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Postoperative serum tumor markers-based nomogram predicting early recurrence for patients undergoing radical resections of pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3211-3223页

作者： Hang He Cai-Feng Zou Feng Yang Yang Di Chen Jin De-liang Fu Department of Pancreatic Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China

BACKGROUND Early recurrence(er)is associated with dismal outcomes in patients undergoing radical resection for pancreatic ductal adenocarcinoma(PDAC).Approaches for predicting er will help clinicians in implementing individualized adjuvant *** serum tumor markers(STMs)are indicators of tumor progression and may improve current systems for predicting *** To establish an improved nomogram based on postoperative STMs to predict er in *** We retrospectively enrolled 282 patients who underwent radical resection for PDAC at our institute between 2019 and *** and multivariate Cox regression analyses of variables with or without postoperative STMs,were performed to identify independent risk factors for er.A nomogram was constructed based on the independent postoperative *** operating characteristic curve analysis was used to evaluate the area under the curve(AUC)of the *** analysis was performed using Kaplan-Meier survival plot and log-rank *** Postoperative carbohydrate antigen 19-9 and carcinoembryonic antigen levels,preoperative carbohydrate antigen 125 levels,perineural invasion,and pTNM stage III were independent risk factors for er in *** postoperative STMs-based nomogram(AUC:0.774,95%CI:0.713-0.835)had superior accuracy in predicting er compared with the nomogram without postoperative STMs(AUC:0.688,95%CI:0.625-0.750)(P=0.016).Patients with a recurrence nomogram score(RNS)>1.56 were at high risk for er,and had significantly poorer recurrence-free survival[median:3.08 months,interquartile range(IQR):1.80-8.15]than those with RNS≤1.56(14.00 months,IQR:6.67-24.80),Perative STMs-based nomogram improves the predictive accuracy of er in PDAC,stratifies the risk of er,and identifies patients at high risk of er for tailored adjuvant therapies.

关键词： Nomogram Postoperative serum tumor markers Early recurrence Predicting accuracy Adjuvant therapy Pancreatic ductal adenocarcinoma

A facile synthesis of the spiroindoline-based growth hormone secretagogue,MK-677

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Chinese Chemical Letters 2012年第6期23卷 661-664页

作者： Xian liang Qi er Qun Yang Jun Tao Zhang Tao Wang Xiao Ping Cao State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

A facile and improved route for the synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677 was described. The key step adopted the Fischer indole/reduction strategy. The preparation of the key intermediates N-protected piperidine carboxaldehyde 5 and the N-Boc-O-benzyl-D-serine （2） are also optimized.

关键词： MK-677 Synthesis Improved route Fischer indole/reduction

凉山州某县未接受抗病毒治疗的HIV-1感染者的耐药情况分析

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中国感染与化疗杂志 2024年第1期24卷 19-24页

作者：刘梅朱芮吴涛俄尔阿沙木袁天茹宋绍芳刘玲梁洪远曹汴川越西县第一人民医院抗病毒治疗中心四川凉山616650 首都医科大学附属北京地坛医院艾滋病临床中心西南医科大学附属医院感染病科结核病科感染与免疫实验室

目的分析凉山州某县未接受抗病毒治疗的HIV-1感染者的传播性耐药(TDR)情况,为了解当地HIV-1耐药株的传播及抗反转录病毒治疗(ART)方案的制定提供理论依据和技术支撑。方法以来源于2022年1—8月在凉山州某县未接受ART的HIV-1感染者为研... 详细信息

