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Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Chinese Journal of Cancer Research 2017年第3期29卷 172-178页

作者： Pei-Hung Chang cheng-Hsu Wang eric yen-chao chen Shih-Wei Yang Wen-Chi Chou Jason Chia-Hsun Hsieh Feng-Che Kuan Kun-Yun Yeh Division of Hemato-oncology Department of Internal MedicineChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445 TaiwanChina Cancer Center Chang Gung Memorial HospitalKeelung 20445TaiwanChina Department of Radiation Oncology Chang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Otolaryngology Head and Neck SurgeryChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Division of Medical Oncology Department of Internal MedicineChang Gung Memorial Hospital at LinkouTaoyuan 33305TaiwanChina Department of Hematology and Oncology Department of MedicineChang-Gung Memorial HospitalChiayi 61363TaiwanChina

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

关键词： Glasgow prognostic score (GPS) head and neck cancer chemoradiation inflammation cachexia nutrition

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Linker gadolinium as charge channel and singlet oxygen activation site in graphitic carbon nitride for enhancing photocatalytic decomposition of tetracycline

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Journal of Rare Earths 2024年第5期42卷 827-837,I0001页

作者： Jianmin Luo Wenqin Li Xinglei Wang eric Lichtfouse Donglan Huang Xiaoyuan chen Yi Zhang Lejie Zhu Chuanyi Wang College of Chemistry and Civil Engineering Shaoguan UniversityShaoguan512005China Key Laboratory of Pollutant Chemistry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China College of Chemistry and Environmental Science Kashi UniversityKashi844006China CNRS IRDINRAEColl FranceCEREGEAix-Marseille UniversityAix en Provence13100France Guangzhou Institute of Industrial Intelligence(GIl) Guangzhou511400China

Reactive oxygen species are essential in photocatalytic water *** this paper,Gd doped carbon nitride(CN)photocatalysts were prepared by simple thermal polymerization for the photocatalytic degradation of tetracycline under visible light *** photodegradation rate of *** is as high as 95%in 18 min,and the photocatalytic performance is much higher than that of *** improvement of photocatalytic performance is mainly attributed to the fact that Gd ion implantation directly provides active sites for oxygen activation and induces the formation of N *** results of characterizations show that the introduction of Gd in CN can improve the conversion ability of activated oxygen,carrier separation and energy band structure ***,1.0GdCN photocatalyst can be employed for efficient photocatalytic synthesis of ***,three ways of photocatalytic degradation of tetracycline were revealed by high performance liquid chromatographymass *** work provides insights into the doping strategy of CN to improve the production of reactive oxygen species for environmental remediation.

关键词： Photocatalysis Tetracycline Hydrogen peroxide Gd doped CN Singlet oxygen Rare earths

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Large contributions of emission reductions and meteorological conditions to the abatement of PM_(2.5)in Beijing during the 24th Winter Olympic Games in 2022

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Journal of Environmental Sciences 2024年第2期136卷 172-188页

作者： Yaping Jiang Shaocai Yu Xue chen Yibo Zhang Mengying Li Zhen Li Zhe Song Pengfei Li Xiaoye Zhang eric Lichtfouse Daniel Rosenfeld Key Laboratory of Environmental Remediation and Ecological Health Ministry of EducationResearch Center for Air Pollution and HealthCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China College of Science and Technology Hebei Agricultural UniversityBaoding 071000China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China Aix-Marseille Univ CNRSColl FranceCNRSIRDINRAEEuropole Mediterraneen de l’ArboisAvenue Louis Philibert13100 Aix en ProvenceFrance Xi’an Jiaotong University State Key Laboratory of Multiphase Flow in Power EngineeringXi’an 710049China Institute of Earth Sciences The Hebrew University of JerusalemJerusalemIsrael

