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Severe asthma exacerbation:Changes in patient characteristics,management,and outcomes from 1997 to 2016 in 40 ICUs in the greater Paris area

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Journal of Intensive Medicine 2024年第2期4卷 209-215页

作者： Romy Younan Jean Loup Augy Bertrand Hermann Bertrand Guidet Philippe Aegerter emmanuel Guerot Ana Novara Caroline Hauw-Berlemont Amer Hamdan Clotilde Bailleul Francesca Santi Jean-Luc Diehl Nicolas Peron Nadia Aissaoui Intensive Care Unit AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Intensive Care Unit AP-HPSaint Antoine HospitalUniversités de SorbonneUniversitéPierre et Marie CurieParisFrance INSERM U1136 ParisFrance Versailles Saint-Quentin-en-Yvelines University INSERM U1018Groupe Interrégional de Recherche Clinique et d'InnovationÎle-de-FranceFrance Respiratory Medicine Department AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Innovative Therapies in Hemostasis INSERM UMR-S1140Universitéde ParisParisFrance Intensive Care Unit and Biosurgical Research Lab(Carpentier Foundation) AP-HPGeorges Pompidou European HospitalParisFrance Paris-Cardiovascular-Research-Center INSERM U970ParisFrance

Background Despite advances in asthma treatments,severe asthma exacerbation(SAE)remains a life-threatening condition in adults,and there is a lack of data derived from adult patients admitted to intensive care units(ICUs)for *** current study investigated changes in adult patient characteristics,management,and outcomes of SAE over a 20-year period in 40 ICUs in the greater Paris *** In this retrospective observational study,admissions to 40 ICUs in the greater Paris area for SAE from January 1,1997,to December 31,2016 were *** primary outcome was the proportion of ICU admissions for SAE during 5-year *** outcomes were ICU and hospital mortality,and the use of mechanical ventilation and *** analysis was performed to assess factors associated with ICU *** A total of 7049 admissions for SAE were *** each 5-year period,the proportion decreased over time,with SAE accounting for 2.84%of total ICU admissions(n=2841)between 1997 and 2001,1.76%(n=1717)between 2002 and 2006,1.05%(n=965)between 2007 and 2011,and 1.05%(n=1526)between 2012 and *** median age was 46 years(interquartile range[IQR]:32–59 years),55.41%were female,the median Simplified Acute Physiology Score II was 20(IQR:13–28),and 19.76%had mechanical *** use of mechanical ventilation remained infrequent throughout the 20-year period,whereas the use of catecholamine *** and hospital mortality rates *** associated with ICU mortality were renal replacement therapy,catecholamine,cardiac arrest,pneumothorax,acute respiratory distress syndrome,sepsis,and invasive mechanical ventilation(IMV).Non-survivors were older,had more severe symptoms,and were more likely to have received *** ICU admission for SAE remains uncommon,and the proportion of cases decreased over *** a slight increase in symptom severity during a 20-year period,ICU and hospital mortality *** requirin

关键词： Epidemiology Intensive care unit Mechanical ventilation Severe asthma exacerbation

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Standardizing MI-TLIF, a Proposal for a Reproducible Technique

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Open Journal of Modern Neurosurgery 2024年第2期14卷 91-103页

作者： Iván Ulises Sámano López Jesús Alberto Pérez Contreras emmanuel Cantú Chávez Diana Chávez Lizárraga Ana Sofía Peña Blesa Thania Karina Gutiérrez Anchondo Á ngeles Pedregal Ciudad de México México

