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Editorial article to:Animal experimental study on magnetic anchor technique-assisted endoscopic submucosal dissection of early gastric cancer

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 51-54页

作者： enrico Fiori Antonietta Lamazza Daniele Crocetti Antonio V Sterpetti Department of Surgery Sapienza University of RomeRome 00161Italy Department of Surgery University of Rome La SapienzaRome 00161Italy

In this editorial we comment on the article published in the recent issue of the World Journal of Gastrointestinal Endoscopy 2023;15(11):*** cancer(GC)remains the fifth most common malignancy and the fourth leading cause of cancer-related death *** overall prevalence of GC has declined,although that of proximal GC has increased over ***,a significant proportion of GC cases and deaths can be avoided if preventive interventions are *** GC(EGC)is defined as GC confined to the mucosa or *** resection is considered the most appropriate treatment for precancerous gastrointestinal lesions improving patient quality of life,with reduced rates of complications,shorter hospitalization period,and lower costs when compared to surgical *** mucosal resection(EMR)and endoscopic sub-mucosal dissection(ESD)are representative endoscopic treatments for EGC and precancerous gastric *** EMR implies injection of a saline solution into the sub-mucosal space,followed by excision of the lesion using a *** resection rates vary depending on the size and severity of the *** using conventional EMR methods for lesions less than 1 cm in size,the complete resection rate is approximately 60%,whereas for lesions larger than 2 cm,the complete resection rate is low(20%-30%).ESD can be used to remove tumors exceeding 2 cm in diameter and lesions associated with ulcers or submucosal *** with EMR,ESD has higher en bloc resection rates(90.2%vs 51.7%),higher complete resection rates(82.1 vs 42.2%),and lower recurrence rates(0.65%vs 6.05%).Thus,innovative techniques have been introduced.

关键词： Gastric cancer Early gastric cancer Endoscopic resection Endoscopic mucosal resection Endoscopic sub-mucosal dissection

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Galvanic Skin Response—Extinction Biofeedback Training for Psychogenic Abdominal Pain: A Validation Protocol

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Journal of Biosciences and Medicines 2024年第5期12卷 190-201页

作者： Maddalena Castelletti enrico Berné Erasmo Dionigio Carlo Castagnoli Alberto Montagna Giorgio Tonon Magenta Medical Center Milan Italy Castagnoli Medical Center Garlasco Italy GEA Soluzioni Turin Italy

Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to high pain interference with daily activities. Cognitive behavioral psychological therapy and neuromodulation with biofeedback are validated therapies for the treatment of this condition. Aim of the present research work is the validation of a therapeutic protocol that involves the use of both techniques in combination. 20 patients diagnosed with psychogenic abdominal pain, of both sexes, aged between 18 and 60 years who had not benefited from pharmacological therapies were enrolled. 10 patients were randomly assigned to the control group (psychological treatment only), another 10 patients were assigned to the study group (neuromodulation with biofeedback-Galvanic skin response-extinction in combination with psychological therapy). For both groups, the pain score, interference of pain with daily living activities, pain relief, and the share of anxiety associated with the pain condition were evaluated (pre- and post-treatment). The patients who underwent the combined treatment achieved statistically significant better scores than patients in the control group, respectively −4.9 ± 0.9 vs −1.0 ± 0.4 for Pain;−5.1 ± 1.1 vs −0.9 ± 0.3 for Interference with life;−7.2 ± 3.7 vs −2.2 ± 2.1 for HAMA;4.6 ± 1.2 vs 1.1 ± 0.6 for Relief.

