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Skeletal microstructures of cheilostome bryozoans(phylum Bryozoa,class Gymnolaemata):crystallography and secretion patterns

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Marine Life Science & Technology 2024年第3期6卷 405-424页

作者： christian Grenier erika Griesshaber Wolfgang Schmahl Björn Berning Antonio G.checa Departamento de Estratigrafía y Paleontología Universidad de Granada18071 GranadaSpain Instituto Andaluz de ciencias de La Tierra CSIC-Universidad de Granada18100 ArmillaSpain Department of Earth and Environmental Sciences Ludwig-Maximilians Universität80333 MunichGermany Institute for Geology University of Hamburg20146 HamburgGermany

Gymnolaemata bryozoans produce cacO3 skeletons of either calcite,aragonite,or *** extensive research,their crystallography and biomineralization patterns remain *** present a detailed study of the microstructures,min-eralogy,and crystallography of eight extant cheilostome species using scanning electron microscopy,electron backscatter diffraction,atomic force microscopy,and micro-computed *** distinguished five basic microstructures,three calcitic(tabular,irregularly platy,and granular),and two aragonitic(granular-platy and fibrous).The calcitic microstruc-tures consist of crystal aggregates that transition from tabular or irregularly platy to granular *** aragonite consists of fibers arranged into *** all cases,the crystallographic textures are axial,and stronger in aragonite than in calcite,with the c-axis as the fiber *** reconstruct the biomineralization sequence in the different species by considering the distribution and morphology of the growth fronts of crystals and the location of the secretory *** bimineralic species,calcite formation always predates aragonite *** interior compound walls,growth proceeds from the cuticle toward the zooecium *** conclude that,with the exception of tabular calcite,biomineralization is remote and occurs within a relatively wide extrapallial space,which is consistent with the inorganic-like appearance of the *** biomineralization mode is rare among invertebrates.

关键词： Biomineralization Bryozoan Skeleton calcite Aragonite Electron backscatter diffraction

Using a novel hemostatic peptide solution to prevent bleeding after endoscopic submucosal dissection of a gastric tumor

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 168-174页

作者： Kuniyo Gomi Yorimasa Yamamoto erika Yoshida Misako Tohata Masatsugu Nagahama Department of Gastroenterology Showa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BAcKGROUND Endoscopic mucosal dissection has become the standard treatment for early gastric ***,post-endoscopic submucosal dissection(ESD)ulcer occurs in 4.4%of *** study hypothesized whether applying PuraStat,a novel hemostatic peptide solution,prevents post-ESD *** To investigate the preventive potential of PuraStat,a hemostatic formulation,against bleeding in post-ESD gastric *** Between May 2022 and March 2023,101 patients(Group P)underwent ESD for gastric diseases at our hospital and received PuraStat(2 mL)for post-ESD *** retrospectively compared this group with a control group(Group c)com-prising 297 patients who underwent ESD for gastric diseases at our hospital between April 2017 and March 2021.P valuescated *** Post-ESD bleeding occurred in 6(5.9%)(95%cI:2.8-12.4)and 20(6.7%)(95%cI:4.4-10.2)patients in Groups P and c,respectively,with no significant between-group *** relative risk was 1.01(95%cI:0.95-1.07).The lesser curvature or anterior wall was the bleeding site in all 6 patients who experienced postoperative bleeding in Group *** multivariate analysis,the odds ratios for resection diameter≥50 mm and oral anticoagulant use were 6.63(95%cI:2.52-14.47;P=0.0001)and 4.04(1.26-0.69;P=0.0164),*** adjusted odds ratio of post-ESD bleeding and PuraStat was 1.28(95%cI:0.28-2.15).cONcLUSION PuraStat application is not associated with post-ESD ***,the study suggests that gravitational forces may affect the effectiveness of applied PuraStat.

关键词： Endoscopic submucosal dissection PuraStat Bleeding Gastric cancer hemostatic forceps Proton pump inhibitor hemostatic peptide solution

Alternative techniques for forecasting mineral commodity prices

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International Journal of Mining Science and Technology 2018年第2期28卷 309-322页

作者： c.A.Tapia cortez S.Saydam J.coulton c.Sammut School of Mining Engineering UNSW Sydney UNSW Business School UNSW Sydney School of computer Science and Engineering UNSW Sydney

Forecasting mineral commodity(Mc) prices has been an important and difficult task traditionally addressed by econometric, stochastic-Gaussian and time series techniques. None of these techniques has proved suitable to represent the dynamic behavior and time related nature of Mc markets. chaos theory(cT) and machine learning(ML) techniques are able to represent the temporal relationships of variables and their evolution has been used separately to better understand and represent Mc markets. cT can determine a system's dynamics in the form of time delay and embedding dimension. However, this information has often been solely used to describe the system's behavior and not for *** to traditional techniques, ML has better performance for forecasting Mc prices, due to its capacity for finding patterns governing the system's dynamics. However, the rational nature of economic problems increases concerns regarding the use of hidden patterns for forecasting. Therefore, it is uncertain if variables selected and hidden patterns found by ML can represent the economic *** their refined features for representing system dynamics, the separate use of either cT or ML does not provide the expected realistic accuracy. By itself, neither cT nor ML are able to identify the main variables affecting systems, recognize the relation and influence of variables though time, and discover hidden patterns governing systems evolution simultaneously. This paper discusses the necessity to adapt and combine cT and ML to obtain a more realistic representation of Mc market behavior to forecast long-term price trends.