Background: Minimally invasive transforaminal lumbar interbody fusion (MI TLIF) is a widely known and performed technique, however its versatility among different physicians continues to hinder its replication and results. Therefore, this study aimed to provide a step-by-step surgical guide to perform a safe MI-TLIF, based on the results obtained in patients operated on by a single surgeon over a period of 12 years. Patients and methods: A retrospective, single center, longitudinal, and observational cohort study was conducted with 931 patients who underwent MI TLIF by a single surgeon between 2010 and 2022 using the technique described on this paper, each with a minimum follow-up of 12 months. Criteria included Schizas classification, listhesis according to Meyerding classification, number of levels treated, cage size, and complications (screw repositioning or cerebrospinal fluid leak). Patient clinical outcomes were assessed using the Oswestry Disability Index (ODI), Visual Analog Scale (VAS) for pre- and postoperative radicular pain. Thin slice CT scans were used to assess the progression of the fusion using the Bridwell classification. In the statistical analysis, percentages, median, and interquartile range (IQR) were calculated. Results: Nine hundred and thirty one patients underwent MI TLIF using the technique described, eight hundred and eighty (94.5%) had a single level treated and fifty one (5.5%) had a 2 level procedure (982 levels), an 8mm cage was placed on five hundred and seventeenlevels (52.7%), six hundred and sixty three levels(67.6%) achieved grade I fusion, two hundred and sixty six levels (27.1%) achieved grade II fusion, 52 levels (5.3) achieved grade III fusion and one level (0.1) achieved a grade IV fusion or non-union. Revision surgery was performed on 3 patients (0.3%) for screw repositioning, cerebrospinal fluid leak was present on 2 patients during surgery and treated before closure. VAS scores and ODI were improved at 12 months postop (V

关键词： MITLIF Lumbar Interbody Fusion Technique Pain Relief and Disability

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基于数字孪生技术的往复式空气压缩机效率预测方法研究

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兰州理工大学学报 2024年第1期50卷 48-52页

作者：余建平胡爽刘兴旺田有文仇宏伟 AKOTO emmanuel 兰州理工大学石油化工学院甘肃兰州730050

通过建立往复式空气压缩机数字孪生体模型,实现压缩机效率预测和参数寻优的方法,具有灵活、成本低、通用性好的优势.但是在多变量条件下,传统的基于BP神经网络孪生模型训练时间长、工作量大,寻优过程易陷入局部最优解,不易实现全局最优... 详细信息

通过建立往复式空气压缩机数字孪生体模型,实现压缩机效率预测和参数寻优的方法,具有灵活、成本低、通用性好的优势.但是在多变量条件下,传统的基于BP神经网络孪生模型训练时间长、工作量大,寻优过程易陷入局部最优解,不易实现全局最优.针对传统孪生体模型存在的问题,提出了基于CIWOA-BPNN算法的孪生体模型构建方法,通过主成分分析法确定孪生体模型关键指标,在BPNN模型基础之上引入改进的鲸鱼优化算法.研究表明,基于CIWOA-BPNN算法的孪生体模型有效避免了BPNN模型陷入局部最优解.用CIWOA-BPNN算法预测压缩机效率相对误差小于0.6%,决定系数为0.99775,与传统模型相比大幅提升了预测精度.

关键词：往复式空气压缩机效率 BP神经网络改进的鲸鱼优化算法

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Blockchain-Based System for Secure and Efficient Cross-Border Remittances: A Potential Alternative to SWIFT

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Journal of Software Engineering and Applications 2024年第8期17卷 664-712页

作者： Omoshola S. Owolabi emmanuel Hinneh Prince C. Uche Nathaniel T. Adeniken Jennifer A. Ohaegbulem Samuel Attakorah Oluwabukola G. Emi-Johnson Chinaza S. Belolisa Harold Nwariaku Department of Data Science Carolina University Winston Salem NC USA Patterson School of Business Carolina University Winston Salem NC USA Department of Statistical Sciences Wake Forest University Winston Salem NC USA Department of Computer Science Fisk University Nashville TN USA Harold & Co Procurement and Supply Chain Consulting Lagos Nigeria

