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4-Hydroxy-2-Oxoglutaric Acid,A KeyMetabolite Involved in Trypsin-Regulation of Arginine Metabolism in Hylocereus undatus during Storage

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 885-900页

作者： Bairu Li Jingyu Jia Hemin Wang Jiaju Sun enyan chen Xin Li College of Food and Bioengineering Henan University of Science and TechnologyLuoyang471023China Henan Engineering Research Center of Food Microbiology Luoyang471023China National Demonstration Center for Experimental Food Processing and Safety Education Luoyang471000China

Trypsin,a novel superoxide scavenger,significantly enhances the storage quality of Hylocereus undatus(***).To elucidate the preservation mechanism of trypsin on ***,a widely targeted metabolomic analysis,and transcriptomics analysis were ***,a total of 453 metabolites were identified,with organic acids and their derivatives constituting the largest proportion(25%).Amino acids and their metabolites,prominent among organic acids,were further *** them,73 metabolites were associated with amino acids,and 37 exhibited significant *** most enriched Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway was arginine biosynthesis(map00220),with polyamine metabolites showing the most pronounced differences,particularly spermine(FC=1.7594).Compared with the control group,4-hydroxy-2-oxoglutaric acid was significantly upregulated(FC=2.117)in the process of spermine ***,the results of Gene Ontology(GO)and KEGG enrichment analysis of the *** transcriptome profile revealed that trypsin treatment led to 187 differentially expressed genes associated with *** GO and KEGG analyses exhibited significant enrichment in the spermine biosynthetic process(GO:0006597)(map:00220)within the arginine biosynthesis ***,most enzymes and metabolites within the spermine biosynthesis pathway in *** were *** results of the PPI network highlighted that ADC,SPDS,and SAMDC,among others,were pivotal proteins involved in trypsin-regulated arginine metabolism and spermine *** study revealed that trypsin could significantly delay postharvest senescence of *** at room *** effect might be attributed to trypsin triggering the synthesis of 4-hydroxy-2-oxoglutaric acid in the fruit peel,thereby promoting the biosynthesis of spermine and other polyamines.

关键词： Trypsin arginine transcriptomics widely targeted metabolomics

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低剂量螺旋CT肺结节扫描与常规剂量CT的对照研究

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当代医学 2019年第19期25卷 157-159页

作者：曾伟胜陈恩炎林杰普宁市人民医院CT科

目的对低剂量螺旋CT肺结节扫描与常规剂量CT肺结节扫描进行对照研究,并对低剂量螺旋CT肺结节扫描的诊断价值进行评价。方法选取2018年1月至2018年12月经本院诊疗的62例肺结节患者为研究对象,所有患者均给予低剂量螺旋CT肺结节扫描和常... 详细信息

目的对低剂量螺旋CT肺结节扫描与常规剂量CT肺结节扫描进行对照研究,并对低剂量螺旋CT肺结节扫描的诊断价值进行评价。方法选取2018年1月至2018年12月经本院诊疗的62例肺结节患者为研究对象,所有患者均给予低剂量螺旋CT肺结节扫描和常规剂量螺旋CT肺结节扫描。对两种扫描检查方式所形成的图像质量、肺结节形态学以及肺结节检出的情况进行对比分析。结果低剂量螺旋CT扫描所获取的图像质量中,A级54例,占比87.10%,B级6例,占比9.68%,C级2例,占比3.22%;常规剂量螺旋CT扫描所获取的图像质量中,A级53例,占比85.49%,B级7例,占比11.29%,C级2例,占比3.22%。两种扫描方式在图像质量方面差异无统计学意义;在扫描到的结节数量方面,低剂量螺旋CT共扫描98个,伴毛刺征37个,占比37.76%,分叶征28例,占比28.57%,胸膜凹陷征23例,占比23.47%,血管聚集征10例,占比10.20%;常规剂量螺旋CT共扫描96个,伴毛刺征35个,占比36.46%,分叶征29例,占比30.21%,胸膜凹陷征24例,占比25%,血管聚集征8例,占比8.33%,两种扫描方式在肺结节数量以及具体形态方面差异无统计学意义;在图像噪声方面,低剂量CT扫描高于常规剂量CT扫描,但在辐射剂量方面,低剂量CT扫描明显低于常规剂量CT扫描,两种扫描方式在图像噪声和辐射剂量方面差异有统计学意义(P<0.05)。结论低剂量螺旋CT肺结节扫描与常规剂量扫描相比,在肺结节检出方面以及图像质量方面未形成明显差异,均能够有效的对肺结节进行初筛和诊断,但低剂量能够使患者所受辐射伤害减少,值得推广应用。

