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Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis:In vitro and in vivo study

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 243-252页

作者： enas m.ali manal A.Alfwuaires Gehan m.Badr Department of Biological Sciences Faculty of ScienceKing Faisal UniversityP.O.Box 380Al-Ahsa 31982Saudi Arabia Department of Botany and microbiology Faculty of ScienceCairo UniversityCairo 12613Egypt Department of Zoology Faculty of ScienceAin Shams UniversityCairo11566Egypt

Objective:To characterize the antifungal activity of methanolic leaf extract of Calotropis gigantea alone or in combination with amphotericin B against invasive pulmonary aspergillosis in ***:GC/mS was used for analysis of active constituents of Calotropis gigantea *** germination assay and broth micro-dilution method were used to determine antifungal potential of Calotropis gigantea/amphotericin B against Aspergillus *** mice were randomly assigned into 5 groups:group 1 was neutropenic(control);group 2 was infected with Aspergillus fumigatus;group 3 was infected with Aspergillus fumigatus,and treated with Calotropis gigantea extract;group 4 was infected with Aspergillus fumigatus and treated with amphotericin B;group 5 was infected with Aspergillus fumigatus and treated with both Calotropis gigantea extract and amphotericin *** lung tissues were histopathologically *** burden and gliotoxin concentration were evaluated in lung ***,superoxide dismutase,and malondialdehyde content were determined in lung ***,tumor necrosis factor-alpha,interleukin-1,and interleukin-17 were also estimated by the sandwich enzyme-linked immuno-sorbent ***:Calotropis gigantea/amphotericin B had a minimum inhibitory concentration and minimum fungicidal concentration of 80 and 160μg/mL,respectively,for Aspergillus ***,Calotropis gigantea/amphotericin B significantly reduced lung fungal burden by 72.95%and inhibited production of gliotoxin in lung tissues from 6320 to 1350μg/g *** gigantea/amphotericin B reduced the oxidative stress of the lung via elevating the activity of antioxidant enzymes and decreasing the levels of lipid *** activity and the production of pro-inflammatory cytokines were also significantly *** electron microscopy revealed deteriorations in the hyphae ultrastructure in Calotropis gigantea/amphotericin B trea

关键词： Aspergillus fumigatus Antifungal Invasive pulmonary aspergillosis Calotropis gigantea Amphotericin B mice

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Corrosion Protection of 5083 AA in SalineWater by Polyacrylonitrile Nanofibers

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Journal of Renewable materials 2021年第11期9卷 1927-1939页

作者： enas H.ali Juman A.Naser Zainab W.Ahmed Taki A.Himdan Department of Chemistry College of Education for Pure Science-Ibn Al-HaithamUniversity of BaghdadBaghdadIraq

Polymeric nanofibers are a promising technology to protect the metal surfaces from *** the literature search,the use of polyacrylonitrile nanofibres(PANNFs)as a corrosion inhibitor coating for aluminum alloys has not been *** work includes the development of a new,lightweight,high surface area and efficient coating of PANNFs that produced using electrospinning process to resist the corrosion of aluminum alloys(AA5083)which immersed in 0.6 m NaCl at alkaline medium(pH=12)and acidic medium(pH=1)at a range of temperatures(293–323)*** PANNFs coating was successfully deposited on AA 5083 specimens,where these samples were considered as a collector electrode in the electrospinning *** corrosion experiments of the aluminum alloys coated with PANNFs before and after immersion in both corrosive mediums were investigated using cyclic potential polarization(CPP).The results confirmed that the PANNFs coating was able to protect the surface of the aluminum specimens from corrosion,by reducing the corrosion current and increasing the surface polarization resistance,thus reducing the corrosion *** protection efficiency was found in the alkaline medium 98.8%while in the acidic medium 83.3%.So,it was in both mediums decreased with the increase in *** shape,distribution and size of the polymeric nanofibers that formed the coating were also examined using field emission scanning electron microscopy(FE-SEm)and the percentages of the structural components of these fibers were detected using the X-ray dispersion spectroscopy(EDS).The surface of aluminum specimens was completely covered by *** electrospun nanofibers have worn out and lined up spacing after immersion in the corrosive *** diameters average of PANNFs was found to be about 200 and 150 nm before and after immersion,respectively.