关键词： Chronic Abdominal and Pelvic Psychogenic Pain (PAP) Biofeedback Training Pain Management Galvanic Skin Response (GSR)

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Physical insights into trapping effects on vertical GaN-on-Si trench MOSFETs from TCAD

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Journal of Semiconductors 2024年第3期45卷 45-52页

作者： NicolòZagni Manuel Fregolent Andrea Del Fiol Davide Favero Francesco Bergamin Giovanni Verzellesi Carlo De Santi Gaudenzio Meneghesso enrico Zanoni Christian Huber Matteo Meneghini Paolo Pavan Department of Engineering“Enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy Department of Information Engineering University of PadovaPadova 35131Italy Department of Sciences and Methods for Engineering(DISMI) University of Modena and Reggio EmiliaReggio Emilia 42122Italy EN&TECH Center University of Modena and Reggio EmiliaReggio Emilia 42122Italy Advanced Technologies and Micro Systems Department Robert Bosch GmbHRenningen 71272Germany

Vertical GaN power MOSFET is a novel technology that offers great potential for power switching *** still in an early development phase,vertical GaN devices are yet to be fully optimized and require careful studies to foster their *** this work,we report on the physical insights into device performance improvements obtained during the development of vertical GaN-on-Si trench MOSFETs(TMOS’s)provided by TCAD simulations,enhancing the dependability of the adopted process optimization ***,two different TMOS devices are compared in terms of transfer-curve hysteresis(H)and subthreshold slope(SS),showing a≈75%H reduction along with a≈30%SS *** allow attributing the achieved improvements to a decrease in the border and interface traps,respectively.A sensitivity analysis is also carried out,allowing to quantify the additional trap density reduction required to minimize both figures of merit.

关键词： vertical GaN trench MOSFET SiO_(2) interface traps border traps hysteresis BTI

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Optimized design and integration of energy storage in Solar-Assisted Ground-Source Heat Pump systems

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Building Simulation 2023年第10期16卷 1933-1948页

作者： Maria Ferrara enrico Fabrizio Department of Energy Politecnico di TorinoTurin10121Italy

The integrated use of multiple renewable energy sources to increase the efficiency of heat pump systems,such as in Solar Assisted Geothermal Heat Pumps(SAGHP),may lead to significant benefits in terms of increased efficiency and overall system performance especially in extreme climate contexts,but requires careful integrated optimization of the different system *** particular,thermal storages take a fundamental role in optimizing the integration of renewable energy sources and the system *** work investigates the potential design optimization of a SAGHP system in a mountain site by exploring many different alternatives to optimize the mutual relationship between the solar field,the geothermal field and the water thermal *** is done through an original simulation-based multi-objective optimization framework considering energy efficiency and economic feasibility,which allows appraising the impact of the different design alternatives on the overall system performance and on the dynamics of the different system *** identify a set of optimized system configurations that optimize the integrated exploitation of the different thermal sources showing a potential increase of the overall system performance leading to 34%lower global cost compared to the initial *** robustness of the optimal design solutions is reported with respect to the current context of high economic uncertainty.

关键词： thermal storage geothermal energy heat pumps building simulation artificial intelligence cost optimization energy flexibility

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A review on membrane distillation in process engineering: design and exergy equations, materials and wetting problems

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Frontiers of Chemical Science and Engineering 2022年第5期16卷 592-613页

作者： Stefano Capizzano Mirko Frappa Francesca Macedonio enrico Drioli Institute of Membrane Technology National Research Council of ItalyRende 87036Italy Department of Environmental Engineering University of CalabriaRendeItaly Nanjing Tech University College of Chemical EngineeringNanjing 211816China

One of the problems that most afflicts humanity is the lack of clean *** stress,which is the pressure on the quantity and quality of water resources,exists in many places throughout the *** represents a valid solution to the scarcity of fresh water and several technologies are already well applied and successful(such as reverse osmosis),producing about 100 million m^(3)·d^(-1) of fresh *** advances in the field of desalination can be provided by innovative processes such as membrane *** latter is of particular interest for the treatment of waste currents from conventional desalination processes(for example the retentate of reverse osmosis)as it allows to desalt highly concentrated currents as it is not limited by concentration polarization *** perspectives have enhanced research activities and allowed a deeper understanding of mass and heat transport phenomena,membrane wetting,polarization phenomena and have encouraged the use of materials particularly suitable for membrane distillation *** work summarizes recent developments in the field of membrane distillation,studies for module length optimization,commercial membrane modules developed,recent patents and advancement of membrane material.