关键词：低剂量螺旋CT 常规剂量肺结节

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增强CT直方图分析与肺癌组织分化程度的相关性研究

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医学影像学杂志 2017年第9期27卷 1698-1700页

作者：彭晓容马春浓陈恩炎广东省普宁市人民医院放射科广东普宁515300 南方医科大学第三附属医院放射科广东广州510630

目的肺癌组织的分化程度对评估肿瘤生物学行为、预后及治疗方式具有重要意义。本研究拟探讨增强CT直方图分析与肺癌组织分化程度的相关性。方法收集我院经手术病理证实的肺癌患者105例,均行CT增强扫描。采用Image J软件手动在肿瘤增强C... 详细信息

目的肺癌组织的分化程度对评估肿瘤生物学行为、预后及治疗方式具有重要意义。本研究拟探讨增强CT直方图分析与肺癌组织分化程度的相关性。方法收集我院经手术病理证实的肺癌患者105例,均行CT增强扫描。采用Image J软件手动在肿瘤增强CT最大层面画取感兴趣区(region of Interest,ROI),测量直方图各参数(平均值、SD、峰度、偏度)。采用单因素方差分析比较不同分化程度间的直方图分析各参数值得差异,用Spearman相关系数分析直方图各参数与不同分化程度之间的相关性。结果高、中、低分化组肺癌的偏度值、峰度值有统计学差异(P<0.001)。高分化组的偏度、峰度绝对值均较中、低分化组肺癌低(P<0.001)。三组肺癌的平均数及SD无统计学差异。偏度值及峰度值与病变不同分化程度存在相关性(偏度值r=-0.267,P=0.006;峰度值r=0、381,P<0.001)。结论增强CT的直方图分析偏度值及峰度值可术前判断肺癌的分化程度。

关键词：肺癌直方图分析分化程度体层摄影术,X线计算机

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多排螺旋CT与MR对胰腺癌的诊断价值探讨

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临床医学工程 2017年第3期24卷 325-326页

作者：彭晓容马春浓陈恩炎黄海涛广东省普宁市人民医院放射科广东普宁515300 南方医科大学附属第三医院广东广州510631

目的探讨多排螺旋CT与MR在胰腺癌诊断中的应用价值。方法选取我院2014年1月至2016年8月收治的70例胰腺癌患者,随机分为两组,每组35例。CT组采用多排螺旋CT扫描,MR组则采用MR扫描。两组均与术后病理学诊断结果进行比较,评价两组扫描检查... 详细信息

目的探讨多排螺旋CT与MR在胰腺癌诊断中的应用价值。方法选取我院2014年1月至2016年8月收治的70例胰腺癌患者,随机分为两组,每组35例。CT组采用多排螺旋CT扫描,MR组则采用MR扫描。两组均与术后病理学诊断结果进行比较,评价两组扫描检查的准确性、敏感度、特异性以及不同时期的显示值。结果 (1)CT组的准确性、敏感度和特异性分别为88.57%、82.86%和74.29%,与MR组的91.43%、80.00%和71.43%比较,差异无统计学意义(P>0.05)。(2)MR组胰腺动脉期、静脉期和延迟期的显示值均显著高于CT组,差异均有统计学意义(P<0.05)。结论多排螺旋CT与MR在胰腺癌诊断中均具有良好的准确性、敏感度和特异性以及较高的应用价值,但在不同时期的显示方面,MR优于多排螺旋CT。

关键词：多排螺旋CT MR 胰腺癌临床诊断应用价值

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Effect of cobalt oxide on performance of Pd catalysts for lean-burn natural gas vehicles in the presence and absence of water vapor

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Journal of Natural Gas Chemistry 2010年第2期19卷 134-138页

作者： enyan Long Xiaoyu Zhang Yile Li Zhimin Liu Yun Wang Maochu Gong Yaoqiang chen Key Laboratory of Green Chemistry ＆ Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 Sichuan China

Pd-based catalysts modified by cobalt were prepared by co-impregnation and sequential impregnation methods,and characterized by X-ray powder diffraction （XRD）,N2 adsorption/desorption （Brunauer-Emmet-Teller method）,CO-chemisorption and X-ray photoelectron spectroscopy （XPS）.The activity of Pd catalysts was tested in the simulated exhaust gas from lean-burn natural gas *** effect of Co on the performance of water poisoning resistance for Pd catalysts was estimated in the simulated exhaust gas with and without the presence of water *** was found that the effect of Co significantly depended on the preparation ***/La-Al2O3 catalyst prepared by co-impregnation exhibited better water-resistant *** results of XPS indicated that both CoAl2O4 and Co3O4 were present in the Pd catalysts modified by *** the catalyst prepared by sequential impregnation method,the ratio of CoAl2O4/Co3O4 was higher than that of the catalyst prepared by co-impregnation *** could be concluded that Co3O4 played an important role in improving water-resistant performance.

