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Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease

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Neural Regeneration Research 2021年第11期16卷 2132-2140页

作者： Tara M.Caffrey emily b.button Jerome Robert Djavad Mowafaghian Center for brain Health University of British ColumbiaVancouverBCCanada Department of Pathology University of British ColumbiaVancouverBCCanada Institute of Clinical Chemistry University Hospital of ZurichZurichSwitzerland

The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and *** supply is coordinated by the action of neurons,glial and vascular cells,known collectively as the neurovascular unit,which temporally and spatially regulate local cerebral blood flow through a process known as neurovascular *** many neurodegenerative diseases,changes in functions of the neurovascular unit not only impair neurovascular coupling but also permeability of the blood-brain barrier,cerebral blood flow and clearance of waste from the *** order to study disease mechanisms,we need improved physiologicallyrelevant human models of the neurovascular *** towards modeling the cellular complexity of the neurovascular unit in vitro have been made using stem-cell derived organoids and more recently,vascularized organoids,enabling intricate studies of non-cell autonomous *** and design innovations in microfluidic devices and tissue engineering are progressing our ability to interrogate the *** advanced models are being used to gain a better understanding of neurodegenerative disease processes and potential *** innovation is required to build more physiologically-relevant models of the neurovascular unit encompassing both the cellular complexity and designed features to interrogate neurovascular unit functionality.

关键词： Alzheimer’s disease cerebrovasculature in vitro model neurodegeneration neurovascular unit

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鸡的繁殖

中国家禽 1982年第1期 35-38+14页

作者： a.b.gilbert 陈开松上海农学院

鸡没有家畜所具有的“发情周期”以及分为“发情期”和“妊娠期”的繁殖时期。只要条件合适,它在同一时期中卵泡连续发育和排卵,现代的雌鸡已是一种“不可限量的产蛋鸡”。

关键词：卵黄物质母鸡公鸡性成熟精子数卵壳腺类固醇激素甾体激素产蛋周期

Analytical and finite-element study of optimal strain distribution in various beam shapes for energy harvesting applications

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Acta Mechanica Sinica 2016年第4期32卷 670-683页

作者： b.L.Ooi J.M.gilbert A.Rashid A.Aziz Faculty of Integrative Sciences and Technology Quest International University Perak (QIUP) Faculty of Science and Engineering School of EngineeringUniversity of Hull Center for Automotive Research and Electric Mobility(CAREM) Universiti Teknologi PETRONAS (UTP)

Owing to the increasing demand for harvesting energy from environmental vibration for use in self-powered electronic applications, cantilever-based vibration energy harvesting has attracted considerable interest from various parties and has become one of the most common approaches to converting redundant mechanical energy into electrical energy. As the output voltage produced from a piezoelectric material depends largely on the geometric shape and the size of the beam, there is a need to model and compare the performance of cantilever beams of differing *** paper presents the study of strain distribution in various shapes of cantilever beams, including a convex and concave edge profile elliptical beam that have not yet been discussed in any prior literature. both analytical and finite-element models are derived and the resultant strain distributions in the beam are computed based on a MATLAb solver and ANSYS finite-element analysis tools. An optimum geometry for a vibration-based energy harvesting system is ***, experimental results comparing the power density for triangular and rectangular piezoelectric beams are also presented to validate the findings of the study, and the claim, as suggested in the literature, is verified.

关键词： harvesting triangular elliptical verified normalized piezoelectric cantilever redundant validate rectangular

Lingual Raynaud's phenomenon in a patient with mixed connective tissue disease

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Rheumatology & Autoimmunity 2021年第2期1卷 101-103页

作者： emily L.gilbert Division of Rheumatology Mayo ClinicJacksonvilleFloridaUSA

1|TEXT I present a case of lingual Raynaud's phenomenon(RP)in a 37-year-old Caucasian woman followed for mixed connective tissue disease(MCTD).During scheduled follow-up,she shared a selfie photograph demonstrating RP of the tongue with deep blue/violet *** was asymptomatic and had not recently eaten or drunk any cold or frozen food or *** tongue returned to normal coloration after about 2 min.

关键词： lingual Raynaud's mixed connective tissue disease

品牌城市，品牌国家：国家与城市品牌的含义就从北京奥运会和上海世博会西方观众

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品牌城市，品牌国家：国家与城市品牌的含义就从北京奥运会和上海...

作者： emily gilbert 复旦大学

学位级别：硕士

夏季奥运会和世界博览会的地方都发生在中国两年内互相年,展示走上了国际舞台世界大事中国的崛起。本文将探讨中国落后的托管的两个事件,从不同的媒介理论观点,其影响。它将讨论国家和城市的品牌,媒体框架,关于这些事件的看法和中国西部... 详细信息

夏季奥运会和世界博览会的地方都发生在中国两年内互相年,展示走上了国际舞台世界大事中国的崛起。本文将探讨中国落后的托管的两个事件,从不同的媒介理论观点,其影响。它将讨论国家和城市的品牌,媒体框架,关于这些事件的看法和中国西部,并寻求了解以及中国和各自城市的参与能够有效地‘品牌’自己。制作使用定性访谈,本研究将比较和对比与西方受访者的回应上述理论。它会结束时指出,虽然这两个事件可能已经成功举办,也促成了事件的中国民族品牌固化从国际视角。