关键词： membrane distillation recent developments heat and mass transfer wetting membrane material

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Integrated fault estimation and fault-tolerant control for a flexible regional aircraft

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Chinese Journal of Aeronautics 2022年第3期35卷 390-399页

作者： Yishi LIU Sheng HONG enrico ZIO Jianwei LIU School of Cyber Science and Technology Beihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Department of Energy Politecnico di MilanoMilano 20133Italy MINES ParisTech PSL Research UniversityCRCSophia Antipolis 06904France Eminent Scholar Department of Nuclear EngineeringCollege of EngineeringKyung Hee UniversitySeoul 02447South Korea

The article focuses on the design and application of an active reconfigurable controller that mitigates the effects of gust load and actuator faults on a flexible aircraft.A novel integrated adaptive output feedback scheme is investigated to address the actuator *** real-time fault values provided by the fault estimation module are considered in the reconfigurable control law to improve the fault-tolerant *** estimate values of faults and control gains are calculated by analyzing the stability of the overall *** proposed controller is simulated using a flexible aircraft model with a discrete‘1-cosine’gust,and the results show that it can effectively mitigate the wing root moments and recover the flight maneuver stability after the aircraft suffered from gusts.

关键词： Adaptive control Fault estimation Fault-tolerant control Flexible aircraft Gust load Integrated strategy

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Proof of concept of a self-tightening needle-less suture using a NiTi shapememory alloy

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生物设计与制造(英文) 2023年第5期6卷 536-549页

作者： Adelaide Nespoli Davide Ninarello enrico Bassani Villiam Dallolio Institute of Condensed Matter Chemistry and Technologies for Energy National Research Council(CNR-ICMATE)23900 LeccoItaly Promev Srl 23900 LeccoItaly

Among surgical procedures,suturing is considered ***,in some situations,suturing is not easy or ***,we present proof of concept of a new self-tightening needle-less suture made of a NiTi *** new device is designed to overcome two demanding steps of traditional suturing:needle introduction and manual *** novel suture is composed only of a short NiTi wire that is able to change shape by exploiting a thermoelastic phase *** shape change is achieved by increasing the temperature from that of the operating room(e.g.,20-22℃)to 32℃using warm *** consists of two steps:suture introduction,in which the suture is in an open configuration,and shape recovery(i.e.,closed configuration).The closed configuration is maintained at human body temperature thanks to peculiar pseudoelastic properties of the NiTi ***,thermal and functional characterization verified the simplicity and effectiveness of the proposed device.

关键词： Suture NiTi Shape memoryalloys Suturing Medical device

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Surroundings affect slip length dynamics in nanoscale friction through contact stiffness and damping

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Friction 2023年第2期11卷 216-227页

作者： Simona SKURATOVSKY Liron AGMON enrico GNECCO Ronen BERKOVICH Department of Chemical Engineering Ben-Gurion University of the NegevBeer-Sheva 8410501Israel Marian Smoluchowski Institute of Physics Jagiellonian UniversityLojasiewicza 11Krakow 30-348Poland Ilze Katz Institute for Nanoscience and Technology Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