关键词： Corrosion protection nanofibers polyacrylonitrile aluminum alloy saline medium protection efficiency

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Budd-Chiari syndrome associated with coeliac disease:case report and literature review

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Gastroenterology Report 2018年第4期6卷 308-312,I0002页

作者： Khaled ali Jadallah enas Walid Sarsak Yara mohammad Khazaleh Rawan mohammad Khair Barakat Department of Internal medicine King Abdullah University HospitalIrbidJordan

We report a case of Budd-Chiari syndrome occurring in a patient with coeliac disease,who presented with symptoms of increased abdominal girth,right upper quadrant pain and shortness of breath for three weeks prior to *** assessment revealed the presence of moderate ascites,hepatosplenomegaly and right-sided pleural *** diagnostic work-up established a diagnosis of chronic Budd-Chiari ***,complete screening for pro-thrombotic factors was negative.A review of the literature on this association disclosed only 28 similar cases,with the majority of them describing individuals of North African ***,in the majority of cases no specific thrombotic factor could be identified,suggesting that coeliac disease may play a role in this thrombotic disorder.

关键词： coeliac disease Budd-Chiari syndrome hepatic vein thrombosis

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A review on zero energy buildings-Pros and cons

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Energy and Built Environment 2023年第1期4卷 25-38页

作者： Tabbi Wilberforce A.G.Olabi enas Taha Sayed Khaled Elsaid Hussein m.maghrabie mohammad ali Abdelkareem mechanical Engineering and Design Aston UniversitySchool of Engineering and Applied ScienceAston TriangleBirmingham B47ETUK Department of Sustainable and Renewable Energy Engineering University of SharjahP.O.Box 27272SharjahUnited Arab Emirates Center for Advanced materials Research University of SharjahPO Box 27272SharjahUnited Arab Emirates Chemical Engineering Department Minia UniversityElminiaEgypt Chemical Engineering Department Texas A&M UniversityTX 77843-3122College StationTXUSA Department of mechanical Engineering Faculty of EngineeringSouth Valley UniversityQena 83521Egypt

Enhancing the energy efficiency of structures has been a staple of energy *** key goal is to slash elec-tricity usage in order to minimize the footprint of *** goal is sought by putting restrictions on the design specifications with respect to the properties of the raw materials and components as well as the exploitation of sustainable sources of *** facts for the basis for zero-energy building(ZEB)being *** novel technology has faced several obstacles impeding its commercialization and future *** inves-tigation therefore holistically explored and evaluated the state of zero energy building and factors impeding their *** review further proposed some suggestion in terms of technology that can be considered by the sector to augment existing ***,the investigation touched on the effect of occupant’s character in zero energy *** in terms of government subsidies and tax rebates were recommended to encourage more investors into the ***,the perception of zero energy building being more expensive compared to the traditional structures can equally be curbed via efficient and effective public sensitization.

关键词： Zero energy buildings Policies Renewable energy Construction industry

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Progress in plant-based bioelectrochemical systems and their connection with sustainable development goals

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Carbon Resources Conversion 2021年第1期4卷 169-183页

作者： enas Taha Sayed mohammad ali Abdelkareem Khaled Obaideen Khaled Elsaid Tabbi Wilberforce Hussein m.maghrabie A.G.Olabi Center for Advanced materials Research University of SharjahPO Box 27272SharjahUnited Arab Emirates Chemical Engineering Department Minia UniversityElminiaEgypt Dept.of Sustainable and Renewable Energy Engineering University of SharjahP.O.Box 27272SharjahUnited Arab Emirates Chemical Engineering Department Texas A&M UniversityCollege StationTX 77843-3122TXUSA mechanical Engineering and Design Aston UniversitySchool of Engineering and Applied ScienceAston TriangleBirmingham B47ETUK Department of mechanical Engineering Faculty of EngineeringSouth Valley UniversityQena 83521Egypt