关键词： Co Pd-only catalyst lean-burn natural gas vehicles methane oxidation water vapor

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CeO_2-ZrO_2-La_2O_3-Al_2O_3 composite oxide and its supported palladium catalyst for the treatment of exhaust of natural gas engined vehicles

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Journal of Natural Gas Chemistry 2009年第2期18卷 139-144页

作者： Xiaoyu Zhang enyan,Long Yile Li Jiaxiu Guo Lijuan Zhang Maochu Gong Minghua Wang Yaoqiang chen Key Laboratory of Green Chemistry ＆ Technology of the Ministry of Education College of Chemistry Sichuan University Chengdu 610064 Sichuan China College of Architecture and Environment Sichuan University Chengdu 610064 Sichuan China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning China Sichuan Tianyi Science ＆ Technology Co. Ltd. Chengdu 610225 Sichuan China

Composite supports CeO2-ZrO2-Al2O3（CZA） and CeO2-ZrO2-Al2O3-La2O3（CZALa） were prepared by co-precipitation method. Palladium catalysts were prepared by impregnation and their purification ability for CH4, CO and NOx in the mixture gas simulated the exhaust from natural gas vehicles （NGVs） operated under stoichiometric condition was investigated. The effect of La2O3 on the physicochemical properties of supports and catalysts was characterized by various techniques. The characterizations with X-ray diffraction （XRD） and Raman spectroscopy revealed that the doping of La2O3 restrained effectively the sintering of crystallite particles, maintained the crystallite particles in nanoscale and stabilized the crystal phase after calcination at 1000 ℃. The results of N2-adsorption, H2-temperatnre-programmed reduction （H2-TPR） and oxygen storage capacity （OSC） measurements indicated that La2O3 improved the textural properties, reducibility and OSC of composite supports. Activity testing results showed that the catalysts exhibit excellent activities for the simultaneous removal of methane, CO and NOx in the simulated exhaust gas. The catalysts supported on CZALa showed remarkable thermal stability and catalytic activity for the three pollutants, especially for NOx. The prepared palladium catalysts have high ability to remove NOx, CH4 and CO, and they can be used as excellent catalysts for the purification of exhaust from NGVs operated under stoichiometric condition. The catalysts reported in this work also have significant potential in industrial application because of their high performance and low cost.

关键词： Pd catalysts natural gas vehicles exhaust methane oxidation NOx conversion CeO2-ZrO2-Al2O3 La2O3

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Influence of CeO_2 and La_2O_3 on properties of palladium catalysts used for emission control of natural gas vehicles

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Journal of Natural Gas Chemistry 2009年第4期18卷 415-420页

作者： Yile Li Xiaoyu Zhang enyan Long Hongmei Li Dongdong Wu Li Cai Maochu Gong Yaoqiang chen Key Laboratory of Green Chemistry ＆ Technology of the Ministry of Education College of Chemistry Sichuan University Chengdu 610064 Sichuan China

Pd/YZ-Al2O3 （Y and Zr modified Al2O3, and hereafter, labelled as A1） catalysts with 4 wt% additive CeO2 and/or La2O3 were prepared and characterized by X-ray photoelectron spectroscopy （XPS）, NO-temperature programmed desorption （NO-TPD）, Nz-adsorption/desorption （Branauer-Emmet-Teller BET method）, X-ray diffraction （XRD） and CO-chemisorption. Catalytic activities for CH4, CO and NO conversion were tested in a gas mixture simulated the emissions from natural gas vehicles （NGVs） operated under stoichiometric conditions. The results indicated that all catalysts exhibited excellent catalytic performances for CH4 and CO oxidation and the promoting effect of CeO2 or La2O3 was significant for NO conversion. XPS results showed that the electron density around Pd was increased by CeO2 and/or La2O3, the binding energy of Pd 3d decreased as the order： Pd/Al 〉 Pd/Ce/Al 〉 Pd/La/Al 〉 Pd/CeLa/Al. The electron-rich Pd showed Rh-like catalytic properties which exhibited good activity for the reduction of NO. NO-TPD results showed that the addition of CeO2 and/or La2O3 increased NO adsorption on surface, and promoted the conversion of NO.

关键词： NGVs under stoichiometric condition palladium catalyst XPS NO-TPD NO conversion methane conversion

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The role of EGCG in the prevention and treatment of Alzheimer's disease

The role of EGCG in the prevention and treatment of Alzheime...

