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An automated multiw.ll plate reading flim microscope for live cell autofluorescence lifetime assays

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 99-113页

作者： Douglas J.Kelly Sean C.w.rren Sunil Kumar Joao L.Lagarto Benjamin T.Dyer Anca Margineanu eric w.-f.lam Chris Dunsby Paul M.w.french Photonics Group Department of PhysicsImperial College London South Kensington CampusLondonSW72AZUK Institute of Chemical Biology Department of Chemistry Imperial College LondonSouth Kensington Campus LondonSWT 2AZUK National Heart&Lung Institute Imperial Centre for Eaperimental&Translational Medicine Du Cane Road LondonW12 ONNUK Department of Surgery and Cancer Imperial Cllege London Du Cane RoadLondonW12 ONNUK Centre for Histopathology Imperial College London Du Cane RoadLondonW120NNUK

fluorescence lifetime imaging(fLIM)is increasingly used to read out cellular autofluorescenceoriginating from the coenzyme NADH in the context of investigating cell metabolic *** here an automated multiw.ll plate reading fLIM microscope optimized for UV illumi-nation w.th the goal of extending high content fluorescence lifetime asays to readouts ofmetabolism,w. demonstrate its application to automated cellular autofluorescence lifetime imaging and discuss the key practical issues associated w.th its *** particular,w.illustrate its capability to read out the NADH-lifetime response of cells to metabolic modulators,thereby illustrating the potential of the instrument for cytotoxicity studies,assays for drugdiscovery and stratified medicine.

关键词： High content analysis fLIM NADH metabolism cisplatin.

Endohepatology:Arrival at the frontier of interventional endosonography

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w.rld Journal of Gastroenterology 2024年第18期30卷 2397-2401页

作者： Shane P Selvanderan eric lam Neal Shahidi Department of Medicine University of British ColumbiaVancouver V6Z 1Y6BCCanada

Endohepatology describes the emerging field w.ere diagnostic and therapeutic endoscopic ultrasound(EUS)are used for the diagnosis and management of liver disease and its *** this editorial w. comment on the article by Gadour et *** spectrum of EUS-guided procedures includes liver parenchymal and lesional biopsy,abscess drainage,treatment of focal liver lesions,diagnosis of portal hypertension and management of gastric *** data suggest that the application of EUS to hepatology is technically feasible and safe,heralding the arrival at a new.frontier for *** data,specifically randomised trials comparing EUS to interventional radiology techniques,and continued partnership betw.en endoscopy and hepatology are required to see this field establish itself outside expert tertiary centres.

关键词： Cancer Cirrhosis Endoscopy Endoscopic ultrasound Liver disease

Effects of length alteration of OPE-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： Jason Koon-lam Poon Sammual Yu-Lut Leung eric Ka-Ho w.ng Vivian w.ng-w.h Yam Institute of Molecular functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes w.th oligo(paraphenylene ethynylene)(OPE)-derived backbone w.th a variation of the lengths of alkoxy chains and OPE backbones w.s *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes w.re systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes w.re also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

Comparing 11 early w.rning scores and three shock indices in early sepsis prediction in the emergency department

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w.rld Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin lam Zonglin Dai eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew.Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early w.rning scores(Ew.s)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:w. performed a retrospective study on consecutive adult patients w.th an infection over 3 months in a public ED in Hong *** primary outcome w.s sepsis(Sepsis-3 definition)w.thin 48 h of ED *** c-statistics and the DeLong test,w. compared 11 Ew.s,including the National Early w.rning Score 2(NEw.2),Modified Early w.rning Score,and w.rthing Physiological Scoring System(w.S),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),w.th Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ failure Assessment(qSOfA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:w. analyzed 601 patients,of w.om 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and w.s significantly better than SIRS,qSOfA,other Ew.s and shock indices,except w.S,at predicting the primary ***,the pooled sensitivity and specificity of NEw.2≥5 for the prediction of sepsis w.re 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all Ew.s and shock indices declined w.en used to predict mortality at a more remote time ***:NEw.2 compared favorably w.th other Ew.s and shock indices in early sepsis prediction but its low.sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early w.rning score Shock index

Sensing nanoscale electromagnetic forces w.en the heat is on

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National Science Review 2024年第7期11卷 64-65页

作者： eric O.Potma Department of Chemistry University of California

In scanning probe microscopy(SPM),a sharp tip scans across a sample to produce an image w.th nanometer-scale resolution or better. SPM contrast is derived from the physical interplay betw.en the tip and the sample. A special class of SPM techniques measures forces w.en the tip–sample junction is illuminated by an external light source. Photo-induced forces can be sensitive to the optical properties of the sample, thus enabling nanoscale imaging w.th spectroscopic,material-specific contrast.

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Multidimensional images and aberrations in STEM

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Chinese Physics B 2024年第9期33卷 68-74页

作者： eric R.Hoglund Andrew.R.Lupini Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831United States

Recent advances in scanning transmission electron microscopy(STEM)have led to increased development of multidimensional STEM imaging modalities and novel image reconstruction *** interest arises because the main electron lens in a modern transmission electron microscope usually has a diffraction-space information limit that is significantly better than the real-space resolution of the same *** state-of-affairs is sometimes shared by other scattering methods in modern physics and contributes to a broader excitement surrounding multidimensional techniques that scan a probe w.ile recording diffraction-space images,such as ptychography and scanning nano-beam ***,the contrasting resolution in the tw. spaces raises the question as to w.at is limiting their effective ***,w. examine this paradox by considering the effects of aberrations in both image and diffraction planes,and likew.se separate the contributions of pre-and post-sample *** consideration provides insight into aberration-measurement techniques and might also indicate improvements for super-resolution techniques.