Living organisms’energy conversion is considered as an essential and sustainable green energy source and future bio-hybrid ***,plants were used after harvesting as biomass in bio-fermentation as an energy *** bio-electrochemical systems,microorganisms work with plants to generate electricity,hydrogen,or *** work discusses the simultaneous pollutant removal and electricity generation in plant-based bio-electrochemical systems(P-BES).Factors affecting the P-BES performance and the removal efficiencies of the different organic and inorganic pollutants were ***,the plant-based bioelectrochemical systems’role in achieving the sustainable development goals(SDGs)was *** SDGs contribution of plant-based bioelectrochemical systems were presented and discussed to evaluate such systems’ability to achieve the three pillars of sustainable development,i.e.,economic,environmental,and social.

关键词： Plant Bioelectrochemical systems Sustainable development goals,pollutant removal Power generation

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Ensemble machine Learning to Enhance Q8 Protein Secondary Structure Prediction

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Computers, materials & Continua 2022年第11期73卷 3951-3967页

作者： moheb R.Girgis Rofida m.Gamal enas Elgeldawi Computer Science Department Faculty of ScienceMinia University61519MiniaEgypt

Protein structure prediction is one of the most essential objectives practiced by theoretical chemistry and bioinformatics as it is of a vital importance in medicine,biotechnology and *** secondary structure prediction(PSSP)has a significant role in the prediction of protein tertiary structure,as it bridges the gap between the protein primary sequences and tertiary structure *** secondary structures are classified into two categories:3-state category and 8-state *** the 3 states and the 8 states of secondary structures from protein sequences are called the Q3 prediction and the Q8 prediction problems,*** 8 classes of secondary structures reveal more precise structural information for a variety of applications than the 3 classes of secondary structures,however,Q8 prediction has been found to be very challenging,that is why all previous work done in PSSP have focused on Q3 *** this paper,we develop an ensemble machine Learning(mL)approach for Q8 PSSP to explore the performance of ensemble learning algorithms compared to that of individual mL algorithms in Q8 *** ensemble members considered for constructing the ensemble models are well known classifiers,namely SVm(Support Vector machines),KNN(K-Nearest Neighbor),DT(Decision Tree),RF(Random Forest),and NB(Naïve Bayes),with two feature extraction techniques,namely LDA(Linear Discriminate Analysis)and PCA(Principal Component Analysis).Experiments have been conducted for evaluating the performance of single models and ensemble models,with PCA and LDA,in Q8 *** novelty of this paper lies in the introduction of ensemble learning in Q8 PSSP *** experimental results confirmed that ensemble mL models are more accurate than individual mL *** also indicated that features extracted by LDA are more effective than those extracted by PCA.

关键词： Protein secondary structure prediction(PSSP) Q3 prediction Q8 prediction ensemble machine leaning boosting bagging

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Physical and geometrical parameters of CVBS XIV:the two nearby systems HIP 19206 and HIP 84425

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Research in Astronomy and Astrophysics 2021年第7期21卷 62-70页

作者： mashhoor A.Al-Wardat enas Abu-Alrob Abdallah m.Hussein mohammad K.mardini ali A.Taani Hatem S.Widyan Zahraa T.Yousef Hamid m.Al-Naimiy Nihad A.Yusuf Department of Applied Physics and Astronomy University of SharjahSharjahUAE Sharjah Academy for Astronomy Space Science and TechnologySharjahUAE Department of Physics Al al-Bayt UniversityMafraq25113 Jordan Key Lab of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Physics Department Faculty of ScienceAl-Balqa Applied University19117 SaltJordan Department of Applied Physics Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Department of Physics Yarmouk UniversityIrbid21163Jordan

