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Signal Tr.nsduction and Tar.eted Therapy 2023年第5期8卷 2085-2087页

作者： Jesús Hernández Fr.ddy Dehesa-canseco Alma B.Vázquez-López Mónica r.séndiz-Sandoval Gr.ciela cair.-Juvera Mar.o Solís-Hernández Olivia Valenzuela Br.no Gómez-Gil verónica Mata-Har. centr. de Investigación en Alimentación y Desar.ollo A.C.HermosilloSonora83304Mexico comisión México-Estados Unidos par. la Pr.vención de la Fiebr. Aftosa y otr.s Enfermedades Exóticas de los Animales(cPA) SENASICASADERCiudad de México05010Mexico Depar.amento de ciencias Químico Biológicas Universidad de SonoraHermosilloSonora83000Mexico

Dear.Editor.The emergence of Omicr.n subvar.ants has r.quir.d additional boosters to induce a highly neutr.lizing antibody r.sponse.1 However,the new Omicr.n subvar.ants BQ.1 and XBB,evade the humor.l r.sponse induced by multiple mr.A vaccinations and infections.2,3 cansinoBio(Ad5-ncoV)is a single-dose adenovir.s vector.based vaccine with high pr.tection against severe disease4 but lower efficacy and antibody r.sponse than mr.A ***,hybr.d immunity induced by infection plus vaccine or.heterologous vaccines has pr.duced a r.bust neutr.lizing antibody r.sponse.

关键词： vaccination vaccine immunity

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中国封建土地关系发展史

中国封建土地关系发展史

Power Test of the Ladder IH-r.Q Accelerator.at Peking University

作者： W.WADan Ni er·丹尼尔 J.c.·特勒

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chinese Physics Letters 2011年第7期28卷 89-92页

作者： LU Yuan-r.ng cHEN Wei NIE Yuan-cun LIU Ge GAO Shu-Li ZENG Hong-Jin YAN Xue-Qing cHEN Jia-er State Key Lab of Nuclear.Physics and Technology Peking UniversityBeijing 100871

A 104-MHz ladder interdigital-H r.dio fr.quency quadr.pole accelerator.T-IH-r.Q)is developed for.applying r.Qs to heavy ion implantation and accelerator.based mass spectr.scopy in r.cent year. at the Institute of Heavy Ion Physics,Peking *** could accelerate ions with a mass-to-char.e r.tio of less than 14,fr.m 2.9 keV/u to 35.7 keV/u within a length of 1.1 *** T-IH-r.Q cavity operating at H21(0)mode was constr.cted *** on a well designed r. power feeding system,the cavity was cold measur.d and tested with high r. *** the case of cold measur.ment,the r. pr.perties were obtained using a vector.networ. analyzer with the help of a pertur.ation *** a high power test,the inter−electr.de voltage was derived fr.m the energy spectr.m of x-r.ys measur.d by a high pur.ty Ge *** r.sults show that the specific shunt impedance of the T-IH-r.Q cavity r.aches 178 kΩm,which could meet the r.quir.ments of beam dynamics design.

关键词： pur.ty implantation applying

New insights into estr.genic r.gulation of O^6-methylguanine DNA-methyltr.nsferase (MGMT) in human br.ast cancer.cells： co-degr.dation of er-α and MGMT pr.teins by fulvestr.nt or.O^6-benzylguanine indicates fr.sh avenues for.therapy

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The Jour.al of Biomedical r.sear.h 2016年第5期30卷 393-410页

作者： Ameya Par.njpe Nathan I. Bailes Santhi Kondur. Geor.e c. Bobustuc Fr.ncis Ali-Osman Mohd. A. Yusuf Sur.ndr. r. Punganur. Hanumantha r.o Madal Debasish Basak AGM Mostofa Kalkunte S. Sr.venugopa Depar.ment of Biomedical Sciences and cancer Biology center School of Pharmacy Texas Tech University Health Sciences Center Amarillo TX 79106 USA Neur.-Oncology Section Aurora Advanced Cancer Care Milwaukee WI 53215 USA Depar.ment of Sur.ery The Preston Robert Tisch Brain Tumor Center Duke University Durham NC 27710 USA

