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nano Research 2022年第9期15卷 8510-8515页

作者： Lukas Hrachowina enrique barrigón Magnus T.Borgström nanoLund and Divison of Solid State Physics Lund UniversityBox 11822100 LundSweden Universidad de Málaga Andalucía TechDepartamento de Física Aplicada ⅠCampus de Teatinoss/nMálaga 29071Spain

nanowires have many interesting properties that are of advantage for solar cells,such as the epitaxial combination of latticemismatched materials without plastic *** could be utilized for the synthesis of axial tandem-junction nanowire solar cells with high efficiency at low material ***-beam-induced current measurements have been used to optimize the performance of single-junction nanowire solar ***,we use electron-beam-induced current measurements to break the barrier to photovoltaic tandem-junction *** particular,we identify and subsequently prevent the occurrence of a parasitic junction when combining an InP n-i-p junction with a tunnel ***,we demonstrate how to use optical and electrical biases to individually measure the electron-beam-induced current of both sub-cells of photovoltaic tandem-junction *** show that with an applied voltage in forward direction,all junctions can be analyzed *** development of this characterization technique enables further optimization of tandem-junction nanowire solar cells.

关键词： Ⅲ-Ⅴnanowire nanowire solar cell tandem-junction Esaki tunnel diode electron-beam induced current(EBIC)

Imaging the influence of oxides on the electrostatic potential of photovoltaic InP nanowires

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nano Research 2021年第11期14卷 4087-4092页

作者： Lukas Hrachowina Xianshao Zou Yang Chen Yuwei Zhang enrique barrigón Arkady Yartsev Magnus T.Borgström nanoLund Lund UniversityBox 11822100LundSweden Divison of Solid State Physics Lund UniversityBox 11822100LundSweden Divison of Chemical Physics Lund UniversityBox 12422100LundSweden Toyota Technological Institute NagoyaAichi 468-8511Japan

nanowires require surface passivation due to their inherent large surface to volume ratio. We investigate the effect of embedding InP nanowires in different oxides with respect to surface passivation by use of electron beam induced current measurements enabled by a nanoprobe based system inside a scanning electron microscope. The measurements reveal remote doping due to fixed charge carriers in the passivating PO_(x)/Al_(2)O_(3) shell in contrast to results using SiO_(x). We used time-resolved photoluminescence to characterize the lifetime of charge carriers to evaluate the success of surface passivation. In addition, spatially resolved internal quantum efficiency simulations support and correlate the two applied techniques. We find that atomic-layer deposited PO_(x)/Al_(2)O_(3) has the potential to passivate the surface of InP nanowires, but at the cost of inducing a field-effect on the nanowires, altering their electrostatic potential profile. The results show the importance of using complementary techniques to correctly evaluate and interpret processing related effects for optimization of nanowire-based optoelectronic devices.

关键词： InP nanowires oxides MOVPE electron beam induced current(EBIC) time-resolved photoluminescence(TRPL) field-effect

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen enrique Santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Wilson's disease in two siblings from Ecuador:Two case reports

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World Journal of Clinical Cases 2025年第3期13卷 50-60页

作者： enrique Carrera Jonathan Alvarado Martina Astudillo Galo Pillajo Department of Gastroenterology and Hepatology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador Faculty of Medicine Pontificia Universidad Catolica del EcuadorQuito 170143PichinchaEcuador Department of Radiology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador

BACKGROUnD Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and *** and treatments are challenging in settings,where advanced diagnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack disease awareness,and medical follow-ups are *** diagnoses and treatments help prevent complications,improve patients’quality of life,and ensure a normal life *** clinical presentations and outcomes of WD can vary within a single *** SUMMARY We present the cases of two siblings(19 and 27 years)from a consanguineous family in rural Ecuador,diagnosed as having WD during a family *** male patient,diagnosed at age 19 after his brother’s death from acute liver failure,presented with compensated cirrhosis,neurological symptoms,and bilateral Kayser-Fleischer *** developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication *** condition improved upon switching to trientine tetrahydrochloride,and his neurological symptoms improved over an 8-year period of *** female patient,diagnosed at age 10,exhibited only biochemical *** treatment history was similar;however,she remained asymptomatic without disease progression over the same follow-up *** discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes,emphasizing the need for research in these areas to optimize therapeutic *** Our patients’medical histories show how early diagnosis and treatment can prevent disease progression;and,how suboptimal treatments impact disease outcomes.

关键词： Wilson disease Kayser-Fleischer rings Copper chelator D-penicillamine Trientine tetrahydrochloride Case report

Olfactory proteotyping: towards the enlightenment of the neurodegeneration

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neural Regeneration Research 2019年第6期14卷 979-981页

作者： Joaquín Fernández-Irigoyen enrique Santamaría Proteored-Institute of Health Carlos Ⅲ (ISCⅢ) Clinical Neuroproteomics UnitNavarrabiomedNavarra Health DepartmentPublic University of NavarraNavarra Institute for Health Research (IdiSNA)

Although phylogenetically ancient,the olfactory system has received less attention than other sensorial ***,olfactory dysfunction is considered an early prodromal event in neurodegenerative diseases(nDs)(Doty,2012;Attems et al.,2014),which may vary from severe smell loss(e.g.,Alzheimer’s and Parkinson’s diseases)to relatively moderate loss(e.g.,progressive supranuclear palsy)(Doty,2017).Recently,a cluster of neuropathological and functional discoveries has evidenced the relevant role of the olfactory bulb(OB)during the neurodegenerative process(Attems et al.,2014;Rey et al.,2018).For instance,the double-transgenic APP/PS1 mouse model of Alzheimer’s disease(AD)develops early proteomic disturbances accompanied by a specific modulation of the focal adhesion kinase(FAK)and mitogen-activated protein kinase(MAPK)dynamics at the level of the OB,demonstrating that olfactory molecular alterations occur prior toβ-amyloid plaque appearance and memory impairments in APP/PS1 transgenic mice(Lachen-Montes et al.,2016).