目的分析凉山州某县未接受抗病毒治疗的HIV-1感染者的传播性耐药(TDR)情况,为了解当地HIV-1耐药株的传播及抗反转录病毒治疗(ART)方案的制定提供理论依据和技术支撑。方法以来源于2022年1—8月在凉山州某县未接受ART的HIV-1感染者为研究对象,采集其血液样本并分离血浆和血细胞,血浆样本用于HIV-1 RNA定量检测和HIV-1 RNA基因型耐药检测,血细胞样本用于HIV-1 DNA定量检测和HIV-1 DNA基因型耐药检测。结果135例研究对象中,男性75例(55.6%),女性60例(44.4%),中位年龄37.5岁,彝族占比最大(96.3%)。性途径传播为HIV-1主要传播方式(83.0%)。发生TDR的有11例,发生率为8.1%。诊断HIV-1感染距耐药检测时间的中位数为11 d。HIV-1 RNA以10001~100000拷贝/mL占比较多(43.7%)。HIV-1 DNA以101~1000拷贝/106 cells占比较多(55.6%)。HIV-1亚型中,以B+C亚型重组占比最高(51.9%),其次为CRF07_BC重组型(43.0%)。135例研究对象中,有23例(17.0%)出现耐药突变位点,与非核苷类反转录酶抑制剂(NNRTI)有关的耐药突变位点有16例(11.9%),K103N是主要的耐药突变位点,依非韦伦和奈韦拉平是主要的耐药药物;与整合酶抑制剂(INSTI)有关的耐药突变位点有6例(4.4%),E157Q是主要的耐药突变位点,埃替拉韦和拉替拉韦是主要的耐药药物;有1例(0.7%)同时出现NNRTI和INSTI耐药突变位点。经过单因素和多因素logistic回归分析,相较于年龄>30岁,年龄≤30岁发生TDR风险更高。结论凉山州某县未接受ART的HIV-1感染者的耐药情况不容忽视,相较于年龄>30岁,年龄≤30岁发生TDR风险更高,建议HIV-1感染者在接受ART前均进行HIV-1耐药检测。

关键词：耐药突变位点传播性耐药人类免疫缺陷病毒抗反转录病毒治疗

Quantitative spectrum occupancy evaluation in China: based on a large scale concurrent spectrum measurement

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The Journal of China Universities of Posts and Telecommunications 2012年第3期19卷 122-128页

作者： YIN liang YIN Si-xing WANG Shuai ZHANG er-qing HONG Wei-jun LI Shu-fang School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Due to the usable frequency becomes more and more crowed, dynamic spectrum access （DSA） is a new hope to solve this problem. However, DSA in China requires a quantitative analysis of the current spectrum utilization in frequency, temporal and spatial domains. In order to free the precious spectrum, spectrum regulation organizations must have a clear, detailed, up-to-date understanding of where, how and by whom spectrum is currently being used--such data is essential to sound policy decisions in the context of cognitive radio （CR）. In this paper, a concurrent spectrum occupancy measurement in south China was conducted to evaluate the practical spectrum occupancy with a digital wideband receiver covering from 20 MHz to 3 GHz. We also propose systemic spectrum measurement methodology, matrix format data storage, duty cycle （DC） evaluation metric and data mining process which can be a guideline for other researchers when they conduct the similar experiments. Quantitative analysis and characterization of the 4 different measurement locations are evaluated to promote the popularization of CR application in China. And a uniform Beta distribution channel occupancy model is also validated using real-scene measurement data. The experimental results demonstrate that there is a significant scope for license-exemption use of the released spectrum using CR technology.

关键词： cognitive radio spectrum measurement spectrum occupancy duty cycle Beta distribution

Up-regulation of a homeodomain-leucine zipper gene HD-1 contributes to trichome initiation and development in cotton

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Journal of Integrative Agriculture 2019年第2期18卷 361-371页

作者： NIU er-li CAI Cai-ping BAO Jiang-hao WU Shuang ZHAO liang GUO Wang-zhen State Key Laboratory of Crop Genetics&Germplasm Enhancement Ministry of Science and Technology/Hybrid Cotton R&D Engineering Research CenterMinistry of Education/College of AgricultureNanjing Agricultural UniversityNanjing 210095P.R.China