关键词： Price forecasting Mineral commodity Market dynamics chaos theory Machine learning

Envita’s Precision cancer care: 35-Fold Improvement in Response Rates

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Journal of cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John c. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart christopher Aussems Jon Moma Shannon Miller Zach Poteet conner coffin courtney Middleton erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel conway chad Burk Ruth Tan-Lim Dino Prato Envita Medical centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National comprehensive cancer Network (NccN) guidelines, utilized by prominent cancer institutions. cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical centers over a two-year period. compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical centers Late-stage cancer Overall Response Rate Quality of Life circulating Tumor cells (cTcs) Mutant Allele Frequency (MAF) Precision care

Assessing spatial variability and erosion susceptibility of soils in hilly agricultural areas in Southern Italy

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International Soil and Water conservation Research 2020年第4期8卷 354-362页

作者： carmen Maria Rosskopf erika Di Iorio Luana circelli claudio colombo Pietro P.c.Aucelli University of Molise Department of Biosciences and Territoryc.da Fonte Lappone86090PescheISItaly University of Molise Department of AgriculturalEnvironmental and Food SciencesVia F.De Sanctis186100CampobassoCBItaly University of Napoli"Parthenope" Department of Environmental SciencesCentro Direzionale Isola C/480143NapoliItaly

Soil erosion is one of the main environmental problems in the Mediterranean *** problem is becoming even more important especially in Italy,in the Apennines,where severe erosive processes occur due to the action of concentrated running *** erodibility(K-Factor)of a soil,estimated using the Revised Universal Soil Loss Equation(RUSLE),is a measure of its susceptibility to erosion and depends on several soil properties such as organic matter,texture and permeability and *** assess the spatial variability of soil properties and soil erodibility in hilly agricultural areas and to investigate the relationships between soil features and landscape morphodynamics,a detailed study in Molise region(southern Italy),in a small drainange basin located along its hilly Adriatic flank,was carried *** this catchment,63 topsoil samples(A horizons)were collected and 10 soil profiles,forming a catena crossing 3 land units,were *** calculated K-Factors ranges between 0.012 and 0.048 t ha h ha-1 MJ-1 mm-1 indicating a complex spatial distribution,due to the several local pedological and geomorphological factors affecting soil *** results give clear evidence about the relationships among soil characteristics,soil erodibility and landscape morpho-dynamics(land units).comparing the soil loss rates estimated for the study area with those reported in literature,a good correspondence can be observed only for the more stable land unit,not characterized by intense erosive *** proposed methodology is suitable to highlight areas characterized by similar morphodynamics features,and comparable soil erodibility,for a more effective spatialization of K factor.

关键词： Hillslope morphodynamics RUSLE equation K factor Mediterranean region Soil catena Land units

Micro- and nanoporous materials capable of absorbing solvents and oils reversibly： the state of the art

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Petroleum Science 2017年第1期14卷 84-104页

作者： Javier S. Acevedo cortez Boris I. Kharisov Thelma E. Serrano Quezada Tomas c. Hernandez Garcia Facultad de ciencias Qufmicas Universidad Autonoma de Nuevo Leon Ave. Universidad s/n66455 San Nicolas de los Garza NL Mexico

Treatment of petroleum spills and organic solvent pollution in general is an important issue; several techniques are under development to remove oil from water. The use of absorbents is one of the most common techniques to tackle this problem. These absorbents can be classified based on their characteristics of recyclability into irreversible and reversible ones. In this review, we discuss the application of several materials as oil absorbents, according to their classification and characteristics such as hydrophobicity, surface area and oil absorption capacity. Also, the fabrication methods for some materials are presented and analyzed.

关键词： Oil spills - composites Reversibility Aerogels - Natural absorbents Micro- and nanoporousmaterials

Possibilities of using silicate rock powder:An overview

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Geoscience Frontiers 2022年第1期13卷 446-456页

作者： claudete Gindri Ramos James c.Hower erika Blanco Marcos Leandro Silva Oliveira Suzi Huff Theodoro Department of civil and Environmental Engineering Universidad de la CostaCalle 58#55-66BarranquillaColombia Departamento de Ingeniería civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru center for Applied Energy Research University of Kentucky2540 Research Park DriveLexingtonKY 40511USA Department of Earth&Environmental Sciences University of KentuckyLexingtonKY 40511USA Postgraduate Program of Environment and Rural Development(PPG-MADER) Área Universitária01Vila Nossa Senhora de Fátima–Campus UnBPlanaltinaDFBrazil

