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Advanced multimodality imaging of inflammatory bowel disease in 2015: An update

World Journal of Radiology 2016年第6期8卷 571-580页

作者： emma stanley Heather K Moriarty Carmel G Cronin Depart-ment of Radiology Mater Misericordiae University Hospital

The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques.

关键词： Crohn’s disease Multimodality imaging Ulcerative colitis Magnetic resonance imaging Positron emission tomography Inflammatory bowel disease Cross sectional imaging

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可触摸的爱人

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设计 2012年第4期25卷 34-34页

作者： emma Drew stanley

在这个数码横行的世界里，触摸所能带来的亲密感对于人类来说仍旧是无可替代的。由纽约设计师Drew stanley设计的“Touchables”概念服装通过触摸的方式表达出衣服也可以有互动性。

关键词：服装设计设计方案情侣衫创意

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Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

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World Journal of Gastroenterology 2020年第30期26卷 4428-4441页

作者： Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance Centre for Inflammatory Bowel Diseases St John of God HospitalSubiaco 6008Western AustraliaAustralia Translational Gastroenterology Unit NIHR Oxford Biomedical Research CentreOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Inflammatory Bowel Disease Research Group Queensland institute of Medical ResearchHerston 4006QueenslandAustralia Department of Gastroenterology Mater HospitalBrisbane 4101QueenslandAustralia Department of Gastroenterology Mater HospitalSouth Brisbane 4101QueenslandAustralia of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Department of Gastroenterology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalFitzroy 3065VictoriaAustralia Department of Gastroenterology Northern HealthEpping 3076VictoriaAustralia Department of Gastroenterology The Alfred HospitalMelbourne 3004VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalDarlinghurst 2010New South WalesAustralia Department of Gastroenterology Flinders Medical CentreBedford Park 5042South AustraliaAustralia Department of Gastroenterology Liverpool HospitalSydney 2170New South WalesAustralia Department of Gastroenterology Royal Adelaide Hospital&University of AdelaideAdelaide 5000South AustraliaAustralia Department of Gastroenterology Townsville HospitalDouglas 4814QueenslandAustralia Institute for Health Research University of Notre DameFremantle 6160Western AustraliaAustralia School of Medicine and Pharmacology University of Western AustraliaCrawley 6009Western AustraliaAustralia

BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)*** To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving *** A retrospective review of Australian and Oxford,United Kingdom data for UC *** response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were *** regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing *** outcomes were *** Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were *** clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo ***-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 *** VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.

关键词： Vedolizumab Ulcerative colitis Outcomes

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感染、炎症、修复 2023年第3期24卷 158-172页

作者： Matilde Monteiro-Soares emma J.Hamilton David A.Russel Gulapar Srisawasdi Ed J.Boyko Joseph L.Mills William Jeffcoate Fran Game on behalf of the International Working Group on the Diabetic Foot 薛婧(译) 王爱红(审校) Higher School of Health of the Portuguese Red Cross LisbonPortugal Department of Community Medicine Information and Health Decision Sciences(MEDCIDS)Faculty of MedicineUniversity of PortoPortoPortugal RISE@CINTESIS Faculty of MedicineOporto UniversityPortoPortugal Department of Endocrinology and Diabetes Fiona Stanley Hospi-talMurdochAustralia University of Western Australia Medical SchoolFiona Stanley HospitalMurdochAustralia Leeds Institute of Clinical Trials Research University of LeedsLeedsUK Leeds Vascular Institute Leeds Teaching Hospitals NHS TrustLeedsUK Department of Rehabilitation Medicine Sirindhorn School of Prosthetics OrthoticsBangkokThailand Faculty of Medicine Siriraj Hospital Mahidol UniversityBangkokThailand Department of Medicine University of WashingtonSeattleWashingtonUSA Veterans Affairs Puget Sound Health Care System SeattleWashingtonUSA Baylor College of Medicine Michael E.DeBakey Department of SurgeryHoustonTexasUSA Nottingham University Hospitals Trust UK University Hospitals of Derby and Burton NHS Foundation Trust 不详战略支援部队特色医学中心北京100101

本文是对国际糖尿病足工作组(IWGDF)2019年指南的更新,针对在日常临床工作中使用的糖尿病伴足溃疡的分类提出了新指南。本指南基于对现有文献的系统综述,确定了149篇文献中涉及的28种分类,随后使用推荐、评估、发展和评价分级(GRADE)方... 详细信息

本文是对国际糖尿病足工作组(IWGDF)2019年指南的更新,针对在日常临床工作中使用的糖尿病伴足溃疡的分类提出了新指南。本指南基于对现有文献的系统综述,确定了149篇文献中涉及的28种分类,随后使用推荐、评估、发展和评价分级(GRADE)方法获取了专家意见。首先,我们通过对诊断试验的判断总结,制定了一份可能适合在临床实践中使用的分类系统的清单,重点关注每个系统在预测溃疡相关并发症的可用性、准确性和可靠性以及资源可及性。其次,经过小组讨论和共识研讨,我们确定了哪些分类系统应该用于特定的临床场景。总之,对于糖尿病合并足溃疡患者,我们推荐:①医务人员之间的沟通:使用部位、缺血、神经病变、细菌感染、溃疡面积、溃疡深度(SINBAD)分类(第一选择)或考虑使用创面、缺血、足感染(WIfI)分类系统(替代选择,当具备所需的设备和专业水平,并且具有可行性时),针对每例患者,应具体描述组成分类系统的每个变量而不是仅仅报告总分;②不推荐任何现有分类系统用以预测特定个体的具体的溃疡结局;③对于描述有感染的溃疡患者的特征:使用美国感染性疾病学会(IDSA)/IWGDF(第一选择)分类或考虑使用WIfI系统(替代选择,当具备所需的设备和专业水平,并且具有可行性时);④对于描述周围动脉病变患者的特征:考虑使用WIfI系统作为对愈合可能性和截肢风险进行分层的手段;⑤对于人群结果的稽查:使用SINBAD评分。基于GRADE分级,本文提出的所有推荐,证据的可信度是低的。然而,基于对当前数据的合理应用,本文的推荐具有临床应用价值。

关键词：糖尿病相关的足病糖尿病相关的足溃疡分类指南国际糖尿病足工作组

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