A facile synthesis of the spiroindoline-based growth hormone secretagogue,MK-677

作     者：Xian Liang Qi Er Qun Yang Jun Tao Zhang Tao Wang Xiao Ping Cao 

作者机构：State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2012年第23卷第6期

页      面：661-664页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0703[理学-化学] 0713[理学-生态学] 10[医学] 

基　　金：supported by the National Basic Research Program of China(973 Program,No.2010CB833203) the National Natural Science Foundation of China(Nos.20972060 and 21061160494) 

主　　题：MK-677 Synthesis Improved route Fischer indole/reduction 

摘      要：A facile and improved route for the synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677 was described. The key step adopted the Fischer indole/reduction strategy. The preparation of the key intermediates N-protected piperidine carboxaldehyde 5 and the N-Boc-O-benzyl-D-serine （2） are also optimized.