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Exploring conservative management for cervical intraepithelial neoplasia grade 2 in organised cervical cancer screening programmes:a multicentre study in Italy

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Family Medicine and Community Health 2024年第S2期12卷 1-7页

作者： Silvia Gori Helena Frayle Alessio Pagan Marika Soldà Cesare Romagnolo Egle Insacco Licia Laurino Mario Matteucci Giuseppe Sordi enrico Busato Manuel Zorzi Tiziano Maggino Annarosa Del Mistro CIN2 study Working Group Veneto Institute of Oncology IOV-IRCCS PadovaItaly Local Health Unit Marca Trevigiana TrevisoItaly Local Health Unit Serenissima VeneziaItaly Obstetrics and Gynecology Azienda Ospedale UniversitàPadovaItaly Local Health Unit Scaligera VeronaItaly Veneto Tumour Registry Azienda ZeroPadovaItaly 不详

Cervical intraepithelial neoplasia grade 2(CIN2)lesions may regress spontaneously,offering an alternative to immediate treatment,especially for women of childbearing age(15–45 years).We conducted a prospective multicentre study on conservative CIN2 management,with semiannual follow-up visits over 24 months,biomarkers’investigation and treatment for progression to CIN3+or CIN2 persistence for more than 12 ***,we assess women’s willingness to participate and adherence to the study *** study was set in population-based organised cervical cancer *** April 2019 to October 2021,640 CIN2 cases were diagnosed in women aged 25–64 participating in the screening *** to our predefined inclusion and exclusion criteria,228(35.6%)women were not eligible;93(22.6%)of the 412 eligible refused,and 319(77.4%)were *** for personal reasons(ie,desire to become pregnant,anxiety,difficulty in complying with the study protocol)and external barriers(ie,residence elsewhere and language problems)accounted for 71%and 17%,*** 9%expressed a preference for *** primary ineligibility factor was the upper age limit of 45 *** enrolment,12(4%)women without evidence of progression requested treatment,125(39%)were lost to follow-up(mostly after 6–12 months)and 182(57%)remained ***,40%of enrolees did not fully adhere to the protocol,whereas only 5%(20/412)of the eligible women desired *** study demonstrates a good acceptance of conservative management for CIN2 lesions by the women,supporting its implementation within cervical screening programmes.

关键词： cervical conservative centre

Pain management in acute musculoskeletal injury: Effect of opioid vs nonopioid medications

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World Journal of Orthopedics 2024年第9期15卷 882-890页

作者： Marco Fiore Luigi Aurelio Nasto Eleni McCaffery Fannia Barletta Angela Visconti Francesca Gargano enrico Pola Maria Caterina Pace Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Orthopaedics University of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine New York Presbyterian-Brooklyn Methodist HospitalNew YorkNY 11215United States Department of Anesthesia and Intensive Care “San Carlo”HospitalPotenza 85100Italy Department of Anaesthesia “San Giuliano”HospitalGiugliano 80014Italy Unit of Anesthesia and Intensive Care The Fondazione Policlinico Universitario Campus Bio-MedicoRome 00128Italy

BACKGROUND The use of opioids for pain is linked to an increased risk of developing opioid use disorder,and has resulted in the emergence of the opioid crisis over the last few *** The systematic review question is“How does the use of opioid medications in pain management,compared with non-opioid medications,affect pain intensity over the short,intermediate,and long-term in adults with acute traumatic pain?”.METHODS The protocol was prospectively registered on the International Prospective Re-gister of Systematic Reviews:*** and Google Scholar were electronically searched for controlled peer-reviewed studies published in full,with the PICO framework:P:Adult patients with traumatic injuries,I:Opioid medications,C:Non-opioid medi-cations,O:A minimum clinically important difference(MCID)in *** After full-text screening,we included 14 studies in the qualitative *** these 14 studies,12 were rando-mized clinical trials(RCTs)and 2 were pseudo-RCTs with a total of 2347 patients *** was heteroge-neity in both medication utilized and outcome in these studies;only two studies were homogeneous regarding the type of study conducted,the opioid used,its comparator,and the outcome *** MCID was evaluated in 8 studies,while in 6 studies,any measured pain reduction was considered as an *** 11 cases,the setting of care was the Emergency Department;in 2 cases,care occurred out-of-hospital;and in one case,the setting was not *** included studies were found to have a low-moderate risk of *** Non-opioids can be considered an alternative to opioids for short-term pain management of acute musculoskeletal *** ketamine may cause more adverse events than other routes of administration.

