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Complement factor P: promoting the antibacterial activity of natural killer cells

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Cellular & Molecular Immunology 2017年第10期14卷 797-799页

作者： Xiaoxuan Zhuang eric O Long Laboratory of Immunogenetics National Institute of Allergy and Infectious DiseasesNIHRockvilleMDUSA

Natural cytotoxicity receptors(NCRs)are expressed on natural killer(NK)cells and other subsets of innate lymphoid cells(ILC).Three NCRs,NKp30,NKp44 and NKp46,are expressed on human NK cells.1 NKp46 is the only NCR shared by primates and rodents,suggesting an essential role for this receptor during evolution.2 While cellular ligands for NKp30 and NKp44 have been identified,a well-characterized non-microbial ligand for NKp46 is still ***,in a recent paper in Science Immunology,Narni-Mancinelli et al.3 reported the identification of complement factor P(CFP,also known as properdin)as a ligand of NKp46.

关键词： killer al. cytotoxicity

Immunotherapeutic approaches in biliary tract carcinoma:Current status and emerging strategies

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 338-346页

作者： eric I Marks Nelson S Yee Department of Medicine Penn State Milton S.Hershey Medical Center Division of Hematology-Oncology Program of Experimental TherapeuticsDepartment of MedicinePenn State Hershey Medical CenterPenn State Hershey Cancer Institute

For biliary tract carcinoma(BTC),complete surgical resection of tumor is only feasible in a minority of patients,and the treatment options for patients with unresectable or metastatic disease are *** in cancer immunology have led to identification of tumor-infiltrating immune cells as indicators of prognosis and response to treatment in *** has also facilitated development of immunotherapy that focuses on enhancing the immune system against biliary *** includes peptide- and dendritic cell-based vaccines that stimulate in-vivo immune responses against tumorspecific *** immunotherapy,which entails the ex-vivo expansion of tumor-infiltrating immune cells for subsequent reintroduction,and cytokinebased therapies have been developed in *** studies indicate that this type of therapy is generally well *** therapy with dendritic cell-based vaccines and adoptive immunotherapy has shown particularly good *** strategies through discovery of novel antigen targets and by reversal of tumor-associated immunosuppression are expected to improve the efficacy of immunotherapy in *** efforts by integration of targeted immunotherapeutics with molecular profiling of biliary tumor will hopefully make a positive impact on advancing towards the goal of developing precision treatment of patients with this highly lethal disease.

关键词： Adoptive immunotherapy Cancer vaccines Biliary tra

Growth and Patterning of Pt Nanowires on Silicon Substrates

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Nano Research 2008年第2期1卷 129-137页

作者： eric P.Lee Younan Xia Department of Biomedical Engineering Washington UniversitySt.LouisMissouri 63130USA

This paper describes a simple procedure for growing dense fi lms of Pt nanowires directly on silicon substrates by modifying the surface through chemical or physical *** the former,a self-assembled monolayer of(3-mercaptopropyl)-trimethoxysilane(MPTMS)is applied which can strongly bind Pt(0)nuclei to the surface through Pt S *** attached,the Pt(0)nuclei can act as catalytic sites for the growth of Pt nanowires along the〈111〉***,relief features are physically created on the surface in order to generate nucleation and binding sites for Pt(0)nuclei,due to the higher free energy associated with a rough ***,Pt nanowires have been successfully produced in well-defined patterns by scouring grooves on the silicon surface or by photochemically patterning the MPTMS monolayers with a shadow *** have also measured the electrochemical properties of these immobilized or patterned Pt *** results provide an effective route to producing dense fi lms of Pt nanowires with high surface areas for various electrochemical applications.

关键词： Platinum nanowires silicon patterned array high surface area electrochemistry

A New Eusauropod Dinosaur from the Lower Cretaceous of Guangxi Province,Southern China

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Acta Geologica Sinica(English Edition) 2010年第6期84卷 1328-1335页

作者： MO Jinyou XU Xing eric BUFFETAUT Faculty of Earth Sciences China University ofGeosciences Wuhan 430074 China Natural History Museum of Guangxi Nanning 530012 China Institute of Vertebrate Paleontology and Paleoanthropology Beijing 100044 China CNRS UMR 8538 Laboratoire de Geologie de l＇Ecole Normale Superieure 24 rue Lhomond 75231 Paris Cedex 05 France

A new sauropod dinosaur,Liubangosaurus hei *** ***.,is erected based on a specimen represented by five articulated middle-caudal dorsal vertebrae,which was discovered in the Lower Cretaceous Napai Formation of Guangxi Province,southern *** new taxon is diagnosed by a unique combination of derived features：prezygapophysis closely contacts with parapophysis,with the prdl and prpl absent;presence of cavity on the dorsal surface of the diapophysis;neural spine very low,with its distal end level with that of diapophysis;distal end of the neural spine strongly expanded laterally to form a platform;marked fossa formed between the infradiapophyseal lamina and the parapophysis;broad,flat area of featureless bone on lateral surface of neural arch;vertically directed infradiapophyseal lamina expands or bifurcates ventrally to form a inverted ＂Y＂;highly positioned parapophyses large and tear-drop in *** discovery of this new taxon increases the diversity of sauropods in China during the Early Cretaceous.