Plant trichomes originate from epidermal *** this work,we demonstrated that a homeodomain-leucine zipper(HD-Zip)gene,Gh_A06G1283(Gh HD-1A),was related to the leaf trichome trait in allotetraploid cotton and could be a candidate gene for the T_1 *** ortholog of GhHD-1A in the hairless accession Gossypium barbadense ***7124 was interrupted by a long terminal repeat(LTR)retrotransposon,while GhHD-1A worked well in the hairy accession Gossypium hirsutum *** and phylogenetic analysis showed that GhHD-1A belonged to the HD-Zip IV gene family,which mainly regulated epidermis hair development in *** of GhHD-1A and its homoeologs GhHD-1D in allotetraploid T586and Hai7124 could significantly reduce the density of leaf hairs and affect the expression levels of other genes related to leaf trichome *** analysis found that GhHD-1A mainly regulated trichome initiation on the upper epidermal hairs of leaves in cotton,while the up-regulated expression of GhHD-1A in different organs/tissues also altered epidermal trichome *** study not only helps to unravel the important roles of GhHD-1A in regulating trichome initiation in cotton,but also provides a reference for exploring the different forms of trichome development in plants.

关键词： leaf trichome map-based cloning a homeodomain-leucine zipper gene HD-1 virus-induced gene silencing (VIGS) functional differentiation

Do Ureaplasma urealyticum infections in the genital tract affect semen quality?

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Asian Journal of Andrology 2006年第5期8卷 562-568页

作者： Yan Wang Cui-Ling liang Jun-Qing Wu Chen Xu Shi-Xiao Qin er-Sheng Gao Shanghai Institute of Planned Parenthood Research Fudan University Shanghai 200032 China Department of Epidemiology Shanghai Institute of Planned Parenthood Research Shanghai 200032 China Institute of Population Studies East China Normal University Shanghai 200062 China Department of Histology and Embryology School of Medicine Shanghai Jiaotong University Shanghai 200025 China

Aim： To investigate the relationship between Ureaplasma urealyticum （UU） infection and semen quality. Methods： From 2001 to 2003, 346 eligible patients aged 20-45 years were invited from two hospitals in Shanghai, China, to participate in an investigation which included questionnaires about general and reproductive health, an external genital tract examination, UU culture and semen analysis. Multiple linear regression models were used to examine whether UU had a significant effect on semen quality after adjustment for confounding factors. Results： Findings suggested that UU infection was associated with higher semen viscosity and lower semen pH value. Sperm concentration was lower in UU positive subjects than that in UU negative subjects （54.04 × 10^6/mL vs.70.58 × 10^6/mL）. However, UU did not significantly affect other semen quality indexes. Conclusion： UU infection of the male genital tract could negatively influence semen quality.

关键词： Ureaplasma urealyticum semen quality sperm concentration seminal plasma questionnaire infection

小儿定喘口服液联合硫酸沙丁胺醇治疗小儿轻中度支气管哮喘的临床研究

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现代药物与临床 2024年第3期39卷 680-684页

作者：梁利红许丽萍梁东阁张婷郑州大学附属儿童医院、河南省儿童医院、郑州儿童医院呼吸科河南郑州450000

目的探讨小儿定喘口服液联合硫酸沙丁胺醇治疗小儿轻中度支气管哮喘的临床疗效。方法选取2022年7月—2023年7月河南省儿童医院收治的轻中度支气管哮喘患儿90例,随机分为对照组(45例)和治疗组(45例)。对照组患者雾化吸入硫酸沙丁胺醇吸... 详细信息

目的探讨小儿定喘口服液联合硫酸沙丁胺醇治疗小儿轻中度支气管哮喘的临床疗效。方法选取2022年7月—2023年7月河南省儿童医院收治的轻中度支气管哮喘患儿90例,随机分为对照组(45例)和治疗组(45例)。对照组患者雾化吸入硫酸沙丁胺醇吸入气雾剂,100µg/次,1次/6 h。治疗组在对照组的基础上口服小儿定喘口服液,10 mL/次,3次/d。两组连服药7 d。观察两组患者临床疗效,比较治疗前后两组患者症状改善时间,血清超氧化物歧化酶(SOD)、内皮素(ET)、一氧化氮(NO)、白细胞介素-6(IL-6)、干扰素-γ(INF-γ)、降钙素原(PCT)和血白三烯C4(LTC4)水平,及不良反应情况。结果治疗后,治疗组患者临床总有效率为97.78%,明显高于对照组(82.22%,P<0.05)。治疗后,治疗组症状改善时间明显早于对照组(P<0.05)。治疗后,两组SOD和INF-γ水平明显升高,而ET、NO、IL-6、PCT、LTC4水平明显降低(P<0.05),且治疗组这些指标水平明显好于对照组(P<0.05)。治疗组不良反应发生率(6.67%)明显低于对照组(20.00%)(P<0.05)。结论硫酸沙丁胺醇联合小儿定喘口服液治疗小儿轻中度支气管哮喘,可有效改善氧化应激反应,并减弱支气管炎性反应。