关键词：北京奥运会上海世博会国家品牌城市品牌诬陷西方的看法

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外弹道数学

外弹道数学

POLYMER SCIENCE AND TECHNOLOGY IN THE PAST AND THE FUTURE:HEROISM,EXPLORATION AND ENLIGHTENMENT

丛书名：本书原名：Mathematics for exterior ballistics

1958年

作者：（美）吉尔勃托（a.b.gilbert）王文藻译

来源：汇雅图书（南通市图书馆... 评论

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Chinese Journal of Polymer Science 2000年第3期18卷 189-193页

作者： RobertG.gilbert Key Centre for Polymer Colloids Sydney University Sydney NSW 2006 Australia

The scientific and technical history of polymerization can be divided into three periods, which will be illustratedfor emulsion polymerization. The first period was when emulsion polymers were originally produced, and was developed asan attempt to copy natural rubber latex. Indeed, the natural process is quite different from the synthetic process of emulsionpolymerization, which in fact does not even need an emulsion to be present: the term is a misnomer! The results werefunctional but limited. In the second period, the first theories appeared, and a huge range of products was madefor surface coatings, adhesives, commodity polymers such as SbR, neoprene, etc. The work of the outstanding pioneers wasbased on limited types of experimental data, and some suppositions are now seen to be incorrect. Nevertheless, manyexcellent products were made and have evolved to many materials currently in everyday use. The third period of emulsionpolymerization is now dawning. The scientific efforts of many teams over previous decades, aided by the advent of newphysical techniques for investigation, have resulted in better understanding of the fundamentals of emulsion *** examples from the author's group involve creating novel materials using controlled seeded emulsion polymerizationfrom natural rubber latex and other polyenes. Latex topology and controlled free-radical chemistry can be combined toproduce a) a comb polymer with hydrophobic backbone and hydrophilic 'teeth', or b) with sufficient in situ compatibilizerbetween two otherwise incompatible polymers to yield a spatially uniform material down to the nanostructure level, and c) toproduce controlled nanostructures.

关键词： Polymer rubber Emulsion polymerization Natural rubber DMAEMA Polybutadiene polyisoprene grafting

Long-term monitoring of cycles in Clethrionomys rutilus in the Yukon boreal forest

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Integrative Zoology 2024年第1期19卷 27-36页

作者： Charles J.KREbS Alice J.KENNEY b.Scott gilbert Rudy bOONSTRA Department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Renewable Resources Management Program Yukon UniversityWhitehorseYukonCanada Department of biological Sciences University of Toronto ScarboroughTorontoOntarioCanada

baseline studies of small rodent populations in undisturbed ecosystems are *** report here 50 years of mon-itoring and experimentation in Yukon of a dominant rodent species in the North American boreal forest,the red-backed vole Clethrionomys *** voles breed in summer,weigh 20–25 g,and reach a maximum density of 20 to 25 per *** populations have shown consistent 3–4-year cycles for the last 50 years with the only change being that peak densities averaged 8/ha until 2000 and 18/ha since that *** the last 25 years,we have measured food resources,predator numbers,and winter weather,and for 1-year social interactions,to estimate their contribution to changes in the rate of summer increase and the rate of overwinter *** these potential limiting factors could contribute to changes in density,and we measured their relative contributions statistically with multiple *** rate of winter decline in density was related to both food supply and winter *** rate of summer increase was related to summer berry crops and white spruce cone *** measure of predator numbers was related to winter or summer changes in vole *** was a large signal of climate change effects in these *** is no density dependence in summer population growth and only a weak one in winter population *** of our results provide a clear understanding of what generates 3–4-year cycles in these voles,and the major missing piece may be an understanding of social interactions at high density.

关键词： boreal forest climate change density dependence population cycles predation winter severity

Pornography use among adolescents and the role of primary care

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Family Medicine and Community Health 2023年第1期11卷 33-38页

作者： Grace b Jhe Jessica Addison Jessica Lin emily Pluhar Department of Psychiatry and behavioral Sciences Boston Children's HospitalBostonMAUSA Department of Psychiatry Harvard Medical SchoolBostonMAUSA Division of Adolescent/Young Adult Medicine Boston Children's HospitalBostonMassachusettsUSA Department of Pediatrics Harvard Medical SchoolBostonMAUSA Division of Adolescent and Transition Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOhioUSA Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOHUSA Division of Sports Medicine Boston Children’s HospitalBostonMAUSA

Given the increase in pornography use among adolescents over the years,we discuss the impact of its use on sexual health development as well as the role of primary care providers(PCPs)in assessing use and providing sexual health *** pornography use is often viewed negatively,it is important to develop unbiased understanding of the use in order to provide non-judgemental,adolescent-focused and educational *** PCPs are often the first point of contact when adolescents experience medical and behavioural health concerns,it is essential for them to be equipped to screen for pornography use effectively,create a confidential and comfortable environment to talk about pornography use and sexuality,and be informed of ways to promote open discussion between youth and *** addition to PCP involvement,parental collaboration,knowledge and comfortability with discussing pornography use with their child are powerful tools in understanding and navigating pornography use in this *** special communication seeks to provide an objective view of adolescents’pornography use,guidelines for screening of pornography use and ways to facilitate conversations about the use between adolescents and caregivers.

关键词： adolescent equipped parental