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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： Laura Huggon emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Predicting Standardized Precipitation Evapotranspiration Index for Fada N’Gourma by 2050 Using CMPI-6 Outputs under SSPs Scenarios

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Journal of Environmental Science and Engineering(A) 2025年第1期14卷 31-42页

作者： Tog-Noma Patricia emma Bontogho Andrew Ireson Dominic Boateng-Gyambiby Abdullahi Dini High Institute of Sustainable Development University Yembila Abdoulaye ToguyéniBP 54 Fada N’GourmaBurkina Faso Global Institute for Water Security School of Environment and SustainabilityUniversity of SaskatchewanSaskatoonCanada Department of Agricultural and Resource Economics University of Energy and Natural Resourcescity P.O.Box 214SunyaniGhana

Extreme weather events,such as floods and droughts,are expected to rise significantly worldwide as a result of climate *** future drought patterns is therefore a key approach for elaborating anticipatory water resources management responses to climate *** this paper,future meteorological drought conditions are investigated based on the SPEI(Standardised Precipitation Evapotranspiration Index).This study makes use of observed and projected *** simulated data were retrieved from the CMIP6(Coupled Model Intercomparison Project Phase 6)over the period 2025-2050,and the Delta change method was adopted to remove the bias in the *** SPEI at various scales has been estimated under four future scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5).The trend analysis of the projected SPEI was performed at p<0.05 using the MMK(Modified Mann-Kendall)test in order to detect the statistically significant trend of the drought against the null hypothesis of no *** show large variability in the magnitude of drought in the past and *** on SPEI at 24 months accumulation,the result shows that under SSP1-2.6,the basin will experience a wet period during the first decade(SPEI=0.60),the second decade will be dry(SPEI24=-0.43).The remaining years will be also dry(SPEI=-0.34).Under SSP2-4.5,SSP3-7.0 and SSP5-8.5 scenarios,the district will experience a wet period during the first two decades with SPEI ranging from 0.38 to *** wet period will be followed by a dry period under these scenarios ranging from-0.14 ***,under SSPs scenarios,two main periods characterized by a rainfall recovery spanning from followed by a moderately prolonged drought are identified within the study *** findings of this study may provide valuable information for developing proactive measures to reduce water insecurity in Fada N’Gourma through effective drought mitigation.

关键词： Climate change drought index CMPI-6 Fada N’Gourma SSP-scenarios.

The birth hour of mammals:insights from intra-specific variation in wild blue monkeys

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Current Zoology 2022年第5期68卷 499-506页

作者： Marina Cords emma Gometz Department of Ecology Evolution and Environmental BiologyColumbia UniversityNew YorkNY 10027USA New York Consortium in Evolutionary Primatology 695 Park AvenueNew YorkNY 10065USA

While most mammals show birth hour peaks at times of the 24-h cycle when they are less active,there are exceptions to this general *** exceptions have been little explored,but may clarify evolutionary reasons for the diel timing of *** investigated intraspecific variation in birth hour in wild blue monkeys Cercopithecus mitis stuhlmanni,a diurnal primate,to identify factors that differentiated daytime versus nighttime *** and life history data from 14 groups over 14 years revealed that 4%of 484 births occurred during the *** of daytime birth varied with mother’s age,peaking at 15.7 *** whose annual timing deviated most from the population’s peak birth months were 5 times more likely to occur during daytime than those that deviated *** was no evidence that mother’s rank or infant sex influenced birth hour,and mixed evidence that daytime births were more probable in larger *** did not differ significantly for infants born during the day versus ***-aged mothers may be able to handle the consequences of an unusual birth hour more successfully than mothers with less experience or those weakened by *** birth may be more advantageous in the off-season because nights are colder at that time of *** findings are consistent with hypotheses relating birth hour to the risk of losing social protection in group-living animals,but are not consistent with those emphasizing risk of conspecific *** of within-species variation can help in evaluating evolutionary hypotheses for non-random birth hour.

关键词： birth timing Cercopithecus mitis circadian pattern diel cycle guenon parturition

Interconnection Gridlock Threatens Transition to Renewable Energy

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Engineering 2024年第5期36卷 3-5页

作者： emma Hiolski Senior Technology Writer

In October 2023,the International Energy Agency(IEA)released a report identifying inadequate grid infrastructure as a key threat to meeting the climate goals laid out by the Paris Agreement[1],the landmark 2015 international treaty in which 196 parties agreed to limit global warming to well below 2℃ above preindustrial levels[2].Importantly,funding for the treaty’s calledfor transition from fossil fuels to clean energy has accelerated[3],with recently legislated massive governmental subsidies and other incentives(e.g.,the Inflation Reduction Act[4])aimed specifically at promoting renewable ***,a commensurate surge in investment in electrical grids has not materialized;instead,it has stagnated for the past decade at around 300 billion USD per year worldwide[1].

