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Proposed age-stratified reference intervals of FSH derived from normozoospermic men

Asian pacific Journal of Reproduction 2021年第4期10卷 162-167页

作者： emily-jane waller Jason Conceicao Phillip Matson John L Yovich School of Medical and Health Sciences Edith Cowan UniversityJoondalupPerthAustralia PIVET Medical Centre LeedervillePerthAustralia School of Pharmacy and Biomedical Sciences Faculty of Health SciencesCurtin UniversityBentleyPerthAustralia

Objective:To demonstrate that serum follicle-stimulating hormone(FSH)in men rises with age,and to explore FSH reference intervals of age-related ***:Men aged 20-50 years(n=1190)underwent semen analysis according to World Health Organization(2010)*** was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur®XP immunoassay *** central 95%intervals after logarithmic transformation based on age were derived from 1037 normozoospermic *** were then applied to oligozoospermic and azoospermic *** producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria,including genetic analysis and surgical ***:Serum FSH in normozoospermic men increased with age(P<0.05),and reference intervals were determined with 10-year brackets:21-30 years[(1.0-8.2)IU/L],31-40 years[(1.4-9.5)IU/L],41-50 years[(1.9-12.0)IU/L].The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men,which in turn was lower among azoospermic men(both P<0.01).The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia,and 86.4%(38/44)men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7%(1/15)men with obstructive azoospermia had high FSH levels,and this was significantly different(P<0.01).Conclusions:FSH concentrations increase in men between 20-50 years,and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals.

关键词： Male infertility FSH Reference intervals Age Obstructive azoospermia Non-obstructive azoospermia

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A 63-Year-Old Male with D-Transposition of the Great Arteries Who Had an Early Form of the Arterial Switch Operation

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Congenital Heart Disease 2024年第1期19卷 65-68页

作者： Michael A.Rebolledo jane S.Yao Jason N.Johnson Umar S.Boston Benjamin R.waller III Division of Pediatric Cardiology Department of PediatricsThe University of Tennessee Health Science CenterThe Heart InstituteLe Bonheur Children’s HospitalMemphisUSA College of Medicine The University of Tennessee Health ScienceMemphisUSA Division of Pediatric Cardiothoracic Surgery Department of SurgeryThe University of Tennessee Health Science CenterHeart InstituteLe Bonheur Children’s HospitalMemphisUSA

We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the *** review the clinical and imaging data that support our *** had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and *** case may represent one example of the experimental surgical work done prior to *** Jatene’s description of theﬁrst successful arterial switch performed in 1975.

关键词： Adult congenital heart disease arterial switch operation great vessel anomaly imaging(all modalities)

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Inhibition of tumor autophagy: a strategy to improve antitumorimmunity?

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Signal Transduction and Targeted Therapy 2021年第1期6卷 3-4页

作者： Andrew JFreeman emily JLelliott jane Oliaro Cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVIC 3000Australia Sir Peter MacCallum Department of Oncology The University of MelbourneParkvilleVIC 3010Australia Department of Immunology and Pathology Monash UniversityMelbourneVIC 3004Australia

In a study recently published in Nature,Lawson et *** several pathways previously implicated in tumor cell sensitivity to cytotoxic T lymphocytes(CTLs),and identify autophagy as an additional pathway involved in mediating tumor immune evasion.1 Autophagy is a regulated and conserved multistep process that enables cells to degrade and recycle intracellular components and is critical for cellular *** has recently been associated with tumor immune evasion in pancreatic ductal adenocarcinoma,2 whereby this process selectively targeted the degradation of major histocompatibility complex I(MHC-I),limiting recognition,and anti-tumor responses by ***,Lawson et *** an additional role for autophagy in tumor immune evasion,by mediating resistance to cytokine-mediated cell death.

关键词： immunity homeostasis limiting

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作者： emily jane Fox.

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Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations:a systematic review and meta-analysis

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World Journal of Pediatric Surgery 2022年第4期5卷 204-210页

作者： Irina Oltean Lamia Hayawi Victoria Larocca Vid Bijelić emily Beveridge Manvinder Kaur Viviane Grandpierre jane Kanyinda Ahmed Nasr Department of Surgery Children's Hospital of Eastern OntarioOttawaOntarioCanada Clinical Research Unit Children's Hospital of Eastern Ontario Research InstituteOttawaOntarioCanada

Background No systematic review and meta-analysis to date has examined multiple child and parent-reported social and physical quality of life(QoL)in pediatric populations affected by Hirschsprung’s disease(HD)and anorectal malformations(ARM).The objective of this systematic review is to quantitatively summarize the parent-reported and child-reported psychosocial and physical functioning scores of such *** Records were sourced from the CENTRAL,EMBASE,and MEDLINE *** that reported child and parent reported QoL in children with HD and ARM,regardless of surgery intervention,versus children without HD and ARM,were *** primary outcome was the psychosocial functioning scores,and the secondary outcomes were the presence of postoperative constipation,postoperative obstruction symptoms,fecal incontinence,and enterocolitis.A random effects meta-analysis was *** Twenty-three studies were included in the systematic review,with 11 studies included in the ***,1678 total pediatric patients with HD and ARM underwent surgery vs 392 healthy *** parent-reported standardized mean(SM)scores showed better social functioning after surgery(SM 91.79,95%CI(80.3 to 103.3),I2=0).The pooled standardized mean difference(SMD)showed evidence for parent-reported incontinence but not for constipation in children with HD and ARM after surgery that had a lower mean QoL score compared with the normal population(SMD−1.24(-1.79 to–0.69),I2=76%and SMD−0.45,95%CI(−1.12 to 0.21),I2=75%).The pooled prevalence of child-reported constipation was 22%(95%CI(16%to 28%),I2=0%).The pooled prevalence of parent-reported postoperative obstruction symptoms was 61%(95%CI(41%to 81%),I2=41%).Conclusion The results demonstrate better social functioning after surgery,lower QoL scores for incontinence versus controls,and remaining constipation and postoperative obstruction symptoms after surgery in children with HD and ARM.

