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Jour.al of Electr.magnetic Analysis and Applications 2016年第1期8卷 1-7页

作者： Silverio Soto Alvar.z Lidia Flor.E. Huerta Alma verónica Var.as Jaime López Jesus Gabr.el Silva césar.A. González Universidad del Ejér.ito y FAM/EMGS Laboratorio Multidisciplinario de Investigación Mexico D.F. Mexico Instituto Politécnico Nacional Escuela Superior de Medicina SEPI Mexico D.F. Mexico

The effectiveness of br.ast cancer ablation by r.diofr.quency (r.) has been associated to the capacity of concentr.ting the electr.magnetic energy in the tumor.r.gion, our.gr.up has pr.posed that this condition could be modulated by appr.pr.ate r. exposur. cycle times as well as modification of tissue electr.cal conductivity. The aim of this wor. was to evaluate analytical and experimental optimal exposur. cycle times to induce tissue ablation by r. assisted with magnetic nanopar.icles. The study was conducted both analytically by multiphysics simulation of the induced cur.ents in cancer tissue given a magnetr.n sour.e and experimentally by the observation of hyperthermic effects induced in agar.phantoms by a magnetr.n device by the use of r. assisted with magnetic nanopar.icles. The temperatur. showed significant incr.ases in shor. periods of time, and was clear.y higher under the condition with nanopar.icles. Appr.pr.ate r. exposur. cycle times as well as modification of tissue electr.cal conductivity by magnetic nanopar.icles seems suitable factor. to modulate the electr.magnetic energy in tumor.l r.gions.

关键词： Br.ast cancer r.diofr.quency Ablation Multiphysics Simulation Magnetic Nanopar.icles

c与Na掺杂AlN电子结构与光学性质的第一性原理研究

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原子与分子物理学报 2024年第2期41卷 24-30页

作者：苏尔琴刘纪博李梦娜于宪省郭思嘉张丽丽赵旭才雷博程伊犁师范大学、物理科学与技术学院、新疆凝聚态相变与微结构重点实验室伊宁835000

基于密度泛函理论(DFT)的平面波超软赝势法,计算了本征AlN,c-AlN,Na-AlN以及c-Na-AlN四种体系的电子结构和光学性质.得出结论:掺杂后各体系与本征AlN相比发生了晶格畸变,c-Na-AlN体系的结合能最小,体系最稳定.掺杂体系相比于本征AlN,禁... 详细信息

基于密度泛函理论(DFT)的平面波超软赝势法,计算了本征AlN,c-AlN,Na-AlN以及c-Na-AlN四种体系的电子结构和光学性质.得出结论:掺杂后各体系与本征AlN相比发生了晶格畸变,c-Na-AlN体系的结合能最小,体系最稳定.掺杂体系相比于本征AlN,禁带宽度都有不同程度的减小,导致电子在体系内跃迁时的概率增大,其中c-Na-AlN体系尤为明显,电子跃迁所需要的能量更小.掺杂后吸收带边发生了红移,拓宽了AlN体系对光的响应范围,增强了光吸收,并且c-Na-AlN体系在可见光区域内光吸收能力最强,在介电函数图的分析中可以得到,c-Na-AlN体系的介电常数最大,表明其电荷束缚能力最强,体系稳定性强,极化能力最好.

关键词： AlN 电子结构光学性质第一性原理

Therapeutic effects of berberine in impair.d glucose tolerance r.ts and its influence on insulin secr.tion

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Acta Phar.acologica Sinica 2004年第4期25卷 98-104页

作者： San-hua LENG, Fu-er LU2, Li-jun XU Institute of Integr.ted Tr.ditional chinese & Western Medicine, Tongji Hospital, TongjiMedical college, Huazhong University of Science & Technology, Wuhan 430030, china Institute of Integr.ted Tr.ditional chinese & Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science & Technology China