To guarantee the blue skies for the 2022 Winter Olympics held in Beijing and Zhangjiakou from February 4 to 20,Beijing and its surrounding areas adopted a series of emission control *** provides an opportunity to determine the impacts of large-scale temporary control measures on the air quality in Beijing during this special ***,we applied the WRF-CMAQ model to quantify the contributions of emission reduction measures and meteorological *** show that meteorological conditions in 2022 decreased PM_(2.5)in Beijing by 6.9 and 11.8μg/m^(3)relative to 2021 under the scenarios with and without emission reductions,*** emission reduction measures implemented in Beijing and seven neighboring provinces resulted in an average decrease of 13.0μg/m^(3)(-41.2%)in PM_(2.5)in *** the entire period,local emission reductions contributed more to good air quality in Beijing than nonlocal emission *** the emission reduction scenario,local,controlled regions,other regions,and boundary conditions contributed 47.7%,42.0%,5.3%,and 5.0%to the PM_(2.5)concentrations in Beijing,*** results indicate that during the cleaning period with the air masses from the northwest,the abatements of PM_(2.5)were mainly caused by local emission ***,during the potential pollution period with the air masses from the east-northeast and west-southwest,the abatements of PM_(2.5)were caused by both local and nonlocal emission reductions almost *** implies that regional coordinated prevention and control strategies need to be arranged scientifically and rationally when heavy pollution events are forecasted.

关键词： PM_(2.5) WRF-CMAQ Meteorological conditions Emission reductions Winter Olympic games

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强磁场下Cu−Co难混溶合金凝固过程中晶体取向和性能的调控

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1878-1892页

作者：魏晨李金山闫育洁贺一轩 eric BEAUGNON 王军西北工业大学凝固技术国家重点实验室西安710072 Univ.Grenoble Alpes INSA ToulouseUniv.Toulouse Paul SabatierEMFLCNRSLNCMI38000 GrenobleFrance

对Cu50Co50合金在不同磁场强度下进行非平衡凝固实验,研究富钴相的取向、显微组织演化和磁性能。结果表明,凝固后相分离的棒状富钴相可以实现排列形态,在5 T强磁场下富钴相的晶体取向为111平行磁场方向。然而,发生二次液−液相分离的富... 详细信息

对Cu50Co50合金在不同磁场强度下进行非平衡凝固实验,研究富钴相的取向、显微组织演化和磁性能。结果表明,凝固后相分离的棒状富钴相可以实现排列形态,在5 T强磁场下富钴相的晶体取向为111平行磁场方向。然而,发生二次液−液相分离的富铜相的取向没有受到HMF的显著影响。在0 T磁场下凝固的合金表现出近磁各向同性行为,而在5 T磁场下凝固的合金则表现出磁各向异性行为。合金的饱和磁化强度略有增加,矫顽力相应降低,这与富钴晶体的取向演化行为密切相关。

关键词：强磁场显微组织演化铜钴合金相分离磁性能

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Laparoscopic Orchidopexy after 4 Weeks of Testicular Traction with Preservation of Blood Supply: A New Concept for the Treatment of Intra-Abdominal Cryptorchidism: Original Article

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Open Journal of Pediatrics 2024年第2期14卷 205-217页

作者： Ntsobe Tobie eric Haijin Liu Nyanit Bob Dorcas Wei Peng Feng chen Ndikontar Raymond Kouna Tsala Irene Nadine Qian Liu Surgery Department Garoua General Hospital Garoua Cameroon Paediatric Surgery Department First Affiliated Hospital of Gannan Medical College Ganzhou China Paediatric Surgery Department China Medical University Shenyang China Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Paediatric Surgery Department Yaounde Central Hospital Yaounde Cameroon China Traditional Medicine University Nanchang China

Background: Testicular atrophy is recurrent after orchidopexy for intra-abdominal cryptorchidism due to damage to vessels. Fowlers-Stephens and Shehata methods proposed staged orchidopexy, but are still associated to a rate of atrophy greater than 10%. Purpose: We set out to present a new technique that preserves testicular vessels. Our study is aimed at investigating testicular vitality after surgery. Patients and Method: We reviewed files of boys who underwent orchidopexy for 2 years in our department. Those who have been operated for intra-abdominal cryptorchidism with the new technique and aged between 6 months and 14 years old were included in our study. We excluded boys who have been operated before 6 months and after 14 years old and those who did not respect their follow-up plane. Ultrasound (US) outcomes were used to measure testicular volumes and blood flow at each postoperative visit. The Sample population was divided into group A and group B representing testes that were followed respectively for 12 and 24 months. Results: 22 boys with 25 testes were included in our study;11 testes in group A and 14 testes in group B. In each group, we noted a significant difference of UDT volumes from the third month after surgery with respective P-values 0.05. There was no statistical difference between UDT and contra lateral testes volumes 12 months after surgery in group A and 24 months in group B with respective P-values of 0.07 and 0.72. All volume differential indexes were Conclusion: This method offers a new perspective in performing safe orchidopexy for intra abdominal undescended testes.

关键词： Laparoscopy Staged-Orchidopexy Testicar Traction Testicular Atrophy

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Radical innovation breakthroughs of biodegradation of plastics by insects:history,present and future perspectives

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 127-165页

作者： Shan-Shan Yang Wei-Min Wu Federica Bertocchini Mark eric Benbow Suja P.Devipriya Hyung Joon Cha Bo-Yu Peng Meng-Qi Ding Lei He Mei-Xi Li chen-Hao Cui Shao-Nan Shi Han-Jun Sun Ji-Wei Pang Defu He Yalei Zhang Jun Yang Deyi Hou De-Feng Xing Nan-Qi Ren Jie Ding Craig S.Criddle State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental Engineering William&Cloy Codiga Resource Recovery CenterStanford UniversityStanfordCA 94305USA Plasticentropy rue Thiers 28Reims 51100France Department of Entomology and Department of Osteopathic Medical Specialties Michigan State UniversityEast LansingMI 48824USA School of Environmental Studies Cochin University of Science and TechnologyKochi 682022India Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Environmental Science and Engineering Tongji UniversityShanghai 200092China China Energy Conservation and Environmental Protection Group CECEP Talroad Technology Co.Ltd.Beijing 100096China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Research Institute for Frontier Science Beihang UniversityBeijing 100191China School of Environment Tsinghua UniversityBeijing 100084China

Insects damaging and penetrating plastic packaged materials has been reported since the *** innovation breakthroughs of plastic biodegradation have been initiated since the discovery of biodegradation of plastics by Tenebrio molitor larvae in 2015 followed by Galleria mellonella in *** we review updated studies on the insect-mediated biodegradation of *** biodegradation by insect larvae,mainly by some species of darkling beetles(Tenebrionidae)and pyralid moths(Pyralidae)is currently a highly active and potentially transformative area of *** the past eight years,publications have increased explosively,including discoveries of the ability of different insect species to biodegrade plastics,biodegradation performance,and the contribution of host and microbiomes,impacts of polymer types and their physic-chemical properties,and responsible enzymes secreted by the host and gut *** date,almost all major plastics including polyethylene(PE),polypropylene(PP),polyvinyl chloride(PVC),polyethylene terephthalate(PET),polyurethane(PUR),and polystyrene(PS)can be biodegraded by *** and ten other insect species representing the Tenebrionidae and Pyralidae *** biodegradation processes are symbiotic reactions or performed by synergistic efforts of both host and gut-microbes to rapidly depolymerize and biodegrade plastics with hourly *** digestive ezymens and bioreagents screted by the insects play an essential role in plasatic biodegradation in certain species of Tenebrionidae and Pyralidae *** research on the insect itself,gut microbiomes,transcriptomes,proteomes and metabolomes has evaluated the mechanisms of plastic biodegradation in *** conclude this review by discussing future research perspectives on insect-mediated biodegradation of plastics.

关键词： Plastics Biodegradation Insects Gut microbiomes Enzymes

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Timed-pNets： a communication behavioural semantic model for distributed systems

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Frontiers of Computer Science 2015年第1期9卷 87-110页

作者： Yanwen chen Yixiang chen eric MADELAINE MoE Engineering Research Center for Software/Hardware Co-design Technology and Application Shanghai Key Laboratory of Trustworthy Computing East China Normal University Shanghai 200062 China INRIA Sophia Antipolis Mediterannee Sophia Antipolis 06902 France University of Nice Sophia Antipolis CNRS Sophia Antipolis 06900 France

This paper presents an approach to build a communication behavioural semantic model for heterogeneous distributed systems that include synchronous and asynchronous communications. Since each node of such system has its own physical clock, it brings the challenges of correctly specifying the system time constraints. Based on the logical clocks proposed by Lamport, and CCSL proposed by Aoste team in INRIA, as well as pNets from Oasis team in INRIA, we develop timed-pNets to model communication behaviours for distributed systems. Timed-pNets are tree style hierarchical structures. Each node is associated with a timed specification which consists of a set of logical clocks and some relations on clocks. The leaves are represented by timed-pLTSs. Non-leaf nodes （called timed-pNets nodes） are synchronisation devices that synchronize the behaviours of subnets （these subnets can be leaves or non-leaf nodes）. Both timed-pLTSs and timed-pNets nodes can be translated to timed specifications. All these notions and methods are illustrated on a simple use-case of car insertion from the area of intelligent transportation systems （ITS）. In the end the TimeSquare tool is used to simulate and check the validity of our model.