关键词： surgery Hirschsprung analysis

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Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 1604-1617页

作者： Katie J.Hogan Hayriye Oztatlı Marissa R.Perez Sophia Si Reyhan Umurhan Elysa Jui Ziwen Wang emily Y.Jiang Sa R.Han Mani Diba K.jane Grande-Allen Bora Garipcan Antonios G.Mikos Department of Bioengineering Rice UniversityMS-1426500 Main StreetHoustonTX 77030USA Baylor College of Medicine Medical Scientist Training Program HoustonTX 77030USA Institute of Biomedical Engineering Bo�gazic¸i University_Istanbul34684Turkey

Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engineering scaffolds with complex geometries and *** methacryloylated gelatin nanoparticles(GNP-MAs)3DP inks have been developed,which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and ***,novel DBM nanoparticles(DBM-NPs,∼400 nm)were fabricated and characterized prior to incorporation in 3DP *** objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks,assess the impact of ultraviolet(UV)crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal *** addition of methacryloylated DBM-NPs(DBM-NP-MAs)to composite colloidal inks(100:0,95:5 and 75:25 GNP-MA:DBM-NP-MA)did not significantly impact the rheological properties associated with printability,such as viscosity and shear recovery or *** crosslinking with a UV dosage of 3 J/cm2 directly impacted the rate of 3DP scaffold swelling for all GNP-MA:DBM-NP-MA ratios with an∼40%greater increase in scaffold area and pore area in uncrosslinked versus photocrosslinked scaffolds over 21 days in phosphate-buffered saline(PBS).Likewise,degradation(hydrolytic and enzymatic)over 21 days for all DBM-NP-MA content groups was significantly decreased,∼45%less in PBS and collagenase-containing PBS,in UV-crosslinked versus uncrosslinked *** incorporation of DBM-NP-MAs into scaffolds decreased mass loss compared to GNP-MA-only scaffolds during collagenase *** in vitro osteogenic study with bone marrow-derived mesenchymal stem cells demonstrated osteoconductive properties of 3DP scaffolds for the DBM-NP-MA contents examine

关键词： demineralized bone matrix colloidal hydrogels 3D printing bone tissue engineering

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呼啸山庄

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英语画刊(高中版) 2017年第30期 3-5页

作者：艾米莉·勃朗特

《呼啸山庄》是英国女作家艾米莉·勃朗特的作品,是19世纪英国文学的代表作之一,根据这部小说改编的影视作品至今久演不衰。它被人认为是英国文学史上一部"最奇特的小说",字里行间充满着丰富的想象和狂飙般猛烈的情感,具有震撼人心的艺... 详细信息

《呼啸山庄》是英国女作家艾米莉·勃朗特的作品,是19世纪英国文学的代表作之一,根据这部小说改编的影视作品至今久演不衰。它被人认为是英国文学史上一部"最奇特的小说",字里行间充满着丰富的想象和狂飙般猛烈的情感,具有震撼人心的艺术力量。本文节选自该书简写版第一章和第二章。

关键词：希斯克利夫呼啸山庄凯瑟琳《圣经》

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母亲从未教我的事

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家庭科技 2014年第11期 18-18页

作者： emily-jane Cl

如何装扮自己我小时候,妈妈从不在自己脸上涂涂抹抹。她不会在早上花几个小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子,也不要求我必须保持裙子干净,更不会把我丢到一个迷你型化妆聚会里,给我买发亮的公主鞋。相反,她... 详细信息

如何装扮自己我小时候,妈妈从不在自己脸上涂涂抹抹。她不会在早上花几个小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子,也不要求我必须保持裙子干净,更不会把我丢到一个迷你型化妆聚会里,给我买发亮的公主鞋。相反,她给我穿短裤和T恤,叫我到户外跟朋友一起玩耍、奔跑。她给我穿上长筒雨靴,看我踩在水坑里,水花四溅。我玩泥巴弄脏了衣服,她一点都不在乎。她从未告诉我,作为女孩,漂亮是最重要的事。我在成长中意识到,有比漂亮更重要的东西,比如友

关键词：妈妈饼干糕点

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母亲从未教我的事

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少年儿童研究 2014年第12期 47-47页

作者： emily-jane Cl

我小时候,妈妈从不在脸上涂涂抹抹。她不会在早上花几小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子、给我穿上必须保持干净的裙子、把我丢到一个迷你型化妆聚会里,或者给我买发亮的公主鞋。相反,她给我穿短裤和T恤,叫... 详细信息

我小时候,妈妈从不在脸上涂涂抹抹。她不会在早上花几小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子、给我穿上必须保持干净的裙子、把我丢到一个迷你型化妆聚会里,或者给我买发亮的公主鞋。相反,她给我穿短裤和T恤,叫我到户外跟朋友一起玩耍、奔跑。她给我穿上长筒雨靴,看我踩在水坑里,水花四溅。我玩泥巴弄脏了衣服,她一点儿都不在乎。

关键词：母亲化妆头发妈妈裙子朋友

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母亲从未教我的事

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学生阅读世界（初中生） 2015年第1期 16-16页

作者： emily-jane CI 英

如何装扮自己小时候，我记得妈妈从不在脸上涂涂抹抹。她不会在早上花几个小时化妆、打理头发或者涂指甲。她从未把我的头发编成法式辫子、给我穿上必须保持干净的裙子、把我丢到一个迷你型化妆聚会里，或者给我买发亮的公主鞋。

关键词：母亲迷你型小时化妆头发

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