THERMO-RESPONSIVE BLOCK COPOLYMERS BASED ON LINEAR-TYPE POLY(ETHYLENE GLYCOL):TUNABLE LCST WITHIN THE PHYSIOLOGICAL RANGE

作     者：Guo-liang Yue Qian-ling Cui Yu-xi Zhang Er-jian Wang 吴飞鹏 

作者机构：Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Graduate School of Chinese Academy of SciencesBeijing100049China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2012年第30卷第5期

页      面：770-776页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：国家自然科学基金 

主　　题：Thermo-responsive Block copolymers Linear PEG Phase transitions. 

摘      要：Therrno-responsive block copolymers poly（ethylene glycol）-block-poly（N-acryloyl-2,2-dimethyl-1,3-oxazolidine）, PEG-b-PADMO, based on linear PEG were prepared via a versatile reversible addition-fragmentation chain transfer （RAFT） polymerization, PEG22 （Mw = 1000） was used as the hydrophilic component, whose dehydration was the main driving force for the phase transition of these copolymers, as demonstrated by the tH-NMR spectra. Their lower critical solution temperatures （LCSTs） could be tuned in the range of 20℃ to 35℃, by adjusting the degree of polymerization （DP） of PADMO between 14-27. Furthermore, a sharp phase transition at ca. 33℃, close to the physiological temperature with minimal hysteresis, was observed for the PEGzz-b-PADMO14 copolymer. Moreover, excellent reversibility and reproducibility were displayed for the same copolymer over 10 cycles of repeated temperature change between 25℃ （below the LCST） and 40℃ （above the LCST）.