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Effect of Different Plant Growth Promoting Rhizobacteria on Maize Seed Germination and Seedling Development

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American Journal of Plant Sciences 2013年第5期4卷 1013-1021页

作者： Pacome A.Noumavo Eméric Kochoni Yédéou O.Didagbé Adolphe Adjanohoun Marcellin Allagbé Rachidatou Sikirou emma w.gachomo Simeon O.Kotchoni Lamine Baba-Moussa Laboratoire de Biologie et de Typage Moléculaire en Microbiologie Département de Biochimie et de Biologie CellulaireUniversitéd’Abomey-CalaviCotonouBénin Centre de Recherches Agri-coles Sud Institut National des Recherches Agricoles du BéninAttogonBénin Laboratoire de Défense des Cultures Centre de Recherches Agricoles d’AgonkanmeyInstitut National des Re-cherches Agricoles du BéninCotonouBénin Department of Biology The State University of New JerseyCamdenUSA Center for Computational and Integrative Biology The State University of New JerseyCamdenUSA

Our study aimed at assessing the effects of 3 Plants Growth Promoting Rhizobacteria (PGPR) either singly or in combination on maize growth under laboratory and greenhouse conditions. Seeds were inoculated with single and combined solution of 108 CFU/ml of Rhizobacteria. Seeds were not inoculated for the control variant. The highest germination percentage was obtained with the combination of Pseudomonas fluorescens and Pseudomonas putida. This combination also recorded the best vigor index, plants circumferences number of leaves and the leaf area. The maximal heights of plants were observed with seeds treated with Azospirillum lipoferum with an increase of 37.32%. The highest rates of underground dry matter were recorded with A. lipoferum, with an increase of more than 56% comparative to control, while the combination P. fluorescens and P. putida increased the aerial dry matter of 59.11%. Finally, the highest value of the aerial biomass was obtained with the plants treated with the combination of P. fluorescens and P. putida and the highest underground biomass was obtained with plants treated only with A. lipoferum. These results suggest that specific combinations of PGPR can be considered as efficient alternative biofertilizers to promote maize seed germination, biomass and crop yield.

关键词： Azospirillum Pseudomonas PGPR Biofertlization Maize Seeds Germination Greenhouse

Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman Lauren V.Terry emma D.McLennan Carolina Chavez emma L.Burrows John w.Scott Robyn M.Murphy Henriette van Praag Martin whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

Genome sequencing and next-generation sequence data analysis: A comprehensive compilation of bioinformatics tools and databases

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American Journal of Molecular Biology 2013年第2期3卷 115-130页

作者： Jose C. Jimenez-Lopez emma w. gachomo Sweta Sharma Simeon O. Kotchoni Department of Biochemistry Cell and Molecular Biology of Plants Estacion Experimental del Zaidin High Council for Scientific Research (CSIC) Granada Spain Department of Biology Rutgers University Camden USA

Genomics has become a ground-breaking field in all areas of the life sciences. The advanced genomics and the development of high-throughput techniques have lately provided insight into whole-genome characterization of a wide range of organisms. In the post-genomic era, new technologies have revealed an outbreak of prerequisite genomic sequences and supporting data to understand genome wide functional regulation of gene expression and metabolic pathways reconstruction. However, the availability of this plethora of genomic data presents a significant challenge for storage, analyses and data management. Analysis of this mega-data requires the development and application of novel bioinformatics tools that must include unified functional annotation, structural search, and comprehensive analysis and identification of new genes in a wide range of species with fully sequenced genomes. In addition, generation of systematically and syntactically unambiguous nomenclature systems for genomic data across species is a crucial task. Such systems are necessary for adequate handling genetic information in the context of comparative functional genomics. In this paper, we provide an overview of major advances in bioinformatics and computational biology in genome sequencing and next-generation sequence data analysis. we focus on their potential applications for efficient collection, storage, and analysis of genetic data/information from a wide range of gene banks. we also discuss the importance of establishing a unified nomenclature system through a functional and structural genomics approach.