关键词： Transition instead massive

On a Generalized Centralizer Ring of a Finite Group Which Det ermines the Group

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Algebra Colloquium 2019年第1期26卷 31-50页

作者： emma L. Rode Department of Mathematics Southern Utah University Cedar City UT 84720 USA

The k-characters are class functions on subsets of G^k called the k-classes of G. For a finite group G, the k-class sums form a basis for a subring of CG^k, which we call the k-S-ring of G、and we think of these rings as generalized centralizer rings. We show that for a finite group G the 3-S-ring determines G. More specifically, the group characters and set products of certain 3-classes of G, which we call “uniform 3-classes", determine G.

关键词： S-ring fc-class centralizer ring

Improving effectiveness of protection efforts in tiger source sites:Developing a framework for law enforcement monitoring using MIST

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Integrative Zoology 2010年第4期5卷 363-377页

作者： emma J.STOKES Wildlife Conservation Society Global Conservation ProgramBronxNew YorkUSA

Wild tigers are in a critical state with an estimated population decline of more than 95%over the past *** the capacity and effectiveness of law enforcement in reducing poaching of tigers is an immediate priority to secure remaining wild populations in source *** 2008-2010,standardized patrol-based law enforcement monitoring(LEM)was established under the Tigers Forever Program across 8 key tiger sites in order to improve and evaluate law enforcement ***-based monitoring has the distinct advantage of providing regular and rapid information on illegal activities and ranger performance,although,until recently,it has received relatively little scrutiny from the conservation *** present paper outlines a framework for implementation of LEM in tiger source sites using MIST,a computerized management information system for ranger-based data *** framework addresses many of the technical,practical and institutional challenges involved in the design,implementation,sustainability and evaluation of *** of such a framework for LEM is a cost-effective strategy to improve the efficiency of law enforcement efforts,to increase the motivation of enforcement staff and to promote the accountability of law enforcement agencies in addressing threats to *** combined with independent,systematic and science-based monitoring of tigers and their prey,LEM has great potential for evaluating the effectiveness of protection-based conservation investments.

关键词： law enforcement monitoring MIST protected areas protection tigers

The effects of acquired paternal obesity on the next generation

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Asian Journal of Andrology 2011年第2期13卷 195-196页

作者： Neil A Youngson emma Whitelaw Queensland Institute of Medical Research 300 HerstonRoad Herston Brisbane 4006 Australia

It is well established that the health of mothers can influence the health of theiroffspring, i ms can occur as a result or me transfer of viruses or toxins via the placenta or the milk, a compromised nutrient supply to the embryo or abnormal behavioural inter- actions between mother and offspring） However, examples of paternal health affecting the next generation are rare.

关键词： Mothers Health Rats Milk Administration Managers Males

Genomic structural variation in tomato and its role in plant immunity

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Molecular Horticulture 2022年第1期2卷 91-100页

作者： emma Jobson Robyn Roberts Montana State University Extension Montana State UniversityBozemanMT 59717United States Agricultural Biology Department College of Agricultural SciencesColorado State UniversityFort CollinsCOUSA

It is well known that large genomic variations can greatly impact the phenotype of an *** Variants(SVs)encompass any genomic variation larger than 30 base pairs,and include changes caused by deletions,inversions,duplications,transversions,and other genome *** to their size and complex nature,until recently,it has been difficult to truly capture these *** advances in sequencing technology and computational analyses now permit more extensive studies of SVs in plant *** tomato,advances in sequencing technology have allowed researchers to sequence hundreds of genomes from tomatoes,and tomato *** studies have identified SVs related to fruit size and flavor,as well as plant disease response,resistance/susceptibility,and the ability of plants to detect pathogens(immunity).In this review,we discuss the implications for genomic structural variation in plants with a focus on its role in tomato *** also discuss how advances in sequencing technology have led to new discoveries of SVs in more complex genomes,the current evidence for the role of SVs in biotic and abiotic stress responses,and the outlook for genetic modification of SVs to advance plant breeding objectives.

关键词： Immunity Structural variation Tomato Genetic engineering Disease Sequencing

Synaptopathy in CHMP2B frontotemporal dementia highlights the synaptic vesicle cycle as a therapeutic target

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Neural Regeneration Research 2023年第2期18卷 315-316页

作者： Miranda Robbins emma L.Clayton MRC Laboratory of Molecular Biology Department of Zoology University of CambridgeCambridgeUK UK Dementia Research Institute at King’s College London Department of Basic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonMaurice Wohl Clinical Neuroscience InstituteLondonUK

Amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD)are both devastating neurodegenerative *** affecting different regions of the nervous system(FTD affecting primarily the frontal and temporal lobes,whilst ALS presents with motor neuron loss),there is significant overlap between these conditions in terms of genetics,pathology,and disease mechanisms,and they are therefore often grouped as a spectrum of symptoms under the heading FTD/ALS(Abramzon et al.,2020).Significantly,there is currently no cure for ALS or ***,recent mechanistic insight points to a novel pathway to target for potential therapeutic intervention.

关键词： therapeutic pathology