AIM: To explor. the anti-diabetic effects of berberine and its influence on insulin secr.tion. METHODS: Impair.d glucose tolerance r.ts induced by iv injection of str.ptozotocin 30 mg/kgwere tr.ated with berberine 187.5 and 562.5 mg/kg while fed with high fat labor.tor. chow. After r.ts were tr.ated for.4 weeks, or.l glucose tolerance was determined, and for.8 weeks, the fasting blood glucose, insulin, lipid series were determined. In insulin secr.tion experiments, berberine 93.75, 187.5, and 562.5 mg/kg was administered or.lly to BALB/c mice at a bolus. The mur.ne serum was collected 2 h after the berberine administr.tion for.insulin determination. Insulin r.leased fr.m HIT-T15 cells and pancr.atic islets incubated with berberine 1-100 μmol/L for.12 h was determined. r.SULTS: The levels of fasting blood glucose (7.4±1.5 or.7.3±1.3 vs 9.3±1.3 mmol/L), tr.glycerides (0.61±0.22 or.0.63± 0.17 vs 1.8±0.7 mmol/L), total cholesterol (1.8±0.3 or.1.9±0.3 vs 2.2±0.2 mmol/L), fr.e fatty acid (456±93 or.460±72 vs 550±113 μmol/L) and apolipopr.tein B (0.37±0.02 or.0.42±0.05 vs 0.46±0.04 g/L) were r.duced gr.atly in berberine-tr.ated gr.ups at doses of 187.5 and 562.5 mg·kg-1·d-1, r.spectively as compar.d with those in contr.l gr.up (Pr.Pereas high densitylipopr.tein-cholesterol (1.5±0.3 or.1.4±0.3vs 1.1±0.1 g/L), apolipopr.tein AI (0.80±0.08 or.0.87±0.08 vs 0.71±0.06 g/L) were significantly incr.ased (Pr.Pr.l glucose tolerance was impr.ved. In vitr. experiment showed that berberine 1-10 μmol/L facilitated insulin secr.tion of HIT-T15 cells and mur.ne pancr.atic islets in a dose-dependent manner. Meanwhile mur.ne serum insulin level (27.5±2.7 or.29±4 or.29±4 vs 24.3±2.8 pIU/L) was undoubtedly pr.moted and blood glucose (4.52±0.31 or.4.45±0.29 or.4.30±0.19 vs 4.87±0.21 mmol/L) was r.duced after berberine administr.tion at doses of 93.75, 187.5, and 562.5 mg/kg, r.spectively in the BALB/c mice. cONcLUSION: Berberine possesses anti-diabetic effec

关键词： berberine diabetes mellitus glucose tolerance test insulin HIT-T15 cells pancr.atic islets lipids

Antagonism between gene therapy and epigenetic therapy on human lar.ngeal car.inoma tumor.bear.ng mice

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chinese Medical Jour.al 2013年第2期126卷 248-253页

作者： LIANMeng WANG Qi FANG Ju-gao WANG Hong FAN er-zhong Depar.ment of Otor.inolar.ngology Head and Neck SurgeryAffiliated Beijing Tongren Hospital Capital Medical UniversityBeijing 100730 China

Backgr.und Gene therapy and epigenetic therapy have gained mor. attention in cancer tr.atment. However, the effect of a combined tr.atment of gene therapy and epigenetic therapy on head and neck squamous cell car.inoma have not been studied yet. To study the mechanism and clinical application, human lar.ngeal car.inoma cell （Hep-2） tumor.bear.ng mice were used. Methods A xenogr.ft tumor.model was established by the subcutaneous inoculation of Hep-2 cells in the r.ght ar.pit of BALB/c nu/nu mice. The mice with well-for.ed tumor.were r.ndomly divided into six gr.ups. Multisite injections of r.d-p53 and/or.5-aza-dc were used to tr.at tumor. Tumor.gr.wth was monitor.d by measur.ng tumor.volume and gr.wth r.te. p53 and E-cadherin pr.tein levels in tumor.tissues were detected by immunohistochemical staining. The mr.A levels were monitor.d with FQ-Pcr. r.sults Gene therapy was much mor. effective than single epigenetic therapy and combined therapy. The gene therapy gr.up has the lowest tumor.gr.wth r.te and the highest expr.ssion levels of p53 and E-cadherin. conclusions The combined tr.atment of gene and epigenetic therapy is not suggested for.tr.ating head and neck car.inoma, because gene therapy shows an antagonistic effect to epigenetic therapy. However, the mechanisms of action ar. still unclear.

关键词： gene therapy, epigenetic therapy, p53 E-cadherin

Distr.bution and isotopic signatur. of 2-alkyl-1,3,4-tr.methylbenzenes in the Lower Paleozoic sour.e r.cks and oils of Tar.m Basin:Implications for.the oil-sour.e cor.elation

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Petr.leum Science 2022年第6期19卷 2572-2582页

作者： Tao-Hua He Wen-Hao Li Shuang-Fang Lu er-Qiang Yang Tao-Tao Jing Jun-Feng Ying Peng-Fei Zhu Xiu-Zhe Wang Wen-Qing Pan Zhong-Hong chen Key Labor.tor. of Oil and Gas r.sour.es and Explor.tion Technology Yangtze UniversityWuhanHubei430100China School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China Key Labor.tor. of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China Sanya Offshor. Oil&Gas r.sear.h Institute Northeast Petroleum UniversitySanyaHainan 572025China Petr.leum Explor.tion&Pr.duction r.sear.h Institute Tarim Oilfield CompanyPetro ChinaKorlaXinjiang841000China

Series of 2-alkyl-1,3,4-tr.methylbenzenes(ATMBs)were detected in most of cr.de oils and sour.e r.cks collected fr.m var.ous str.ta and locations of the Tar.m *** appear.d to have heavy car.on isotopic signatur.s(δ13c,up to~-16‰)compar.d to those hydr.car.ons fr.m oxygenic phototr.phic or.anisms,indicating that the unequivocal sour.e of gr.en sulfur.bacteria(GSB)and photic zone euxinia(PZE)existed in the or.ginal *** the high paleopr.ductivity,the PZE may have enhanced the pr.servation of or.anic matter,which tr.ggered the for.ation of extr.mely or.anic-r.ch sour.e r.cks with TOc up to 29.8%for.the Lower.cambr.an Yuertus For.ation(€1y).The coexistence of ATMBs and the diagnostic pr.ducts fr.m secondar. alterations(e.g.,abundant 25-nor.opanes,thiadiamondoids,and diamondoids)indicated a str.nger ability of *** with the r.sults of quantitatively de-convoluting mixed oil,the oil-sour.e cor.elation based on ATMBs fr.m a lar.e number of Lower Paleozoic samples of the Tar.m Basin suggested that the abundant deep cr.de oil r.sour.es co ntained a dominant contr.bution(>50%)fr.m the€1y sour.e ***,the ATMBs,as diagnostic biomar.ers indicating unequivocal pr.cur.or. under special habitat conditions,might pr.vide impor.ant insights for.the explor.tion of deep Lower Paleozoic cr.de oils in the Tar.m Basin.

关键词： 2-alkyl-1,3,4-tr.methylbenzenes car.on isotopes Deep lower paleozoic cr.de oils Thiadiamondoid Oil-sour.e cor.elation Tar.m Basin

Decomposition of multi-par.icle azimuthal cor.elations in Q-cumulant analysis

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chinese Physics c 2023年第10期 182-200页

作者： L.Na??er? J.Milo?evi? D.Devetak 王福强 Depar.ment of physics "VIN?A" Institute of Nuclear Science-National Institute of the Republic of Serbia University of Belgrade Str.ng coupling Physics International r.sear.h Labor.tor. Huzhou University college of Science Huzhou University Depar.ment of Physics and Astr.nomy Purdue University

The method of Q-cumulants is a powerful tool for.studying the fine details of azimuthal anisotr.pies in high energy nuclear.*** paper pr.sents a new method,based on mathematical induction,to evaluate the analytical for. of high-or.er *** capability of this method is demonstr.ted via a toy model that uses the elliptic power distr.bution to simulate the anisotr.pic emission of par.icles,quantified in terms of Four.er flow har.onics *** method can help in studying the lar.e amount of event statistics that can be collected in the futur. and allow measur.ments of the very high centr.l moments of the *** can in tur.,facilitate pr.gr.ss in understanding the initial geometr.,the input to the hydr.dynamic calculations of medium expansion in high energy nuclear.collisions,and the constr.ints on it.

关键词：

碳、碳氮和硼碳氮纳米管场发射性能的比较研究

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物理学报 2005年第12期54卷 5931-5936页

作者：李强梁二军郑州大学物理工程学院材料物理教育部重点实验室东华大学应用物理系上海200051

采用高温热解法在860℃分别制备出了碳、碳氮和硼碳氮纳米管,提纯后利用丝网印刷工艺分别将它们制备成薄膜,并测试了它们的场发射性能.结果表明碳纳米管、碳氮纳米管和硼碳氮纳米管薄膜的开启电场分别为2.22,1.1和4.4V/μm,当电场增加到... 详细信息

采用高温热解法在860℃分别制备出了碳、碳氮和硼碳氮纳米管,提纯后利用丝网印刷工艺分别将它们制备成薄膜,并测试了它们的场发射性能.结果表明碳纳米管、碳氮纳米管和硼碳氮纳米管薄膜的开启电场分别为2.22,1.1和4.4V/μm,当电场增加到5.7V/μm时,它们的电流密度分别达到1400,3000μA/cm2和小于50μA/cm2.碳和碳氮纳米管薄膜的场增强因子分别为10062和11521.可见,碳氮纳米管的场发射性能优于碳纳米管,而硼碳氮纳米管的场发射性能比前两者要差.解释了这三种纳米管场发射性能差别的原因.

关键词：碳纳米管碳氮纳米管硼碳氮纳米管场发射

龙柴降血方治疗原发性血小板增多症随机对照研究

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中国中西医结合杂志 2024年第7期44卷 806-813页

作者：孙妍杨二鹏李雨蒙牛继聪陈科邹吉轩王明镜刘为易吕妍陈卓胡晓梅北京中医药大学研究生院北京100029 中国中医科学院西苑医院血液科北京100091

目的评价龙柴降血方治疗原发性血小板增多症(ET)的有效性、抗凝作用和对阿司匹林抵抗(Ar.的影响。方法纳入2021年10月—2022年12月在中国中医科学院西苑医院血液科就诊符合纳入标准的原发性血小板增多症患者72例,采用随机数字表法分... 详细信息

目的评价龙柴降血方治疗原发性血小板增多症(ET)的有效性、抗凝作用和对阿司匹林抵抗(Ar.的影响。方法纳入2021年10月—2022年12月在中国中医科学院西苑医院血液科就诊符合纳入标准的原发性血小板增多症患者72例,采用随机数字表法分为对照组和观察组,每组36例。对照组予羟基脲1.0 g/d或短效干扰素900万U/w或长效干扰素180μg/w,阿司匹林100 mg/d;观察组在此用药基础上加用龙柴降血方。治疗周期为4个月。观察治疗前后患者血小板计数、骨髓增殖性肿瘤总症状评估量表(MPN-10)评分、有无疾病进展及血栓形成或出血事件。采用凝血酶原时间(PT)、纤维蛋白原浓度(FIB)、D-二聚体(D-Di)、活化部分凝血活酶时间(APTT)、血小板计数(PLT)、凝血指数(cI)、血栓最大振幅(MA)评估患者是否存在高凝状态,并观察龙柴降血方的抗凝作用。应用血栓弹力图中花生四烯酸(AA)诱导的AA抑制率,评估ET患者是否存在Ar.及龙柴降血方对Ar.影响。结果 72例患者中,7例患者脱落,可评价患者65例,观察组32例,对照组33例。与对照组比较,观察组有效率升高,PLT计数及MPN-10积分下降(Pr.生率为46.15%(30/65),对照组16例,观察组14例。与对照组比较,观察组AA抑制率显著升高(P<0.05)。两组未出现明显不良反应。结论龙柴降血方能有效地降低原发性血小板增多症患者的血细胞计数,改善症状,提高有效率,并能改善ET患者高凝状态和阿司匹林抵抗。

关键词：原发性血小板增多症龙柴降血方血小板计数高凝状态阿司匹林抵抗中西医结合随机对照试验

Issues and Oppor.unities in Exotic Hadr.ns

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chinese Physics c 2016年第4期40卷 8-21页

作者： r.A.Br.ceno T.D.cohen S.coito J.J.Dudek E.Eichten c.S.Fischer M.Fr.tsch W.Gr.dl A.Jackur. M.Kor.icer G.Kr.in r.F.Lebed F.A.Machado r.E.Mitchell c.J.Mor.ingstar.M.Pear.on M.r.Pennington K.Peters J.M.r.char. c.P.Shen M.r.Shepherd T.Skwar.icki E.S.Swanson A.P.Szczepaniak c.Z.Yuan Thomas Jefferson National Accelerator.Facility 12000 Jefferson Avenue Newport News VA 23606 USA Depar.ment of Physics Old Dominion University Norfolk VA 23529 USA Mar.land center for.Fundamental Physics University of Maryland College Park MD USA Institute of Modern Physics CAS Lanzhou 730000 China Theor.tical Physics Depar.ment Fermilab IL 60510 USA Institut fut Theor.tische Physik Justus-Liebig-Universitat Gieben Heinrich-Buff-Ring 16 D-35392 GieBen Germany Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45 D-55099 Mainz Germany Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45 D-55099 Mainz Germany Physics Depar.ment Indiana University Bloomington IN 47405 USA University of Hawaii Honolulu Hawaii 96822 USA Instituto de Física Teor.ca Universidade Estadual Paulista Rua Dr. Bento Teobaldo Ferraz 271 - Bloco II 01140-070 Sgo Paulo SP Brazil Depar.ment of Physics Arizona State University Tempe Arizona 85287-1504 USA Depar.ment of Physics and Astr.nomy University of Pittsburgh Pittsburgh PA 15260 USA Indiana University Bloomington Indiana 47405 USA Depar.ment of Physics Carnegie Mellon University Pittsburgh PA 15213 USA School of Mathematics Trinity College Dublin 2 Ireland GSI Helmholtzcentr. for.Heavy Ion r.sear.h GmbH D-64291 Darmstadt Germany Universite de Lyon Institut de Physique Nucleaire de Lyon IN2P3-CNRS-UCBL 4 rue Enrico Fermi Villeurbanne France Beihang University Beijing 100191 China Syr.cuse University Syracuse NY USA Theor. center Thomas Jefferson National Accelerator Facility 12000 Jefferson Avenue Newport News VA 23606 USA center for.Explor.tion of Energy and Matter Indiana University Bloomington IN 47403 USA Institute of High Energy Physics Beijing 100049 China

