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Open Journal of Animal Sciences 2013年第4期3卷 1-7页

作者： emilio pimentel Luz M. Vidal Martha Patricia Cruces Mariusz Krzysztof Janczur Departamento de Biología Instituto Nacional de Investigaciones Nucleares (ININ) Ocoyoacac México Facultad de Ciencias Universidad Autónoma del Estado de México Toluca México

Protoporphyirin-IX (PP-IX) is a precursor of the biosynthesis of the hemo group, most of the cytochromes and the chlorophylls. The PP-IX is used for medical purposes, and recently a report indicated that it exhibits a dual action since it can decrease or increase the genetic damage caused by N-nitroso-N-ethylurea (ENU) in somatic cells of Drosophila. PP-IX is known to be able to act as an anti-or pro-oxidant agent. The aim of the present research was to study the role of PP-IX on the lifespan of Drosophila melanogaster, taking into account the fact that increasing levels of ROS can accelerate the aging process. The Canton-S strain (CS) was used as well as Sod and Cat which are deficient in the endogenous enzymes, superoxide dismutase and catalase, respectively. Groups of females and males were treated separately with 5 mg/ml of PP-IX solution. The comparison of survival curves indicates that this pigment extended the lifespan of CS. In contrast, Sod strain showed that the opposite effect and had no effect in Cat strain. The fact that PP-IX reduces the mean lifespan in Sod deficient strain might suggest a pro-oxidant action of PP-IX, and consequently the cumulating of ROS as a superoxide could have a mutagenic effect as was shown recently. The results presented evidence of the dual effect of PP-IX.

关键词： Protoporphyrin IX (PP-IX) Lifespan Sod Cat Reactive Oxygen Species Longevity Drosophila melanogaster

A new method of discriminating different types of post-Archean ophiolitic basalts and their tectonic significance using Th-Nb and Ce-Dy-Yb systematics

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Geoscience Frontiers 2015年第4期6卷 481-501页

作者： emilio Saccani Dipartimento di Fisica e Scienze della Terra Università di Ferrara

In this paper, a new discrimination diagram using absolute measures of Th and Nb is applied to postArchean ophiolites to best discriminate a large number of different ophiolitic basalts. This diagram was obtained using 〉2000 known ophiolitic basalts and was tested using -560 modern rocks from known tectonic settings. Ten different basaltic varieties from worldwide ophiolitic complexes have been examined. They include two basaltic types that have never been considered before, which are：（1） medium-Ti basalts （MTB） generated at nascent forearc settings; （2） a type of mid-ocean ridge basalts showing garnet signature （G-MORB） that characterizes Alpine-type （i,e., non volcanic） rifted margins and ocean-continent transition zones （OCTZ）. In the Th-Nb diagram, basalts generated in oceanic subductionunrelated settings, rifted margins, and OCTZ can be distinguished from subduction-related basalts with a misclassification rate 〈 1%. This diagram highlights the chemical variation of oceanic, rifted margin, and OCTZ basalts from depleted compositions to progressively more enriched compositions reflecting, in turn, the variance of source composition and degree of melting within the MORB-OIB array. It also highlights the chemical contributions of enriched （OIB-type） components to mantle sources. Enrichment of Th relative to Nb is particularly effective for highlighting crustal input via subduction or crustal contamination. Basalts formed at continental margin arcs and island arc with a complex polygenetic crust can be distinguished from those generated in intra-oceanic arcs in supra-subducrion zones （SSZ） with a misclassification rate 〈1%. Within the SSZ group, two sub-settings can be recognized with a misclassification rate 〈0.5%. They are：（1） SSZ influenced by chemical contribution from subduction- derived components （forearc and intra-arc sub-settings） characterized by island arc tholeiitic （IAT） and boninitic basalts; （2） SSZ with no contribution from subduction-derived comp

关键词： Basalts Ophiolite Discrimination diagram Trace elements Plate tectonics

Predicting 2D silicon allotropes on SnS2

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Nano Research 2017年第5期10卷 1697-1709页

作者： emilio Scalise Michel Houssa Max-Planck-lnstitut fur Eisenforschung GmbH Max-Planck-StraBe 1 40237 Dusseldorf Germany Semiconductor Physics Laboratory Department of Physics and Astronomy University of Leuven Celestijnenlaan 200 D B-3001 Leuven Belgium