关键词： Although phylogenetically olfactory system considered

Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

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Friction 2021年第2期9卷 415-428页

作者： Jose enrique MARTÍn-ALFOnSO María Jose MARTÍn-ALFOnSO Concepción VALEnCIA María Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remarkable lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

Caving performance through the integration of microseismic activity and numerical modeling at DOZ-PT Freeport,Indonesia

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International Journal of Minerals,Metallurgy and Materials 2009年第1期16卷 1-6页

作者： Rubio enrique napitupulu Daulat Mining Engineering Department Universidad de Chile Geotechnical Engineering Department PT Freeport IndonesiaTembagapuraIndonesia

This article describes an undergoing research at PT Freeport, Indonesia, in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed infrastructure. At the moment, several numerical experiments have been conducted to correlate the mining activity with the microseismic events using the data collected during year 2005 and 2006. As a result of the preliminary analysis a micro- and a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events. Stresses have been computed using standard elastic continuous boundary element models. The correlation between the average source radius and the stress performance has provided a method to propose a macrocracking criterion. Several techniques have been tested to nucleate the microseismic activity around different geological features. This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts. A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model. This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismicity density. The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months. The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure.

关键词： microseism underground mining block caving stress distribution microcrack criterion

Internal Controllability for Parabolic Systems Involving Analytic non-local Terms

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Chinese Annals of Mathematics,Series B 2018年第2期39卷 281-296页

作者： Pierre LISSY enrique ZUAZUA This article is dedicated to Phillippe G. Ciarlet in the occasion of his 80th birthday with gratitude and admiration/or his mastery and continuous support. Merci Philipp

This paper deals with the problem of internal controllability of a system of heat equations posed on a bounded domain with Dirichlet boundary conditions and perturbed with analytic non-local coupling terms. Each component of the system may be controlled in a different subdomain. Assuming that the unperturbed system is controUable--a property that has been recently characterized in terms of a Kalman-like rank condition--the authors give a necessary and sufficient condition for the controllability of the coupled system under the form of a unique continuation property for the corresponding elliptic eigenvalue system. The proof relies on a compactness-uniqueness argument, which is quite unusual in the context of parabolic systems, previously developed for scalar parabolic equations. The general result is illustrated by two simple examples.

关键词： Parabolic systems non-local potentials Analyticity null controllability Kalma~ rank condition Spectral unique continuation

On the material dependence of experimental shear fracture orientation

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Science China Earth Sciences 2015年第12期58卷 2357-2362页

作者： enrique GOMEZ-RIVAS Albert GRIERA Department of Geology and Petroleum Geology School of Geosciences King’s College University of Aberdeen Departament de Geologia Universitat Autònoma de Barcelona

It is not uncommon to observe shear fractures in ductile rocks oriented at more than 45° with respect to the maximum compression direction. Since these orientations cannot be explained with the classic Mohr-Coulumb or Tresca yield criteria, Zheng et al.(Journal of Structural Geology, 35: 1394–1405, 2011) proposed the maximum effective moment(MEM) failure criterion. This rule suggests that shear fractures in ductile rocks form at ?55° with the maximum compression axis and that this orientation is material-independent and, therefore, universal. Zheng et al.(Science China: Earth Sciences, 57(11): 2819–2824, 2014) used data from our own experiments as supporting evidence of their failure criterion. In this contribution we discuss why shear fracture formation in ductile rocks indeed strongly depends on the mechanical properties of the deforming medium, and why experimental data should not be taken to prove the validity of the MEM criterion. The formation mechanisms and orientations of shear fractures in our experiments significantly vary depending on the material strength and degree and type of anisotropy(composite and intrinsic). We therefore demonstrate using experimental data that a universal failure angle in ductile and anisotropic rocks does not apply. Additionally, we highlight some inconsistencies of the MEM criterion.

关键词： shear fracture anisotropy fracture orientation material properties failure criteria ductile deformation

A UnIFIED FRAMEWORK FOR SITE SELECTIOn AnD BUSInESS FORECASTInG USInG AnP

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Journal of Systems Science and Systems Engineering 2006年第2期15卷 178-188页

作者： enrique MU Katz Graduate School of Business University of PittsburghUSA

This paper reports an on-going application of the Analytic network Process （AnP） in the context of a non-profit organization： The Latin American Studies Association （LASA）. This institution organizes a large international conference every eighteen months and needs to estimate conference attendance in advance （for logistic purposes） as well as selecting a host city where the combination of hotel infrastructure, conference costs, and so on, makes it a sound financial choice. In this paper, AnP will be used to： first, create a model to predict the relative number of attendees to the forthcoming 2009 LASA conference; and second, to create a Benefit-Cost-Risk （BCR） model to select the most suitable Latin American city as the conference site, This paper shows how the combination of these two AnP models, one for prediction and one for selection, can be used together for effective decision-making.

关键词： AnP AHE non-profit decision-making predictive models site selection