This paper proposes a blockchain-based system as a secure, efficient, and cost-effective alternative to SWIFT for cross-border remittances. The current SWIFT system faces challenges, including slow settlement times, high transaction costs, and vulnerability to fraud. Leveraging blockchain technology’s decentralized, transparent, and immutable nature, the proposed system aims to address these limitations. Key features include modular architecture, implementation of microservices, and advanced cryptographic protocols. The system incorporates Proof of Stake consensus with BLS signatures, smart contract execution with dynamic pricing, and a decentralized oracle network for currency conversion. A sophisticated risk-based authentication system utilizes Bayesian networks and machine learning for enhanced security. Mathematical models are presented for critical components, including transaction validation, currency conversion, and regulatory compliance. Simulations demonstrate potential improvements in transaction speed and costs. However, challenges such as regulatory hurdles, user adoption, scalability, and integration with legacy systems must be addressed. The paper provides a comparative analysis between the proposed blockchain system and SWIFT, highlighting advantages in transaction speed, costs, and security. Mitigation strategies are proposed for key challenges. Recommendations are made for further research into scaling solutions, regulatory frameworks, and user-centric designs. The adoption of blockchain-based remittances could significantly impact the financial sector, potentially disrupting traditional models and promoting financial inclusion in underserved markets. However, successful implementation will require collaboration between blockchain innovators, financial institutions, and regulators to create an enabling environment for this transformative system.

关键词： Interoperability Tokens AML/KYC Compliance Peer-to-Peer Transfers Financial Inclusion

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A Unified Spatio-Temporal Framework of the Cuerno-Barabasi Stochastic Continuum Model of Surface Sputtering

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Communications in Theoretical Physics 2012年第7期58卷 165-170页

作者： Oluwole emmanuel Oyewande Department of Physics University of Ibadan

The nonlinear continuum model proposed by Cuerno and Barabasi is the most successful and widely acceptable theoretical description of oblique incidence ion sputtered surfaces to date and is quite robust in its predictions of the time evolution and scaling of interfaces driven by ion bombardment. However, this theory has thus far predicted only ripple topographies and rough surfaces for short and large scales, respectively. As a result, its application to the interpretation and study of nanodots, predicted by Monte Carlo simulations for, and observed in experiments of, oblique incidence sputtering is still unclear and, hence, an open problem. In this paper, we provide a new insight to the theory, within the same length scale, that explains nanodot formation on off-normal incidence sputtered surfaces, among others, and propose ways of observing the predicted topographies of the MC simulations, as well as possible control of the size of the nanodots, in the framework of the Cuerno-Barabasi continuum theory.

关键词： topographic phase diagrams surface nanostructures surface nanodots Cuerno-Barabasi model

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Abiraterone acetate for prostate cancer： a new era ot hormonal therapies

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Asian Journal of Andrology 2011年第5期13卷 663-664页

作者： emmanuel S Antonarakis Johns Hopkins Sidney Kimmel Comprehensive CancerCenter Baltimore MD 21231 USA

Therapies targeting the androgen receptor （AR） axis have constituted the HolyGraft in the management of advanced prostate cancer for seven decades） These hormonal therapies have traditionally taken two main forms： those that suppress gonadal androgen synthesis （e.g., the gonadotropin releasing hormone agonists/antagonists, such as leuprolide）, and those that inhibit the AR directly （e.g., the anti-androgens, such as bicalutamide）. However, although the vast majority of patients with prostate cancer initiaUy respond favorably to androgen-ablative therapies （manifested by tumor regressions and symptomatic improvements）, all patients will eventually develop further disease progression after a median of 18-24 months. This transformed disease state, known as castration-resistant prostate cancer （CRPC）, is invariably fatal.

关键词： Abiraterone hormonal therapies

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Recent developments in the application of oil palm fibers in cement composites

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 94-108页

作者： emmanuel Owoichoechi MOMOH Adelaja Israel OSOFERO School of Engineering University of AberdeenAberdeenAB243UEUK

Fibers obtained from different parts of the oil palm tree(Elaeis guineensis)have been under investigation for possible use in *** have been carried out investigating the engineering properties and possible applications of these ***,the experimental methods employed and the values of mechanical and physical properties recorded by various authors are *** has therefore become necessary to organize information which would be useful in the design of oil palm fiber cement composites and help researchers and engineers make informed decisions in further research and *** review provides information about fibers from different parts of the oil palm,their properties,enhancement techniques,current and potential application in cement composites.

