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hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 577-582页

作者： Sha Chen Meng-qi Li Wei-Jia Duan Bu-er Li Shu-Xiang Li Ting-Ting Lv Lin Ma Ji-Dong Jia Liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center for Digestive Diseases95 Yong’an RoadBeijing 100050China

Background:Primary biliary cholangitis(PBC)patients often have concomitant extrahepatic autoimmune(EHA)diseases including Sjögren’s syndrome(SS),systemic sclerosis(SSc),rheumatoid arthritis(RA),and autoimmune thyroid *** present study aimed to describe the prevalence of EHA diseases in PBC and explore the impact of EHA diseases on the long-term outcomes of PBC in Chinese ***:Medical records of PBC patients diagnosed in our institute were retrospectively ***-tients were followed up by a standardized telephone *** endpoints were defined as liver-related death and/or liver ***:Totally 247 of the 985(25.1%)PBC patients enrolled in the study had at least one concomi-tant EHA ***ögren’s syndrome(n=140,14.2%)was the most frequent one,followed by rheuma-toid arthritis(RA)(n=56,5.7%)and Hashimoto’s thyroiditis(n=45,4.6%).Patients with EHA dis-eases were more common in females(Perall,no differences were found between PBC patients with and without EHA dis-eases in terms of biochemical response rates to ursodeoxycholic acid,the incidence of hepatic events,or transplant-free *** and EHA≥2 were protective factors for hepatic events in univariate Cox analysis,but the results became insignificant in multivariate ***:Concomitant EHA diseases were common in PBC patients but did not compromise the long-term outcomes of PBC.

关键词： Primary biliary cholangitis Extrahepatic autoimmune diseases Sjögren’s syndrome Rheumatoid arthritis Prognosis

基于马尔可夫链模型的EWMA控制图性能分析与优化

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系统工程与电子技术 2008年第6期30卷 1127-1130页

作者：何曙光何桢齐二石天津大学管理学院天津300072

建立了基于马尔可夫链的EWMA控制图性能分析模型,并编制了基于Matlab平台的EWMA控制图性能分析程序。在此基础上,分析了EWMA控制图的两个主要参数(控制限参数L和平滑系数r)对EWMA控制性能的影响。分析发现,对于不同的L,存在均值偏移量δ... 详细信息

建立了基于马尔可夫链的EWMA控制图性能分析模型,并编制了基于Matlab平台的EWMA控制图性能分析程序。在此基础上,分析了EWMA控制图的两个主要参数(控制限参数L和平滑系数r)对EWMA控制性能的影响。分析发现,对于不同的L,存在均值偏移量δ*和δ**,当偏移量0δ**时,参数对EWMA控制图的性能影响很小。据此对不同应用环境下的EWMA控制图参数选择给出了相应的建议。

关键词：统计过程控制 EWMA控制图性能分析马尔可夫链模型参数优化

Improvement in antibacterial ability and cell cytotoxicity of Ti-Cu alloy by anodic oxidation

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Rare Metals 2022年第2期41卷 594-609页

作者： Shuang Cao Zi-Ming Zhang Jia-qi Zhang Ren-Xian Wang Xiao-Yan Wang Lei Yang Da-Fu Chen Gao-Wu qin er-Lin Zhang School of Materials Science and Engineering Key Laboratory for Anisotropy and Texture of MaterialsEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Departments of Immunology College of Basic MedicineJiamusi UniversityJiamusi 154007China Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China School of Metallurgy Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Ti-Cu alloy has potential to be used in plastic surgery and dental implants due to its strong antibacterialproperties,high strength and good corrosion *** this paper,Ti-5Cu was anodic-oxidized to enhance the surface *** influence of the oxidation on the corrosion resistance,antibacterial properties and biological properties was investigated.X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results showed that a double-layer oxide coating with dense inner layer and porous outside layer was formed on Ti-Cu *** oxide coating consisted mainly of TiO2,CuzO and small amount of CuO,improved the corrosion resistance of Ti-Cu alloy by one order of magnitude due to the formation of the dense oxide inner layer,but high Cu ion release was *** plate count results showed that the antibac-terial activity of Ti-Cu sample was improved to≥99%due to the comprehensive function of CuO and Cu_(2)O in the coating and Cu^(2+)*** test results showed that thecoating exhibited good cell compatibility,the porous sur-face structure improved the adhesion of cells,and Cu ion release promoted the cell proliferation.