A first principles study on the stability and structural and electronic properties of two-dimensional silicon allotropes on a semiconducfing layered metal-chalcogenide compound, namely SnS2, is performed. The interactions between the two- dimensional silicon layer, commonly known as silicene, and the layered SnS2 template are investigated by analyzing different configurations of silicene. The calculated thermodynamic phase diagram suggests that the most stable configuration of silicene on SnS2 belongs to a family of structures with Si atoms placed on three different planes; so-called dumbbell silicene. This particular dumbbell silicene structure preserves its atomic configuration on SnS2 even at a temperature of 500 K or as a ＂flake＂ layer （i.e., a silicene cluster terminated by H atoms）, thanks to the weak interactions between the silicene and the SnS2 layers. Remarkably, an electric field can be used to tune the band gap of the silicene layer on SnS2, eventually changing its electronic behavior from semiconducting to （semi）metallic. The stability of silicene on SnS2 is very promising for the integration of silicene onto semiconducting or insulating substrates. The tunable electronic behavior of the silicene/SnS2 van der Walls heterostructure is very important not only for its use in future nanoelectronic devices, but also as a successful approach to engineering the bang-gap of layered SnS2 paving the way for the use of this layered compound in energy harvesting applications.

关键词： silicene tin sulfide van der Waals (vdW)heterostructure dumbbell chalcogenide

Smart inverter operation in distribution networks with high penetration of photovoltaic systems

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Journal of Modern Power Systems and Clean Energy 2015年第4期3卷 504-511页

作者： emilio GHIANI Fabrizio PILO Department of Electrical and Electronic Engineering University of CagliariCagliariItaly

With the growing number and capacity of photovoltaic(PV)installations connected to distribution networks,power quality issues related to voltage regulation are becoming relevant problems for power distribution companies and for PV *** many countries,like Italy,this has required the revision of the standards concerning the connection to the public distribution network of distributed renewable *** new standards require a flexible operation of generation plants that have to be capable to change the active and reactive power dynamically in function of the network parameters(*** and network local voltage)in local control or following external ***,this paper investigates the use of smart inverter in a critical PV installation,where relevant voltage fluctuations exist.A case study,with real network parameters monitoring data and measurements,is discussed in the paper with the aim of showing how‘smart’features of new inverters can be implemented to increase PV plant integration in low voltage distribution networks.

关键词： Distributed generation Photovoltaic installations Voltage profile Radial distribution networks Measurements on power systems

Adaptive phase field modelling of crack propagation in orthotropic functionally graded materials

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Defence Technology（防务技术） 2021年第1期17卷 185-195页

作者： Hirshikesh emilio Martínez-Paneda Sundararajan Natarajan Department of Mechanical Engineering Indian Institute of Technology MadrasChennai600036India Department of Civil and Environmental Engineering Imperial College LondonLondonSW72AZUK

In this work,we extend the recently proposed adaptive phase field method to model fracture in orthotropic functionally graded materials(FGMs).A recovery type error indicator combined with quadtree decomposition is employed for adaptive mesh *** proposed approach is capable of capturing the fracture process with a localized mesh refinement that provides notable gains in computational *** implementation is validated against experimental data and other numerical experiments on orthotropic materials with different material *** results reveal an increase in the stiffness and the maximum force with increasing material orientation *** study is then extended to the analysis of orthotropic *** is observed that,if the gradation in fracture properties is neglected,the material gradient plays a secondary role,with the fracture behaviour being dominated by the orthotropy of the ***,when the toughness increases along the crack propagation path,a substantial gain in fracture resistance is observed.

关键词： Functionally graded materials Phase field fracture Polygonal finite element method Orthotropic materials Recovery based error indicator

Principles of surgical resection in hilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 139-146页

作者： emilio Ramos Department of General Surgery Hospital Universitario de BellvitgeUniversidad de Barcelona08907 BarcelonaSpain

The aim of this article is to describe the surgical techniques for the treatment of hilar cholangiocarcinoma(HC).Resection with microscopically negative margin(R0) is the only way to cure patients with ***,resection of the caudate lobe and part of segment Ⅳ,combined with a right or left hepatectomy,bile duct resection,lymphadenectomy of the hepatic hilum and sometimes vascular resection,is the standard surgical procedure for *** frozen-section examination of proximal and distal biliary margins is necessary to confirm the suitability of *** lymphadenectomy probably has little direct effect on survival,inaccurate staging information may influence post resection treatment *** venous and arterial resections should be undertaken in selected cases to achieve a R0 *** concept of 'no-touch proposed' in 1999 by Neuhaus et al combine an extended right hepatectomy with systematic portal vein resection and caudate lobectomy avoiding hilar dissection and possible intraoperative microscopic dissemination of cancer *** recently minor liver resections have been proposed for treatment of *** the hilar bifurcation of the bile ducts is near to liver segments Ⅳ,Ⅴ and Ⅰ,adequate liver resection of these segments together with the bile ducts can result in cure.