关键词： Acute musculoskeletal injury Acute traumatic pain Non-opioid analgesia Non-opioid pain control Opioid-sparing analgesia Opioid crisis Opioid disorder Systematic review

Physical insights into trapping effects on vertical GaN-on-Si trench MOSFETs from TCAD

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Journal of Semiconductors 2024年第3期45卷 45-52页

作者： NicolòZagni Manuel Fregolent Andrea Del Fiol Davide Favero Francesco Bergamin Giovanni Verzellesi Carlo De Santi Gaudenzio Meneghesso enrico Zanoni Christian Huber Matteo Meneghini Paolo Pavan Department of Engineering“Enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy Department of Information Engineering University of PadovaPadova 35131Italy Department of Sciences and Methods for Engineering(DISMI) University of Modena and Reggio EmiliaReggio Emilia 42122Italy EN&TECH Center University of Modena and Reggio EmiliaReggio Emilia 42122Italy Advanced Technologies and Micro Systems Department Robert Bosch GmbHRenningen 71272Germany

Vertical GaN power MOSFET is a novel technology that offers great potential for power switching *** still in an early development phase,vertical GaN devices are yet to be fully optimized and require careful studies to foster their *** this work,we report on the physical insights into device performance improvements obtained during the development of vertical GaN-on-Si trench MOSFETs(TMOS’s)provided by TCAD simulations,enhancing the dependability of the adopted process optimization ***,two different TMOS devices are compared in terms of transfer-curve hysteresis(H)and subthreshold slope(SS),showing a≈75%H reduction along with a≈30%SS *** allow attributing the achieved improvements to a decrease in the border and interface traps,respectively.A sensitivity analysis is also carried out,allowing to quantify the additional trap density reduction required to minimize both figures of merit.

关键词： vertical GaN trench MOSFET SiO_(2) interface traps border traps hysteresis BTI

Experimental rigs for testing components of advanced industrial applications

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Friction 2019年第1期7卷 59-73页

作者： enrico CIULLI Department of Civil and Industrial Engineering University of Pisa

This paper presents experimental rigs of the Research Centre for the Mechanics of Turbomachinery of the Department of Civil and Industrial Engineering of the University of Pisa. Most of them were designed and constructed to allow investigations of real machine components and to furnish more realistic results than basic tribological test rigs. Tilting pad journal bearings, as well as gears and complete gearboxes for advanced industrial applications, can be tested using the rigs described in the paper. A novel test rig with a power rating of approximately 1 MW allows investigations of the static and dynamic characteristics of high-performance tilting pad journal bearings for turbomachinery. A twin disc machine and closed loop gear test rig are used to investigate the different kinds of wear mechanisms occurring in gears. Functional and durability tests on planetary gearboxes for new turbo-fan engines could be performed using another novel large test rig. A circulating power configuration was adopted for most of the rigs so that only the power needed to cover the friction losses has to be supplied, while the circulating power can be more than 20 times higher. All the test rigs include very complex load applications and lubrication plants, as well as dedicated control and data acquisition systems. The rigs and related plants were designed and constructed through strong and fruitful collaborations between the university and some large and small–medium companies. Despite some limitations in the publication of the results as a result of the industrial sensitivity of the data, the synergy among these different actors was stimulating and fundamental for the realization of new advanced industrial applications.

关键词： experimental rigs tilting pad journal bearings twin disc machine gears gearboxes

Single-particle spectral function of the Hubbard chain:frustration induced

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Chinese Physics B 2009年第6期18卷 2475-2480页

作者：王竞 enrico Arrigoni Department of Physics Fudan University Institute of Theoretical Physics and Computational Physics Graz University of Technology

The one-electron spectral function of a frustrated Hubbard chain is computed by making use of the cluster perturbation theory. The spectral weight we found turns out to be strongly dependent on the frustrating next-nearest-neighbor hopping t′. A frustration induced pseudogap arises when the system evolves from a gapful Mott insulator to a gapless conductor for an intermediate value of the frustration parameter ｜t′｜. Furthermore, the opening of a pseudogap in the density of states already in the metallic side leads to a continuous opening of the true gap in the insulator. For the hole-doped case, the pseudogap is pinned at the Fermi energy, while the Mott gap is shifted in energy with increasing Hubbard interaction U. The separation of the pseudogap and Mort gap in the hole-doped system demonstrates the validity of the existence of a pseudogap.

