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The efficacy of full-thickness endoscopic resection of subepithelial tumors in the gastric cardia

World Journal of Gastrointestinal Oncology 2023年第12期15卷 2111-2119页

作者： en-pan xu Zhi-Peng Qi Bing Li Zhong Ren Ming-Yan Cai Shi-Lun Cai Zhen-Tao Lyv Zhang-Han Chen Jing-Yi Liu Qiang Shi Yun-Shi Zhong endoscopy Center Zhongshan Hospital Fudan UniversityShanghai 200032China

BACKGROUND Gastric subepithelial tumors(SETs)may harbor potential *** it is well recognized that large SETs should be resected,the precise treatment strategy remains *** to surgical resection,endoscopic resection(ER)has many advantages;however,ER of SETs in the cardia is *** To evaluate the safety and efficacy of endoscopic full-thickness resection(EFTR)for the treatment of gastric cardia *** We retrospectively reviewed data from all patients with SETs originating from the muscularis propria layer in the gastric cardia that were treated by EFTR or submucosal tunneling ER(STER)at Zhongshan Hospital Fudan University between November 2014 and May *** characteristics and clinical outcomes,including procedure times and complications rates,were compared between groups of patients receiving EFTR and *** A total of 171 tumors were successfully removed[71(41.5%)tumors in the EFTR and 100(58.5%)tumors in the STER group].Gastrointestinal stromal tumors(GISTs)were the most common *** en bloc resection rate was 100%in the EFTR group vs 97.0%in STER group(P>0.05).Overall,the EFTR group had a higher complete resection rate than the STER group(98.6%vs 91.0%,Pence in total complications between the two groups(21.1%vs 22.0%,P=0.89).CONCLUSION EFTR of gastric cardia SETs is a very promising method to facilitate complete resection with similar complications and reduced operative times compared to *** cases of suspected GISTs or an unclear diagnosis,EFTR should be recommended to ensure complete resection.

关键词： endoscopic full-thickness resection Submucosal tunneling endoscopic resection Gastrointestinal stromal tumor Gastric cardia Gastric subepithelial tumors

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Efficacy of image-enhanced endoscopy for colorectal adenoma detection:A multicenter,randomized trial

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World Journal of Gastrointestinal Oncology 2023年第5期15卷 878-891页

作者： Zhi-Peng Qi en-pan xu Dong-Li He Yan Wang Bai-Sheng Chen xue-Si Dong Qiang Shi Shi-Lun Cai Qi Guo Ni Li Xing Li Hai-Yan Huang Bing Li Di Sun Jian-Guang xu Zhang-Han Chen Ayimukedisi Yalikong Jin-Yi Liu Zhen-Tao Lv Jian-Min xu Ping-Hong Zhou Yun-Shi Zhong endoscopy Center Zhongshan Hospital of Fudan UniversityShanghai 200030China endoscopy Center Shanghai Xuhui Central HospitalShanghai 200030China endoscopy Center Traditional Chinese Medical HospitalRongcheng 264300Shandong ProvinceChina Department of endoscopy Center Xiamen Branch of Affiliated Zhongshan Hospital of Fudan UniversityXiamen 361000Fujian ProvinceChina Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Gastroenterology Pingxiang People’s HospitalPingxiang 337000Jiangxi ProvinceChina Department of Clinical Medicine Xiaogang HospitalNingbo 315000Zhejiang ProvinceChina endoscopy Center Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina Department of General Surgery Zhongshan Hospital of Fudan UniversityShanghai 200030China

BACKGROUND Improved adenoma detection at colonoscopy has decreased the risk of developing colorectal ***,whether image-enhanced endoscopy(IEE)further improves the adenoma detection rate(ADR)is *** To compare IEE with white-light imaging(WLI)endoscopy for the detection and identification of colorectal *** This was a multicenter,randomized,controlled *** were enrolled between September 2019 to April 2021 from 4 hospital in *** were randomly assigned to an IEE group with WLI on entry and IEE on withdrawal(n=2113)or a WLI group with WLI on both entry and withdrawal(n=2098).The primary outcome was the *** secondary endpoints were the polyp detection rate(PDR),adenomas per colonoscopy,adenomas per positive colonoscopy,and factors related to adenoma *** A total of 4211 patients(966 adenomas)were included in the analysis(mean age,56.7 years,47.1%male).There were 2113 patients(508 adenomas)in the IEE group and 2098 patients(458 adenomas)in the WLI *** ADR in two group were not significantly different[24.0%vs 21.8%,1.10,95%confidence interval(CI):0.99-1.23,P=0.09].The PDR was higher with IEE group(41.7%)than with WLI group(36.1%,1.16,95%CI:1.07-1.25,P=0.01).Differences in mean withdrawal time(7.90±3.42 min vs 7.85±3.47 min,P=0.30)and adenomas per colonoscopy(0.33±0.68 vs 0.28±0.62,P=0.06)were not *** analysis found that with narrowband imaging(NBI),between-group differences in the ADR,were not significant(23.7%vs 21.8%,1.09,95%CI:0.97-1.22,P=0.15),but were greater with linked color imaging(30.9%vs 21.8%,1.42,95%CI:1.04-1.93,P=0.04).the second-generation NBI(2G-NBI)had an advantage of ADR than both WLI and the first-generation NBI(27.0%vs 21.8%,P=0.01;27.0%vs 21.2.0%,P=0.01).CONCLUSION This prospective study confirmed that,among Chinese,IEE didn’t increase the ADR compared with WLI,but 2G-NBI increase the ADR.