This study evaluates the on use of crushed rocks(remineralizers)to increase soil fertility levels and which contributed to increase agricultural productivity,recovery of degraded areas,decontamination of water,and carbon *** use of these geological materials is part of the assumptions of rock technology and,indirectly,facilitates the achievement of sustainable development goals related to soil management,climate change,and the preservation of water *** over the past 50 years on silicate rocks focused on soil fertility management and agricultural *** recently,the combined use with microorganisms and organic correctives have shown positive results to mitigate soil degradation;to expand carbon sequestration and storage;and to contribute to the adsorption of contaminants from water and *** this article we show results obtained in several countries and we show that this technology can contribute to the sustainability of agriculture,as well as to reverse global *** mineral nutrients are released more slowly from these types of inputs,they remain in the soil for a longer time,stimulating the soil *** addition,they are a technology to soluble synthetic fertilizers replace,since the few nutrients derived from such inputs not consumed by plants are lost by leaching,contaminating groundwater and water *** addition,conventional methods rely heavily on chemical pesticides which cause damage to soil’s microfauna(responsible for the decomposition of organic matter and nutrient cycling)and the loss of organic carbon(in the form of dioxide),which is quickly dispersed in the *** rock powders are applied in natura,have long-lasting residual effects and reduce greenhouse gas emissions.

关键词： Rock powder Soil management carbon storage Water contaminant adsorption

MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2101-2113页

作者： Loraine Kay D cabral cynthia A Mapua Filipinas F Natividad caecilia H c Sukowati Edgardo R cortez Ma Luisa D Enriquez Research and Biotechnology Group St.Luke's Medical CenterQuezon City 1112Philippines centro Studi Fegato Fondazione Italiana Fegato ONLUSTrieste 34149Italy Department of Surgery St.Luke's Medical CenterQuezon City 1112Philippines center for Natural Science and Environmental Research De La Salle UniversityManila 1004Philippines

BAcKGROUND colorectal cancer(cRc)ranks third in terms of incidence and second in mortality *** cRc,the silencing of mismatch repair genes,including the mutL homolog 1(hMLH1)has been linked to microsatellite instability(MSI),the lengthening or shortening of microsatellite *** limited data have been presented so far on the link of hMLH1 methylation and MSI in Southeast Asia populations with sporadic cRc,and on its clinical *** To investigate the significance of the MSI status and hMLH1 methylation in cRc Filipino *** Fifty-four sporadic cRc patients with complete clinical data were included in this *** DNA from cRc tumor biopsies and their normal tissue counterparts were profiled for MSI by high resolution melting(HRM)analysis using the Bethesda Panel of Markers(BAT25,BAT26,D2S123,D5S346,and D17S250).hMLH1 methylation screening was performed using bisulfite conversion and methylation specific polymerase chain *** analysis was conducted to calculate their associations to clinicopathological characteristics and survival relevance(Kaplan-Meier curves and the log-rank test).RESULTS hMLH1 methylation was observed in 9%and 35%of cRc and normal samples,*** incidence of consistently methylated hMLH1 found in both normal and cRc was noticed for relation to location of tumor(Pcommon unstable microsatellite and MSI-high(MSIH)was the most common MSI profile,counted for 46%and 50%of normal and cRc tissues,*** presence of MSI-low(MSI-L)and microsatellite stable(MSS)was 43%and 11%for normal,and 31%and 19%for cRc *** mean month of patients’survival was shorter in patients whose normal and tumor tissues had methylated compared to those with unmethylated hMLH1 and with MSI-H compared to those with MSI-L/MSS(Pcant difference in Kaplan-Meier with log-rank *** data indicated that hMLH1 methylation

关键词： Sporadic colorectal cancer DNA methylation Microsatellite instability Population genetic colorectal cancer

Strategies for fast breeding and improvement of Actinidia species

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Horticulture Research 2023年第3期10卷 266-270页

作者： Dinum Herath Tianchi Wang charlotte Voogd Yongyan Peng Mikaela Douglas Joanna Putterill erika Varkonyi-Gasic Andrew c.Allan The New Zealand Institute for Plant and Food Research Limited(Plant&Food Research)Mt Albert Private Bag 92169Auckland Mail CentreAuckland 1142New Zealand School of Biological Sciences University of AucklandPrivate Bag 92019AucklandNew Zealand

Perspective Ensuring food security for a rapidly growing world population will need new *** include speed breeding and new breeding technologies,which have been established for major staple *** of woody perennial fruit tree species has progressed at a much slower pace and has met many *** fruit production will face major challenges with climate change,such as the loss of winter chilling needed for f lowering,a potential decrease in pollinator availability,and increasing pest and disease *** chinensis(kiwifruit)is an important fresh fruit crop,with varieties only several generations removed from the wild accessions and carrying only a fraction of the available genetic diversity[1,2].Improvement of traits such as fruit quality and storage,and resistance to emergent diseases underpin the breeding efforts,which are hampered by a long generation time,large plant size,dependence on chilling for budbreak and f lowering,dioecy and different ploidy *** addition to kiwifruit,the genus Actinidia consists of more than 50 species with edible fruit,all showing tremendous potential as future fruit crops[3].Their fast domestication and improvement will enable production of high-quality healthy fruit,contributing to food security in the changing climate conditions.

关键词： breeding crops removed