关键词： Databases Computational Biology Genomics Proteomics Next-Generation Sequencing

Review of primary sclerosing cholangitis with increased IgG4 levels

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world Journal of Gastroenterology 2020年第23期26卷 3126-3144页

作者： Charis D Manganis Roger w Chapman emma L Culver Translational Gastroenterology Unit and Oxford NIHR Biomedical Research Centre John Radcliffe HospitalOxford OX39DUUnited Kingdom

Primary sclerosing cholangitis(PSC) is a chronic progressive liver disease. Subtypes of PSC have been described, most recently PSC with elevated serum and/or tissue IgG4 subclass. we aim to summarise the clinical phenotype,disease associations, differential diagnosis, response to therapy and pathogenic mechanisms underlying PSC-high IgG4 subtype. we reviewed Pub Med,MEDLINE and Embase with the search terms "primary sclerosing cholangitis","IgG4", and "IgG4-related sclerosing cholangitis(IgG4-SC)". Elevated serum IgG4 are found in up-to one-quarter, and abundant IgG4-plasma cell infiltrates in the liver and bile ducts are found in up-to one-fifth of PSC patients. This group have a distinct clinical phenotype, with some studies reporting a more aggressive course of liver and associated inflammatory bowel disease, compared to PSCnormal IgG4 and the disease mimic IgG4-SC. Distinguishing PSC-high IgG4 from IgG4-SC remains challenging, requiring careful assessment of clinical features,organ involvement and tissue morphology. Calculation of serum IgG4:IgG1 ratios and use of a novel IgG4:IgG RNA ratio have been reported to have excellent specificity to distinguish IgG4-SC and PSC-high IgG4 but require validation in larger cohorts. A role for corticosteroid therapy in PSC-high IgG4 remains unanswered, with concerns of increased toxicity and lack of outcome data. The immunological drivers underlying prominent IgG4 antibodies in PSC are incompletely defined. An association with PSC-high IgG4 and HLA class-II haplotypes(B*07, DRB1*15), T-helper2 and T-regulatory cytokines(IL4, IL10,IL13) and chemokines(CCL1, CCR8) have been described. PSC-high IgG4 have a distinct clinical phenotype and need careful discrimination from IgG4-SC,although response to immunosuppressive treatments and long-term outcome remains unresolved. The presence of IgG4 likely represents chronic activation to persistent antigenic exposure in genetically predisposed individuals.

关键词： Primary sclerosing cholangitis IgG4 IgG4-related disease IgG4-related sclerosing cholangitis

High-performance size exclusion chromatography with a multi-wavelength absorbance detector study on dissolved organic matter characterisation along a water distribution system

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Journal of Environmental Sciences 2016年第6期28卷 235-243页

作者： Huiping Huang emma Sawade David Cook Christopher w.K.Chow Mary Drikas Bo Jin School of Chemical Engineering The University of Adelaide Australian water Quality Centre SA Water Corporation250 Victoria Square School of Earth and Environmental Sciences The University of Adelaide

This study examined the associations between dissolved organic matter（DOM） characteristics and potential nitrification occurrence in the presence of chloramine along a drinking water distribution system. High-performance size exclusion chromatography（HPSEC） coupled with a multiple wavelength detector（200–280 nm） was employed to characterise DOM by molecular weight distribution, bacterial activity was analysed using flow cytometry, and a package of simple analytical tools, such as dissolved organic carbon, absorbance at 254 nm, nitrate,nitrite, ammonia and total disinfectant residual were also applied and their applicability to indicate water quality changes in distribution systems were also evaluated. Results showed that multi-wavelength HPSEC analysis was useful to provide information about DOM character while changes in molecule weight profiles at wavelengths less than 230 nm were also able to be related to other water quality parameters. Correct selection of the UV wavelengths can be an important factor for providing appropriate indicators associated with different DOM compositions. DOM molecular weight in the range of 0.2–0.5 kDa measured at210 nm correlated positively with oxidised nitrogen concentration（r = 0.99）, and the concentrations of active bacterial cells in the distribution system（r = 0.85）. Our study also showed that the changes of DOM character and bacterial cells were significant in those sampling points that had decreases in total disinfectant residual. HPSEC-UV measured at210 nm and flow cytometry can detect the changes of low molecular weight of DOM and bacterial levels, respectively, when nitrification occurred within the chloraminated distribution system.