关键词： scanning transmission electron microscopy (STEM) aberrations

Taxonomy,distribution,and contemporary exposure of terrestrial mammals to floods and human pressure across different areas for biodiversity conservation in China

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Integrative Zoology 2024年第3期19卷 458-467页

作者： Roman SHARNUUD eric I.AMECA MOE Key Laboratory for Biodiversity Science&Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijingChina Climate Change Specialist Group Species Survival CommissionInternational Union for Conservation of NatureGlandSwitzerland

A significant research focus is placed on identifying animal species and areas at future risk to human-induced alterations of the environment and long-term changes in climatic ***,the extent to w.ich exposure to extreme climatic events and intense human pressure can increase the risk of harmful impacts on species remains poorly *** on terrestrial mammals in China,one of the w.rld’s megadiverse countries,w. investigated patterns of contemporary exposure to floods and human pressures and determined their taxonomic representation and distribution across three major area-based conservation schemes,namely,national nature reserves(NNRs),priority areas for biodiversity conservation(PABCs),and key biodiversity areas(KBAs).Among the 440 species assessed w.th moderate or high exposure to floods,327(∼75%)also qualified as moderate or high in exposure to intense human *** species mainly belong to the orders Chiroptera,Eulipotyphla,and ***,there w.re 305,311,and 311 species w.th moderate or high exposure to flood and intense human pressure represented across NNRs,PABCs,and KBAs,*** findings support the prioritization of KBAs for expansion of site-based protection efforts such as NNRs in China,considering threats to species from exposure to adverse effects from both extreme climate and human pressure.

关键词： conservation floods human pressure mammals taxonomy

Larval development and voracity of Eupeodes americanus (Diptera: Syrphidae): comparison of the focal prey Aphis gossypi (Hemiptera: Aphididae) and the banker prey Rhopalosiphum padi (Hemiptera: Aphididae)

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Insect Science 2024年第2期31卷 575-586页

作者： Arlette fauteux Antonio Onofre Soares eric Lucas Laboratoire de lutte biologique Departement des sciences biologiquesUniversite du Quebec a Montreal(UQAM)MontrealQuebecCanada faculty of Science and Technology Center for Ecology Evolution and Environmental ChangesAzorean Biodiversity Group(cE3c-ABG)&CHANGE-Global Change and Sustainability InstitutePonta DelgadaPortugal

Unlike European species,the potential of Nearctic syrphids as biological control agents is still poorly ***,the American hoverfly,Eupeodes americanus(w.edemann),has recently demonstrated promising traits as a biocontrol agent,notably against the foxglove aphid,Aulacorthum solani Kaltenbach,on *** present study aims to extend our know.edge of the American hoverfly by evaluating its potential as a biocontrol agent in a banker plant system against the melon aphid,Aphis gossypi Glover,in a greenhouse cucumber *** preimaginal development and voracity of *** w.re compared w.en preying upon the focal prey/pest(***)or the banker prey(bird cherry-oat aphid,Rhopalosiphum padi L.)by daily observations of larvae from egg to *** development time,survival rate,and occurrence of deformation w.re similar on both prey *** w.ight of third instar and pupae,how.ver,w.s higher for larvae that fed on the banker *** ad libitum voracity of the syrphid larvae w.s generally very high and did not significantly differ betw.en prey species,except for the third-instar larvae w.ich consumed more focal *** suggest that a banker plant system involving the bird cherry-oat aphid may be a promising tactic for utilizing *** for melon aphid biocontrol.

关键词： american hoverfly banker plant system biological control bird cherry-oat aphid greenhouse cucumber melon aphid

Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 101-116页

作者： eric f. Tanlaka Torri Trojand faculty of Nursing University of Windsor Windsor Canada

Background: Stroke survivors w.o exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer functional outcomes than those w.thout impaired cognition. Differences in functional outcomes betw.en stroke survivors w.th and w.thout impaired cognition may be attributed to age, level of cognitive impairment, and severity of stroke. Materials and Methods: A retrospective secondary data analysis w.s conducted using health-related administrative data acquired from a Southw.stern Ontario hospital’s stroke rehabilitation database. The aim w.s to explore potential linkages betw.en post-stroke impaired cognition and functional gains, rehabilitation stays, and living settings after discharge from rehabilitation. Results: An aggregate sample of 393 males and 314 females subclassified as experiencing mild, moderate, and severe stroke w.s analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients w.re significantly (p 0.001) older, had (mostly) moderate to severe stroke w.th significantly (p = 0.012) more moderate cognitive impairment, had significantly (p 0.001) longer rehabilitation stays, and a high propensity for being discharged to longer-term care facilities compared to non-cognitively impaired patients. Conclusion: Presence of significant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors w.th and w.thout cognitive impairment is attributed to the age of the patient, level of cognitive impairment, and rigorous rehabilitation interventions.

关键词： Stroke Impaired Cognition Inpatient Rehabilitation functional Outcomes