检索结果-南通市图书馆

Update of transmission modelling and projections of gambiense human African trypanosomiasis in the Mandoul focus, Chad

引用

Infectious Diseases of Poverty 2022年第1期11卷 34-46页

作者： Kat S.Rock Ching-I huang Ronald E.Crump Paul R.Bessell Paul E.Brown Inaki Tirados Philippe Solano Marina Antillon Albert Picado Severin Mbainda Justin Darnas emily h.crowley Steve J.Torr Mallaye Peka Mathematics Institute University of WarwickAcademic Loop RoadCoventryCV47ALUK Zeeman Institute for Systems Biology&Infectious Disease Epidemiology Research(SBIDER) University of WarwickAcademic Loop RoadCoventryCV47ALUK Independent Consultant EdinburghUK Department of Vector Biology Liverpool School of Tropical MedicineLiverpoolUK Institut de Recherche pour le Développement UMR INTERTRYP IRD-CIRADUniversitéde Montpellier34398MontpellierFrance Swiss Tropical and Public health Institute BaselSwitzerland University of Basel BaselSwitzerland Foundation for Innovative New Diagnostics(FIND) GenevaSwitzerland Programme National de Lutte contre la Trypanosomiase humaine Africaine(PNLThA) MoundouChad

Background:In recent years,a programme of vector control,screening and treatment of gambiense human African trypanosomiasis(ghAT)infections led to a rapid decline in cases in the Mandoul focus of *** represent the biology of transmission between humans and tsetse,we previously developed a mechanistic transmission model,fitted to data between 2000 and 2013 which suggested that transmission was interrupted by *** present study outlines refinements to the model to:(1)Assess whether elimination of transmission has already been achieved despite low-level case reporting;(2)quantify the role of intensified interventions in transmission reduction;and(3)predict the trajectory of ghAT in Mandoul for the next decade under different ***:Our previous ghAT transmission model for Mandoul was updated using human case data(2000-2019)and a series of model *** include how diagnostic specificity is incorporated into the model and improvements to the fitting method(increased variance in observed case reporting and how underreporting and improvements to passive screening are captured).A side-by-side comparison of fitting to case data was performed between the ***:We estimated that passive detection rates have increased due to improvements in diagnostic availability in fixed health facilities since 2015,by 2.1-fold for stage 1 detection,and 1.5-fold for stage *** find that whilst the diagnostic algorithm for active screening is estimated to be highly specific(95%credible interval(CI):99.9-100%,Specificity=99.9%),the high screening and low infection levels mean that some recently reported cases with no parasitological confirmation might be false *** also find that the focus-wide tsetse reduction estimated through model fitting(95%CI:96.1-99.6%,Reduction=99.1%)is comparable to the reduction previously measured by the decline in tsetse catches from monitoring *** line with previous results,the model suggests that transmission was

关键词： Gambiense human African trypanosomiasis (ghAT) Modelling Elimination of transmission Validation Tsetse Vector control Glossina Diagnostics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Female Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

引用

Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie emily M. Dantes Jennifer h. Shaw Dani Zoorob health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Department of Biomedical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between female infertility and obesity across various regions of the United States, utilizing data from the NIh’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese females at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in medically underserved areas where healthcare access is limited. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its impact on infertility. Further, these results advocate for enhanced public health education and policies aimed at improving healthcare accessibility, with the goal of mitigating the adverse effects of obesity on reproductive health.

关键词： Female Infertility Medical Deserts Obesity South

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对h_(2)O_(2)良性应激的动态响应

引用

Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 emily Woodcock 杨羲 hiromi Nishikawa Elena V.Sviderskaya Masanobu Oshima Christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(h_(2)O_(2))*** clinical trials targeting h_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell h_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(hPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular h_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and h_(2)O_(2)*** to 0.1 or 1 mmol/L h_(2)O_(2)eustress increased the extracellular to intracellular h_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L h_(2)O_(2)*** h_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some h_(2)O_(2)-targeted therapies due to their ineffectiveness in generating h_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of h_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of h_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other h_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of an esfenvalerate plus methoprene aerosol for the control of eggs and fifth instars of Plodia interpunctella （Lepidoptera： Pyralidae）

引用

Insect Science 2010年第1期17卷 21-28页

作者： emily A. Jenson Frank h. Arthur James R. Nechols Kansas State University USDA-ARS Grain Marketing and Production Research Center Manhattan KS USA