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2020年浙江省医学会精神病学学术大会浙江省医师协会精...

作者： chen Yan YU enyan Department of Psychiatry Zhejiang Provincial People's Hospital Clinical Psychology Zhejiang cancer Hospital

As one of the oldest and most popular beverages in the world,tea is rich in polyphenols with strong antioxidant activity,which is closely related to human *** green tea catechins(GTCs) are polyphenolic compounds extracted from the leaves of tea family Camellia sinensis,and have shown numerous beneficial properties,such as anticancer activity,anti-inflammatory ability,antioxidative properties,and antibacterial function GTCs are predominantly comprised of four constituents:epicatechin(EC),epigallocatechin,epicatechin gallate,and epigallocatechin gallate(EGCG),among which the EGCG is the major component of GTCs accounting for approximately 59% of the total polyphenols,and it is also the most complicated and principal ***,it was thought that EGCG had low bioavailability and it was difficult to show acute clinical ***,with the in-depth study of the pharmacokinetics of EGCG in the body in recent years,it has been found that oral EGCG can be rapidly absorbed in the digestive tract and widely distributed in the *** is worth noting that the latest research shows that EGCG can pass through the blood-brain *** discovery provides an important theoretical basis for EGCG may act on the central nervous system.

关键词： EGCG Alzheimer’s disease β-amyloid nAChR

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默认网络静息态脑功能磁共振成像在轻度认知功能障碍评估和诊断中的应用

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中华老年医学杂志 2018年第4期37卷 381-385页

作者：陈嫣于恩彦浙江中医药大学 310053 浙江省人民医院精神卫生科杭州医学院附属人民医院 310014

轻度认知功能障碍（MCI）被认为是介于正常老龄化与痴呆之间的一个临床阶段。美国研究报道65岁以上人群MCI患病率为18．8％。我国60岁以上老年人中MCI的发生率为3．2％～19．3％。每年MCI向痴呆的转化率为10％～15％。因此，在MCI阶段... 详细信息

轻度认知功能障碍（MCI）被认为是介于正常老龄化与痴呆之间的一个临床阶段。美国研究报道65岁以上人群MCI患病率为18．8％。我国60岁以上老年人中MCI的发生率为3．2％～19．3％。每年MCI向痴呆的转化率为10％～15％。因此，在MCI阶段早期识别及干预已成为目前专家共识，并被广泛研究。静息态功能磁共振成像（rs—fMRI）是指被试在清醒并不进行任何系统性思考的休息状态下进行的功能磁共振扫描，

关键词：磁共振成像轻度认知功能障碍默认网络

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基于血清小分子核糖核酸的阿尔茨海默病诊断模型构建与验证

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中华精神科杂志 2021年第5期54卷 331-336页

作者：廖峥娈苏衡陈嫣于恩彦浙江省人民医院精神卫生科浙江省心理保健基地浙江省医学重点学科杭州310014 中国科学院大学附属肿瘤医院临床心理科杭州310022

目的基于血清小分子核糖核酸(microRNA,miRNA)构建阿尔茨海默病(Alzheimer′s disease,AD)预测诊断模型。方法从高通量基因表达数据库下载1021例AD患者和288名健康对照者血清miRNA芯片数据,共1309个样本。按年龄匹配AD患者和健康对照者... 详细信息

目的基于血清小分子核糖核酸(microRNA,miRNA)构建阿尔茨海默病(Alzheimer′s disease,AD)预测诊断模型。方法从高通量基因表达数据库下载1021例AD患者和288名健康对照者血清miRNA芯片数据,共1309个样本。按年龄匹配AD患者和健康对照者,筛选出494例样本用于训练和验证诊断模型。将miRNA表达值从高到低排序选取前1000个探针进入下一步研究。按照7∶3的比例将494例样本分为训练组和验证组。采用LASSO回归筛选miRNA,结合性别、载脂蛋白E4基因型和miRNA数据,采用逐步回归进一步筛选自变量并构建多因素诊断模型。采用受试者工作特征曲线(receiver operating characteristic,ROC)和校准曲线,在训练组、验证组、训练组+验证组以及1309例总样本中验证模型的准确性,并绘制诺莫图进行实际案例预测。结果多因素诊断模型在训练组、验证组、训练组+验证组以及1309例总样本的ROC曲线下面积分别为0.870、0.831、0.842和0.826,具有较高的预测效力。诺莫图显示,1例男性患者的预测值总分521分(P=0.0228),提示该样本为AD,和实际结果一致。结论基于11个血清miRNA、性别以及载脂蛋白E4基因型的诊断模型能较好地预测AD。

关键词：阿尔茨海默病微RNAs 人工智能诊断模型

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