关键词： endoscopy Image-enhanced endoscopy Adenoma detection rate White-light imaging Narrowband imaging

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m6A修饰在结直肠肿瘤发生发展中的研究进展及潜在治疗价值

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世界华人消化杂志 2021年第23期29卷 1373-1381页

作者：刘婧依李冰徐恩盼钟芸诗复旦大学附属中山医院内镜中心上海市200032 上海消化内镜诊疗工程技术研究中心上海市200032

近年来,作为表观遗传修饰的重要组成部分,DNA组学和蛋白质组学在肿瘤发生发展中的作用机制研究已取得一定突破,而研究者也将目光聚焦在RNA的修饰上.N6-甲基腺嘌呤(N6-methyladenosine,m6A)是真核生物mRNA中主要的内部表观遗传修饰,具有... 详细信息

近年来,作为表观遗传修饰的重要组成部分,DNA组学和蛋白质组学在肿瘤发生发展中的作用机制研究已取得一定突破,而研究者也将目光聚焦在RNA的修饰上.N6-甲基腺嘌呤(N6-methyladenosine,m6A)是真核生物mRNA中主要的内部表观遗传修饰,具有动态且可逆的特点.m6A分别受到甲基化酶(Writers)、去甲基化酶(Erasers)和优先识别m6A修饰的蛋白质(Readers)调控,进一步调节RNA运输、定位、翻译及降解等,在肿瘤的发生发展中发挥促癌或抑癌的作用,并且具有成为恶性肿瘤治疗靶点的潜力.本文将对m6A的生物学特征、m6A RNA的修饰调控机制、m6A RNA甲基化修饰在结直肠肿瘤发生发展中的作用和相关靶向治疗进行综述,旨在为进一步寻找生物标记物和治疗靶点提供依据.

关键词： m6A甲基化表观遗传修饰结直肠肿瘤靶向治疗

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-en xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (ent was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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On water in nominally anhydrous minerals from mantle peridotites and magmatic rocks

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Science China Earth Sciences 2016年第6期59卷 1157-1172页

作者： HUI HeJiu xu YongJiang pan Ming'en State Key Laboratory for Ore Deposit Research School of Earth Sciences and Engineering Nanjing University

Trace amount of water associated with the lattice defects of nominally anhydrous minerals （NAMs） can be measured using Fourier transform infrared spectroscopy （FTIR） and secondary ion mass spectrometry （SIMS）. Lots of data on water in NAMs from different lithologies, especially mantle peridotite xenoliths, have been published. The water distribution in olivine from peridotite xenoliths often displays a diffusion profile with high water concentration in the core and low at the rim, which indicates water loss via diffusion during the ascent of host magma. On the other hand, water is homogeneously distributed in pyroxene and its concentration is typically interpreted to represent a mantle value. The water concentration of magma in equilibrium with NAM can be estimated using specific partition coefficient, from which the water content of parental magma and the mantle source can be inferred. The accuracy of this method, however, depends on the selection of appropriate partition coefficient for the system. Using hydrogen isotope compositions and H2O/Ce ratios of mantle NAMs, water source regions can be traced and water heterogeneity can be mapped in the upper mantle. Water plays an important role in the stability of cratonic mantle. The water contents and vertical distribution patterns can be significantly different among different cratonic manties, which may result from different geologic activities. However, the mantle-plume interaction may not necessarily result in significant change of water content in cratonic mantle. The estimation of the water content in the upper mantle is still largely based on geochemical models due to the limitations of data on water in mantle NAMs.

