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Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

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Open Journal of Gastroenterology 2014年第2期4卷 73-80页

作者： engin altintas Zuhal Mert altintas Orhan Sezgin Enver Ucbilek Erdinc Nayir Mehmet Emin Erdal Ayse Polat Gulhan Orekeci Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey Department of Medical Biology and Genetic Faculty of Medicine University of Mersin Mersin Turkey Department of Pathology Faculty of Medicine University of Mersin Mersin Turkey Gastroenterology Department Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: The mechanism of steatosis in Hepatitis C virus infection is multifactorial;therefore, it is complex and unclear. The aim of this study was to investigate the effects of methylentetrahydrofolate reductase (MTHFR) gene polymorphisms on the course of chronic hepatitis C virus infection and the development of steatosis due to hepatitis C virus. Methods: This study included 109 patients with chronic hepatitis C virus infection. Necroinflammatory activity, degrees of fibrosis and steatosis and MTHFR gene polymorphisms were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to determine MTHFR C677T and A1298C polymorphisms. Results: Fibrosis was correlated with age (r = 0.336, p = 0.002), platelet (r = ?0.448, p < 0.0001), ALT (r = 0.241, p = 0.026), AST (r = 0.361) and GGT (r = 0.224, p = 0.039). Steatosis was only correlated with fibrosis. MTHFR C677T and A1298C polymorphisms did not have a significant effect on the degree of steatosis (p = 0.857, p = 0.202 respectively). There was a relation between MTHFR C677T and the degree of fibrosis but not A1298C (p = 0.014, p = 0.187 respectively). Conclusion: We found that MTHFR C677T polymorphism contributed to the development of fibrosis in patients with chronic hepatitis C virus infection.

关键词： Fibrosis Hepatitis C Gene Polymorphism Methylenetetrahydrofolate Reductase Steatosis

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Effects of terlipressin on systolic pulmonary artery pressure of patients with liver cirrhosis: An echocardiographic assessment

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World Journal of Gastroenterology 2004年第15期10卷 2278-2280页

作者： engin altintas Necdet Akkus Ramazan Gen M.Rami Helvaci Orhan Sezgin Dilek Oguz Division of Gastroenterology Mersin UniversitySchool of MedicineMersinTurkey Cardioiogy Department Mersin UniversitySchool of MedicineMersinTurkey Internal Medicine Department Mersin UniversitySchool of MedicineMersinTurkey Gastroenterology

AIM: Portopulmonary hypertension is a serious complication of chronic liver disease. Our aim was to search into the effect of terlipressin on systolic pulmonary artery pressure among cirrhotic ***: Twelve patients (6 males and 6 females) with liver cirrhosis were recruited in the study. Arterial blood gas samples were obtained in sitting position at rest. Contrast enhanced echocardiography and measurements of systolic pulmonary artery pressure were performed before and after the intravenous injection of 2 mg ***: Of 12 patients studied, the contrast enhanced echocardiography was positive in 5, and the positive findings in contrast enhanced echocardiography were reversed to normal in two after terlipressin injection. The mean systolic pulmonary artery pressure was 25.5+3.6 mmHg before terlipressin injection, and was 22.5+2.5 mmHg after terlipressin (P=0.003). The systolic pulmonary artery pressure was above 25 mmHg in seven of these 12 *** the terlipressin injection, systolic pulmonary artery pressure was <25 mmHg in four of these cases (58.3% vs25%, P=-0.04).CONCLUSION: Terlipressin pulmonary artery pressure incan decrease the systolicpatients with liver cirrhosis.

关键词：心脏收缩肺动脉压肝硬化心血管声像图并发症

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Erythrocyte Membrane Protein Band 3 Predicts Interferon Ribavirin-Induced Anemia

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Open Journal of Regenerative Medicine 2019年第2期8卷 5-16页