Endocr.ne therapy using estr.gen r.ceptor.u （er-α） antagonists for.attenuating hor.2one-dr.ven cell pr.liferation is a major.tr.atment modality for.br.ast cancers. To exploit any DNA r.pair.deficiencies associated with endocr.ne therapy, we investigated the functional and physical inter.ctions of er-α with O^6-methylguanine DNA methyltr.nsferase （MGMT）, a unique DNA r.pair.pr.tein that confers tumor.r.sistance to var.ous anticancer alkylating agents. The er-α -positive br.ast cancer.cell lines （McF-7, T47D） and er- negative cell lines （MDAMB- 468, MDAMB-231）, and established inhibitor. of er-α and MGMT, namely, IcI-182,780 （Faslodex） and O^6- benzylguanine, r.spectively, were used to study MGMT- er inter.ctions. The MGMT gene pr.moter was found to har.or.one full and two half estr.gen-r.sponsive elements （erEs） and two antioxidant-r.sponsive elements （Ar.s）. MGMT expr.ssion was upr.gulated by estr.gen, downr.gulated by tamoxifen in Western blot and pr.moter-linked r.por.er assays. Similar.y, both tr.nsient and stable tr.nsfections of Nr.-2 （nuclear.factor.erythr.id 2-r.lated factor.2） incr.ased the levels of MGMT pr.tein and activity 3 to 4-fold r.flecting novel r.gulator. nodes for.this dr.gr.sistance determinant. Of the different er-α antagonists tested, the pur. anti-estr.gen fulvestr.nt was most potent in inhibiting the MGMT activity in a dose, time and er-α dependent manner, similar.to O^6-benzylguanine. Interestingly, fulvestr.nt exposur. led to a degr.dation of both er-α and MGMT pr.teins and O^6-benzylguanine also induced a specific loss of er-a and MGMT pr.teins in McF-7 and T47D br.ast cancer.cells with similar.kinetics. Immunopr.cipitation r.vealed a specific association of er-a and MGMT pr.teins in br.ast cancer.cells. Fur.hermor., silencing of MGMT gene expr.ssion tr.ggered a decr.ase in the levels of both MGMT and er-a pr.teins. The involvement of pr.teasome in the dr.g-induced degr.dation of both pr.teins was also demonstr.ted. Fulvestr.nt enhanced th

关键词： estr.gen signaling MGMT DNA r.pair ubiquitin-pr.teasome pathway br.ast cancer anti-estr.gens

Quantitatively unmixing method for.complex mixed oil based on its fr.ctions car.on isotopes: A case fr.m the Tar.m Basin, NW china

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Petr.leum Science 2023年第1期20卷 102-113页

作者： Tao-Hua He Wen-Hao Li Shuang-Fang Lu er-Qiang Yang Tao-Tao Jing Jun-Feng Ying Peng-Fei Zhu Xiu-Zhe Wang Wen-Qing Pan Bao-Shou Zhang Zhong-Hong chen Key Labor.tor. of Oil and Gas r.sour.es and Explor.tion Technology Yangtze UniversityWuhanHubei 430100China School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China Sanya Offshor. Oil&Gas r.sear.h Institute Northeast Petroleum UniversitySanyaHainan 572025China Petr.leum Explor.tion&Pr.duction r.sear.h Institute Tarim Oilfield CompanyPetroChinaKorlaXinjiang841000China Key Labor.tor. of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China

Deep mixed oils with secondar. alterations have been widely discovered in the Tar.m Basin,but cur.ent methods based on biomar.ers and isotopes to de-convolute mixed oil cannot calculate the exact mixing pr.por.ion of different end-member oils,which has seriously hindered fur.her explor.tion of deep hydr.car.ons in the study *** solve this pr.blem,we constr.cted a novel method based on the car.on isotope(δ13c)of the gr.up components to de-convolute mixed liquid hydr.car.ons under the material balance *** r.sults showed that the mixed oil in the Tazhong Uplift was dominantly contr.buted at an average pr.por.ion of 68% by an oil end-member with heavier d13c that was believed to be generated fr.m the cambr.an-Lower Or.ovician sour.e r.cks,whereas the mixed oil in the Tabei Uplift was pr.dominantly contr.buted at an average pr.por.ion of 61% by an oil end-member with lighter d13c that was believed to be generated fr.m the Middle-Upper Or.ovician sour.e *** indicates that,on the basis of the detailed descr.ption of the distr.bution of effective sour.e r.cks,the pr.posed method will be helpful in r.alizing differential explor.tion and fur.her impr.ving the efficiency of deep liquid hydr.car.on explor.tion in the Tar.m *** addition,compar.d to tr.ditional δ13c methods for.whole oil and individual n-alkanes in de-convoluted mixed oil,the pr.posed method has a wider r.nge of applications,including for.mixed oils with var.ations in color.and density,indicating potential for.pr.moting the explor.tion of deep complex mixed oils in the Tar.m Basin and even ar.und the wor.d.

关键词： Mixed cr.de oil car.on isotopes End-member oil De-convolution Secondar. alteration Tar.m Basin

Decoupling the adsor.tion mechanisms of ar.enate at molecular.level on modified cube-shaped sponge loaded superpar.magnetic ir.n oxide nanopar.icles

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Jour.al of Envir.nmental Sciences 2022年第11期34卷 1-12页

作者： Xiang-Yang Lou r.berto Boada veronica verdugo Laur. Simonelli Gustavo Pér.z Manuel Valiente GTS-UAB r.sear.h Gr.up Department of ChemistryFacultat de CiènciesUniversitat Autonoma de Barcelona08193 BellaterraSpain ALBA Synchr.tr.n Carrer de la llum 2-26Cerdanyola del Valles08290 BarcelonaSpain centr. de Excelencia en Nanotecnologia Leitat ChileSantiago 7500724Chile

In this study, a commercial cube-shaped open-celled cellulose sponge adsor.ent was modified by in-situ co-pr.cipitation of superpar.magnetic ir.n oxide nanopar.icles(SPION) and used to r.move As(V) fr.m aqueous solutions. Fe K-edge X-r.y absor.tion spectr.scopy(XAS) and TEM identified maghemite as the main ir.n phase of the SPION nanopar.icles with an average size 13 nm. Batch adsor.tion experiments at 800 mg/L showed a 63% incr.ase of adsor.tion capacity when loading 2.6 wt.% mass fr.ction of SPION in the *** determination of the adsor.tion thermodynamic par.meters indicated that the As(V) adsor.tion on the composite material is a spontaneous and exothermic *** K-edge XAS r.sults confir.ed that the adsor.tion enhancement on the composite can be attr.buted to the nanopar.icles loaded. In addition, adsor.ed As(V) did not get r.duced to mor. toxic As(Ⅲ) and for.ed a binuclear.cor.er-shar.ng complex with SPION. The advantageous cube-shape of the sponge-loaded SPION composite together with its high affinity and good adsor.tion capacity for.As(V), good r.generation capability and the enhanceddiffusion attr.buted to its open-celled str.ctur. make this adsor.ent a good candidate for.industr.al applications.

关键词： Adsor.tion cube composite adsor.ent Ar.enate r.moval r.generation X-r.y absor.tion spectr.scopy

Effect of BaF2 addition on luminescence pr.perties of er3+/Yb3+ co-doped phosphate glasses

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Jour.al of r.r. Ear.hs 2018年第1期36卷 58-63页

作者： K.Linganna r.Nar.o-Gar.ía P.Manasa H.Desir.na E.De la r.sa c.K.Jayasankar Depar.ment of Physics Sri Venkateswara University centr. de Investigaciones en Optica Advanced Optical Lens r.sear.h center Korea Photonics Technology Institute (KOPTI) centr. de Física Aplicada y Tecnología Avanzada UNAM

