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Wound healing effect of methanolic leaf extract of Napoleona vogelii(Family:Lecythidaceae) in rats

Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 620-624页

作者： Adiele LC Adiele RC enye jc Department of Pharmacology and Toxicology Faculty of PharmacyMadonna UniversityEleleRiver StateNigeria Department of Pharmacy Federal Medical CenterOwerriImo StateNigeria Department of Anatomy and Cell Biology Division of Biomedical SciencesCollege of MedicineUniversity of SaskatchewanSaskatoonSKS7N 5E5Canada Cameco MS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K 0M7Canada

Objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric ***:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant *** the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),*** w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or *** wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under *** first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,***:The percentage yield of the extract was 49.80%w/w dry *** phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,***,steroids,proteins,and *** LD_(50) was beyond our experimental limit and was not *** concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANOVA,P<0.05) healing effect on the incision wounds giving rise to 125%-140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine.

关键词： Wound healing Napoleona vogelii Petroleum jelly Neobacin Folkloric medicine

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HIV/AIDS selective infectivity-report of two peculiar cases

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 1006-1008页

作者： Azikiwe CCA Ifezulike CC Amazu LU enye jc Nwosu Pjc Osuala FN Department of Pharmacology Madonna University Elele CampusElele Rivers StateNigeria Department of Paediatrics Anambra State HospitalOnisha Department of immunology Madonna UniversityEleleRivers StateNigeria

We report two peculiar cases that were observed in two communities of Anambra State,South East *** first case was a woman of 44 with a history of blood transfusion from a donor of questionable HIV status.A pint of blood was transfused in a private Hospital on the 15th January. *** has had no form of antiviral therapy until 22nd April.2008 when she came to the hospital for routine medical check *** HIV result came out confirmed positive while that of her husband came out *** has had active sexual life with her husband in the previous eight years as they have had some difficulties in getting their desired extra two children having earlier gotten a boy and a *** second case involves a family of six.A couple with four children of ages about 6 months,2 years,3 years and 5 *** youngest,a female presented with fever and multiple *** tested HIV positive and so was her mother and her second *** her father and two other siblings remained negative at post three and six months intervals from their very first test date with *** reported cases appear to go contrary to earher formed opinion on HIV *** support the opinion on a naturally,occurring substance,APOBEC3G which possibly confers permanent immunity against the HIV *** recommend clinical trials of the characterized APOBEC3G as a vaccine for non HIV infected persons of all ages and to people living with HIV/AIDS as a therapeutic drug.

关键词： AP0BEC3G HIV peculiar cases HIV vaccine

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Antiinflammatory activity of the methanolic extract of the seeds of Carica papaya in experimental animals

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Asian Pacific Journal of Tropical Medicine 2010年第11期3卷 884-886页

作者： Amazu LU Azikiwe CCA Njoku CJ Osuala FN Nwosu Pjc Ajugwo AO enye jc Department of Pharmacology Madonna UniversityElele CampusRivers state.Nigeria Department of Pharmacognosysis Faculty of PharmacyMadonna UniversityElele Nigeria Department of Haematology/Immunology Madonna UniversityElele CampusNigeria

Objective:To scientifically verify the claims of our traditional healers on the anti-inflammatory activity of Carica papaya(***) and possibly deduce its ***:0.1 mL of fresh egg albumin was injected into the right hind-paw of adult white Wistar rats to induce inflammation an hour post intraperitoneal(IP) administration of 50-200 mg/kg doses of the extract to 3 groups of 5 rats per *** 4th group of 5 rats was used as negative control and received 2 mL/kg(IP) of physiological saline,while the 5th group of 5 rats was used as positive-comparative control and received(IP) 150 mg/kg of *** in diameter of the paw were measured with the aid of Veneer Calipers before extract administration and at interval of 30 minutes post administration for further 2 *** inhibition of oedema was calculated for each dose group and results were subjected to statistical analysis using student /-test and analysis of variance(ANOVA).Results:All doses of extract showed a dose and time dependent inhibition effects of oedema(P<0.05).Conclusions:This work is at present though limited to animals,the anti-inflammatory activity of the seeds of *** is perhaps proven.

