying BET’s, GAB’s, Henderson’s and Oswin’s mathematical models, it was possible to identify that the equations for two models were perfectly adjusted to the experimental results of mango pulp powder. Henderson’s model was the best adjusted experimental curve and showed the lowest average error (E) and the highest determination coefficient (R2) at all temperatures studied.

关键词： Spray-Dryer Water Activity Hygroscopicity Mathematical Models

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Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

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World Journal of Hepatology 2020年第4期12卷 137-148页

作者： Cliviany Borges da Silva Diego Alves Vieira Luisa freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Medical undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Division of Endocrinology Department of Internal MedicineFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Epidemiology of Infectious and Parasitic Diseases Laboratory Department of ParasitologyInstitute of Biological SciencesUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes *** the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune *** serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C *** To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same *** between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC *** Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively *** 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes ***,biochemical,histological and radiological methods were used for the diagnosis of the liver ***-6 polymorphism was evaluated by Taqman SNP genotyping *** data were analysed by logistic regression *** Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,*** frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C *** identification of potential inflammatory mediato

关键词： Chronic Hepatitis C Type 2 diabetes mellitus Interleukin 6-174G/Cgenepromoter single nucleotide polymorphism Blood hypertension Healthy control subjects

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Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats

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World Journal of Gastroenterology 2014年第15期20卷 4345-4352页

作者： erica Martins Ferreira Gotardo Gilberto de Almeida Ribeiro Thayane Rodrigues Leite Clemente Camila Henrique Moscato Renata Bortolin Guerra Tome Thalita rocha Jose Pedrazzoli Jr Marcelo Lima Ribeiro Alessandra Gambero Clinical Pharmacology and Gastroenterology Unit Sao Francisco University Medical SchoolBraganca PaulistaSP 12916-900Brazil

AIM:To investigate hepcidin expression,interleukin-6(IL-6)production and iron levels in the rat colon in the presence of trinitrobenzene sulfonic acid(TNBS)-induced ***:In rats,we evaluated the severity of colitis induced by repeated TNBS administration using macroscopic and microscopic scoring systems and myeloperoxidase activity *** colonic levels of hepcidin,tumor necrosis factor alpha(TNF-α),IL-10 and IL-6 were measured by Enzyme-Linked Immunosorbent Assay,and hepcidin-25 expression and iron deposition were analyzed by immunohistochemistry and the Prussian blue reaction,***-3 phosphorylation was assessed by Western blot *** parameters,iron and transferrin levels,and transferrin saturation were also ***,the ability of iron,pathogen-derived molecules and IL-6 to induce hepcidin expression in HT-29 cells was ***:Repeated TNBS administration to rats resulted in macroscopically and microscopically detectable colon lesions and elevated colonic myeloperoxidase ***-25 protein levels were increased in colonic surface epithelia in colitic rats(10.2±4.0pg/mg protein vs 71.0±8.4 pg/mg protein,P6 levels(8.2±1.7 pg/mg protein vs 14.7±0.7 pg/mg protein,Pdetected in colitic *** deposition in the colon was only observed during *** gene expression was increased in HT-29 cells after IL-6 and lipopolysaccharide[a toll-like receptor 4(TLR-4)ligand]***,ferric citrate and peptidoglycan(a TLR-2 ligand)were unable to alter the in vitro expression of hepcidin in HT-29 ***:Colitis increased local hepcidin-25 expression,which was associated with the IL-6/Stat-3 signaling *** increase in local iron sequestration was also

关键词： Hepcidin-25, Interleukin-6, Iron, Stat-3, Anemia, Toll-like receptor 4

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Use of Initial Modified RECIST Tumor Response Evaluation Criteria for Predicting Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization with Drug-Eluting Beads

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Journal of Cancer Therapy 2015年第13期6卷 1115-1123页

作者： Natália Sousa freitas Queiroz Luciana Kikuchi Regis Otaviano Franca Bezerra Regiane S. S. M. Alencar Aline Lopes Chagas Cláudia Megumi Tani Márcio Augusto Diniz Aline Cristine Barbosa Santos Airton Mota Moreira Manoel de Souza rocha Luiz Augusto Carneiro D’Albuquerque Francisco César Carnevale Flair José Carrilho Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Gastroenterology University of Sao Paulo School of Medicine Sao Paulo Brazil Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Radiology University of Sao Paulo School of Medicine Sao Paulo Brazil

Introduction: Transarterial chemoembolization (TACE) reduces tumor growth and increases survival in patients with hepatocellular carcinoma (HCC). Drug-eluting beads (deB) deliver slow-release chemotherapy and reduce systemic toxicity during TACE. This study correlated initial tumor response according to modified RECIST (mRECIST) criteria and 1-year survival in patients with HCC treated with TACE-deB, and identified predictors of tumor response. Methods: Fifty-two patients with HCC received TACE-deB loaded with doxorubicin 75 mg during a 6-month period. Tumor response was evaluated 1 month after the procedure according to mRECIST criteria. Results: Most patients were cirrhotic and etiology of liver disease was hepatitis C in 26/52 (50%). Similar numbers of patients had Barcelona Clinic Liver Cancer (BCLC) A and BCLC B disease. Most patients had one nodule (66%). Complete response (CR) was achieved in 12/52 (23%), partial response in 19/52 (37%), stable disease in 4/52 (8%) and progressive disease in 17/52 (32%). Largest HCC ≤58 mm and BCLC stage A were associated with CR. The 1-year survival was 74%, with survival rates of 95% and 56% in the BCLC A and B groups, respectively. Variables reflecting tumor extension were associated with better survival. CR according to mRECIST criteria was a predictor of better 1-year survival (100% vs. 64%, P deB. Further studies are needed to evaluate other predictors of survival and to determine if tumor response predicts long-term survival.

关键词： Hepatocellular Carcinoma mRECIST Criteria Transarterial Chemoembolization Overall Survival Drug-Eluting Beads

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