Data release 2(DR2) from the Gaia mission was of great help in precise determination of fundamental parameters of Close Visual Binary and multiple Systems(CVBmSs), especially masses of their components, which are crucial parameters in understanding formation and evolution of stars and galaxies. This article presents the complete set of fundamental parameters for two nearby close visual binary systems(CVBSs), which are HIP 19206 and HIP 84425. We utilised a combination of two methods;the first one is Tokovinin's dynamical method to solve the orbit of the system and to estimate orbital elements and the dynamical mass sum, and the second one is Al-Wardat's method for analysing CVBmSs to estimate the physical parameters of the individual components. The latest method employs grids of Kurucz lineblanketed plane parallel model atmospheres to build synthetic Spectral Energy Distributions(SEDs) of the individual components. Trigonometric parallax measurements given by Gaia DR2 and Hipparcos catalogues are used to analyse the two systems. The difference in these measurements yielded slight discrepancies in the fundamental parameters of the individual components, especially masses. So, a new dynamical parallax is suggested in this work based on the most convenient mass sum as given by each of the two methods. The new dynamical parallax for the system HIP 19205 of 22.97±0.95 mas coincides well with the trigonometric one reported recently(in December 2020) by Gaia EDR3 of 22.3689 ± 0.4056 mas. The positions of the components of the two systems on the evolutionary tracks and isochrones are plotted, which suggest that all components are solar-type main sequence stars. Their most probable formation and evolution scenarios are also discussed.

关键词： binaries:close binaries:visual-stars:fundamental parameters stars:individual:HIP 19206 and HIP 84425

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Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression

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World Journal of Gastroenterology 2016年第10期22卷 2931-2948页

作者： enas A Abd El-Haleim Ashraf K Bahgat Samira Saleh Department of Pharmacology and Toxicology Faculty of PharmacyCairo University Currently Faculty of Pharmaceutical Sciences and Pharmaceutical Industries Future University in Egypt

AIm: To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in ***: Giving a fructose-enriched diet (FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats (150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate (FENO) (100 mg/kg), resveratrol (RES) (70 mg/kg) and combined treatment (FENO + RES) (half the doses). All treatments were given orally from the 9th week till the end of experimental period. Body weight, oral glucose tolerance test (OGTT), liver index, glucose, insulin, insulin resistance (HOmA), serum and liver triglycerides (TGs), oxidative stress (liver mDA, GSH and SOD), serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α (TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3 (SOCS-3), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), malonyl CoA decarboxylase (mCD), transforming growth factor-β1 (TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were ***: Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, oxidative stress and dyslipidemia. As for gene expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis (NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, mDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance (OGTT, HOmA), serum and liver TGs, hepatic mDA, serum AST, AST/ALT rat

关键词： Fructose Nonalcoholic steatohepatitis Suppressor of cytokine signaling-3 Sterol regulatory element binding protein-1c Fatty acid synthase malonyl CoA decarboxylase Leptin Adiponectin Transforming growth factor-β Tumor necrosis factor-α

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CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair

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Journal of molecular Cell Biology 2018年第4期10卷 341-357页

作者： enas R. Abu-Zhayia Samah W. Awwad Bella m. Ben-Oz Hanan Khoury-Haddad Nabieh Ayoub Department of Biology Technion-Israel Institute of Technology Haifa 3200003 Israel