关键词： Titanium-copper alloy Anodic oxidation Corrosion resistance Antibacterial activity Cell adhesion Surface modification

Land subsidence induced by groundwater extraction and building damage level assessment—a case study of Datun, China

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Journal of China University of Mining and Technology 2008年第4期18卷 556-560页

作者： FENG qi-yan LIU Gang-jun MENG Lei FU er-jiang ZHANG Hai-rong ZHANG Ke-fei Jiangsu Key Laboratory of Resources and Environmental Information Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China School of Mathematical ＆ Geospatial Sciences Royal Melbourne Institute of Technology University Melbourne 3001 Australia

As in many parts of the world, long-term excessive extraction of groundwater has caused significant land-surface sub- sidence in the residential areas of Datun coal mining district in East China. The recorded maximum level of subsidence in the area since 1976 to 2006 is 863 mm, and the area with an accumulative subsidence more than 200 mm has reached 33.1 km2 by the end of 2006. Over ten cases of building crack due to ground subsidence have already been observed. Spatial variation in ground subsi- dence often leads to a corresponding pattern of ground deformation. Buildings and underground infrastructures have been under a higher risk of damage in locations with greater differential ground deformation. Governmental guideline in China classifies build- ing damages into four different levels, based on the observable measures such as the width of wall crack, the degree of door and window deformation, the degree of wall inclination and the degree of structural destruction. Building damage level (BDL) is esti- mated by means of ground deformation analysis in terms of variations in slope gradient and curvature. Ground deformation analysis in terms of variations in slope gradient has shown that the areas of BDL III and BDL II sites account for about 0.013 km2 and 0.284 km2 respectively in 2006, and the predicted areas of BDL (define this first) III and II sites will be about 0.029 km2 and 0.423 km2 respectively by 2010. The situation is getting worse as subsidence continues. That calls for effective strategies for subsidence miti- gation and damage reduction, in terms of sustainable groundwater extraction, enhanced monitoring and the establishment of early warning systems.

关键词： land subsidence groundwater extraction ground deformation slope gradient building damage level Datun China

Thermal effect of the accumulated water with different depths on permafrost subgrade in cold regions

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Advances in Climate Change Research 2023年第2期14卷 179-189页

作者： er-Xing PENG Xiao-Ying HU Yu SheNG Ji-Chun WU Wei CAO qi-Fan YANG Xiang-Bin ZHAO Ji CheN State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Beiluhe Observation and Research Station on Frozen Soil Engineering and Environment in qinghai‒Tibet Plateau State Key Laboratory of Frozen Soil EngineeringNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

In cold regions,the thermal effect of accumulated water on underlying permafrost and permafrost subgrade remains a significant hazard causing engineering *** depth of accumulated water may be an important influence factor of permafrost thermal stability,but there is lack of qualitative and quantitative research about *** this study,equivalent thermal conductivity theory and solid heat transfer theory have been used to establish the calculation model for simulating heat transfer in water and ***,the accuracy and reliability of the calculation model are checked by monitored data and subsequently used to analyze the thermal erosion of water on underlying permafrost and permafrost under the *** simulation results show that shallow water can protect permafrost and deeper water disrupts the thermal stability of underlying *** thermal effect extent of water is primarily determined by its depth,and the concept of critical depth and stable depth of accumulated water has been ***,the temperature field of permafrost under embankment can be changed by the slope toe *** addition,the thermal effect range of the slope toe water is limited by the thermal influence radius,which increases with the depth of standing *** findings provide support as well as a fundamental base for environmental issues arising from the accumulated *** observations will,thus,also be valuable to further engineering environment studies in cold regions.

关键词： Accumulated water Water depth Permafrost Embankment Thermal effect

Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter

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Regenerative Biomaterials 2021年第1期8卷 112-123页

作者： Long-Mei Zhao Mei Gong Rui Wang qi-Juan Yuan Yi Zhang Jin-Kui Pi Xiu-he Lv Yan Xie Hui-qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyKeyuan Road 4Gaopeng Street ChengduSichuan 610041China Research Core Facility West China HospitalSichuan UniversityKeyuan Road 4Gaopeng StreetChengduSichuan 610041China Department of Gastroenterology West China HospitalSichuan UniversityNo.37 Guo Xue XiangChengduSichuan 610041China

Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side ***-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD *** this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine ***/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in ***,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in *** a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer ***/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight *** findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair.

关键词： ESD-induced ulc er small inte stinal submucosa polyurethane bio-a dhesion pH-sensitive

Dissolution Properties of 2-(Dinitromethylene)-5-methyl-1,3-diazacyclopentane in Dimethyl Sulfoxide and N-Methyl Pyrrolidone

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Chemical Research in Chinese Universities 2012年第4期28卷 743-746页

作者： XIAO Li-bai XING Xiao-ling ZHAO Feng-qi XU Kang-zheng YAO er-gang TAN Yi HAO Hai-xia Science and Technology on Combustion and Explosion Laboratory Xi'an Modern Chemistry Research InstituteXi'an 710065P.R.China School of Chemical Engineering Northwest UniversityXi'an 710065P.R.China

The molar enthalpies of dissolution for 2-（dinitromethylene）-5-methyl-1,3-diazacyclopentane（DNMDZ） in dimethyl sulfoxide（DMSO） and N-methyl pyrrolidone（NMP） were measured using an RD496-2000 Calvet microcalorimeter at 298.15 K under atmospheric *** formulae for the calculation of the molar enthalpies of dissolution（Δ diss H） were obtained from the experimental data of the dissolution processes of DNMDZ in DMSO or *** relationships between the rate constant（k） and the molality（b） and between the reaction order（n） and the molality（b） were *** corresponding kinetic equations describing the two dissolution processes were dα/dt=10^-2.16（1-α） ^1.01 for the dissolution of DNMDZ in DMSO,and dα/dt=10^-2.02（1-α）^ 0.85 for the dissolution of DNMDZ in NMP,respectively.

