Combining active immunotherapy with immune checkpoint blockade for the treatment of advanced prostate cancer
Combining active immunotherapy with immune checkpoint blockade for the treatment of advanced prostate cancer作者机构：Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Baltimore MD 21231 USA
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2012年第14卷第4期
页 面：520-521页
核心收录：
学科分类：0710[理学-生物学] 090602[农学-预防兽医学] 07[理学] 08[工学] 09[农学] 0906[农学-兽医学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
主 题：DOSE-ESCALATION TRIAL IPILIMUMAB
摘 要：Combination immunotherapy is emerging as a promising approach for the treatment of advanced prostate cancer. This research highlight discusses the combination of a PSA-directed pox-viral vaccine and a monoclonal antibody blocking an important immune checkpoint molecule to treat men with metastatic castration- resistant prostate cancer. The results demonstrate feasibility and safety, as well as intriguing clinical responses to this combination therapy.
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