关键词： Cholangiocarcinoma Surgery Technique

A human translational model based on neuroplasticity for pharmacological agents potentially effective in Treatment-Resistant Depression: focus on dopaminergic system

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Neural Regeneration Research 2020年第6期15卷 1027-1029页

作者： Ginetta Collo emilio Merlo Pich Department of Molecular and Translational Medicine Section of PharmacologyUniversity of BresciaBresciaItaly Department of Biomedicine University of BaselBaselSwitzerland(Collo G)Neuroscience Therapeutic Area UnitTakeda Pharmaceuticals InternationalZurichSwitzerland Division of Brain Science Imperial CollegeLondonUK(Merlo Pich E

Major depressive disorder(MDD)is a common psychiatric condition characterized by two main symptoms,low mood and *** 15–30%of people suffering from MDD do not respond to standard-of-care antidepressants,e.g.,the serotonin re-uptake inhibitors(SSRI),and are considered affected by Treatment-Resistant Depression(TRD).The neurobiology of this condition is presently *** attempts of developing novel treatments for TRD have been driven by four major breakthroughs:(1)Increasing dopaminergic neurotransmission improves TRD symptoms;(2)Anhedonia occurs when central dopaminergic neurotransmission is low;(3)Enhanced neuroplasticity is critical for the action of antidepressants;(4)Ketamine shows antidepressant properties in TRD patients and triggers neuroplasticity in preclinical animal *** breakthroughs are at the basis of a putative human translational cellular model for antidepressant agents that we are proposing in this *** rationale is briefly described here.

关键词： breakthrough plasticity translational

Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods

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World Journal of Gastroenterology 2014年第37期20卷 13325-13342页

作者： emilio Marengo Elisa Robotti Department of Sciences and Technological Innovation University of Piemonte Orientale

Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this f

关键词： Pancreatic cancer Biomarker identification Multivariate analysis Principal component analysis Ranking principal component analysis

The pharmacological treatment of epilepsy:recent advances and future perspectives

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Acta Epileptologica 2021年第1期3卷 141-151页

作者： emilio Perucca Department of Internal Medicine and Therapeutics Division of Clinical and Experimental PharmacologyUniversity of PaviaVia Ferrata 927100 PaviaItaly Department of Neuroscience Central Clinical SchoolMonash UniversityMelbourneVictoria 3004Australia

The pharmacological armamentarium against epilepsy has expanded considerably over the last three decades,and currently includes over 30 different antiseizure *** this large armamentarium,about one third of people with epilepsy fail to achieve sustained seizure freedom with currently available *** sobering fact,however,is mitigated by evidence that clinical outcomes for many people with epilepsy have improved over the *** particular,physicians now have unprecedented opportunities to tailor treatment choices to the characteristics of the individual,in order to maximize efficacy and *** present article discusses advances in the drug treatment of epilepsy in the last 5 years,focusing in particular on comparative effectiveness trials of second-generation drugs,the introduction of new pharmaceutical formulations for emergency use,and the results achieved with the newest *** article also includes a discussion of potential future developments,including those derived from advances in information technology,the development of novel precision treatments,the introduction of disease modifying agents,and the discovery of biomarkers to facilitate conduction of clinical trials as well as routine clinical management.

关键词： Epilepsy Seizures Drug therapy Antiepileptic drugs Antiseizure medications Advances Review

Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression

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Neural Regeneration Research 2018年第4期13卷 645-646页

作者： Ginetta Collo emilio Merlo Pich Department of Molecular and Translational Medicine Section of PharmacologyUniversity of Brescia Department of Biomedicine University of Basel Neuroscience Therapeutic Area Unit Takeda Pharmaceuticals International Division of Brain Science Imperial College

Depression refers to a series of mental health issues characterized by loss of interest and enjoyment in everyday life,low mood and selected emotional,cognitive,physical and behavioral *** is a common disorder,affecting 5–15%of the general *** diagnosed as major depressive disorder（MDD）,patients are currentlytreated with pharmacological agents such as serotonin or noradren- aline uptake inhibitors （SSRI or SNRI） or tricyclics.

关键词： MEK ERK Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression TRD MDD