Aerosol insecticides may provide an alternative to fumigants for control of the Indianmeal moth, Plodia interpunctella （hübner）, the Indianmeal moth, a major insect pest of stored processed food. In this study, eggs and larvae （5th instars） ofP. interpunctella were exposed to aerosol applications of the pyrethroid esfenvalerate and insect growth regulator methoprene, alone and in combination, in open and obstructed positions inside small sheds. When larvae were exposed to methoprene alone, adult emergence from those exposed larvae was 7.1% ± 1.5%. In contrast, adult emergence was 92.5% ± 3.5% when larvae were exposed to esfenvalerate alone. When eggs were exposed to methoprene, adult emergence of those exposed eggs was approximately 75%; however, when eggs were exposed to esfenvalerate, adult emergence was approximately 35%. In the combination treatment of methoprene plus esfenvalerate at their respective label rates, adult emergence following larval exposure was 0.91% ±0.61% compared to 16.3% ± 9.6% when eggs were exposed. Based on our results, methoprene alone is highly effective in reducing adult emergence after larval exposure. however, it is not as effective on eggs as esfenvalerate. A combination treatment of esfenvalerate plus methoprene could be used to control eggs and the wandering-phase larval stages ofP. interpunctella. An economic risk analysis also supports a strategy of combining methoprene and esfenvalerate.

关键词： control Indianmeal moth Plodia interpunctella

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ’long-haulers’?

引用

Chronic Diseases and Translational Medicine 2021年第1期7卷 14-26页

作者： emily Wood Katherine h.hall Warren Tate Department of Biochemistry Health Sciences DivisionUniversity of OtagoDunedinNew Zealand Department of General Practice and Rural health Otago Medical School-Dunedin CampusUniversity of OtagoDunedinNew Zealand

A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.

关键词： Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using self-determination theory to identify organizational interventions to support coal mineworkers’ dust-reducing practices

引用

International Journal of Mining Science and Technology 2019年第3期29卷 371-378页

作者： emily J.haas Centers for Disease Control and Prevention National Institute for Occupational Safety and Health

Advancing the application of safety and health(S&h)technologies is likely to remain a value in the mining ***,any information that technologies generate must be translated from the organization to the workforce in a targeted way to result in sustainable *** a case study approach with continuous personal dust monitors(CPDMs),this paper argues for an organizational focus on technology *** CPDMs provide mineworkers with near real-time feedback about their respirable coal dust exposure,they do not ensure that workers or the organization will continuously use the information to learn about and reduce exposure *** study used self-determination theory(SDT)to help three mines manage and communicate about information learned from the CPDM ***,35 mineworkers participated in two mixed-method data collection efforts to discuss why they do or do not use CPDMs to engage in dust-reducing ***,the data was analyzed to better understand how organizations can improve the integration of technology through their management *** indicate that using the CPDM to reduce sources of dust exposure is consistent with mineworkers’self-values to protect their health and not necessarily because of compliance to a manager or mine.

关键词： Autonomous organization Continuous personal dust monitor Respirable coal mine dust Safety and health management system Self-determination theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of conspecifics and personal experience on behavioral avoidance of contaminated flowers by bumblebees

引用

Current Zoology 2019年第4期65卷 447-455页

作者： Bertrand Fouks emily G. Robb h. Michael G. Lattorff lnstitut fur Biologie Molekulare Okologie Martin-Luther-Universitat Halle-Wittenberg Hoher Weg Halle (Saale) Germany Centre for Ecological and Evolutionary Synthesis (CEES) Department of Biosciences University of Oslo Oslo Norway Microbes and Pathogens Biology The Institute for Global Food Security School of Biological Sciences Queen's University Belfast United Kingdom lnternational Centre of Insect Physiology and Ecology (ICIPE) Nairobi Kenya German Centre for Integrative Biodiversity Research (iDiv) halle-Jena-Leipzig Deutscher Platz Leipzig Germany

Pollinators use multiple cues whilst foraging in eluding direct cues from flowers and in direct cues from other pollinators. The use of indirect social cues is common in social in sects, such as honeybees and bumblebees, where a social environment facilitates the ability to use such cues. Bumblebees use cues to forage on flowers according to previous foraging experiences. Flowers are an essential food source for pollinators but also pose a high risk of parasite infection through the shared use of flowers leading to parasite spillover. Nevertheless, bumblebees have evolved behavioral defense mechanisms to limit parasite infection by avoiding contaminated flowers. Mechanisms underlying the avoidance of contaminated flowers by bumblebees are poorly understood. Bumblebees were recorded having the choice to forage on non-contaminated flowers and flowers contaminated by a trypan osome gut parasite, Crithidia bombi. The use of different treatments with presence or absence of con specifics on both con taminated and non-contami nated flowers allowed to investigate the role of social visual cues on their pathogen avoidance behavior. Bumblebees are expected to use social visual cues to avoid contaminated flowers. Our study reveals that the presence of a con specific on flowers either con taminated or not does not help bumblebee foragers avoiding contaminated flowers. Nevertheless, bumblebees whereas gaining experie nee tend to avoid their con specific when placed on contami nated flower and copy it whe n on the non-contami nated flower. Our experime nt suggests a detrime ntal impact of floral see nt on disease avoidanee behavior.