Cells have evolved DNA damage response （DDR） to repair DNA lesions and thus preserving genomic stability and impeding carcinogenesis. DNA damage induction is accompanied by transient transcription repression. Here, we describe a previously unrecognized role of chromodomain Y-like （CDYL1） protein in fortifying double-strand break （DSB）-induced transcription repression and repair. We showed that CDYL1 is rapidly recruited to damaged euchromatic regions in a poly （ADP-ribose） polymerase 1 （PARP1）-dependent, but ataxia telangiectasia mutated （ATm）-independent, manner. While the C-terminal region, containing the enoyl-CoA hydratase like （ECH） domain, of CDYL1 binds to poly （ADP-ribose）（PAR） moieties and mediates CDYL1 accumulation at DNA damage sites, the chromodomain and histone H3 trimethylated on lysine 9 （H3K9me3） mark are dispensable for its recruitment. Furthermore, CDYL1 promotes the recruitment of enhancer of zeste homolog 2 （EZH2）, stimulates local increase of the repressive methyl mark H3K27me3, and promotes transcription silencing at DSB sites. In addition, following DNA damage induction, CDYL1 depletion causes persistent G2/m arrest and alters H2AX and replication protein A （RPA2） phosphorylation. Remarkably, the ‘traffic-light reporter’ system revealed that CDYL1 mainly promotes homology-directed repair （HDR） of DSBs in vivo. Consequently, CDYL1-knockout cells display synthetic lethality with the chemotherapeutic agent, cisplatin. Altogether, our findings identify CDYL1 as a new component of the DDR and suggest that the HDR-defective ‘BRCAness’ phenotype of CDYL1-deficient cells could be exploited for eradicating cancer cells harboring CDYL1 mutations.

关键词： CDYL1 PARP1 double-strand breaks homology-directed repair non-homologous end joining H3K27me3 EZH2

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Changing dietary n-6:n-3 ratio using different oil sources affects performance,behavior,cytokines mRNA expression and meat fatty acid profile of broiler chickens

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Animal Nutrition 2018年第1期4卷 -页

作者： Doaa Ibrahim Rania El-Sayed Safaa I.Khater enas N.Said Shefaa A.m.El-mandrawy Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineZagazig University Department of Biochemistry Faculty of Veterinary MedicineZagazig University Department of Veterinary Public Health Faculty of Veterinary MedicineZagazig University Department of Clinical Pathology Faculty of Veterinary MedicineZagazig University

Typical formulated broiler diets are deficient in n-3 poly-unsaturated fatty acids(PUFA) due to widening n-6:n-3 PUFA ratio which could greatly affect performance,immune system of birds and,more importantly,meat *** study was conducted to evaluate the effect of modifying dietary n-6:n-3 PUFA ratio from plant and animal oil sources on performance,behavior,cytokine m RNA expression,antioxidative status and meat fatty acid profile of broiler ***(n=420) were fed 7 diets enriched with different dietary oil sources and ratios as follows: sunflower oil in control diet(C); fish oil(FO); 1:1 ratio of sunflower oil to FO(C1 FO1); 3:1 ratio of sunflower oil to fish oil(C3 FO1); linseed oil(LO); 1:1 ratio of sunflower oil to linseed oil(C1 LO1); 3:1 ratio of sunflower oil to linseed oil(C3 LO1),resulting in dietary n-6:n-3 ratios of approximately 40:1,1.5:1,4:1,8:1,1:1,2.5:1 and 5:1,*** best final body weight,feed conversion ratio as well as protein efficiency ratio of broilers were recorded in the C1 FO1 and C1 LO1 *** with the control group,the dressing percentage and breast and thigh yield were highest in the C1 FO1 and C1 LO1 *** the dietary n-6:n-3 ratio increased(P meat contents of eicosapentaenoic acid and docosahexaenoic acid increased(P m FO and LO clearly decreased(P m total cholesterol,triglycerides and very low-density lipoproteins and enhanced antioxidative *** feeding frequency was decreased(P mpared to plant oil,to broiler diets enhanced the relative m RNA expression of interferon gamma,interleukin-1 beta,interleukin-2 and

关键词： Broiler n-6:n-3 PUFA ratio Performance Antioxidant status meat Immunity

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