Friction force microscopy (FFM) explores the interaction in a sliding contact on the nanoscale, providing information on the frictional dynamics and lateral contact stiffness with lattice resolution. Recent FFM measurements on a NaCl crystal immersed in liquid (ethanol) surroundings displayed an increase of the effective contact stiffness, K_(eff), with the applied load, differently from similar measurements performed under ultra-high vacuum (UHV) conditions, where K_(eff) showed negligible load dependency. Additionally, under UHV conditions multiple slip length friction with increasing load was reported, while in ethanol surroundings only single (lattice unit length) slips were observed. Our current understanding of this behavior relates the transition from single jumps to multiple jumps dynamics to the normal load (manifested through the amplitude of the interaction potential at the contact, U0) and to the damping of the system. Here we have incorporated the effect of the load dependency on both U0 and K_(eff) within Prandtl‒Tomlinson based simulations, accompanied by variations in the damping coefficient of the system. Introducing the experimentally observed load dependency to K_(eff) resulted indeed in single slip jumps at critical damping, while multiple slip jumps were obtained at constant K_(eff). The average slip length increased with the normal load, particularly when the system became underdamped. Our work provides a glimpse on the relation between the characteristic observables in atomic-scale sliding friction (maximal slip forces, stiffness, and slip dynamics) with respect to their governing parameters (corrugation energy, effective stiffness, and damping). While common understanding in nanotribology relates the effect of surrounding media mainly to the interaction potential at the contact, here we show that the media can also greatly affect the elastic interaction, and consequently play an important role on the transition from single to multiple stick-s

关键词： friction force microscopy(FFM) nanoscale friction multiple jumps Prandtl‒Tomlinson model effective stiffness damping

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The application of reinforcement learning to NATM tunnel design

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Underground Space 2022年第6期7卷 990-1002页

作者： enrico Soranzo Carlotta Guardiani Wei Wu University of Natural Resources and Life Sciences Feistmantelstraße 4Vienna 1180Austria

The New Austrian Tunnelling Method(NATM)tunnel design is performed by testing support classes against the geological *** propose to replace this manual process with reinforcement learning,a generic framework within the realm of artificial intelligence that solves control *** studies have demonstrated this possibility,albeit with methodological *** coupled the Finite Difference Method with a Python script,used the output of the first to train the machine learning model implemented in the latter and improved the choice of the support *** benchmark tests,we demonstrated that our method was capable of choosing the optimal support classes for various geological sets and showed the relation between its performance and the number of training episodes.

关键词： Deep Q-Network NATM Reinforcement learning Support classes Tunnelling

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External anal sphincter electromyography in multiple system atrophy:implications for diagnosis,clinical correlations,and novel insights into prognosis

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Neural Regeneration Research 2023年第9期18卷 1903-1907页

作者： Massimiliano Todisco Giuseppe Cosentino enrico Alfonsi Translational Neurophysiology Research Unit IRCCS Mondino FoundationPaviaItaly Movement Disorders Research Center IRCCS Mondino FoundationPaviaItaly Department of Brain and Behavioral Sciences University of PaviaPaviaItaly

Multiple system atrophy is a sporadic,progressive,adult-onset,neurodegenerative disorder characte rized by autonomic dysfunction symptoms,parkinsonian features,and cerebellar signs in va rious *** early diagnosis of multiple system atrophy is of utmost impo rtance for the proper prevention and management of its potentially fatal complications leading to the poor prognosis of these *** current diagnostic criteria incorporate several clinical red flags and magnetic resonance imaging marke rs supporting diagnosis of multiple system ***,especially in the early disease stage,it can be challenging to differentiate multiple system atrophy from mimic disorders,in particular Parkinson’s *** of the external anal sphincter represents a useful neurophysiological tool for diffe rential diagnosis since it can provide indirect evidence of Onuf’s nucleus degeneration,which is a pathological hallmark of multiple system ***,the diagnostic value of external anal sphincter electromyography has been a matter of debate for three decades due to controve rsial reports in the *** this review,after a brief ove rview of the electrophysiological methodology,we first aimed to critically analyze the available knowledge on the diagnostic role of external anal sphincter *** discussed the conflicting evidence on the clinical correlations of neurogenic abnormalities found at external anal sphincter electro ***,we repo rted recent prognostic findings of a novel classification of electromyography patterns of the external anal sphincter that could pave the way toward the implementation of this neurophysiological technique for survival prediction in patients with multiple system atrophy.

关键词： bowel dysfunction differential diagnosis dysautonomia electrophysiology multiple system atrophy Onuf’s nucleus degeneration parkinsonism Parkinson’s disease prognostic prediction urogenital symptoms

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