关键词： cluster perturbation theory pseudogap metal-insulator transitions

Optimized design and integration of energy storage in Solar-Assisted Ground-Source Heat Pump systems

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Building Simulation 2023年第10期16卷 1933-1948页

作者： Maria Ferrara enrico Fabrizio Department of Energy Politecnico di TorinoTurin10121Italy

The integrated use of multiple renewable energy sources to increase the efficiency of heat pump systems,such as in Solar Assisted Geothermal Heat Pumps(SAGHP),may lead to significant benefits in terms of increased efficiency and overall system performance especially in extreme climate contexts,but requires careful integrated optimization of the different system *** particular,thermal storages take a fundamental role in optimizing the integration of renewable energy sources and the system *** work investigates the potential design optimization of a SAGHP system in a mountain site by exploring many different alternatives to optimize the mutual relationship between the solar field,the geothermal field and the water thermal *** is done through an original simulation-based multi-objective optimization framework considering energy efficiency and economic feasibility,which allows appraising the impact of the different design alternatives on the overall system performance and on the dynamics of the different system *** identify a set of optimized system configurations that optimize the integrated exploitation of the different thermal sources showing a potential increase of the overall system performance leading to 34%lower global cost compared to the initial *** robustness of the optimal design solutions is reported with respect to the current context of high economic uncertainty.

关键词： thermal storage geothermal energy heat pumps building simulation artificial intelligence cost optimization energy flexibility

Imprinted membranes for sustainable separation processes

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 775-792页

作者： Laura Donato enrico Drioli Research Institute on Membrane Technology CNR-ITMUniversity of Calabria87030 Rende(CS)Italy Department of Engineering and of the Environment University of Calabria87030 Rende(CS)Italy College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China Centre of Excellence in Desalination Technology King Abdulaziz UniversityJeddah 21589Saudi Arabia

The rapid industrial growth and the necessity of recovering and recycling raw materials increased the interest in the production of highly selective and efficient separation *** this perspective,a relevant input was given by the membrane-based technology and the production of imprinted membranes,which possess specific recognition properties at molecular and ionic level,offers the possibility of developing sustainable and green ***,the integration of imprinted membranes with traditional or membrane-based approaches is a promising strategy in the logic of process intensification,which means the combination of different operations in a single *** work discusses the concept and separation mechanisms of imprinted ***,it presents an overview of their application in organic solvent nanofiltration,for the removal of toxic agents and recovery solvent,as well as valuable *** recent advances in water treatment,such as pesticide removal and recovery of metal ions,are also ***,potential applications of imprinted membranes in hybrid processes are highlighted,and a look into the future of membrane separations for water treatment and recovery of critical raw materials is offered.

关键词： sustainable processes membrane separation molecular recognition imprinted membranes water treatment

Evolution of computers and simulations: from science and technology to the foundations of society

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Science China Chemistry 2014年第10期57卷 1317-1329页

作者： CLEMENTI enrico International Academy of Quantum Molecular Science

We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.

关键词： constraints for Homo Sapiens evolution of continents human life electronic computers knowledge the scientificmethod vs. tradition computational chemistry inter-disciplinary science

Ligninolytic Peroxidase-Like Activity of a Synthetic Metalloporphine Immobilized onto Mercapto-Grafted Crosslinked PVA Inspired by the Active Site of Cytochrome P450

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催化学报 2011年第11期32卷 1663-1666页

作者： Paolo ZUCCA Antonio RESCIGNO enrico SANJUST Dipartimento di Scienze e Tecnologie Biomediche Università di Cagliari Monserrato 09042 Italy Consorzio per lo Sviluppo dei Sistemi a Grande Interfase Sesto Fiorentino 50019 Italy

A synthetic metalloporphine was immobilized onto a PVA-based and mercapto-grafted solid support, emulating the active site of cytochrome P450. Its ligninolytic peroxidase-like catalytic activity was studied. The coordinated mercapto ligand significantly affected the catalytic features of the catalyst because the oxidation of lignin-model compounds was very slow by comparison with imidazoleand pyridine-coordinated immobilized metalloporphines. Conversely, the catalyst efficiently bleached several industrial dyes and thus demonstrated promising activity for this application. Based on this altered substrate specificity the oxygen-donor catalytic route seems to be more favorable than a single electron oxidation pathway.

关键词： porphine porphyrin lignin peroxidase cytochrome P450 biomimetic