关键词： Nominally anhydrous minerals Fourier transform infrared spectroscopy Craton stability Water in the upper mantle Magma ascent rate Water in magma

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Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng xu Jing-Kai Wang Bo Chen Hao xu Deng pan Yu-Yang Ma Kun pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

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Radiation dose effects on the morphological development of M_(1) generation pea(Pisum sativum)

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Nuclear Science and Techniques 2021年第11期32卷 63-76页

作者： Da-Peng xu Hu-Yuan Feng Jian-Bin pan Ze-en Yao Jun-Run Wang School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Life Sciences Lanzhou UniversityLanzhou 730000China engineering Research Center for Neutron Application Technology Ministry of EducationLanzhou UniversityLanzhou 730000China

We irradiated pea seeds with neutrons from a ^(252)Cf source and studied the radiation dose effects on various morphological development parameters during the growth of M_(1) generation *** found that in the dose range of 0.51-9.27 Gy,with the increase in neutron-absorbed dose,the morphological development parameters of M_(1) generation peas at the initial seedling stage showed an obvious trend with three *** the development of pea,this trend gradually *** analysis and verification showed that the main trend in the M_(1) generation of pea seeds was an inhibitory effect induced by neutron irradiation and there was a good linear correlation between the inhibitory effect and neutron absorption dose We successfully demonstrated the background removal of mutant plants and defined morphological developmen parameters for peas that match the overall development of *** results will positively impact neutron mutation breeding and automatic agriculture.

关键词： Neutron irradiation Pea(Pisum sativum) ^(252)Cf source Radiation does effects Absorbed dose Morphological development

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A Confidence-based Consensus Model for Multi-Attribute Group Decision Making:Exploring the Bounded Trust Propagation and Personalized Adjustment Willingness

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Journal of Systems Science and Systems engineering 2023年第4期32卷 483-513页

作者： Ling pan Zeshui xu Business School Sichuan UniversityChengdu 610064China

Social trust network(STN)and minimum cost consensus(MCC)models have been widely used to address consensus issues in multi-attribute group decision-making(MAGDM)problems with limited ***,most researchers have overlooked the decision maker‘(DMs)’confidence levels(CLs)and adjustment willingness implicit in their *** address these problems,this paper explores a confidence-based MCC model that considers DMs’adjustment willingness in the *** proposed model includes several modifications to the traditional trust propagation and consensus optimization ***,the improved method for measuring CLs of DMs and the confidence-based normalization approach are defined,***,the bounded trust propagation operator is proposed,which considers the credibility of mediators to complete the ***,the identification rules based on the consensus index and CL are defined,and the MCC model with personalized cost functions and acceptable adjustment thresholds is built to automatically generate adjustment values for non-consensus ***,a model to identify the non-cooperative behavior at the element level is established and the hybrid MCC model with persuasion strategies is ***,a case study is processed to verify the applicability of the proposed model,and comparison and sensitivity analysis are conducted to highlight its benefits.

关键词： Confidence level social trust network bounded trust propagation minimum cost consensus models multi-attribute group decision making

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An energy minimization algorithm based on distributed dynamic clustering for long term evolution(LTE) heterogeneous networks

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Science China(Information Sciences) 2015年第4期58卷 103-114页

作者： TONG en DING Fei pan ZhiWen YOU Xiao Hu National Mobile Communications Research Laboratory Southeast University Research and Development Center China Mobile Group Jiangsu Co. Ltd.

energy saving has become an important issue in wireless communications from both environment and economic considerations. In this paper, an energy minimization algorithm based on distributed dynamic clustering(DDCEM) with lower complexity, higher performance, and better adaptability for heterogeneous network(Het Net) is proposed. A Het Net could be divided into several clusters, which is defined as one group of a network node and users served by the node. A energy efficient user association, which dynamically changes according to real-time energy efficiency(EE) evaluation with traffic load and location distribution of each cluster, can be employed to save consumed energy. Then, the optimal sleeping relay is found as follows. First,the sleeping probability cost of each relay station(RS) is computed and ranked based on the user traffic and the position distribution of each cluster, and the relay with minimum sleeping probability is selected to be switched off. Hence, the sleep node is selected taking into account the traffic load and location of the Evolved Node B(e NB) and all the RSs. The complexity of the algorithm is greatly reduced because the user association operation and network load evaluation are fulfilled cluster by cluster. Simulation results show that the proposed DDCEM strategy offers EE gain with low system complexity.

关键词： energy efficiency heterogeneous network traffic cluster sleeping probability cost

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