关键词： broom cement composite concrete oil palm fiber Natural fiber-concrete sustainability

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Combining active immunotherapy with immune checkpoint blockade for the treatment of advanced prostate cancer

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Asian Journal of Andrology 2012年第4期14卷 520-521页

作者： emmanuel S Antonarakis Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Baltimore MD 21231 USA

Combination immunotherapy is emerging as a promising approach for the treatment of advanced prostate cancer. This research highlight discusses the combination of a PSA-directed pox-viral vaccine and a monoclonal antibody blocking an important immune checkpoint molecule to treat men with metastatic castration- resistant prostate cancer. The results demonstrate feasibility and safety, as well as intriguing clinical responses to this combination therapy.

关键词： DOSE-ESCALATION TRIAL IPILIMUMAB

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Natural and modified food hydrocolloids as gluten replacement in baked foods:Functional benefits

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Grain & Oil Science and Technology 2023年第4期6卷 163-171页

作者： emmanuel Anyachukwu Irondi Yunus Temitayo Imam emmanuel Oladipo Ajani emmanuel Oladeji Alamu Department of Biochemistry Kwara State UniversityMaletePMB 1530IlorinNigeria Food and Nutrition Sciences Laboratory International Institute of Tropical AgriculturePMB 5320Oyo RoadIbadanOyo StateNigeria Food and Nutrition Sciences Laboratory International Institute of Tropical AgricultureSouthern AfricaResearch and Administration Hub(SARAH)Campus PO Box 310142ChelstoneLusaka 10101Zambia

Gluten,the protein responsible for the superior viscoelastic properties of refined wheat flour dough over glutenfree cereals,causes celiac disease in people susceptible to ***,the sustainability of using wheat flour in baked foods is threatened by its high cost,especially in countries that depend on imported wheat for their bakery *** has shown that hydrocolloids serve as gluten replacements in baked foods,in response to these *** hydrocolloids are a class of high-molecular weight polysaccharides and proteins,which serve as functional ingredients in the food industry that modify the foods’rheological and textural *** function as stabilizers,viscosity modifiers,gelling agents,water binders,fibres,and inhibitors of ice crystal in ***,food hydrocolloids have also been reported to possess health-promoting properties,such as lowering of postprandial blood glucose and plasma cholesterol concentrations,colon cancer prevention,and modulation of intestinal transit and *** are obtained from plants,animals or microorganisms,and can be used in their natural or modified *** aim of this paper is to review the functional benefits of natural and modified hydrocolloids as gluten replacements in baked foods,emphasizing their physicochemical,nutraceutical,and sensorial *** application effects of food hydrocolloids as gluten substitutes in gluten-free baked products’quality were ***,some practical approaches to improve the quality of gluten-free baked products,in response to an increasing consumers’demand and the rising cost of refined wheat flour were highlighted.

关键词： Food hydrocolloids Baked food Functional importance Gluten-free food Nutraceutical benefits Sensory quality

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Spatiotemporal characteristics of white mold and impacts on yield in soybean fields in South Dakota

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Geo-Spatial Information Science 2020年第2期23卷 182-193页

作者： Confiance Mfuka emmanuel Byamukama Xiaoyang Zhang Department of Agronomy Horticulture and Plant ScienceSouth Dakota State UniversityBrookingsSDUSA Geospatial Sciences Center of Excellence South Dakota State UniversityBrookingsSDUSA

White mold of soybeans is one of the most important fungal diseases that affect soybean production in South ***,there is a lack of information on the spatial characteristics of the disease and relationship with soybean *** relationship can be explored with the Normalized Difference Vegetation Index(NDVI)derived from Landsat 8 and a fusion of Landsat 8 and the Moderate Resolution Imaging Spectroradiometer(MODIS)*** study investigated the patterns of yield in two soybean fields infected with white mold between 2016 and 2017,and estimated yield loss caused by white *** show evidence of clustering in the spatial distribution of yield(Moran's I=0.38;p<0.05 in 2016 and Moran's I=0.45;p<0.05 in 2017)that can be explained by the spatial distribution of white mold in the observed *** loss caused by white mold was estimated at 36%in 2016 and 56%in 2017 for the worse disease pixels,with the most accurate period for estimating this loss on 21 August and 8 September for 2016 field and 2017 field,*** study shows the potential of free remotely sensed satellite data in estimating yield loss caused by white mold.

关键词： Soybean white mold Landsat MODIS fusion Kriging NDVI

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