Stem cell heterogeneity and regenerative competence:the enormous potential of rare cells

作     者：Emily A.B.Gilbert Cindi M.Morshead Emily A.B. Gilbert;Cindi M. Morshead

作者机构：Terrence Donnelly Centre for Cellular and Biomolecular ResearchDivision of AnatomyDepartment of SurgeryUniversity of TorontoTorontoONCanada Institute of Biomedical and Biochemical EngineeringInstitute of Medical ScienceUniversity of TorontoKITEToronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第2期

页      面：285-286页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：organs rare potential 

摘      要：Reconstitution of complex multi-tissue organs is one of the most impressive feats of biology and is observed across regeneration-competent vertebrate species,including teleost fish(e.g.,zebrafish),urodeles(e.g.,axolotls and newts),and some *** ability within these species ranges from muscle(including cardiac),skeletal structures,to complex systems such as the brain,spinal cord and parts of the eye which are all capable of structural and functional repair following injury(Tanaka and Ferretti,2009).In stark contrast,re-establishment of multi-tissue structures is very rarely observed following embryogenesis in regeneration-incompetent *** of digit tips is the most dramatic example of mammalian regeneration,but pales in comparison to other species in the animal ***,a complete recapitulation of complex organs or structures in mammals will remain out of reach for a considerable time;however,an improved understanding of regenerat i ve mechanisms would likely enhance the development of novel regenerative medicine *** we focus on the diversity and commonalities of stem cells,which could underlie complex tissue regeneration.