关键词：小儿定喘口服液硫酸沙丁胺醇吸入气雾剂小儿轻中度支气管哮喘超氧化物歧化酶内皮素降钙素原

Photometric investigation of the K-type extremely shallow contact binary V1799 Orion

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Research in Astronomy and Astrophysics 2014年第9期14卷 1157-1165页

作者： Nian-Ping Liu Sheng-Bang Qian Wen-Ping Liao Jia-Jia He er-Gang Zhao liang Liu Yunnan Observatories Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences University of Chinese Academy of Sciences

New multi-color light curves of the very short period K-type eclipsing binary V1799 Ori were obtained and analyzed with the Wilson-Devinney code. The photometric solutions reveal that the system is a W-type shallow-contact binary with a mass ratio of q = 1.335（4-0.005） and a degree of contact of about f = 3.5（-4-1.1）%. In general, the results are in good agreement with what is reported by Samec. Dramatic manifestations of the O＇Connell effect that appear in the light curves can be explained well by employing starspots on the binary surface, which confirms that the system is active at present. Several new times of light minimum were obtained. All the avail- able times of light minimum were collected, along with the recalculated and newly obtained values. Applying a least-squares method to the constructed O - C diagram, a new ephemeris is derived for V1799 Ori. The orbital period is found to show a continuous weak increase at a rate of 1.8（±0.6） × 10^-8 d yr^-1. The extremely shallow contact, together with the period increase, suggests that the binary may be at a critical stage predicted by thermal relaxation oscillation theory.

关键词： binaries: close -- binaries: eclipsing -- stars: individual (V1799 Off)

Nanoparticle(NP)-mediated APOC1 silencing to inhibit MAPK/erK and NF-κB pathway and suppress breast cancer growth and metastasis

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Science China(Life Sciences) 2023年第11期66卷 2451-2465页

作者： Shaomin Liu Fengqian Zhang Yixia liang Guo Wu Rong Liu Xiuling Li Phei er Saw Zhonghan Yang Department of Biochemistry Molecular Cancer Research CenterSchool of MedicineSun Yat-sen UniversityShenzhen 518107China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalFoshan 528200China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study Institute of Pharmacy&PharmacologySchool of Pharmaceutical ScienceUniversity of South ChinaHengyang 421001China

Breast cancer is one of the most common malignant tumors with high mortality and poor prognosis in *** is an urgent need to discover new therapeutic targets for breast cancer ***,we identified that Apolipoprotein C1(APOC1)was up-regulated in primary tumor of breast cancer patient that recurrence and metastasis by immunohistochemistry(IHC).Kaplan-Meier Plotter database showed that high levels of APOC1 in breast cancer patients were strongly associated with worse overall survival(OS)and relapse-free survival(RFS).Mechanistically,APOC1 silencing significantly inhibits MAPK/erK kinase pathway and restrains the NF-κB to decrease the transcription of target genes related to growth and metastasis in *** on this regulatory mechanism,we developed these findings into potential therapeutic drugs,glutathione(GSH)responsive nanoparticles(NPs)were used for systemic APOC1 siRNA delivery,NPs(siAPOC1)silenced APOC1 expression,and subsequently resulted in positive anti-tumor effects in orthotopic and liver metastasis models in *** together,GSH responsive NPmediated siAPOC1 delivery was proved to be effective in regulating growth and metastasis in multiple tumor *** findings show that APOC1 could be a potential biomarker to predict the prognosis of breast cancer patients and NP-mediated APOC1 silencing could be new strategies for exploration of new treatments for breast cancer metastasis.

关键词： cancer metastasis APOC1 nanoparticles siRNA delivery