关键词： HPSEC-UV Distribution system DOM Sum of nitrate and nitrite concentration

High-Intensity Interval Training Prescribed within the Secondary Severe-Intensity Domain Improves Critical Speed But Not Finite Distance Capacity

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Journal of Science in Sport and Exercise 2020年第2期2卷 154-166页

作者： emma JThomas Robert w.Pettitt Mark Kramer Biokinetics and Sport Science Unit Nelson Mandela UniversityPort Elizabeth 6070South Africa Rocky Mountain University of Health Professions ProvoUT 84606USA Physical Activity Sport and Recreation Research Focus AreaNorth West UniversityPotchefstroom 2520South Africa

Purpose Improvements in D'(the fatigability constant for running)subsequent to training interventions remain ***-intensity interval training(HIIT)within the severe intensity domain for short durations(was to assess this in a group of moderately trained *** Eighteen participants completed graded exercise testing(GXT),40-m sprint testing and a 3-min all-out test(3MT)for running to determine key mechanistic and physiological *** were randomly assigned into one of two groups based on intensity prescription(G140%=140%of critical speed[CS]),or time intervals(G90-s=90-s)to complete a twice-weekly training intervention for 6-weeks followed by *** No between-group differences were present either prior to or following the *** and meaning-ful improvements were detected during the post-intervention period for both groups for VO2max(G140%:+7.60%;G90-s:+11.67%),speed evoking VO2max(sVO2max;G140%:+4.33%;G90_s:+2.92%),gas exchange threshold(GET;G140%:+12.02%;G90-s:+20.52%),speed evoking GET(sGET;G140%:+4.17%;G90_s:+7.92%),CS(G140%:M=0.62 m/s;G90-s:M=0.46 m/s),D'(G140%:M=-56.34 m;G90-s:M=-18.36 m),FI%(G140%M=-6.75%;G90-s:M=-4.38%)and maximal distance(G140%:M=49.67 m;G90_s:M=58.38 m).Conclusions The prescribed intensities and durations were insufficient to elicit improvements in D'.Improvements in D'may be dependent on very short-duration intervals(i.e.w maximal sprint speed.

关键词： Moderately active Severe intensity Threshold

ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling

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Neural Regeneration Research 2022年第11期17卷 2472-2483页

作者： Nadia McMillan Gregory w.Kirschen Sanket Desai emma Xia Stella E.Tsirka Adan Aguirre Program in Neuroscience and Medical Scientist Training Program Renaissance School of Medicine at Stony Brook UniversityStony BrookNYUSA Department of Pharmacological Sciences Renaissance School of Medicine at Stony Brook UniversityStony BrookNYUSA Department of Neurology Beth Israel Deaconess Medical Center/Harvard Medical SchoolBostonMAUSA Department of Gynecology and Obstetrics Johns Hopkins HospitalBaltimoreMDUSA

The mechanisms that regulate neural stem cell(NSC)lineage progression and maintain NSCs within diffe rent domains of the adult neural stem cell niche,the subventricular zone are not well *** NSCs are arranged at the apical ventricular wall,while mitotically activated NSCs are found in the basal,vascular region of the subventricular ***,we found that ADAM 10(a disintegrin and metalloproteinase 10)is essential in NSC association with the ventricular wall,and via this adhesion to the apical domain,ADAM10 regulates the switch from quiescent and undiffe rentiated NSC to an actively prolife rative and differentiating cell *** of JAMC(junctional adhesion molecule C)by ADAM 10 increases Rap1 GAP *** molecular machinery promotes NSC transit from the apical to the basal compartment and subsequent lineage *** the molecular mechanisms responsible for regulating the proper positioning of NSCs within the subventricular zone niche and lineage progression of NSCs could provide new targets for drug development to enhance the regenerative prope rties of neural tissue.

关键词： ADAM10 adhesion junctional adhesion molecule C neural stem cells neurogenesis olfactory bulb Rap1Gap sub-ventricular zone

Evolving role of magnetic resonance techniques in primary sclerosing cholangitis

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world Journal of Gastroenterology 2019年第6期25卷 644-658页

作者： emmanuel A Selvaraj emma L Culver Helen Bungay Adam Bailey Roger w Chapman Michael Pavlides Oxford Centre for Clinical Magnetic Resonance Research Division of Cardiovascular Medicine Radcliffe Department of Medicine University of Oxford John Radcliffe Hospital Translational Gastroenterology Unit Nuffield Department of Medicine University of OxfordJohn Radcliffe Hospital Oxford NIHR Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust and the University of Oxford Department of Radiology John Radcliffe Hospital

Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis(PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in *** resonance imaging/magnetic resonance cholangiopancreatography(MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance(MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC.

关键词： Primary sclerosing cholangitis Magnetic resonance imaging Magnetic

Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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world Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs w.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne w.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome