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Chinese Journal of Polymer Science 2012年第5期30卷 770-776页

作者： Guo-liang Yue Qian-ling Cui Yu-xi Zhang er-jian wang 吴飞鹏 Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing100190China Graduate School of Chinese Academy of Sciences Beijing100049China

Therrno-responsive block copolymers poly（ethylene glycol）-block-poly（N-acryloyl-2,2-dimethyl-1,3-oxazolidine）, PEG-b-PADMO, based on linear PEG were prepared via a versatile reversible addition-fragmentation chain transfer （RAFT） polymerization, PEG22 （Mw = 1000） was used as the hydrophilic component, whose dehydration was the main driving force for the phase transition of these copolymers, as demonstrated by the tH-NMR spectra. Their lower critical solution temperatures （LCSTs） could be tuned in the range of 20℃ to 35℃, by adjusting the degree of polymerization （DP） of PADMO between 14-27. Furthermore, a sharp phase transition at ca. 33℃, close to the physiological temperature with minimal hysteresis, was observed for the PEGzz-b-PADMO14 copolymer. Moreover, excellent reversibility and reproducibility were displayed for the same copolymer over 10 cycles of repeated temperature change between 25℃ （below the LCST） and 40℃ （above the LCST）.

关键词： Thermo-responsive Block copolymers Linear PEG Phase transitions.

INTRA-ION PAIR ELECTRON TRANSFer OF PHOTOEXCITED METHYLENE BLUE BORATE

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Chinese Chemical Letters 1995年第7期6卷 597-600页

作者： Xiu Zhi wang Han Qing CHEN er jian wang (Institute of Photographic Chemistry, Academia Sinica, Beijing 100101National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou,730000) Acad Sinica Inst Photog Chem Beijing 100101 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

The photochemical reaction of methylene blue (n-butyltriphenyl) borate, MBRBPh3 was examined. The ultrafast quenching rate and large negative value of Delta G indicated that the intra-ion pair ET plays an important role in photoreaction of MBRBPh3. The sequent boron- carbon bond cleavage of butyltriphenylboranyl radical intermediate was found by GC-MS and photo-CIDNP studies.

关键词： ION INTRA-ION PAIR ELECTRON TRANSFer OF PHOTOEXCITED METHYLENE BLUE BORATE

PHOTOINDUCED CHARGE TRANSFer REACTION OF BENZOPHENONE WITH AMINE IN VESICLES

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Chinese Chemical Letters 1993年第7期4卷 587-590页

作者： Wei Dong YANG Miao Zhen LI er jian wang Institute of Photographic Chemistry, Academia, Sinica, Beijing 100101

Photoinduced charge transfer reaction of benzophenone(BP) with, mine was carried out in the vesicles of dicetyldimethylammonium bromide (DCDAB) over wide ranges of amine concentration (0. 01～4. 0M). Linear plots of φ^(-1) vs. [TEA]^(-1) at low concentration of amine (ere obtained. Kinetic data demonstrate that the electron transfer is promoted significantly by DCDAB vesicles and proton transfer becomes more efficient at high Rmlne concentrations, leading to a decrease of Kd/Kr and increase of Kh/Ke. The kinetic expressions of photoreaction of BP bound to DCDAB bilayer are developed.

关键词： BP TEA PHOTOINDUCED CHARGE TRANSFer REACTION OF BENZOPHENONE WITH AMINE IN VESICLES

9－ANTHROIC　ACID　SENSITIZED　PHOTOLYSIS　OF　DIPHENYLIODONIUM　SALTS　THROUGH　INTRA－ION　PAIR　ELECTRON　TRANSFer

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Chinese Chemical Letters 1994年第10期5卷 831-834页

作者： Xiu Zhi wang er jian wang (Institute of Photographic Chemistry. Academia Sinica, Beijing. 100101 National Laboratory of Applied orpeic Chemistry.Lanzhou University, Lanzhou. 730000)

We have studied 9-anthroic acid sensitized photolysis of dipbenyliodonius salts through fluorescence quenching, products analysis and Photo-CIDNP. The photoinduced electron transfer rate constant bas calculated to be 8.6×10 10/mol s. From photo-CIDNP study, both diphenyliodo and pbenyl radicals were confirmed as intermediates. Benzene is a cage escaped product from a singlet radical pair and diphenyliodonium Salt is a recombination preduct from a triplet radical pair.

关键词： ION INTRA PAIR SENSITIZED ACID ANTHROIC

Multiple liver metastases of unknown origin:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： Ying-Jin wang Ze-Chuan Liu jian wang Yin-Mo Yang Department of Hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China Department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review

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World Journal of Gastroenterology 2025年第2期31卷 27-41页

作者： Jing Ye jian-Guo wang Rong-Qiang Liu Qiao Shi Wei-Xing wang Department of General Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pancreatic Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

Intrapancreatic fat deposition(IPFD)has garnered increasing attention in recent *** prevalence of IPFD is relatively high and associated with factors such as obesity,age,and ***,the pathophysiological mechanisms underlying IPFD remain unclear,with several potential contributing factors,including oxida-tive stress,alterations in the gut microbiota,and hormonal *** was found to be highly correlated with the occurrence and prognosis of exocrine pan-creatic *** imaging techniques remain the primary diagnostic approach for IPFD,an expanding array of biomarkers and clinical scoring systems have been identified for screening ***,effective treatments for IPFD are not available;however,existing medications,such as glucagon-like peptide-1 receptor agonists,and new therapeutic approaches explored in animal models have shown considerable potential for managing this *** paper reviews the pathogenesis of IPFD,its association with exocrine pancreatic disea-ses,and recent advancements in its diagnosis and treatment,emphasizing the significant clinical relevance of IPFD.

关键词： Intrapancreatic fat deposition Pancreatic steatosis Nonalcoholic fatty pancreas disease Pancreatitis Pancreatic cancer

Mimicking aneurysm in a patient with chronic occlusion of the left middle cerebral artery

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World Journal of Clinical Cases 2025年第3期13卷 20-23页

作者： Xue-jian wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

The chronic occlusion of intracranial arteries generally has no or mild clinical symptoms,and the clinical symptoms of acute cerebral artery occlusion are mostly manifested as severe cerebral infarction symptoms,which often make early diagnosis difficult,thus losing the best treatment *** cerebral infarction occurs,the consequences are difficult to *** is also an important reason for the high misdiagnosis rate and mortality of this *** this paper,the characteristics of the disease were analyzed to provide clinical reference.

关键词： Chronic occlusion Misdiagnose Arterial occlusion Middle cerebral artery occlusion Aneurysm

Insulin-induced severe thyrotoxic periodic paralysis:A case report

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World Journal of Clinical Cases 2025年第7期13卷 46-51页

作者： Yan-Li wang jian Li Department of Endocrinology and Metabolism Zigong First People's HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's ***,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of *** article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP *** SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening *** medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week *** was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade *** department tests showed hypokalemia of 1.6 mmol/*** paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g *** in the arms and legs *** was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing *** stopped his insulin and he was discharged with a potassium level of 4.0 mmol/*** Insulin is a trigger for TPP and should be avoided in patients with *** recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.

关键词： Thyrotoxic periodic paralysis Potassium metabolism disorders Insulin Triggers of paralysis Case report

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian wang Yun-Feng wang Fan Yang jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-Ming Pan Wei Li Rui-Qiong Ma jian-Liu wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network