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Analgesic and anti-inflammatory activities of the ethanol extract of the leaves of Helianthus Annus in Wistar rats

Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 341-347页

作者： Ejebe Daniel Emamuzo Siminialayi Iyeopu Miniakiri emudainowho joseph oghenebrorie tedwin Ofesi Ufouma Morka Lucky Department of Pharmacology and Therapeutics Delta State University Department of Pharmaccology University of Port-Harcourt Institute of Science Laboratory Technology Delta State University Abraka

Objective:To investigate the anti-inflammatory and analgesic effects of the ethanol extract of leaves of Helianthus annus L.(***) in acclimatized Wistar ***:It was undertaken using the albumin induced paw edema model of inflammation as well as both the hotplate and tail immersion analgesic test *** of the extract tested in experimental rats were 0.5 g/kg,2 g/kg and 4 g/kg while negative and positive control rats received distilled water and indomethacin ***:It was shown that treatment with the tested doses of the extract effectively inhibited paw edema induced by egg *** effect was comparable if not better than the observations made in rats treated with 10 mg/kg of indomethacin *** with the extract was also observed to have significantly increased the mean tolerance time of rats to thermal noxious stimuli compared to control animals that had distilled water and appeared to be more effective than 10 mg/kg of indomethacin ***: These observations confirmed the presence of a strong anti-inflammatory and anti-noiciceptive activity in the ethanol extract of the leaves of *** and therefore validated the folkloric use of the leaves of this plant in treatment of pro-inflammatory,post traumatic situations.

关键词： Analgesic Anti-inflammatory Activities Helianthus annus Rats

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Effects of ethanol extract of leaves of Helianthus annus on the fecundity of Wistar rats

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 435-438页

作者： Ejebe Daniel Emamuzo Siminialayi Iyeopu Miniakiri Emudainohwo joseph oghenebrorie tedwin Kagbo Hope Delesi Amadi Precious Department of Pharmacology Delta State University AbrakaNigeria Department of Pharmacology University of Port HarcourtNigeria Institute of Science Laboratory and Technology Delta State UniversityAbraka Nigeria

Objective:To evaluate the effects of ethanol extract of leaves of Helianthus annus(***) on the fecundity of Wistar ***:Forty(20 male and 20 female) Wistar rats,grouped into control,ethanol extract treated rats and untreated,were used for the *** rats had 0.5 g/kg of ethanol extract orally for 2 weeks;control rats had 5%alcoholic water(solvent);and untreated rats had their normal feed and clean drinking *** treatment,the animals were sub-grouped into 5 mating groups to observe the coital frequency,pregnancy rate and average number of pups per group in ***:The results showed that coital frequency was unaffected by the extract treatment but pregnancy rate and number of pups per rat and per group were reduced significantly in groupsⅡ,ⅢandⅣcompared to those of groupⅠandⅤrats which were not treated with the ethanol extract of leaves of ***:The histodegenerative in the gonads reportedly induced by this ethanol extract in previous studies may be responsible for the reduced fecundity observed in treated adult rats.

关键词： Ethanol extract Helianthus annus Leaves Fecundity Rats

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