关键词： host-parasite in teractions social learning pollinators inadvertent social information behavioral immunity copying behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

highly efficient GaAs solar cells by limiting light emission angle

引用

Light(Science & Applications) 2013年第1期2卷 236-241页

作者： emily D Kosten Jackson h Atwater James Parsons Albert Polman harry A Atwater Thomas J.Watson Laboratories of Applied Physics California Institute of TechnologyPasadenaCA 91125 USA Center for Nanophotonics FOM-Institute AMOLFScience Park 1041098XG AmsterdamThe Netherlands

In a conventional flat plate solar cell under direct sunlight,light is received from the solar disk,but is re-emitted *** isotropic emission corresponds to a significant entropy increase in the solar cell,with a corresponding drop in ***,using a detailed balance model,we show that limiting the emission angle of a high-quality GaAs solar cell is a feasible route to achieving power conversion efficiencies above 38%with a single *** highest efficiencies are predicted for a thin,light trapping cell with an ideal back reflector,though the scheme is robust to a non-ideal back *** with a conventional planar cell geometry illustrates that limiting emission angle in a light trapping geometry not only allows for much thinner cells,but also for significantly higher overall efficiencies with an excellent rear ***,we present ray-tracing and detailed balance analysis of two angular coupler designs,show that significant efficiency improvements are possible with these couplers,and demonstrate initial fabrication of one coupler design.

关键词： detailed balance GaAs solar cell light trapping photovoltaics two photon lithography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Altered physiology of gastrointestinal vagal afferents following neurotrauma

引用

Neural Regeneration Research 2021年第2期16卷 254-263页

作者： emily N.Blanke Gregory M.holmes emily M.Besecker Department of health Sciences Gettysburg CollegeGettysburgPAUSA Department of Neural and Behavioral Sciences Penn State University College of MedicineHersheyPAUSA

The adaptability of the central nervous system has been revealed in several model *** particular interest to central nervous system-injured individuals is the ability for neural components to be modified for regain of *** both types of neurotrauma,traumatic brain injury and spinal cord injury,the primary parasympathetic control to the gastrointestinal tract,the vagus nerve,remains anatomically ***,individuals with traumatic brain injury or spinal cord injury are highly susceptible to gastrointestinal *** gastrointestinal dysfunctions attribute to higher morbidity and mortality following traumatic brain injury and spinal cord *** the vagal efferent output remains capable of eliciting motor responses following injury,evidence suggests impairment of the vagal *** sensory input drives motor output,this review will discuss the normal and altered anatomy and physiology of the gastrointestinal vagal afferents to better understand the contributions of vagal afferent plasticity following neurotrauma.

关键词： gastrointestinal functions microbiome neurotrauma nodose ganglia sensory neuropathy spinal cord injury traumatic brain injury vagal afferents visceral reflexes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Variations in Typhoon Landfalls over China

引用

Advances in Atmospheric Sciences 2006年第5期23卷 665-677页

作者： emily A.FOGARTY James B. ELSNER Thomas h. JAGGER Kam-biu LIU Kin-sheun LOUIE Department of Geography The Florida State University TallahasseeFlorida Department of Anthropology and Geography The Louisiana State University Department of Public and Social Administration City University of hong Kong

The interannual variability in typhoon landfalls over China is investigated using historical and modern records. For the purpose of substantiating and elaborating upon the claim of north to south variation in tropical cyclone activity over China, a north-to-south anti-correlation in yearly activity is confirmed in the historical cyclone records. When cyclone activity over the province of Guangdong is high （low）, it tends to be low （high） over the province of Fujian. A similar spatial variation is identified in the modern records using a factor analysis model, which delineates typhoon activity over the southern provinces of Guangdong and hainan from the activity over the northern provinces of Fujian, Taiwan, Zhejiang, Shanghai, Jiangsu, and Shandong. A landfall index of typhoon activity representing the degree to which each year follows this pattern of activity is used to identify correlated climate variables. A useful statistical regression model that includes sea-level pressure differences between Mongolia and western China and sea-surface temperature （SST） over the northwestern Pacific Ocean during the summer explains 26% of the interannual variability of the landfall index. It is suggested that a stronger than normal north-south pressure gradient increases the surface easterly wind flow over northern China： this, coupled with lower SST over the Pacific, favors typhoons taking a more westerly track toward southern China.

关键词： typhoons southern China historical record climate variables

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：