关键词： ITS logical time formal method timed specification synchronous and asynchronous communication

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The effects of Spirulina on anemia and immune function in senior citizens

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Cellular & Molecular Immunology 2011年第3期8卷 248-254页

作者： Carlo Selmi Patrick SC Leung Laura Fischer Bruce German chen-yen Yang Thomas P Kenny Gerry R Cysewski M eric Gershwin Division of Rheumatology Allergy and Clinical ImmunologyUniversity of California at DavisDavisCAUSA Department of Medicine IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Department of Food Science and Technology University of California at DavisDavisCAUSA Cyanotech Kailua-KonaHIUSA

Anemia and immunological dysfunction(***)are commonly found in older subjects and nutritional approaches are sought to counteract these *** is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant *** hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of *** enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic *** took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the *** cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of *** study participants completed the entire study and the data obtained were *** the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both *** addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male *** women appeared to benefit more rapidly from Spirulina ***,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina *** may ameliorate anemia and immunosenescence in older *** encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.

关键词： functional food immunosenescence red blood cell IDO

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Sky reconstruction for the Tianlai cylinder array

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Research in Astronomy and Astrophysics 2016年第10期16卷 71-80页

作者： Jiao Zhang Shi-Fan Zuo Reza Ansari Xuelei chen Yi-chao Li Feng-Quan Wu Jean-eric Campagne Christophe Magneville Key Laboratory of Computational Astrophysics National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China Universite Paris-Sud LALUMR 8607F-91898 Orsay CedexFrance&CNRS/IN2P3F-91405 OrsayFrance University of Chinese Academy of Sciences Beijing 100049China Center for High Energy Physics Peking UniversityBeijing 100871China CEA DSM/IRFUCentre d'Etudes de SaclayF-91191 Gif-sur-YvetteFrance

We apply our sky map reconstruction method for transit type interferometers to the Tianlai cylin- der array. The method is based on spherical harmonic decomposition, and can be applied to a cylindrical array as well as dish arrays and we can compute the instrument response, synthesized beam, transfer func- tion and noise power spectrum. We consider cylinder arrays with feed spacing larger than half a wavelength and, as expected, we find that the arrays with regular spacing have grating lobes which produce spurious images in the reconstructed maps. We show that this problem can be overcome using arrays with a different feed spacing on each cylinder. We present the reconstructed maps, and study the performance in terms of noise power spectrum, transfer function and beams for both regular and irregular feed spacing configura- tions.

关键词： cosmology: observation -- HI intensity mapping -- method: transit telescope -- map making

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Emerging roles for insulin-like growth factor binding protein like protein 1

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Neural Regeneration Research 2019年第2期14卷 258-259页

作者： Yingqian Li eric Zhao Dong Feng chen Schepens Eye Research Institute of Massachusetts Eye and Ear Department of Ophthalmology Harvard Medical School

Insulin-like growth factors (IGFs) mediate diverse cellular processesin various tissues, including the central nervous system (CNS)and thus require robust and delicate regulatory mechanisms. Itis now known that IGF signaling is regulated by a superfamily ofIGF binding proteins (IGFBPs) which share significant sequencehomology and are secreted to the extracellular environment tobind IGF (Nguyen et al., 2013). Currently, there are 6 known IGFBPsand 10 IGFBP related proteins. A new member of the IGFBPsuperfamily, IGFBP like protein 1 (IGFBPL1), was then identifiedand shown to have tumor suppressor like properties (Smith et al.,2007). Since then, little has been reported about the physiologicalroles of IGFBPL1. Recently, IGFBPL1 was found to be criticallyinvolved in mediating IGF-1 signaling to control CNS axon growthand regeneration (Guo et al., 2018). The study has uncovered a newsignaling loop in the regulation of the pleiotropic functions of IGF-1 and presents a possible novel pharmacological manipulation forpromoting nerve regeneration and repair.

关键词： et al IGFBPL CNS

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