关键词： Eusauropoda Liubangosaurus hei Napai Formation Early Cretaceous Guangxi China

End-of-Life Decision making in circular economy using generalized colored stochastic Petri nets

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Autonomous Intelligent Systems 2022年第1期2卷 32-49页

作者： Gautier Vanson Pascale Marangé eric Levrat Universitéde Lorraine CRANUMR 7039Campus SciencesBP 70239Vandoeuvre-lès-Nancy54506France

Circular economy enables to restore product value at the end of life *** no longer used or ***,the product life cycle is extended and this economy permits to reduce waste increase and resources *** are several revaluation options(reuse,remanufacturing,recycling,...).So,decisionmakers need to assess these options to determine which is the best ***,we will present a study about an End-Of-Life(EoL)decision making which aims to facilitate the industrialization of circular *** this,it is essential to consider all variables and parameters impacting the decision of the product trajectory.A first part of the work proposes to identify the variables and parameters impacting the decision making.A second part proposes an assessment approach based on a modeling by Generalized Colored Stochastic Petri Net(GCSPN)and on a Monte-Carlo *** approach developed is tested on an industrial example from the literature to analyze the efficiency and effectiveness of the *** first application showed the feasibility of the approach,and also the limits of the GCSPN modelling.

关键词： Circular economy Sustainability Decision making Generalized colored stochastic Petri net Monte-Carlo simulation

Solar aided power generation:A review

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Energy and Built Environment 2020年第1期1卷 11-26页

作者： Jiyun Qin eric Hu Xiaohua Li China Institute of FTZ Supply Chain Shanghai Maritime UniversityShanghai 201306 China School of Mechanical Engineering the University of AdelaideSA 5005 Australia Department of Building Engineering Hunan Institute of Engineering411104 HunanChina

Solar Aided Power Generation(SAPG)is the most efficient and economic ways to hybridise solar thermal energy and a fossil fuel fired regenerative Rankine cycle(RRC)power plant for power generation *** such an SAPG plant,the solar thermal energy is used to displace the extraction steam by preheating the feedwater to the *** displaced/saved extraction steam can,therefore,expand further in the steam turbine to generate *** research and development of the SAPG technology started in the *** paper is trying to reviews and summarises the progress of research and development of the SAPG plant technology in last almost 30 or so years,including the technical and economic advantages of SAPG over other solar thermal power generation tech-nologies(*** alone power generation),various modelling techniques used to simulate SAPG perforamnce,impacts of SAPG plant’s configuration,size of solar field and strategies to adjust mass flow rate of extraction steam on the plant perforamnce,exergy analysis of SAPG plant and operation strategies to maximise plant’s economic returns *** addition,the directions for future R&D about SAPG technology have been pointed/proposed in this paper.

关键词： Solar thermal power system Hybrid power system Solar preheating Solar Aided Power Generation

High-Order Low Dissipation Conforming Finite-Element Discretization of the Maxwell Equations

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Communications in Computational Physics 2012年第3期11卷 863-892页

作者： Sebastien Jund Stephanie Salmon eric Sonnendrucker IRMA UMR 7501 Universite de Strasbourg and CNRSand CALVI project-teamINRIA Nancy Grand Est7 rue Rene DescartesF-67084 STRASBOURG Cedex Laboratoire de Mathematiques EA 4535 Universite de ReimsU.F.R.Sciences Exactes et NaturellesMoulin de la Housse-BP 1039F-51687 REIMS cedex 2

In this paper,we study high order discretization methods for solving the Maxwell equations on hybrid triangle-quad *** have developed high order finite edge element methods coupled with different high order time schemes and we compare results and efficiency for several *** introduce in particular a class of simple high order low dissipation time schemes based on a modified Taylor expansion.

关键词： Maxwell’s equations edge finite element method mass lumping time discretization schemes

IDMI Analysis of Regional Low-Carbon Development Based on System Dynamic Simulation

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Transactions of Tianjin University 2013年第5期19卷 338-344页

作者：贺媛媛 Hu eric 谭欣 School of Environmental Science and Technology Tianjin University School of Mechanical Engineering University of Adelaide

During the decision-making process, especially in multi-disciplinary complex cases, assessment technique is needed to assist policy-makers in making the right decision. Many of such assessment techniques have been developed for policy-makers, but the inevitable subjectivity of policy-makers often becomes the main obstacle in making the right or proper policy. Interlink decision-making index （IDMI） is a newly proposed assessment method with the advantages of being simple to use and having less human interference over other methods, as it does not require a weighting process of each selection criterion. This paper implements IDMI to assist with decision-making in national or regional low-carbon development, using China as a case study. The Chinese government has annotmced its carbon emission reduction target along with other development targets by 2020. Many policy settings can be chosen in order to achieve those targets. The problem is how to determine the best setting and the means by which decision-makers can avoid subjectivity and extremes. A number of policy setting options are generated carefully by a system dynamic model under different policy scenarios. The IDMI demonstrates a perfect way to assist in selecting the ＂best＂ among all the options that can achieve the goals within the acceptable range.

关键词： IDMI decision-making low-carboneconomy system dynamics

Celiac disease:a model disease for gene-environment interaction

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Cellular & Molecular Immunology 2011年第2期8卷 93-95页

作者： Raivo Uibo Zhigang Tian M eric Gershwin Immunology Group IGMPUniversity of TartuRavila 19TartuEstonia University of Science and Technology of China HefeiChina Division of Rheumatology Allergy and Clinical ImmunologyUniversity of California at Davis School of MedicineDavisCAUSA

Celiac sprue remains a model autoimmune disease for dissection of genetic and environmental influences on disease *** 2010 Congress of Autoimmunity included several key sessions devoted to genetics and *** papers from these symposia were selected for in-depth discussion and *** issue is devoted to this *** goal is not to discuss genetic and environmental interactions,but rather to focus on key elements of diagnosis,the inflammatory response and the mechanisms of autoimmunity.

关键词： environment andautoimmunity geoepidemiology autoimmunity