er/Ybco-doped phosphate glasses(PO-AlO-BaO-BaF-KO-erO-YbO) with var.ing BaFcontent,were pr.par.d by a conventional melt quenching technique and their.spectr.scopic pr.perties were examined thr.ugh the r.man, absor.tion, emission and decay measur.ments. r.man spectr.(350-1400 cm) of the er/Ybco-doped phosphate glasses with var.ing BaFcontent, were r.cor.ed upon laser excitation at 785 nm. Near.infr.r.d luminescence spectr. were measur.d in the1400-1600 nm r.gion under 970 nm diode laser excitation and char.cteristic band was observed at1533 nm cor.esponding to ~4Ⅰ→~4Ⅰtr.nsition of erion. The decay cur.es for.the ~4Ⅰlevel of erion, were measur.d and the lifetime is found to decr.ase fr.m 7.94 to 7.70 ms when BaFcontent incr.ases fr.m 0 to 8 mol% and then incr.ases up to 7.83 ms with fur.her incr.ase in BaFcontent(12 mol%). The emission *** and figur. of merit for.the ~4Ⅰ→~4Ⅰtr.nsition of erion were evaluated and compar.d to the other host matr.ces. The upconversion luminescence was measur.d and intense r.d emission was observed for.all the studied samples.

关键词： er3+/Yb3+co-doped phosphate glasses r.man spectr. Absor.tion and emission cr.ss-sections Lifetime r.r. ear.hs

“类风湿关节炎患者湿热及寒湿痹阻证辨识系统”的建立及在临床实践中的应用

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风湿病与关节炎 2024年第7期13卷 12-15,26页

作者：刘二雄钟兵乾灿王宏斌高乐女陈雪猛王勇陆军军医大学附属西南医院重庆400038 重庆纯一天讯科技有限公司重庆401121

目的:建立“类风湿关节炎(r.)患者湿热及寒湿痹阻证辨识系统”(简称:r.证候辨识系统),并通过该系统的Logistic回归方程在临床实践中辨识湿热痹阻证与寒湿痹阻证r.。方法:根据2018版《类风湿关节炎病证结合诊疗指南》,采用传统的主症,次... 详细信息

目的:建立“类风湿关节炎(r.)患者湿热及寒湿痹阻证辨识系统”(简称:r.证候辨识系统),并通过该系统的Logistic回归方程在临床实践中辨识湿热痹阻证与寒湿痹阻证r.。方法:根据2018版《类风湿关节炎病证结合诊疗指南》,采用传统的主症,次症及舌脉象,在陆军军医大学附属西南医院门诊收集湿热痹阻证及寒湿痹阻证r.患者342例。同时,基于Logistic回归方程建立移动端和个人电脑端的“r.证候辨识系统”,对r.患者进行证型判定及疾病活动度评分。结果:与《类风湿关节炎病证结合诊疗指南》标准相比,342例r.患者的“r.证候辨识系统”判对率可达93.5%。湿热痹阻证多见于高疾病活动度的r.患者,寒湿痹阻证以中低活动度r.患者为主(Pr.的红细胞沉降率及c反应蛋白水平均较寒湿痹阻证明显增高(P0.05)。结论:“r.证候辨识系统”有助于临床实践中湿热痹阻证与寒湿痹阻证r.的分型识别与数据研究,值得推广使用。

关键词：类风湿关节炎湿热痹阻证寒湿痹阻证辨证回归方程

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中国封建土地关系发展史

中国封建土地关系发展史

Blockade of complement activation in bullous pemphigoid by using r.combinant cD55-cD46 fusion pr.tein

作者： W.WADan Ni er·丹尼尔 J.c.·特勒

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chinese Medical Jour.al 2021年第7期134卷 864-866页

作者： Pei Qiao Yi-Xin Luo Da-Long Zhi Gang Wang er-Le Dang Depar.ment of Dermatology Xijing HospitalFourth Military Medical UniversityXi'anShaanxi 710032China

To the Editor.Bullous pemphigoid(BP)is an autoimmune blistering disease that is caused by autoantibodies and is associated with complement activation.[1]Autoantibody-mediated complement activation is involved in BP ***-r.gulator. pr.teins(cr.s)including cD35,cD46,cD55,and cD59 compr.se an impor.ant class of r.gulator. pr.teins in the complement system that contr.l the enzyme cascades,assembly of the membr.ne-attack complex,and complement system homeostasis.[2]classically,both cD55 and cD46 negatively r.gulate complement system activation by inhibiting the pr.duction of new c3 and c5 convertases and accelerating the degr.dation of those alr.ady for.ed,thereby pr.tecting cells fr.m complement activation-induced damage.

关键词： cD55 cD46 damage