The last few year. have been witness to a pr.liferation of new r.sults concerning heavy exotic ***, many new signals have been discovered that could be pointing towar.s the existence of tetr.quar.s,pentaquar.s, and other exotic configur.tions of quar.s and gluons. Theor.tically, advances in lattice field theor. techniques place us at the cusp of understanding complex coupled-channel phenomena, modelling gr.ws mor. sophisticated, and effective field theor.es ar. being applied to an ever gr.ater r.nge of situations. It is thus an oppor.une time to evaluate the status of the field. In the following, a series of high pr.or.ty experimental and theor.tical issues concerning heavy exotic hadr.ns is pr.sented.

关键词： quar. meson exotic flavor.pointing char. Belle sophisticated hadr.n situations

养阴清肺汤抑制矽肺模型小鼠TLr.信号的机制

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中国煤炭工业医学杂志 2024年第3期27卷 246-253页

作者：王佳宁尔佳丽靳馥宇李雅倩李田徐洪徐丁洁华北理工大学中医学院河北省唐山市063210 华北理工大学公共卫生学院华北理工大学医学部

目的探讨养阴清肺汤通过对Toll样受体4(TLr.)信号和核因子κB受体激活剂配体(r.NKL)信号的调控,发挥抑制矽肺小鼠肺纤维化的作用机制。方法将72只SPF级c57BL/6J雄性小鼠随机分为对照组、矽肺组、吡非尼酮组和养阴清肺汤高、中、低剂量组... 详细信息

目的探讨养阴清肺汤通过对Toll样受体4(TLr.)信号和核因子κB受体激活剂配体(r.NKL)信号的调控,发挥抑制矽肺小鼠肺纤维化的作用机制。方法将72只SPF级c57BL/6J雄性小鼠随机分为对照组、矽肺组、吡非尼酮组和养阴清肺汤高、中、低剂量组,每组12只。采用气管一次性灌注5mg SiO_(2)建立矽肺小鼠模型,2周后予以200mg/kg/d吡非尼酮,1000、500、250mg/kg/d高、中、低剂量养阴清肺汤连续灌胃2周。HE染色、Masson染色观察肺组织病理形态和胶原沉积。微小计算机断层扫描(micr.-cT)重建肺三维结构;全身体积描记系统(WBP)检测肺功能;免疫荧光染色标记Toll样受体4(TLr.);抗酒石酸酸性磷酸酶(Tr.P)染色标记肺组织阳性细胞;免疫印迹法检测肺组织I型胶原蛋白(coL I)、波形蛋白(Vimentin)、Toll样受体4(TLr.)、髓样分化因子88(MyD88)、核因子κB(NF-κB)、白细胞介素6(IL-6)、核因子κB受体激活因子(r.NK)、核因子κB受体激活因子配体(r.NKL)的蛋白表达。结果与矽肺模型组比较,养阴清肺汤可减少矽结节面积和胶原沉积(PcolI、vimentin、TLr.、MyD88、NF-κB、IL-6、r.NK和r.NKL蛋白水平均明显下调(Pr.和r.NKL信号的活化,改善肺功能和减轻矽肺小鼠肺纤维化进展。

关键词：矽肺 SiO_(2) 养阴清肺汤吡非尼酮 Toll样受体4 核因子κB受体激活因子配体