关键词： 2-(Dinitromethylene)-5-methyl-1 3-diazacyclopentane Dissolution Kinetics Dimethylsulfoxide N-Methyl pyrrolidone

Pseudo-rapidity distributions of charged particles in asymmetric collisions using Tsallis thermodynamics

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Nuclear Science and Techniques 2023年第11期34卷 120-127页

作者： Jun‑qi Tao Hong‑Bin he Hua Zheng Wen‑Chao Zhang Xing‑Quan Liu Li‑Lin Zhu Aldo Bonasera Key Laboratory of Quark&Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710119China Institute of Nuclear Science and Technology Sichuan UniversityChengdu 610064China Department of Physics Sichuan UniversityChengdu 610064China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA Laboratori Nazionali del Sud INFN95123 CataniaItaly

The pseudo-rapidity distributions of the charged particles produced in the asymmetric collision systems p+Al,p+Au and ^(3)he+Au at√S_(NN)=200 GeV GeV are evaluated in the framework of a fireball model with Tsallis *** fireball model assumes that the experimentally measured particles are produced by fireballs following the Tsallis distribution and it can effectively describe the experimental *** results as well as previous results for d+Au collisions at√S_(NN)=200 GeV GeV and p+Pb collisions at√S_(NN)=5.02 TeV TeV validate that the fireball model based on Tsallis thermodynamics can provide a universal framework for pseudo-rapidity distribution of the charged particles produced in asymmetric collision *** predict the centrality dependence of the total charged particle multiplicity in the p+Al,p+Au and 3he+Au ***,the dependences of the fireball model parameters(y_(0a),y_(0A),σ_(a) and σ_(A))on the centrality and system size are studied.

关键词： Tsallis thermodynamics Fireball model Pseudo-rapidity distribution heavy-ion collisions Charged particles

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企业整体式模式在航天高科技企业的应用

系统工程与电子技术 2005年第9期27卷 1572-1575,1613页

作者：刘尔琦齐中英中国航天科工集团第二研究院北京100854 哈尔滨工业大学黑龙江哈尔滨150001

针对航天高科技企业技术综合性和系统集成性强,知识密集性和技术密集性程度高,并处于特殊的军工行业,在产业方面具有经营的非均衡性和技术驱动性的特点,提出利用企业整体式模式理论,建构航天高科技企业整体式模式,对该模式的作用机理、... 详细信息

针对航天高科技企业技术综合性和系统集成性强,知识密集性和技术密集性程度高,并处于特殊的军工行业,在产业方面具有经营的非均衡性和技术驱动性的特点,提出利用企业整体式模式理论,建构航天高科技企业整体式模式,对该模式的作用机理、目标、主要内容、构建过程及效果进行了系统的分析。阐明了运用整体观点进行整合管理,在提高企业协调能力和适应能力上的优越性。

关键词：企业整体式模式功效方程协同高科技企业模式理论整体式航天应用技术综合非均衡性作用机理整合管理

A Processor Performance Prediction Method Based on Interpretable Hierarchical Belief Rule Base and Sensitivity Analysis

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Computers, Materials & Continua 2023年第3期74卷 6119-6143页

作者： Chen Wei-wei he Wei Zhu Hai-long Zhou Guo-hui Mu Quan-qi Han Peng College of Computer Science and Information Engineering Harbin Normal UniversityHarbin150500China Rocket Force University of Engineering Xi’an710025China

The prediction of processor performance has important referencesignificance for future processors. Both the accuracy and rationality of theprediction results are required. The hierarchical belief rule base (HBRB)can initially provide a solution to low prediction accuracy. However, theinterpretability of the model and the traceability of the results still warrantfurther investigation. Therefore, a processor performance prediction methodbased on interpretable hierarchical belief rule base (HBRB-I) and globalsensitivity analysis (GSA) is proposed. The method can yield more reliableprediction results. Evidence reasoning (er) is firstly used to evaluate thehistorical data of the processor, followed by a performance prediction modelwith interpretability constraints that is constructed based on HBRB-I. Then,the whale optimization algorithm (WOA) is used to optimize the ***, to test the interpretability of the performance predictionprocess, GSA is used to analyze the relationship between the input and thepredicted output indicators. Finally, based on the UCI database processordataset, the effectiveness and superiority of the method are verified. Accordingto our experiments, our prediction method generates more reliable andaccurate estimations than traditional models.

关键词： Hierarchical belief rule base(HBRB) evidence reasoning(er) interpretability global sensitivity analysis(GSA) whale optimization algorithm(WOA)