关键词： Carica papaya Medicinal plants Antiinflammation

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A comparative laboratory diagnosis of malaria:microscopy versus rapid diagnostic test kits

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 307-310页

作者： Azikiwe CCA Ifezulike CC Siminialayi IM Amazu LU enye jc Nwakwunite OE Department of Pharmacology Anambra State University Department of Pharmacology University of Port Harcourt Department of Immunology/Parasitology Madonna University

Objective:To compare the two methods of rapid diagnostic tests(RDTs)and microscopy in the diagnosis of ***:RDTs and microscopy were carried out to diagnose malaria. Percentage malaria parasitaemia was calculated on thin films and all non-acute cases of plasmodiasis with less than 0.001%malaria parasitaemia were regarded as *** were simply presented as percentage positive of the total number of patients under *** results of RDTs were compared to those of microscopy while those of RDTs based on antigen were compared to those of RDTs based on ***' follow-up was made for all ***: All the 200 patients under present study tested positive to RDTs based on malaria antibodies(serum)method(100%).128 out of 200 tested positive to RDTs based on malaria antigen(whole blood)method(64%),while 118 out of 200 patients under present study tested positive to visual microscopy of Lieshman and diluted Giemsa(59%).All patients that tested positive to microscopy also tested positive to RDTs based on *** patients on the second day of follow-up were non-febrile and had antimalaria ***;We conclude based on the present study that the RDTs based on malaria antigen(whole blood)method is as specific as the traditional microscopy and even appears more sensitive than *** RDTs based on antibody(serum)method is unspecific thus it should not be *** is most likely that Africa being an endemic region,formation of certain levels of malaria antibody may not be *** present study also supports the opinion that a good number of febrile cases is not due to malaria. We support WHO's report on cost effectiveness of RDTs but,recommend that only the antigen based method should possibly,be adopted in Africa and other malaria endemic regions of the world.

关键词： Rapid diagnostic tests Microscopy Malaria diagnosis Malaria Parasitaemia Plasmodiasis Antigen Antibody Antimalaria Serum Whole blood

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10KA基于SCR技术的功率电感脉冲测量系统

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磁性元件与电源 2024年第7期 134-135,141页

作者： jc Sun Christian Teske 曹欣欣杨建民 Bs&T Frankfurt am Main GmbH 东莞铭普光磁股份有限公司

一款新的基于SCR(Semiconductor Control Rectifier半导体控制整流器)的高脉冲电流处理能力而开发的用于功率电感测量的脉冲测试系统。该测试系统可以通过高达10KA的脉冲电流对功率电感进行饱和性能测试和功耗测试,而且不会产生热应力... 详细信息

一款新的基于SCR(Semiconductor Control Rectifier半导体控制整流器)的高脉冲电流处理能力而开发的用于功率电感测量的脉冲测试系统。该测试系统可以通过高达10KA的脉冲电流对功率电感进行饱和性能测试和功耗测试,而且不会产生热应力。测试系统具有短路保护功能,可以避免因输出短路造成对测试系统的损坏。受益于SCR器件的高脉冲电流处理能力,该脉冲测试系统有一些独特的特性,并且和基于IGBT的测试系统相比具有一些突出的优点。

关键词： SCR半导体器件脉冲电流测试功耗测试功率电感饱和特性

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Peptide synthesis using pentafluorophenyl diphenylphosphate (FDP) as coupling reagent

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Chinese Journal of Chemistry 1995年第2期13卷 175-189页

作者： CHEN, SQ XU, jc CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Comparison of the reaction speed and yield with its analogues and some conventional peptide coupling reagents, pentafluorophenyl diphenylphosphate (FDP) was shown to be a more preferable ''active ester'' type reagent for the peptide synthesis. The synthesis of oligopeptides using FDP was achieved with high yields. The influences of several reaction parameters such as solvent, base, additive and temperature on the coupling reaction were studied using HPLC method. The degree of racemization with FDP determined by HPLC or Young test was shown to be lower than that of DCCI. Octapeptide Gly-Cys(Bzl)-Ser-Gly-Lys-Leu-Ile-Cys(Bzl)-OH, corresponding to the amino acid sequence of gp41 of HIV-1, was successfully synthesized by 5+3 approach using FDP with high yield.

关键词： PEPTIDE SYNTHESIS COUPLING REAGENT PENTAFLUOROPHENYL DIPHENYL PHOSPHATE

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A CRACK CLOSURE MODEL FOR BRITTLE ROCK SUBJECTED TO COMPRESSIVE-SHEAR LOADING

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中国有色金属学会会刊：英文版 1999年第2期9卷 223-228页

作者： Chen, F Sun, ZQ Xu, jc Cent S Univ Technol Opening Lab Mech Changsha 410083 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＣｏｍｐｒｅｓｓｉｏｎｓｈｅａｒｆｒａｃｔｕｒｅｏｆｒｏｃｋｗａｓｉｎｖｅｓｔｉｇａｔｅｄｂｙｍａｎｙｒｅｓｅａｒｃｈｅｒｓ，Ｒａｏｅｔａｌ［１］ｓｔｕｄｉｅｄｔｈｉｓｆａｉｌｕｒｅｍｏ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＣｏｍｐｒｅｓｓｉｏｎｓｈｅａｒｆｒａｃｔｕｒｅｏｆｒｏｃｋｗａｓｉｎｖｅｓｔｉｇａｔｅｄｂｙｍａｎｙｒｅｓｅａｒｃｈｅｒｓ，Ｒａｏｅｔａｌ［１］ｓｔｕｄｉｅｄｔｈｉｓｆａｉｌｕｒｅｍｏｄｅｕｓｉｎｇｆｏｕｒｐｏｉｎｔｂ...

关键词： crack closurecompressiveshear loadingstress intensity factor

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A Novel Sieving Medium for Separation of DNA Fragments-Poly(acrylamide-dimethylacrylamide)

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Chinese Chemical Letters 2000年第11期11卷 1015-1018页

作者： Ren, jc Fang, ZF Hunan Normal Univ Coll Chem & Chem Engn Dept Chem Changsha 410081 Peoples R China

A short chain poly (acrylamide-dimethylacrylamide) was synthesized in water phase using isopropanol as a chain transfer agent. This copolymer can form a stable dynamic coating on the inner surface of the capillary, thereby suppressing the electroosmotic flow and DNA-capillary wall interaction. The high efficient separation of DNA fragments and SSCP analysis were obtained in bare capillaries using this copolymer as a sieving medium.

关键词： poly (acrylamide-dimethylacrylamide) DNA capillary electrophoresis

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Total Synthesis of Saprorthoquinone

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Chinese Chemical Letters 1997年第8期8卷 695-696页

作者： Duan, WH Cai, jc CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

Saprorthoquinone (1), isolated from the roots of salvia prionitis Hance, was synthesized starting from p-methoxyphenylacetic acid.

关键词： Total Synthesis of Saprorthoquinone

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Synthesis of F-alkylated MDP Analogs

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Chinese Chemical Letters 1996年第11期7卷 993-994页

作者： Zhang, MZ Xu, jc GUANGXI NORMAL UNIV DEPT CHEMGUILIN 541004GUANGXIPEOPLES R CHINA ACAD SINICA SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Four F-alkylated muramyl dipeptides were synthesized by an efficient coupling reagent, Benzotriazol-1-yloxy-bis(pyrrolidino)carbo hexafluoro-phosphate(BBC)([1]).

关键词： MDP Synthesis of F-alkylated MDP Analogs

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