作者： engin altintas Serap Yalin Orhan Sezgin Enver Ucbilek Anil Tombak Arzu Kanik Department of Gastroenterology Faculty of Medicine University of Mersin Mersin Turkey Faculty of Pharmacy University of Mersin Mersin Turkey Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: It was proposed that the differences in erythrocyte membrane protein contents—especially band 4—take a role in the serious anemia related to interferon plus ribavirin (I/R). The aim of this study is to evaluate whether the erythrocyte membrane protein contents predict anemia related to I/R or not. Methods: 180 mcg interferon α 2a once a week and weight adjusted ribavirin daily were given for 48 weeks to fifty patients with chronic hepatitis C. It was diagnosed as anemia when haemoglobin concentration was Results: Anemia developed in 17 patients (34%). The levels of erythrocyte membrane proteins were as;spectrin: 20.468 ± 2.5902, ankyrin: 4.576 ± 1.2706, B3: 19.240 ± 2.8358, B4.1: 5.628 ± 1.8832, and B4.2: 5.848 ± 1.8030. When the relation between the development of anemia and erythrocyte membrane proteins was investigated, a relation was only found at B3 which was not statistically significant (p = 0.058). When ROC analysis was performed, 95% CI p = 0.035 for B3 (0.517 - 0.792) was found. In patients whose B3 level was below 17.7%, the sensitivity of anemia development risk was calculated as 64.7% and the specificity thereof was calculated as 66.7%. Erythrocyte membrane protein contents by gender were only different at B3 (p = 0.042). Anemia developed in 17 patients (34%). 14 of these patients were of female and 3 were of male gender;the gender played a significant role in terms of anemia (p = 0.003). Conclusions: Erythrocyte membrane protein B3 is not only useful in predicting the patient under the risk of developing anemia, but also it may be useful in preventing it and it may explain why women inclined to anemia.

关键词： Anemia Erythrocyte Membrane Protein Interferon Ribavirin

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Effect of interferon and ribavirin combined with amantadine in interferon and ribavirin non-responder patients with chronic hepatitis C (genotype 1)

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World Journal of Gastroenterology 2005年第4期11卷 580-583页

作者： Dilek Oguz Bahattin Cicek Levent Filik Bulent Odemis Mesut Kilic engin altintas Neslihan Zengin Emin Altiparmak Turkiye Yuksek Ihtisas Hospital Gastroenterology Clinic Mersin University Department of Gastroenterology Turkiye Yuksek Ihtisas Hospital Department of Pathology Turkiye Yuksek Ihtisas Hospital Gastroenterology Clinic

AIM: To evaluate the efficacy of amantadine plus interferonalpha and ribavirin in non-responder patients with chronic hepatitis ***: Twenty-six non-responder patients received the regimen of IFN-α-2a at a dose of 6 million units three times a week, 1 000-1 200 mg of ribavirin daily, and 200 mg of amantadine daily in divided doses over 48 wk. After the end of treatment, at the 72nd wk, a sustained viral response rate was ***: An early (after 12 wk of therapy) response was seen in 34.6% (9/26) of patients. Response rate at the 24th wk was 42.3% (11/26). End of treatment response (ETR) was 53.8% (14/26). Sustained viral response (SVR) was 42.3% (11/26). There was a statistically significant difference between 0 and 12 wk (P = 0.04), 0 and 24 wk (P = 0.01), 0 and 48 wk (P = 0.00), and 0 and 72 wk (P = 0.001). No patient had severe adverse effects during the ***: Combination regimen of interferon-α,ribavirin and amantadine can enhance sustained viral response on IFN-α and ribavirin non-responder patients with HCV. Triple therapy with amantadine should be evaluated in further studies.

关键词：干扰素病毒唑氨基三环癸烷慢性丙型肝炎 IFN-α-2a

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通用螺旋立铣刀的力学和动力学模型（一）

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国外金属加工 2003年第2期24卷 36-42页

作者： S.engin Y.altintas 吴喜让宗荣珍不详南阳理工学院机电系河南南阳473004

在工业上使用各种形状的螺旋立铣刀。在航空和宇航、汽车和模具工业上，广泛使用螺旋圆柱、螺旋球头、圆锥螺旋球头、大圆角和专用立铣刀。每种铣刀的形状可能不同，但在每个刀刃切割点切削过程的力学和动力学是共同的。本文介绍工业上... 详细信息

在工业上使用各种形状的螺旋立铣刀。在航空和宇航、汽车和模具工业上，广泛使用螺旋圆柱、螺旋球头、圆锥螺旋球头、大圆角和专用立铣刀。每种铣刀的形状可能不同，但在每个刀刃切割点切削过程的力学和动力学是共同的。本文介绍工业上使用的大多数螺旋立铣刀的广义数学模型。立铣刀形状用绕参数包络包缠的螺旋槽建模。沿参数螺旋槽的刀刃点的坐标用数学表出。应用包含刀具和工件两者振动结构的纯铣削运动学，估计出每一切削点处的切屑厚度。沿和工件接触的每一切削刃进行积分，对任意立铣可预测出切削力、振动、尺寸表面粗糙度和颤振稳定性图。预测出的切削力、表面粗糙度和稳定性图，对于球头、螺旋锥球头和大圆角立铣，可证实本文提出的广义立铣分析方法的可行性。。

关键词：螺旋立铣刀动力学模型力学模型切削力颤振

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